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INDONESIA
Jurnal Kefarmasian AKFARINDO
Published by Akademi Farmasi Indonesia Yogyakarta
ISSN : 25287257     EISSN : 25287265     DOI : -
Core Subject : Health, Science, Social,
Immunology & microbiology Medicine & Pharmacology Social Sciences
The journal includes various fields of pharmaceuticals sciences such as: -Pharmacology and Toxicology -Pharmacokinetics -Community and Clinical Pharmacy -Pharmaceutical Chemistry -Pharmaceutical Biology -Pharmaceutics -Pharmaceutical Technology -Biopharmaceutics -Pharmaceutical Microbiology and Biotechnology -Alternative medicines
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 8 Documents
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Search results for , issue "Vol 7 No 2 (2022)" : 8 Documents clear
PERAN miRNA-21 PENEKAN GEN PTEN PENSIYALAN PI3K/AKT PADA KANKER KOLOREKTAL Ismail, Ismail; Pulio, Arisanti; Bura, Elvin; Selfiana; Mutmainnah, Nur
Jurnal Kefarmasian Akfarindo Vol 7 No 2 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.121

Abstract

Colorectal cancer is one of the leading causes of death in the world caused by various factors such as genetic mutations, epigenetics, dysregulation of communication signaling pathways and gut microbiota. In the presence of genetic, epigenetic mutations, there is a loss of expression and function of PTEN (Phosphatase and TENsin homologues) resulting in continued activation of the PI3K/Akt intracellular signaling cascade involved in colorectal carcinogenesis. The solution to this problem is to use miRNA-21. which plays an important role by suppressing the biological marker PTEN gene that is useful for diagnosis and treatment in colorectal cancer. The aim of this study was to determine the specifi c binding of miRNA-21 with the PTEN gene that plays a role in colorectal cancer based on the AGhybrid and Logistic Probability values. Complete sequences of PTEN genes were obtained from FASTA NCBI and CDS data were obtained from Refseq. Prediction of the binding of mature miRNA-21 with the PTEN gene was carried out using the StarMir Sfold 2.2 website. The predicted results of miRNA-21 binding with 1 target obtained 296 binding models. Specific binding was seen from AGhybrid -23.600 and logistic probability 0.818, there was a binding between PTEN gene binding and miR-21-5p at seedless CDS position 3627-3653 as evidenced by the lowest AGhybrid value of all bindings that occurred.
HUBUNGAN MEDICATION RELATED BURDEN DENGAN KEPATUHAN TERAPI PADA PASIEN STROKE DI RUMAH SAKIT PKU MUHAMMADIYAH GAMPING PERIODE OKTOBER – NOVEMBER 2021 Hanita Christiandari; Supadmi, Woro; Sudibyo, Joko
Jurnal Kefarmasian Akfarindo Vol 7 No 2 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.122

Abstract

Stroke menduduki urutan ketiga terbesar penyebab kematian setelah penyakit jantung dan kanker, dengan laju mortalitas 18 % sampai 37 % untuk stroke pertama dan 62 % untuk stroke berulang. Stroke membutuhkan perawatan pengobatan jangka panjang, yang dapat menimbulkan beban pengobatan pada pasien. Beban pengobatan dalam jangka panjang tersebut dapat mengurangi kepatuhan terapi. Penelitian bertujuan mengetahui beban pengobatan, tingkat kepatuhan pasien, dan hubungan antara beban pengobatan dengan tingkat kepatuhan pasien Stroke di RS PKU Muhammadiyah Gamping. Penelitian ini merupakan penelitian observasional dengan pendekatan deskriptif potong lintang (cross-sectional). Adapun pengambilan data dilakukan secara prospektif berdasarkan wawancara langsung terhadap pasien meliputi beban pengobatan dengan kuesioner Living With Medicine Questionaire (LMQ) dan kepatuhan terapi dengan kuesioner Medication Adherence Rating Scale (MARS). Data dianalisis dengan uji Spearman Rho untuk menentukan hubungan antara medication related burden dengan kepatuhan pasien. Berdasarkan kuisioner LMQ sebanyak 8 pasien (16,32%) mengalami beban rendah dan 41 pasien (83,67%) mengalami beban sedang. Tingkat kepatuhan pada pasien stroke di RS PKU Muhammadiyah Gamping diketahui bahwa sebanyak 29 pasien (59,18%) memiliki tingkat kepatuhan sedang dan sebanyak 20 pasien (40,81%) memiliki tingkat kepatuhan tinggi. Berdasarkan nilai koefisien korelasi VAS dengan MARS menunjukkan korelasi negatif (CP = -0,186 dan P=0,201), hal ini berarti bahwa semakin tinggi beban pengobatan maka pasien akan semakin tidak patuh dan tidak ada hubungan yang signifikan antara beban pengobatan dengan kepatuhan pasien. Berdasarkan nilai koefisien korelasi VAS dengan MARS menunjukkan korelasi negatif (CP = -0,186 dan P=0,201), hal ini berarti bahwa semakin tinggi beban pengobatan maka pasien akan semakin tidak patuh dan tidak ada hubungan yang signifikan antara beban pengobatan dengan kepatuhan pasien. Kata Kunci : Stroke, Medication Related Burden, Kepatuhan Terapi
POTENSI PENGGUNAAN OBAT TIDAK TEPAT PADA PASIEN RAWAT JALAN GERIATRI BERDASARKAN KRITERIA BEERS 2019 Rahmawati, Reza; Harianti Putri, Yona; Handayani, Dian; Pertiwi, Reza; Putri Nurlita, Septia; Kamilla Putri, Dwi; Alawiya Simanullang, Khairatul
Jurnal Kefarmasian Akfarindo Vol 7 No 2 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.125

