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Jurnal Riset Kefarmasian Indonesia
Published by Asosiasi Pendidikan Diploma Farmasi Indonesia
ISSN : 2656131x     EISSN : 26558289     DOI : https://doi.org/10.33759/jrki
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health
JURNAL RISET KEFARMASIAN INDONESIA adalah jurnal yang diterbitkan online dan diterbitkan dalam bentuk cetak. Jurnal ini diterbitkan 3 kali dalam 1 tahun (Januari, Mei dan September) Jurnal ini diterbitkan oleh APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia) Lingkup jurnal ini mencakup Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Organik Bahan Alami, Biokimia, Analisis Kimia, Kimia Fisik, Biologi, Mikrobiologi, Kultur Jaringan, Botani dan hewan yang terkait dengan produk farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Nutrisi dan Kesehatan Masyarakat.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 121 Documents
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FORMULASI DAN UJI IRITASI SEDIAAN LULUR KRIM CANGKANG SOTONG (Sepia sp.) TERHADAP KELINCI (Oryctolagus cuniculus) Arfiani Arifin; Nur Ida; Rosmiyanti Rosmiyanti
Jurnal Riset Kefarmasian Indonesia Vol 5 No 1 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i1.359

Abstract

Cuttlefish shell (Sepia sp.) contains calcium carbonate which has benefits in removing dead skin cells, regulating skin pigmentation, shrinking pores, removing acne and black spots and making skin brighter. The aims of this study were to formalize dosage form of cuttlefish shell cream scrub (Sepia sp.) that meets the physical quality requirements and to determine the potential irritation of cuttlefish shell (Sepia sp.) cream scrubs in rabbits (Oryctolagus cuniculus). Reseacrh methods include the dosage form of cuttlefish shell powder using sieve mesh 44, cream scrub formulations with variations in cuttlefish shell powder concentrations by 15%, 20% and 25%. Physical quality test carried iut includes organoleptic tests, homogeneity tests, scatter power tests and sticking power tests. The cream scrub formula irritation test was carried out by patch test method in rabbit test animals. The results of the study obtained that cuttlefish shell cream scrubs have qualified physical quality tests and the degree of irritation value of F1 cream scrubs (cuttlefish shell 15%) of 0,2 which is categorized means very mild irritation.
HUBUNGAN LAMA KERJASAMA TERHADAP KEPERCAYAAN PELANGGAN PBF BINA PRIMA SEJATI Umul Angga Brahmono; Sahat Saragi; Nurita Andayani
Jurnal Riset Kefarmasian Indonesia Vol 5 No 1 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i1.324

Abstract

The large number of pharmacies is not proportional to the number of PBF in DKI Jakarta, causing intense competition in drug distribution activities to pharmacies. The main concept of partnership or cooperation with customers is trust. Building trust will have an impact on bringing loyalty to continue working with the company. This study aims to determine the effect of the length of cooperation between PBF and pharmacies on customer trust. This research was conducted by survey and observation methods. The sampling technique was carried out by Probability Sampling with a Proportionate Stratified Random Sampling approach in order to obtain 69 pharmacies. The results showed that the length of cooperation from 69 pharmacies was 7-12 months for 1 pharmacy, 13-24 months for 8 pharmacies and >24 months for 60 pharmacies. The highest pharmacy confidence level is 85.51%, moderate is 13.04% and low is 1.45%. Based on the results of the Pearson correlation test, a sig value of >0.05 indicates that there is no relationship between length of cooperation and customer trust in PBF. This shows that there is no relationship between the length of time of cooperation with the level of trust the Pharmacy has in PBF Bina Prima Sejati.
EFEK LARVASIDA EKSTRAK ETANOL DAUN BINTANGUR (Chalophyllum inophyllum L.) TERHADAP MORTALITAS LARVA NYAMUK AIR KOTOR (Culex sp.) Ahmad Purnawarman Faisal; Adhisty Nurpermatasari; Pratiwi Rukmana Nasution
Jurnal Riset Kefarmasian Indonesia Vol 5 No 2 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i2.350

