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Jurnal Riset Kefarmasian Indonesia
Published by Asosiasi Pendidikan Diploma Farmasi Indonesia
ISSN : 2656131x     EISSN : 26558289     DOI : https://doi.org/10.33759/jrki
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health
JURNAL RISET KEFARMASIAN INDONESIA adalah jurnal yang diterbitkan online dan diterbitkan dalam bentuk cetak. Jurnal ini diterbitkan 3 kali dalam 1 tahun (Januari, Mei dan September) Jurnal ini diterbitkan oleh APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia) Lingkup jurnal ini mencakup Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Organik Bahan Alami, Biokimia, Analisis Kimia, Kimia Fisik, Biologi, Mikrobiologi, Kultur Jaringan, Botani dan hewan yang terkait dengan produk farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Nutrisi dan Kesehatan Masyarakat.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 228 Documents
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Pemanfaatan Ekstrak Daun Teh (Camellia sinensis L) Dari Perkebunan Kemuning Kab. Karang Anyar dalam Pembuatan Sabun Padat Transparan dan Uji Aktivitas Antibakteri pada Staphyloccocus aureus Setiawan, Iwan; Saryati, Dwi; Astian, Astian
Jurnal Riset Kefarmasian Indonesia Vol. 1 No. 1 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v1i1.7

Abstract

Kemuning’s plantations in Karang Anyar Regency are famous for their lush tea plantations and good quality. Tea leaves contain several substances including flavonoids, 30- 40% polyphenols, caffeine, essential oils and tannins. The famous tea leaf polyphenols are catechins. Catechins have properties as antidiarrheal, antibacterial, especially against Staphyloccocus aureus bacteria, which is one of the gram-positive bacteria that cause infections in the skin. Based on this, tea leaf extract can be used as a natural supplement in the manufacture of transparent soap products. In this study tea leaf extract became one of the components in making transparent soap by adding tea leaf extract to formula 1 (0%), formula 2 (1.5%), formula 3 (3%) and formula 4 (4, 5%). Then transparent soap preparations were tested for organoleptic and quality quality including moisture and vaporizing soap content, amount of fatty acids, free alkali content and levels of unbunned fractions and anti-bacterial activity against the growth of Staphyloccocus aureus bacteria. Based on the results of the study, it was found that transparent 4 solid soap with 4.5% tea leaf extract content had the darkest color of solid soap, evaporated water and substance content, free alkali content, fatty acid, acidity level (pH), unbonded fraction level and the highest foam stability. Formula 4 solid soap also has the best inhibitory power against the growth of Staphyloccocus aureus bacteria.
PENGARUH EDUKASI FARMASIS TERHADAP MOTIVASI DAN KEPATUHAN PENGGUNA PROGRAM TERAPI RUMATAN METADON DI PUSKESMAS TAMBORA PADA BULAN FEBRUARI - APRIL 2015 Halim, Marta; Kumala, Shirly; Hersunaryati, Yetti
Jurnal Riset Kefarmasian Indonesia Vol. 1 No. 1 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v1i1.8

Abstract

This study was triggered by the large number of users of Methadone Maintenance Therapy Program (MMTP) who Dropped Out due to lack of motivation and compliance. The purpose of this study was to increase the motivation and compliance of the Tambora Community Health Center MMTP users. The study design used the quasi-experimental method with the pretest-the posttest the group was not comparable. Voluntary research samples amounted to 100 with a distribution of @ 50 for the control group (KK) and @ 50 for the treatment group (KE). Based on the results of data analysis, the following results were obtained: (1) There was an increase in the motivation and compliance variables for the group given education with lectures and leaflets. (3) Pharmacist education (variable knowledge, attitudes and actions) simultaneously can increased the motivation of users with a score of 15.4% (p value 0.00 <0.05) in MMTP at the Tambora Community Health Center. (3) Pharmacist education (variable knowledge, attitudes and actions) simultaneously increases the compliance of service users in MMTP Tambora Community Health Center with a score of 12.7% (p value 0.00 <0.05). The Conclusion pharmacist education can increase motivation and compliance to users of Tambora Community Health Center MMTP services.
POLA PENGGUNAAN OBAT ANTIRETROVIRAL (ARV) PADA RESEP PASIEN RAWAT JALAN DARI KLINIK HIV/AIDS SALAH SATU RUMAH SAKIT SWASTA DI KOTA BANDUNG Anggriani, Ani; Lisni, Ida; Liku, Olga Susana
Jurnal Riset Kefarmasian Indonesia Vol. 1 No. 1 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v1i1.10

Abstract

ABSTRACT The Human Immunodeficiency Virus (HIV) continues to be a major global public health issue, which targets the human immune system. The using of ARVs in the treatment of HIV / AIDS increased life expectancy for PLHIV (People With HIV / AIDS). This study aims to determine the description of the using of ARV drugs in outpatients of the HIV / AIDS Clinic and assessed their suitability with established treatment standards. This research was carried out in a descriptive non-experimental manner, with data collection carried out retrospectively, used patient prescription data from April to December 2017. The results of quantitative studies showed 87% were male patients, and the largest age group was 20-29 years (39%) . Class of antiretroviral drugs used were Nucleoside / Nucleotide Reverse Transcriptase Inhibitors (NRTIs), Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs), and Protease Inhibitors (PI), with a combination of antiretroviral drugs most was the combination of first-line tenofovir + lamivudine + efavirenz (69%) while the second-line drug zidovudine + lamivudine + lopinavir / ritonavir was 1%. The most commonly used comorbid drug was cotrimoxazole. For qualitative data, the accuracy of combination and dose of ARV drugs was 100% in accordance with Permenkes No. 87/ 2014, with 79% of patients adhered to antiretroviral treatment every month. The potential for most ARV drug interactions with other drugs for the moderate category was zidovudin + cotrimoxazole (11%) which occured pharmacokinetically by decreasing renal clearance of zidovudine and glucuronide metabolites. In conclusion, the pattern of used of ARV drugs had met the standard of Permenkes No.87/2014, with the most used were the first line combination of tenofovir + lamivudine + efavirenz.
KAJIAN PENGOBATAN TRADISIONAL CACAR MENURUT TERJEMAHAN LONTAR USADA KACACAR Sutrisna, I Nyoman Gede Tri; Widyastuti, Ni Luh Gede; Cahyadi, Kadek Duwi
Jurnal Riset Kefarmasian Indonesia Vol. 1 No. 1 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v1i1.12

Abstract

The Traditional medicine in Bali is a concept of Balinese culture that is used for generations. Usada is a knowledge of traditional Balinese medicine as a source of concepts to solve problems in the health sector. Healing (usada) is found in lontar called lontar usada. Lontar Usada Kacacar is one of the usada which discusses smallpox. The purpose of this study is to find out information contained in Lontar Usada Kacacar. Information includes the type of smallpox, treatment ingredients, dosage form and method of use. In addition, in research can be inform a plants that are used as traditional smallpox drugs. Healing in Bali is based on lontar, the research this time was carried out on eaves of Usada Kacacar. This research was conducted descriptively to the translation of Lontar Usada Kacacar translated by I Gusti Ngurah Wiriawan, S.S. The results of the translation of Lontar Usada Kacacar made in table form include the types of smallpox, medicinal herbs, how to use and use spells. The results of the table found information on 100 medicinal herbs, 75 types of smallpox, 107 types of plants, 10 types of methods of use and 16 methods of treatment accompanied by spells.
PERBANDINGAN METODE EKSTRAKSI EKSTRAK UMBI BAWANG RAMBUT (Allium chinense G.Don.) MENGGUNAKAN PELARUT ETANOL 70% TERHADAP RENDEMEN DAN SKRINING FITOKIMIA Supomo, Supomo; Warnida, Husnul; Said, Bagus Moch
Jurnal Riset Kefarmasian Indonesia Vol. 1 No. 1 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v1i1.15

Abstract

Allium chinense are plants that contain bioactive compounds such as alkaloids, flavonoids, and saponins. The rendement of an extract may be affected by the extraction mentod used. This study aims to determine the effect of maseration and digestion extraction method on rendemen and identification of secondary metabolite in the extract of the hair onion bulbs. Research conducted is an experimental study. The samples used were hair bulbs obtained in Kota Bangun, East Kalimantan, extracted wiyh 2 extraction methods of maceration and digestion using ethanol 70% solvent and done as much as 3 times replication. Identification of secondary metabolite compounds was performed by phytochemical screening including test of alkaloids, flavonoids, saponins, tannins, and steroids. From the test data is processed by statistical analysis. The result of rendement with 3 times replikation of digesti mentod obtained by 20,02 gram, 19,03 gram, and 19,17 gram. While the maseration method obtained for 12,38 grams, 12,45 grams, and 15,91 grams. So there are differences between the results of the results of digestion mentod and maseration mentod. Based on phytochemical screening tets showed that the thick extract of hair onion bulbs contain compounds alkaloids, flavonoids, and saponins.
PERBEDAAN KUALITAS TANAMAN MINT (Mentha spicata L) HIDROPONIK DAN KONVENSIONAL BERDASARKAN MORFOLOGI TANAMAN, PROFIL KROMATOGRAM, DAN KADAR MINYAK ATSIRI Pratiwi, Pramita Yuli; Mardiyaningsih, Ana; Widarti, Emi
Jurnal Riset Kefarmasian Indonesia Vol. 1 No. 2 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v1i2.18

Abstract

Mint is one of the essential oil-producing plants. Essential oils of Mentha spicata L or spearmint are widely used as raw materials in the food, beverage and pharmaceutical preparations industries. The main components of spearmint are karvon, limonen, cineol, dihydrocarvol, myrcene, and 0.5% menthol. The components contained in spearmint have properties as herbal remedies. Plant cultivation greatly determined the results of standardized drug ingredients. Cultivation with the right planting system can affect the quality of simplicia. This research were a descriptive study to differentiate the quality of plants. This study aimed to determine differences in plant morphology, chromatogram profile and levels of spearmint essential oil between hydroponic and conventional planting systems. Observation of plant morphology includes the size, color of the stem and leaves. Essential oil content is calculated from refined oil by steam and water distillation method. Spearmint oil was analyzed on thin layer chromatography methode using the silica gel F254 as a stationary phase and hexane-ethyl acetate (8: 2) as a mobile phase, with spot visualization under UV254 and anisaldehyde-H2SO4 . The results showed that the morphology of Mentha spicata L with hydrophonic planting systems had a bigger size in stem and leaves, but the leaves had more bright green than a conventional plant. The chromatogram profile did not show differences in the number of spots and Rf. Mentha spicata L with conventional planting systems had a sharper intensity of color on one of the volatile oil spot, and suggested due to menthol. The levels volatile oil of Mentha spicata L hydroponic and conventional were determined as 0.0326% and 0.0323% . The Independent T-test analysis showed that there were not a significant differences.
Formulasi Dan Uji Aktivitas Anti Bakteri Masker Gel Peel-Off Ekstrak Daun Pacar Air (Impatiens balsamina linn.) Dengan Kombinasi Basis PVA dan HPMC Saputra, Sony Andika; Lailiyah, Munifatul; Erivina, Adella
Jurnal Riset Kefarmasian Indonesia Vol. 1 No. 2 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v1i2.20

Abstract

Peel-off gel mask is one of the practical masks, because after dry the mask can be directly removed without rinsing. In this research, a peel-off gel mask formulation from a pacar air leaf extract (Impatiens balsamina Linn.) Has antibacterial activity against Staphylococus Aureus bacteria. The peel-off gel mask is prepared in 3 formulas by varying the PVA and HPMC concentrations of F1 (1: 2,6), F2 (1: 3), F3 (1: 3,5). Evaluation of gel quality used is organoleptic test, viscosity, adhesion, drying time, dispersion, pH. Testing of antibacterial activity was done by using the diffusion method of wells. The positive control used was clindamycin phosphate 1.2%, the negative control used was the base of the peel-off gel mask. Results of physical evaluation and antibacterial activity test were analyzed using SPSS software with trust level of 0.05. Based on the results obtained F3 is the optimum formula, because F3 has a corresponding pH of 5.2 ± 0.10, the corresponding depth of 6.85 ± 0.13, the fastest drying time of 21.68 ± 0.33 and the anti-activity the best bacteria. Based on testing of antibacterial activity of F1, F2 and F3 have antibacterial activity against Staphylococus Aureus bacteria.
PENINGKATAN DISOLUSI ROSUVASTATIN CALSIUM DARI SEDIAAN TABLET DENGAN TEKNIK LIQUISOLID DAN PEMBENTUKAN KOMPLEKS INKLUSI Sutiswa, Shandra Isasi; Cahyati, Yeyet; Mudhakir, Diky
Jurnal Riset Kefarmasian Indonesia Vol. 1 No. 2 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v1i2.21

Abstract

Rosuvastatin calcium is a salt form of rosuvastatin with antilipidemia activity. Rosuvastatin Calcium classified in class two of Biopharmaceutics Clasification System (BCS) has low solubility in water (17.96 mg / L) and high permeability. Based on this, rosuvastatin calcium needs to be formulated appropriately in order to produce high bioavailability and maximum therapeutic effect. The bioavailability of BCS 2 drug is determined by the dissolution rate of the drug in gastrointestinal fluid so that a technique is needed in formulating the drug. This study aims to develop a formulation technique for rosuvastatin calcium tablets through liquisolid technique and formation of inclusion complexes with β-cyclodextrin in order to increase the rate of dissolution. Tablet formulation with liquisolid technique was made with a concentration of 10% rosuvastatin calcium in propylene glycol, with a ratio of US2® (carrier) and Aerosil 200 (coating) made with a ratio of 10: 1 and 20: 1. In addition to the formulation with liquisolid technique, formulations were also carried out with the complex inclusion technique of rosuvastatin calcium-β-cyclodextrin using kneading method and freeze drying method with a mol ratio of 1: 1 and 1: 2. The liquisolid system and inclusion complexes formed were characterized using FTIR and SEM. Characterization results indicated changes in the form of polymorphous rosuvastatin calcium. Tablet formulations were made by direct compression using a liquisolid system and an inclusion complex equivalent to 10 mg of rosuvastatin calcium. Based on the results of the ANOVA statistical test and further LSD tests showed that calcium rosuvastatin tablets made with liquisolid and inclusion complexes can increase the dissolution rate compared to pure rosuvastatin calcium tablets and inovator rosuvastatin calcium tablets. The highest dissolution rate was produced by liquisolid R20: 1 tablet at 60 minutes at 85.53 ± 1.02% in an enzyme-free simulated gastric fluid dissolution medium and 110.02 ± 1.71% in an enzyme-free simulated intestinal fluid dissolution medium.
DAYA ANTIBAKTERI SEDIAAN GEL EKSTRAK ETANOL DAUN MURBEI (Morus alba L.) SEBAGAI OBAT LUKA PADA KULIT TERHADAP Staphylococcus aureus Asri, Muhammad; Bahar, Fahril
Jurnal Riset Kefarmasian Indonesia Vol. 1 No. 2 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v1i2.22

Abstract

A research concerning the antibacterial effect of mulberry leaves (Morusalba L.) ethanol extract gel as cure of skin wounds against Staphylococcus aureus bacteria.This research is aimed to know the antibacterial effect of mulberry leaves (Morusalba L.) ethanol extract gel as cure of skin wounds against Staphylococcus aureus bacteria and determine inhibitor concentration minimum value. It was an experimental research which conducted in the laboratory to test the antibacterial effect of mulberry leaves (Morusalba L.) ethanol extract gel as cure of skin wounds against Staphylococcus aureus bacteria. The result of observation showed that 1% concentration produced diameter of resistance zone average as 0.83 mm, 3% concentration were 0.97 mm and 5% concentration were 1.13 mm. It can be concluded that; 1) mulberry leaves ethanol extract gel stock on 1%, 3%, and 5% concentration have a weak resistance based on Antimicrobial resistor category ;2) inhibitor concentration minimum value of 1% concentration, was the lowest concentration that still giving antibacterial effect to against of Staphylococcus aureus bacterial
PENETAPAN KADAR FENOLIK TOTAL FRAKSI POLR DAN NONPOLAR DAUN RAMBAI LAUT (Sonneratia caseolaris L.) DENGAN METODE SPEKTROFOTOMETRI UV-Vis Jubaidah, Siti; Sundu, Reksi; Sabriningsih, Nur
Jurnal Riset Kefarmasian Indonesia Vol. 1 No. 2 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v1i2.23

Abstract

Rambai laut (Soneratia caseolaris L.) is a type of tree that grows in riverbank swamps or mangrove forests which contains one of the secondary metabolites in the form of phenolic compounds. The purpose of this study was to determine the total phenolic content of polar and nonpolar fractions of sea rambai leaves using UV-Vis spectrophotometry method. Research conducted is non-experimental. The stages of the study included the determination of plants, sampling, making samples, making extracts, determining the water content of extracts, fractionation using polar and nonpolar fractions, phytochemical screening test of ethanol extract and fractionation results and determination of total phenolic levels by UV-Vis spectrophotometry. The results showed that rambai laut leaf in polar fraction had a total phenolic content of 213.49 ± 1.2227 mg GAE / g, which means that in each gram the polar fraction is equivalent to 213.49 mg of gallic acid, whereas in the nonpolar fraction of rambai laut leaves is obtained 55.79 ± 1.0809 mg GAE / g which means that in each gram the nonpolar fraction is equivalent to 55.79 mg of gallic acid. Total phenolic content is greater in the polar fraction.

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