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ad-Dawaa : Journal of Pharmaceutical Sciences
Published by Universitas Islam Negeri Alauddin Makassar
ISSN : 26547392     EISSN : 26546973     DOI : 10.24252/djps
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
ad-Dawaa Journal of Pharmaceutical Sciences (DJPS) merupakan jurnal yang terbit dua kali dalam setahun, yaitu setiap Juni dan Desember. Jurnal ini fokus pada seluruh bidang terkait ilmu farmasi, termasuk biologi farmasi, farmakokimia, farmakologi, farmasi klinik dan teknologi farmasi. Jurnal ini juga mempublikasikan artikel terkait integrasi Islam dengan ilmu farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 9 Documents
 1 
Search results for , issue "Vol 5 No 2 (2022)" : 9 Documents clear
The Nano Curcumin - The Little One with The Big Impact : A Review Tanfil. T, Ardy; Setiadi, Feri; Ridhayanah, Muthiah
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 2 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i2.29539

Abstract

Curcumin is a compound contained in Curcuma longa, and this compound has many health benefits. One of the problems of this compound is its poor bioavailability, but methods to solve this problem have been found. One way to overcome the problem of curcumin bioavailability is to make curcumin in nano dosage forms. This article discusses the potential of curcumin nano as a future therapy for various diseases. We take a variety of sources by considering the source based on the index owned by the source. Scopus, Web of Science and Sinta are our main parameters. Articles not indexed by all three indexers are included in our rating. In conclusion, we found that curcumin in nano form has a very good potential to be used as a future therapy. However, further research is still needed to see the side effects of nano curcumin if used in the long term
HMG-CoA Reductase Inhibitory Activity Potential of Iota-, Kappa-, and Lambda-carrageenan: A Molecular Docking Approach Setiawansyah, Arif; Muh Ikhlas Arsul; Adliani, Nur; Wismayani, Leni
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 2 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i2.32721

Abstract

HMG-CoA reductase is an essential enzyme responsible for the biosynthesis of cholesterol. Hyperactivity of HMG-CoA reductase will increase cholesterol production, leading to the elevation of blood cholesterol levels. Inhibition of HMG-CoA reductase is one way to block cholesterol biosynthesis to lower blood cholesterol levels. This study evaluated the inhibitory potential of iota-, kappa-, and lambda-carrageenan against HMG-CoA reductase. The study was undertaken by in silico method using a molecular docking approach via Autodock 4.2 assisted by ADT graphical user interface. HMG-CoA reductase co-crystal structure was used as the target, and iota-, kappa-, and lambda-carrageenan as the test ligands. The result revealed that iota- and lambda-carrageenan possess an excellent affinity to HMG-CoA reductase with the free binding energy of -12.44 and -11.87 kcal/mol and Ki value of 0.765 and 2.01 nM, respectively, which is found to be better than Simvastatin and the native ligand. The compounds' chemical properties influenced the molecules' molecular interactions affecting their affinity. The number of SO4 groups is assumed to affect the HMG-CoA reductase inhibitory activity of iota-, kappa-, and lambda-carrageenan. KEYWORDS: iota-, kappa-, and lambda-carrageenan; HMG-CoA reductase; inhibitory activity; molecular docking
Formulation and Effectivity of Henna Leaves (Lawsonia inermis L.) Extract Ointment Against Burn Healing of Rabbit (Orctolagus cuniculus) Wandira, Ayu; Astriani, Dian; Wahyudin, Munifah
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 2 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i2.36124

Abstract

Burns are tissue injury resulting from contact with a source of heat. The henna leaves extract (Lawsonia inermis L.) contains tannin, which acts as an astringent to treat wounds. This research seeks to determine the efficacy and quality of henna leaves ointment (Lawsonia inermis L.). The extraction method for henna leaves (Lawsonia inermis L.) entailed maceration with a 96% ethanol solvent. The phytochemical analysis of the 96% ethanol extract of henna leaves revealed the presence of flavonoids, tannins, saponins, and terpenoids. Variable concentrations of henna leaves extract were used to formulate ointments: 2.5% (F1); 5% (F2); 10% (F3); negative control (C-); and bioplacenton® as the positive control. Organoleptic assays, homogeneity, pH, spreadability, and adhesion were used to evaluate the quality of the formulations. In rabbits with inflicted burns, administer ointments F1, F2, F3, C-, and C+ to determine the efficacy of burn treatment. The healing effect is evaluated based on the time it takes for the wound to close (maturation phase), which is characterised by the incision being covered with new tissue. The ointment made from 96% ethanol extract of henna leaves with various concentrations of F1, F2, and F3 met the test requirements for organoleptic, homogeneity, pH, spreadability, and adhesion, according to the results of the ointment quality test. The ANOVA analysis of the effect test revealed that F1, F2, and F3 had a healing effect on wounds. The lesion healing effect of Formula F3 (10%) was not significantly different from the positive control after 11 days
Formulation and Antibacterial Activity of Bidara (Ziziphus mauritiana Lamk.) Leaf Toothpaste Against Streptococcus mutans Hurria Hurria; Arifuddin Yunus
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 2 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i2.36355