Abstract

The Bintangur plant is a plant that can often be found around the house, its existence as a plant makes its properties less known to the public, all parts of this plant are known to be very useful for various pharmacological effects. Various efforts to prevent diseases transmitted by Culex sp. one of them uses larvicides, so an alternative larvicide from natural ingredients is needed, namely Bintangur. The purpose of this study was to determine the activity of the ethanol extract of Bintangur leaves in killing Culex sp larvae with the control being the larvae that were not given the ethanol extract of Bintangur leaves. The type of research on the activity test of the Bintangur leaf ethanol extract used an experimental research type with a true experiment design with a posttest only control group design. The results showed that the ethanol extract of Bintangur leaves (Chalophyllum Inophyllum L.) was active in killing Culex sp. larvae. with the results of the Reed and Muench test with an LC50 value of 281.84 ppm
UJI AKTIVITAS ANTIBAKTERI SEDIAAN SABUN CAIR MINYAK ATSIRI KULIT BUAH JERUK BALI (Citrus maxima) Andi Juaella Yustisi; Sri Wahyuningsih; Nielma Auliah
Jurnal Riset Kefarmasian Indonesia Vol 5 No 2 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i2.355

Abstract

Pomelofruit (Citrus maxima) has several chemical compounds, one of which is essential oil, 6.68g of essential oil was found in the peel of the pomelofruit (Citrus maxima) which has an active compound, namely limonene (94.96%). The essential oil provided strong antibacterial activity against S. aureus isolates. The purpose of the study was to formulate the essential oil of pomelofruit peel (Citrus maxima) into liquid soap preparations that met physical stability and to test the antibacterial activity of liquid soap preparations of pomelofruit (Citrus maxima) peel essential oil against S. aureus bacteria. The method used in testing the stability of liquid soap preparations is cycling test and in the antibacterial activity test using the Disk diffusion method. The results obtained that the essential oil of pomelofruit peel (Citrus maxima) can be formulated in the form of liquid soap because it meets the physical stability test, namely before and after the cycling test and activity tests. antibacterial against S. aureus. at 1% concentration of 18.9mm (strong), 3% of 20.4mm (very strong), and 5% of 21.1mm (very strong). Based on this, the essential oil of pomelofruit peel (Citrus maxima) can be made into liquid soap preparations that meet the physical stability test and have antibacterial activity in very strong category at a concentration of 5% in inhibiting the growth of S. aureus bacteria.
IDENTIFIKASI SENYAWA ANTIOKSIDAN DARI EKSTRAK ETANOL DAUN PANDAN WANGI (Pandanus amaryllifolius) DENGAN METODE 2,2-DIPHENYL-1-PICRYL-HYDRAZYL ( DPPH ) A Rufaidah Hashary; Utami Putri Damayanti; Rusdiaman Rusdiaman; An Nisaa Nurzak
Jurnal Riset Kefarmasian Indonesia Vol 5 No 2 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i2.360

Abstract

Pandan wangi (Pandanus amaryllifolius) is one type of monocotyledonous in the Pandanaceae family that has leaves with a characteristic fragrant aroma. There is a chemical content in the leaves of pandan wangi (Pandanus amaryllifolius) namely alkaloids, flavonoids, saponins, tannins, and polyphenols that can be used as natural antioxidants. This study aims to identify the presence of antioxidant compounds in ethanol extract of pandan wangi leaves (Pandanus amaryllifolius). The research method is an experimental method. The extraction process by maceration and antioxidant testing of pandan wangi leaves (Pandanus amaryllifolius) ethanol extract used the DPPH method where Vitamin C being a positive control, and IC50 value as a parameter. The results stated that ethanol extract of Pandan wangi leaves (Pandanus amaryllifolius) has antioxidant activities that are classified as effective with an IC50 value of 27.65 ppm, while Vitamin C as positive control is classified as an effective antioxidant with an IC50 value of 2.58 ppm. Based on the results of the research that has been done, it can be concluded that the ethanol extract of Pandan Wangi leaves has a good antioxidant content in counteracting free radicals.
FORMULASI SEDIAAN SPRAY GEL EKSTRAK DAUN BANDOTAN (Ageratum conyzoides.L) SEBAGAI ANTINYAMUK Anastasia Reni Mangalik; Rusdiati Helmidanora; Hayatus Sa'adah
Jurnal Riset Kefarmasian Indonesia Vol 5 No 2 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i2.364