Abstract

Geriatric population continues to increased globally. In Indonesia, estimation of geriatric population is 7% and will be increase over years. One of geriatric medication problem is potentially inappropriate medication (PIM). Beers criteria 2019 is one of a tool to evaluate potentially inappropriate medication in geriatric. Therefore, this study aims to indentify the prevalence of potentially inappropriate medication incidence in geriatric outpatient at Pharmacy X in Bengkulu and risk factors associated with PIM. This research was done in cross sectional and prospective study. Data collection was done in 2 months from August-October 2021. The incidence of potentially inappropriate medication was analyzed using descriptive analysis according to Beers Criteria 2019 and risk factors were analyzed using logistic regression. This research reported that from 115 geriatric patients above ≥ 65 years old, out of 56 patients (48,70%) found with at least 1 potentially inappropriate medication (PIM). There were 101 PIM with average of PIM 1,8 PIM/patient. Drug should be avoid in almost geriatrics were 34,65%, drug used with caution in geriatrics were 54,46%, and drug interaction should be avoid in geriatric were 10,89%. Diuretic agents like furosemide and spironolactone were frequently used in geriatric patients but potentially inappropriate. Logistic regression showed that the number of drugs used is associated with the incidence of PIM in geriatric outpatient.
POTENSI ANTIBAKTERI EKSTRAK DAUN KOPASANDA (Chromolaena odorata L) TERHADAP Pseudomonas aeruginosa DAN Staphylococcus aureus Nurhanifah; St. Ratnah; Rante Pakadang, Sesilia
Jurnal Kefarmasian Akfarindo Vol 7 No 2 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.132

Abstract

Infectious disease is a human health problem that will develop from time to time. Skin infections can be caused by bacteria. Kopasanda Leaf Extract contains secondary metabolite compounds that act as antibacterial agents. The purpose of this study was to determine the class of chemical compounds and the antibacterial activity of Kopasanda leaf extract (Chromolaena odorata L) against Pseudomonas aeruginosa and Staphylococcus aureus based on the diameter of the inhibition zone. The working method used is the manufacture of simplicia, extraction, phytochemical screening, antibacterial activity testing with the disc diffusion method. Based on the results of the study, the average inhibition zone on Pseudomonas aeruginosa 2% was 11.3 mm, 4% concentration was 13.3 mm, 8% concentration was 19.3 mm and the positive control was 16.6 mm and the negative control was obtained. 0 mm. While the results of the measurement of the diameter of the inhibition zone on Staphylococcus aureus with a concentration of 2% of 12.6 mm, 4% concentration of 15.6 mm, 8% concentration of 18.6 mm, and 16.3 mm in positive control and 0 mm in negative control. which means it has no inhibition zone. The conclusion of this study was that all concentrations of kopasanda leaf extract used had antibacterial potential against Pseudomonas aeruginosa and Staphylococcus aureus.
FORMULASI GRANUL EFFERVESCENT DARI KUNYIT (Curcumae domestica) DAN ASAM JAWA (Tamarindus indica) Arifuddin, Arisanty; Al Akram, M. Faathir; Ibrahim, Ismail
Jurnal Kefarmasian Akfarindo Vol 7 No 2 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.134

Abstract

Effervescent dosage form is another way to develop attractive soft drink products and provide variety in presentation because apart from being practical, it can also give a sparkle effect or a soda-like taste and can also cover some unwanted flavors of certain ingredients. The benefits of Jamu Turmeric Tamarind have been proven empirically. Jamu Turmeric is efficacious as an antibiotic, preventing sprue, analgesic (relieves pain), antipyretic (lowers body temperature during fever), and anti-inflammatory. The purpose of this research was to formulate and evaluate the physical properties of effervescent granules from turmeric (Curcumae domestica) and tamarind (Tamarindus indica). This type of research is an experimental study conducted to formulate turmeric (Curcumae domestica) and tamarind (Tamarindus indica) in the dosage form of effervescent granules in 2 formula forms with varying acid concentrations and then evaluate their physical properties. The evaluation of granules includes water content test, angle of repose test, flow rate test, compressive density test, dispersion time test and pH test. The results showed that turmeric (Curcumae domestica) and Tamarind (Tamarindus indica) could be formulated in effervescent granule dosage form. For the flow velocity test, it was found that the flow properties of the granules were low in the two formulations
FORMULASI DAN UJI STABILITAS SEDIAAN LOTION EKSTRAK AIR BUAH TOMAT (Solanum lycopersicum L.) Karim, Nuraeni; Arisanty; Rante Pakadang, Sesilia
Jurnal Kefarmasian Akfarindo Vol 7 No 2 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.142