Abstract

Bidara (Ziziphus mauritiana Lamk.) is a native plant of Central Asia that has been widely cultivated in Indonesia. Bidara leaves contain many flavonoids, polyphenolic hydrolysable tannins, triterpenoids, sterols, and alkaloids. Bidara has potential as an antibacterial and has been widely used. The antibacterial activities of Bidara are used to formulate toothpaste against bacteria in the mouth. The study aimed to formulate a toothpaste from bidara leaves that have good physical stability and can be against Streptococcus mutans which causes dental plaque. This type of research is an experimental laboratory using the maceration method and formulated into toothpaste. After that, the physical stability of the toothpaste was tested, and antibacterial activity against S. mutans using the agar diffusion method. Bidara leaves can be used to formulate toothpaste against S. mutans bacteria. The research produced a toothpaste formula from Bidara leaf extract. Formula III is the best formula based on physical stability tests and Streptococcus mutans anti-bacterial tests.
Antioxidant Activity Study of Zingiber Zerumbet Rhizome Extract and Fraction Haeria Doloking; Mukhriani; Rima Amalia; Andri Anugrah Pratama
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 2 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i2.37351

Abstract

Zingiber zerumbet is a member of the Zingiberaceae family with known pharmacological potentials. This study aims to characterize the phytochemical elements and evaluate the antioxidant potential of the methanol extract, soluble ethyl acetate, and n-hexane-soluble fractions of Zingiber zerumbet rhizome. Identify secondary metabolites for the alkaloids, saponins, flavonoids, polyphenols, tannins, and steroids/triterpenoids using the chemical reaction method in test tubes. Antioxidant activity was determined based on DPPH absorbance measurements using UV-Vis Spectrophotometry. The methanolic extract contained alkaloids, flavonoids, polyphenols/tannins, steroids, and triterpenoids. The ethyl acetate soluble fraction contained flavonoids and polyphenols/tannins, and the n-hexane soluble fraction contained alkaloids and flavonoids. The free radical scavenging activities of ascorbic acid, methanol extract, ethyl acetate, and the n-hexane soluble fraction were 7.79; 100,956; 69,476, and 77,780 ppm, respectively. The findings indicated that the methanolic extract, ethyl acetate, and n-hexane soluble fraction were suitable sources of natural antioxidants.
Analysis of Borax Contaminants in Sempol Snacks in Gonilan Village Kartasura Nuzulia Sari Asyifa'; Reni Ariastuti; Fadilah Qonitah
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 2 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i2.37435

Abstract

Sempol is a snack made from processed meat that is quite popular among the public. In its manufacture, there is still a lot of misuse of prohibited additives, one of which is borax, in order to obtain a more supple shape and a longer shelf life. This study aims to determine the content and levels of borax in sempol snacks circulating in Gonilan Kartasura Village. The methods used in this study were qualitative using turmeric paper and quantitative using UV-Vis spectrophotometry. The results of the qualitative study showed that of the 7 samples of sempol snacks, there were 2 that positively contained borax, namely samples F and G. The quantitative results showed that the level of borax in sample F was 101,55±0,75 mg/g and in sample G was 166,69±0,67 mg/g. KEYWORDS: Borax; Sempol; UV-Vis Spectrophotometry
English English Fitril Imani; Yusnita Rifai; Herlina Rante; Ansari Masri; Andri Anugrah Pratama; Musabbiha
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 2 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i2.37548

Abstract

This study aims to predict the compounds from Ocimum basillicum that have potential as glioma inhibitors by inhibiting the enzyme isocitrate dehydrogenase (IDH). Forty-two compounds from Ocimum basillicum were carried out by molecular docking to the IDH receptor using the AutodockTools 1.5.7 program and continued prediction of pharmacokinetic profile and toxicity using ADMETab 2.0 and Toxtree. The validation of the molecular docking method showed an RMSD value of 1.8509 A. As a result of the research, we discovered several compounds had the best interactions in our investigation. Those compounds were Apigenin, Catechin, Chloronergic Acid, Ellagic Acid, Quercetin, Rutin, Eriodictyol, and Chicoric Acid, with binding affinity values of -7.1, -6.7, -7.1, -7.1, -7.1, -8.5, -7.2, and -6.5, respectively. Several compounds are predicted to have the potential to be developed as glioma inhibitors. Furthermore, the ADMET's predictions show that these potential compounds still require improvement in pharmacokinetics and toxicity. However, further laboratory investigations like in vitro and in vivo assays need to be conducted.
Profiling Secondary Metabolite of Fresh and Fermented Marigold Flowers and Butterfly Pea Flowers Ni Luh Putu Kris Monika Yanti; Sukrasno; Defri Rizaldy; Arif Al Iman
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 2 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v5i2.37714

Abstract

Communities in Bali use "Usada" as an essential plant for traditional medicine. Utilization of a plant as herbal medicine is based on the metabolites contained therein, such as in the marigold flower (Tagetes erecta L.) and butterfly pea flower (Clitoria ternatea L.). Identification of secondary metabolite profiles was carried out by aerobic fermentation. This study aims to identify the secondary metabolite profiles of untreated extracts compared to fermented extracts. Aerobic fermentation is carried out by stacking fresh samples. Extraction by percolation using n-hexane for marigold flowers and methanol for butterfly pea flowers. The extract profile was analyzed by densitometric thin-layer chromatography (TLC). Separation pattern, retention time, and m/z fragmentation with LC-MS/MS. Determined antioxidant activity using the DPPH method, calculating the levels of total phenol (TPC), total flavonoids (TFC), and total carotenoids in each sample. The TLC profiles of control extracts and marigold flower fermentation were similar, However, in the fermented pea flower extract, the intensity of the spots was thicker, and a new compound was formed from the TLC pattern. The TPC of the control and fermented extracts ranged from 0,816 - 1,154 g GAE/100 g extract, the TFC ranged from 0,067 - 0,610 g QE/100 g extract, and the highest total carotenoid was in the fermented marigold flower extract with levels of 215 mg/g simplicia. All control and fermented extracts had antioxidant activity ranging from 46,71 ppm-75,30 ppm. LC-MS/MS analysis showed five compounds from the fermented butterfly pea flower extract, while the control only identified one compound. The fermentation process for each extract experienced changes in the profile of secondary metabolites, starting from UV absorption, spot intensity, compound levels, types of compounds contained, and their antioxidant activity.
The Use of an Ambroxol Solution to Assess Acute Dermal Irritation on Rabbit Skin Munifah Wahyuddin; Mukhriani; Vera Olfiana; Ika Puspita Sari; Rizka Humardewayanti Asdie; Titik Nuryastuti
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 5 No 2 (2022)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.38401

Abstract

Ambroxol can overcome infections due to the presence of biofilms in the body by interfering with the formation of sticky biofilms and reducing biofilm production, so it has the potential to be used in topical preparations for the treatment of infections. This study aimed to measure the irritating effect on the skin of rabbits resulting from the ambroxol solution to assess the safety of the ambroxol solution. The methods refers to BPOM 2020, namely by dabbing 0.5 ml of ambroxol solution on the back skin of rabbits, then covering it with gauze and non-irritant plasters, after 4 hours of cleaning of residues is then observed at 1 , 24, 48 and 72 hours to see whether or not there was an effect of erythema and edema arising from the influence of the experiment, and at the end of the investigation, a histopathological test was carried out. The results of the research are Macroscopically the ambroxol solution did not show any erythema and edema, so the primary irritation index score was obtained for all test solutions with a score of 0. In contrast, in the microscopic irritation test, the score for erythema was 4 and for edema was 3. . From this research, it can be concluded that the ambroxol solution non-irritating to the skin. KEYWORDS: Biofilm, ambroxol solutions, acute irritation test.

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