Abstract

There are many types of mosquitoes that cause disease in humans, one of which is the Anopheles mosquito that spreads malaria. Bandotan plants are used to treat colic, flu, fever, antidiarrheal, diarrhoea. The purpose of this study was to determine the concentration of bandotan (Ageratum conyzoides.L) leaf extract that provides the best physical properties and anti-mosquito activity in spray gel preparations. The research method conducted was experimental. The object studied was the formulation of bandotan leaf preparation as an antinyamite. The research stages include plant determination, sample collection, simplisia preparation, extraction using maceration method with 70% ethanol solvent, identification of secondary metabolite compounds, preparation of spray gel formula, and preparation evaluation. Bandotan leaf extract was formulated into anti-mosquito spray gel preparations with concentration variants of 10%, 15%, 20%, and using positive control of X brand anti-mosquito spray as a comparison. The preparation testing included organoleptic test, homogeneity test, pH test, viscosity test, and mosquito repellency test. The results of data collection were analysed statistically. A good preparation formula is found in the negative control formula because it has a stable consistency and pH. The results showed that the ethanol extract of bandotan leaves was not significantly different from the organoleptic test, homogeneity test, viscosity test, and pH test. The greatest mosquito repellency was at a concentration of 20% which was 66.33%, at concentrations of 10% and 15% had an average anti-mosquito activity of 22.83% and 57.83% respectively for the positive control with brand X of 99.30%.
IDENTIFIKASI JENIS SAPONIN DAN UJI AKTIVITAS ANTIBAKTERI EKSTRAK METANOL KULIT BATANG SEKILANG (Embelia borneensis Scheff.) TERHADAP BAKTERI Pseudomonas aeruginosa ATCC 9027 DAN Streptococcus mutans ATCC 25175 Maria F.K. Hayon; Risa Supriningrum; Nurul Fatimah
Jurnal Riset Kefarmasian Indonesia Vol 5 No 2 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i2.368

Abstract

Sekilang stem bark (Embelia borneensis Scheff.) contains secondary metabolites, such as alkaloids, flavonoids, tannins, and saponins. Saponin compounds are divided into two types, namely steroids and triterpenoids which have the ability as antibacterial, antifungal, antidiabetic and expectorant. The purpose of this study was to determine the type of saponin and to determine the antibacterial activity of the methanolic extract of sekilang bark against Streptococcus mutans and Pseudomonas aeruginosa bacteria. The research stages included plant determination, sample collection, simplicia making, extract preparation by maceration method using methanol, phytochemical screening, identification of saponins and antibacterial activity test of methanol extract of sekilang stem bark by disc diffusion method against Streptococcus mutans and Pseudomonas aeruginosa bacteria with a concentration of 15% , 20%, 25%, 30%, and 35%. The results showed that the methanol extract of sekilang stem bark contained triterpenoid saponins and had antibacterial activity against Streptococcus mutans bacteria at concentrations of 15%, 20%, 25%, 30%, and 35% with an inhibition zone formed of 7.65 mm, 7.89 mm, 7.67 mm, 7.98 mm, and 7.13 mm the criteria for antibacterial strength were categorized as moderate. The methanolic extract of the bark of sekilang did not show antibacterial activity against Pseudomonas aeruginosa bacteria, because there was no inhibition zone formed around the paper disc. The positive control used was amoxicillin 0.1% and the negative control used 1% DMSO.
POTENSI ANTIBAKTERI EKSTRAK ETANOL DAUN SELUTUI PUKA (Tabernaemontana macrocarpa Jack.) TERHADAP BAKTERI Streptococcus mutans DAN Porphyromonas gingivalis Sheila Dwi Sabatini; Fitri Handayani; Reksi Sundu
Jurnal Riset Kefarmasian Indonesia Vol 5 No 2 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i2.372

