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Jurnal Riset Kefarmasian Indonesia
Published by Asosiasi Pendidikan Diploma Farmasi Indonesia
ISSN : 2656131x     EISSN : 26558289     DOI : https://doi.org/10.33759/jrki
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health
JURNAL RISET KEFARMASIAN INDONESIA adalah jurnal yang diterbitkan online dan diterbitkan dalam bentuk cetak. Jurnal ini diterbitkan 3 kali dalam 1 tahun (Januari, Mei dan September) Jurnal ini diterbitkan oleh APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia) Lingkup jurnal ini mencakup Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Organik Bahan Alami, Biokimia, Analisis Kimia, Kimia Fisik, Biologi, Mikrobiologi, Kultur Jaringan, Botani dan hewan yang terkait dengan produk farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Nutrisi dan Kesehatan Masyarakat.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 228 Documents
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HUBUNGAN PENDIDIKAN TERHADAP TINGKAT KEPATUHAN MINUM OBAT DAN PENGARUHNNYA PADA KADAR GULA DARAH SEWAKTU PASIEN DIABETES MELITUS TIPE II DI RUANG RAWAT INAP RUMAH SAKIT  X JAKARTA Chusun, Chusun; Mira, Husni Sanjaya; Endang, Choiriah Lilis
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 1 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i1.675

Abstract

Type 2 Diabetes Mellitus is a non-communicable chronic and progressive disease that can lead to increased blood glucose levels. Patient adherence to medication is essential for achieving therapeutic success. The objective of this study is to determine the relationship between education and medication adherence levels of Type 2 Diabetes Mellitus patients to blood glucose levels in the Emergency Department of the Polri Hospital, East Jakarta. This research method is non-experimental with an observational approach and a cross-sectional design using prospective data from medical records and direct interviews with patients in the inpatient room of Hospital X in Jakarta. The results of the study on 134 patients showed that the characteristics of Type 2 Diabetes Mellitus patients were: 34.3% (the majority) aged between 56 and 65 years, 60.4% female, 63.4% unemployed, 61.9% had elementary school education, and 60.4% had suffered from diabetes for more than 5 years. The most common comorbidity was CHF (Congestive Heart Failure), with 21 patients (15.6%). The level of medication adherence among patients was low, at 64.9%, and more than half (62.7%) had uncontrolled blood glucose levels. Meanwhile, the role of health education in reminding patients was categorized as good, at 91%. Based on the Bivariate Chi-Square analysis, there was a significant relationship between education and medication adherence, with a significance value of 0.000 (<0.005), and also between medication adherence and blood glucose levels (GDS) with a significance value of 0.000 (<0.005). It can be concluded that education affects medication adherence.
UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL UMBI BAWANG DAYAK (Eleutherine palmifolia) TERHADAP MENCIT YANG DIINDUKSI KARAGENIN Milasari, Novi; Adhila, Ghina; Syamsul, Eka Siswanto
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 1 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i1.679

Abstract

            Inflammation is a normal response to protect tissue injury from toxic chemicals, physical trauma, or microbial agents. Treatment of inflammation generally uses synthetic drugs, but the use of these drugs in addition to eliminating inflammation also has many side effects and is relatively expensive. