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INDONESIA
Jurnal Riset Kefarmasian Indonesia
Published by Asosiasi Pendidikan Diploma Farmasi Indonesia
ISSN : 2656131x     EISSN : 26558289     DOI : https://doi.org/10.33759/jrki
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health
JURNAL RISET KEFARMASIAN INDONESIA adalah jurnal yang diterbitkan online dan diterbitkan dalam bentuk cetak. Jurnal ini diterbitkan 3 kali dalam 1 tahun (Januari, Mei dan September) Jurnal ini diterbitkan oleh APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia) Lingkup jurnal ini mencakup Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Organik Bahan Alami, Biokimia, Analisis Kimia, Kimia Fisik, Biologi, Mikrobiologi, Kultur Jaringan, Botani dan hewan yang terkait dengan produk farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Nutrisi dan Kesehatan Masyarakat.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 228 Documents
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IMPLEMENTASI CARA DISTRIBUSI OBAT YANG BAIK (CDOB) PADA STANDAR OPERASIONAL PROSEDUR (SOP) PENGIRIMAN DI PBF Y: PERSPEKTIF APOTEKER PENANGGUNG JAWAB Santika, Putu Ria Madhuvidya; Lestari, Ni Putu Carina Srivinka; Ugrasena, Putu Yudha
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 3 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/V7I3.784

Abstract

Drug distribution is an important stage in the pharmaceutical service system that plays a role in maintaining the quality, safety, and effectiveness of therapy to the hands of patients. Good Drug Distribution Practices (CDOB) are a reference in ensuring the quality of distribution, including in the preparation and implementation of Standard Operating Procedures (SOP) for delivery at Pharmaceutical Wholesalers (PBF). This study aims to evaluate the implementation of CDOB in the delivery SOP at PBF Enseval, with a focus on the role of the Responsible Pharmacist (RP). The study used a descriptive qualitative method with an evaluative approach through regulatory analysis and interviews. The results showed that most aspects of CDOB have been implemented, including the completeness of SOPs, documentation, training, and internal audits. However, there are still limitations in the involvement of RP at the SOP preparation stage, the real-time temperature monitoring for cold chain products is not optimal, and the Corrective and Preventive Action (CAPA) documentation is not fully digital. It is necessary to strengthen the role of RP, integrate temperature monitoring technology, and digitize documentation as an effort to improve the quality of drug distribution.
ANALISIS KADAR FLAVONOID TOTAL EKSTRAK ETANOL BUAH JAMBU BIJI MERAH (Psidium guajava L.) SECARA SPEKTROFOTOMETRI VISIBEL Anggraini, Devina Ingrid; Lutfiah, Dhiya Hasna
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 3 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/v7i3.786

Abstract

Guava fruit (Psidium guajava L.) is recognized for its local wisdom and health benefits due to its high antioxidant content, specifically flavonoids. This study aims to determine the total flavonoid content in ethanol extracts of guava fruit using the visible spectrophotometry method. The extraction process for P. guajava was conducted using the maceration method with a 70% ethanol solvent. Qualitative tests confirmed the presence of flavonoids in the extract. For the quantitative analysis, a visible spectrophotometer was used, operating for 23 minutes at a wavelength of 426.0 nm. The study found that the flavonoid content in the guava fruit extract was 24.3850 mg of quercetin equivalents (QE) per gram of extract, with a coefficient of variation of 1.2063%.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL 96% DAUN KALANGKALA (Litsea angulata Bl) TERHADAP BAKTERI Cutibacterium acnes Trialiani, Lydia; Saputri, Revita; Sari, Putri Kartika
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 3 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/v7i3.788

Abstract

            Acne is an infectious disease of the face skin caused by the Cutibacterium acnes, which can be treated by utilizing plants. Kalangkala plant (Litsea angulate Bl) is a plant that has antibacterial activity. The purpose of this study is to identify the secondary metabolite compounds in the 96% ethanol extract of Kalangkala leaves (Litsea angulata Bl) and to determine the area of inhibition showing no bacterial growth, as well as the MIC value against Cutibacterium acnes bacteria using the diffusion method.. The research method used in this study is a posttest-only control group design and an experimental research type. Extraction using the maceration method with 96% ethanol solvent. Testing antibacterial activity of the extract using the well diffusion method against C. acnes bacteria with concentrations of 12,5%, 25%, 50%, 75%, 100%, clindamycin 2 µg/disk (positive control), and Na-CMC 0,5% (negative control). Phytochemical screening results ethanol extract 96% Kalangkala leaves (Litsea angulata Bl) contains alkaloid, flavonoid, tannin, saponin, triterpenoid, and phenol. The result of antibacterial activity of 96% ethanol extract of Kalangkala leaves (Litsea angulata Bl) obtained the average diameter result of inhibition zone of 12,5% concentration is 0,00 mm which there is no inhibition zone and at concentrations of 25%, 50%, 75%, and 100%, has 0.46 mm, 1.32 mm, 2.20 mm, and 3.80 mm with a weak category and positive control with an inhibition zone of 20.50 mm has a strong category. Based on the research, it can be concluded that 96% ethanol extract of Kalangkala leaves (Litsea angulata Bl) has antibacterial activity in inhibiting Cutibacterium acnes with a weak category.
ANALISA TINGKAT PENGETAHUAN REMAJA PUTRI TENTANG KONSUMSI TABLET TAMBAH DARAH Sri, Istikayati Nur; Saleh, Chusun; Nurlaila, Khairani
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 3 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/v7i3.790

Abstract

The four health problems that are considered most often experienced by adolescent girls in Indonesia are iron deficiency (anemia), short stature (stunting), chronic energy deficiency (CED), and obesity. Anemia is a body condition characterized by the results of a hemoglobin (Hb) examination in the blood that is lower than normal, which can be caused by a lack of red blood cells. Based on data from the 2023 Indonesian Health Survey (SKI), the prevalence of anemia in the 15-24 year age group was 13.2%, where women had a higher prevalence of anemia. This study aims to determine the level of knowledge of adolescent girls about consuming iron tablets. This study uses a quantitative descriptive method with a cross-sectional approach. Sampling using a total sampling technique totaling 121 respondents. Data were analyzed using univariate analysis and bivariate analysis. Bivariate analysis was carried out using chi square. The results of the study showed that the majority of respondents were aged >13-17 years, namely 78 teenage girls (64.5%), the most common source of information was obtained from the School Health Service (UKS) as many as 107 teenage girls (88.4%). Of the 121 respondents, 105 teenage girls (86.8%) had consumed Iron Tablets, and there were still quite a lot of teenage girls whose knowledge level was lacking, namely 53 teenage girls (43.8%). The description of the relationship between Information Sources and the Level of Knowledge of Teenage Girls about Consuming Iron Tablets analyzed using multiple responses and crosstabs was categorized as lacking, sufficient and good. Of the 16 teenage girls who had a low level of knowledge, 12 teenage girls (75.0%) did not consume iron tablets. There was a significant relationship between the consumption of Iron Tablets and the Level of Knowledge of teenage girls with a P value of 0.022 (p <0.05).
FORMULASI DAN UJI EVALUASI FISIK SEDIAAN GEL PEEL-OFF SEBAGAI MASKER WAJAH DARI SARI WORTEL (DAUCUS CAROTA L.) Alensia Putri, Nofellia; Dwiningrium, Riza; Suswidiantoro, Vicko; Pratiwi, Mida
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 3 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/v7i3.792

Abstract

Carrots (Daucus carota L.) are rich in beta-carotene, vitamins A, C, and E, which possess antioxidant activity and potential for use as active ingredients in cosmetic formulations. This study aimed to formulate and evaluate the physical characteristics of peel-off gel mask preparations containing carrot juice at varying concentrations. A laboratory-based experimental design was used to develop three formulations containing 5 %, 10 %, and 15 % carrot juice. Physical evaluations included organoleptic properties, homogeneity, pH, drying time, spreadability, adhesiveness, protective effect, and skin moisture. All formulations demonstrated acceptable physical stability. The 10% concentration formula showed the most ideal drying time, balanced spreadability and adhesiveness, and the most significant increase in skin moisture. These findings indicate that carrot juice can be effectively used as a single active ingredient in peel-off gel mask formulations, with 10 % identified as the most optimal concentration. For future development, further studies are recommended to include long-term stability testing, dermatological evaluations on human subjects, and exploration of combinations with other natural ingredients to enhance effectiveness and support broader applications in herbal-based cosmetic industries.
POLA PERESEPAN  OBAT ANTIHIPERTENSI PASIEN RUJUK BALIK (PRB) BPJS KESEHATAN DI APOTEK X JAKARTA TIMUR Poppy, Indrianti; Chusun; Restu, Octaviani
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 3 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/v7i3.798

Abstract

Hypertension is an increase in systolic blood pressure greater than or equal to (≥) 140 mmHg and/or diastolic blood pressure greater than or equal to (≥) 90 mmHg. Hypertension is one of the chronic diseases that receives services from the Referral Program (PRB). This program aims to facilitate access to health services for BPJS participants with chronic diseases. Hypertension, or high blood pressure, is one of  the causes of death worldwide, with 90-95% of cases dominated by essential hypertension. This disease is considered a silent killer because people are unaware of their hypertension until they have their blood pressure checked. This study aims to determine the number and types of antihypertensive medications most frequently prescribed, identify antihypertensive medications that are and are not compliant with the National Formulary, and identify the most frequently prescribed antihypertensive drug classes for BPJS Referral Patients (PRB). This study used a quantitative descriptive method with retrospective data, namely all prescription sheets containing antihypertensive medications from October 1 to December 31, 2024. In conclusion, the results of this study indicate that hypertension patients were predominantly female (387 patients, 65.9%), and 221 patients (37.6%) were in the age group over 65 years. The most commonly prescribed antihypertensive medication was Amlodipine, with 397 prescriptions (67.6%). The most commonly prescribed antihypertensive medication class was Calcium Channel Blockers (CCBs). The compliance rate for antihypertensive medications with the National Formulary was 89.8%, while the non-compliance rate was 10.2%. This should not occur as it would impact the administrative process between pharmacies and the Social Security Administration Agency (BPJS). Therefore, ideally, 100% of antihypertensive prescriptions should be in accordance with the National Formulary.
FORMULASI DAN EVALUASI FISIK SEDIAAN LIPTINT EKSTRAK DAUN JATI (Tectona Grandis Linn.f) Christiandari, Hanita; Hernawan, Jarot Yogi; Laila, Wahyu Kumil
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 3 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/v7i3.807

Abstract

Teak leaves (Tectona grandis L.f.) are known to contain anthocyanin compounds that function as natural dyes and have antioxidant activity. This study aims to formulate and evaluate lip tint preparations using teak leaf extract as a natural dye. Method: extraction using a maceration method with 70% ethanol solvent acidified with citric acid, resulting in the characteristic red color of anthocyanins. Three lip tint formulas were created with varying extract concentrations (40%, 50%, and 60%) and evaluated through organoleptic, homogeneity, pH, spreadability, and hedonic tests. The results showed that all formulas were homogeneous, thick in texture, with colors varying from pink to deep red. The pH of the formulas was within the safe range for lips (4.6–5.5), and the spreadability met the standards for comfortable use. Formula 3 with a 60% extract concentration showed the best results in terms of color, pH, and panelist preference. Conclusion: teak leaf extract has the potential to be used to develop safe, high-quality, and environmentally friendly herbal lip tints.
PENGARUH SUPLEMENTASI MINYAK SAWIT MERAH TERHADAP KADAR HS-CRP TIKUS MALNUTRISI Astani, Ameliora; Milasari, Novi; Rosalina, Rosalina; Supriono, Supriono
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 3 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/v7i3.847

Abstract

Red palm oil (RPO) is a processed product derived from oil palm that is rich in β-carotene, a precursor of vitamin A. Vitamin A is known to play a beneficial role in reducing inflammatory responses, which are among the risk factors that exacerbate stunting. This study aimed to evaluate the effectiveness of RPO in reducing levels of the inflammatory marker high-sensitivity C-reactive protein (Hs-CRP). It is expected that RPO supplementation may help suppress inflammation, thereby contributing to the improvement of nutritional status. An in vivo experimental design was employed using male Sprague Dawley rats, which were divided into five groups: a healthy control group (K+), a malnourished group (K−), and three treatment groups receiving RPO at different dosages (P1: 0.16 ml/200 g BW/day; P2: 0.26 ml/200 g BW/day; and P3: 0.56 ml/200 g BW/day). The intervention lasted for eight weeks, consisting of a four-week malnutrition induction phase followed by a four-week RPO supplementation phase. RPO administration resulted in a significant increase in body weight among the malnourished rats in all treatment groups (P1, P2, and P3) (p < 0.05). However, Hs-CRP levels did not show statistically significant changes following RPO supplementation in malnourished rats. The potential of red palm oil in mitigating malnutrition warrants further investigation by considering inflammatory markers and conducting a comprehensive analysis of vitamin A status.
Patterns of Antihypertensive Drug Prescribing and Refill Adherence Among BPJS Referral-Back Patients: A Study at Pharmacy “X”, Pontianak Isnindar Isnindar; Shahiroh Haulaini Shahiroh Haulaini; Hestiva Hestiva; Berlian Rizky Putra
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 1 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v8i1.902

Abstract

High blood pressure often develops without obvious symptoms, causing many individuals to remain unaware of the condition until organ damage has already occurred. The absence of noticeable signs makes hypertension a major contributor to the increasing incidence of complications within the cardiovascular system. It has become a government priority to control hypertension through the National Health Insurance Program (JKN) BPJS, particularly the Referral Back Program (Program Rujuk Balik/PRB). This study aims to describe medication refill adherence and prescribing patterns of antihypertensive drugs among BPJS Kesehatan participants at “X” Pharmacy, Pontianak. This research employed a descriptive observational design with retrospective data from prescriptions and the Pharmacy–BPJS application for the period of October 2025. The analyzed data included sex, age, and the types of antihypertensive therapy used. Adherence was asessed using the Medication Possession Ratio (MPR) method. The results showed that medication refill adherence among PRB patients at Pharmacy “X” was predominantly in the adherent category. The most frequently prescribed antihypertensive drug was candesartan, an angiotensin receptor blocker (ARB), with a tendency toward combination therapy. Most patients were within the 60–75 age group and were predominantly female. In conclusion, medication refill adherence among PRB antihypertensive patients was generally good, supporting long-term therapeutic effectiveness. The prescribing patterns observed were largely consistent with clinical practice guidelines for hypertension management. Continuous education and monitoring are recommended to further improve adherence and therapeutic outcomes.  
Antioxidant Activity Test of Tampoi Fruit Peel Extract (Baccaurea pyriformis Gage) using the DPPH (2,2-Difenil-1-Pkrihidrazil) Method Novi Milasari; Reksi Sundu Reksi Sundu; Hayatus Sa’adah Hayatus Sa’adah; Stevani Olivia Stevani Olivia; Ghina Adhila; Nurul Fatimah
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 1 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v8i1.908

Abstract

Excessive oxidation reactions in the body can cause various harmful effects, mainly due to the uncontrolled production of free radicals. Antioxidant compounds are needed to protect the body from free radical attacks. One natural source of antioxidants is the tampoi fruit (Baccaurea pyriformis Gage). This fruit is known to contain metabolites such as flavonoids, phenolics, tannins, and saponins, which act as natural antioxidants. The purpose of this study was to determine the antioxidant activity of tampoi fruit peel (Baccaurea pyriformis Gage) using the DPPH method. This was an experimental study with the independent variable being ethanol extract of tampoi fruit peel and the dependent variable being antioxidant activity. The research stages included plant determination, slimpisia preparation, maceration extraction, phytochemical screening, determination of extract moisture content, and antioxidant activity testing with DPPH. The results showed a drying shrinkage of 5.6%, an extract yield of 13%, and an extract moisture content of 14.77%, which is classified as a thick extract. Phytochemical screening showed the presence of alkaloids, flavonoids, tannins, and saponins. Antioxidant test results showed that tampoi fruit peel ethanol extract had an average IC value of 11.8165 ppm (very strong category), and vitamin C as a comparison had an IC value of 7.5019 ppm. Thus, tampoi fruit peel ethanol extract has strong antioxidant activity.

Page 11 of 23 | Total Record : 228

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