Abstract

The Dayak people in West Kutai, East Kalimantan use selutui puka leaves for the treatment of toothache and canker sores. Bacteria that often cause infections in the oral cavity are Streptococcus mutans and Porphyromonas gingivalis. The aim of this study was to determine the activity of the ethanol extract of selutui puka leaves as an antibacterial against Streptococcus mutans and Porphyromonas gingivalis. The research phase involved collecting samples, plant determination, preparing simplicia, preparing extracts and testing antibacterial activity using the paper disc diffusion method with extract concentrations of 15%, 30% and 45%, DMSO negative control 1%, positive control Ciprofloxacin 0.1%. The results showed that the average diameter of the inhibition zone for Streptococcus mutans at an extract concentration of 15% was 17.70 mm (strong), 30% was 19.43 mm (strong), and 45% was 23.60 mm (very strong). ) and against Porphyromonas gingivalis bacteria at an extract concentration of 15% of 17.43 mm (strong), 30% of 23.33 mm (very strong), and 45% of 26.03 mm (very strong).
ANALISIS RESEP TIDAK TERLAYANI PASIEN RAWAT JALAN DI INSTALASI FARMASI RSU X JAKARTA Ika Agustina; Farida Tuahuns; Charles Charles; Arfie Nur Adina
Jurnal Riset Kefarmasian Indonesia Vol 5 No 2 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i2.374

Abstract

Pharmacy service is inseparable from health service system of a hospital. The service of pharmacy unit shall be a priority because an effective and efficient service will affect in the fulfillment of prescriptions. Furthermore, the management on the pharmaceutical stock will influence the revenue of the hospital (part of revenue center). The purpose of this research is to find out the percentage of unfilled prescriptions of outpatients from many different units, its reasons, and Therapeutic Class of unserved drug items. The research applies descriptive method using prospective data i.e. 25,259 R/ sheets of prescriptions obtained by total sampling technique. The research was conducted in three months from February to April 2021. The result of the research shows that there are unfilled 467 R/ prescriptions due to several factors, such as the drugs are not listed in the formularies, the drugs are out of stock, and the prescribed or patient-requested drugs are not covered by the insurance. Internal medicine unit has the most unfilled prescriptions (160 out of 467). The main reason is the drugs are out of stock (133 out of 467). Medicines for Gastritic, Respiratory, Heart Diseases and Allergicare the top lists in the Therapeutic Class, which is in accordance with data showing that Intenal Medicine, Emergency Department dan General Practisioners, Pulmonary, Dermatology and Venereology, and Obstetrics and Gynecology are the top 5 polyclinics with the number of unserved prescriptions due to out of stock.
UJI ANTIOKSIDAN EKSTRAK ETANOL BIJI KOPI ARABIKA (Coffea arabica L.) LERENG GUNUNG ARGOPURA KABUPATEN JEMBER PADA BERBAGAI KONDISI PENYANGRAIAN Iski Weni Pebriarti; Agustin Nourma Diana
Jurnal Riset Kefarmasian Indonesia Vol 5 No 2 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i2.381

Abstract

Coffee (Coffea arabica L.) is a plant which has been cultivated in Indonesia and it is one of natural source of antioxidants. The main bioactive component which contain antioxidant properties is chlorogenic acid. The roasting process can cause chlorogenic acid in coffee beans to decrease as the temperature increases and the length of roasting, so the way coffee is served as a source of antioxidants which may need to be considered. The purpose of this study was to determine the group of compounds and antioxidant activity contained in Arabica coffee beans obtained from the slopes of Mount Argopura at various conditions of roasting. The samples of Arabica coffee beans each done roasting in advance at a temperature of 160°C - 180°C; 190°C - 210°C; and 220°C - 240°C before it is milled. The used of extraction method is maceration using 80% ethanol solvent. Antioxidant activity testing was done by DPPH method. Antioxidant activity is expressed based on the IC50 value (Inhibitor Concentration 50%). The highest value of antioxidant activity was obtained from Arabica coffee beans roasted at a moderate temperature with a value of IC50 26.41 ± 0.182 ppm. The result of the T-test obtained a sig value < 0.05 which indicates a difference in the antioxidant activity produced by the extract of Arabica coffee beans at various conditions of roasting.

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