Abstract

Tomato (Solanum lycopersicum L.) has antioxidant active compounds that can prevent skin cell damage due to the influence of free radicals. Lotion is a cosmetic product whose consistency is lower than cream, so that the use of lotion can be evenly distributed on the skin. This research purposed to formulated the preparation of tomatoes (Solanum lycopersicum L.) Water Extract lotion and to know the physical quality stability of the preparation of Tomato (Solanum lycopersicum L.) Water Extract lotion. Tomatoes was extracted by using freeze dryer and then it was formulated with concentration 1%, 3%, and 5% by using lotion base that consist of Stearic Acid, Dimethicone, Glycerin, Nipagin, Nipasol, Liquid Paraffin, Cetyl Alcohol, Triethanolamine, Vitamin E, Fragrance, Aquadest. The inspection of preparation quality consist of organoleptic test, homogeneity, pH, dispersion, viscosity, adhesion before and after accelerated stability storage. The results showed that the lotion preparation of Tomato Fruit Water Extract at all concentrations (1%, 3%, 5%) before and after storage was accelerated homogeneously, had a pH ranging from 7 – 7.81, viscosity 2622 – 5180 cp.s, dispersion power. 5.2 – 8 cm, and adhesion ranged from 10.09 – 44.71 seconds. Lotion preparations with concentrations of tomato fruit extract 1%, 3%, 5%, have met the requirements for topical preparations except for formula 1. Key words : Lotion, Tomato Fruit (Solanum lycopersicum L.) Water Extract, Stability Test, Formulation, Skin.
SKRINING FITOKIMIA DAN PENETAPAN KADAR FLAVONOID TOTAL EKSTRAK BUAH OKRA (Abelmoschus esculentus L.) Panca, Pra Panca Bayu Chandra; Ratih Laksmitawati, Dian; Rahmat, Deni
Jurnal Kefarmasian Akfarindo Vol 7 No 2 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.149

Abstract

Okra (Abelmoschus esculentus L.) merupakan salah satu tanaman yang digunakan sebagai sayuran. Bagian tanaman yang sering digunakan adalah buah. Buah okra mengandung flavonoid yang berpotensi sebagai bahan alam yang berkhasiat sebagai obat. Penelitian tentang skrining fitokimia dan penetapan kadar flavonoid total dari ekstrak buah okra (Abelmoschus esculentus L.) telah dilakukan. Penelitian ini bertujuan untuk mengetahui kandungan fitokimia dan kadar flavonoid total ekstrak buah okra. Ekstraksi ini menggunakan metode maserasi pelarut etanol 70 %. Hasil ekstraksi maserasi kemudian dilakukan proses penguapan hingga diperoleh ekstrak kental. Ekstrak kental lalu di identifikasi secara kualitatif menggunakan pereaksi kimia. Hasil identifikasi kualitatif diperoleh bahwa ekstrak buah okra mengandung flavonoid, alkaloid, saponin, tannin, triterpenoid, kumarin, fenolik dan glikosida. Kandungan flavonoid total ditetapkan menggunakan metode kolorimetri-Aluminium Klorida dengan instrumen spektrofotometri UV-Vis diperoleh kadar flavonoid total ekstrak buah okra sebesar 319.18 mg/100 gram dengan nilai SD 0.18.
INTENSI SWAMEDIKASI DI KALANGAN MASYARAKAT KECAMATAN UMBULHARJO YOGYAKARTA PADA MASA PANDEMI COVID-19: TINJAUAN THEORY OF PLANNED BEHAVIOR De Karos, Vlorent Anggi; Widayati, Aris
Jurnal Kefarmasian Akfarindo Vol 7 No 2 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.155

Abstract

Self-medication is the first and most common effort made by the community to overcome their health complaints. During the COVID-19 pandemic, 70% of patients with chronic diseases were absent from routine control and 12% missed the treatment process, increasing the mortality rate by 1.3%. Some of the impacts that occurred due to the impact of the COVID-19 pandemic on changes in health seeking became the basis for conducting this research. The purpose of this study was to determine the factors that contributed to the intention of self-medication among the community during the COVID 19 pandemic. The intention factor will be reviewed using the theoretical framework of Theory of Planned Behavior (TPB). This research is an analytic observational study with a cross sectional design. The sample was selected using the Cluster Sampling with a total sample of 144 respondents. Data analysis was carried out descriptively followed by multiple linear regression. The results of this study, the attitude (p value ≤ 0,05) and perceived behavioral control (p value ≤ 0,05) showed a partial contribution to self-medication intentions. While subjective norm (p value ≥ 0,05) partially has no effect on self-medication intentions. The construct of perceived behavioral control was the most contributing factor to the self-medication intention (β= 0,017). The results of the F test showed that attitude, subjective norm, and perceived behavioral control simultaneously contributed 26.4% to self-medication intentions (p value 0,05, F count > F table, R Square = 0.264). The results of this study can be used as consideration for the Yogyakarta Public Health Office in preparing a health promotion program related to good self-medication to the community.

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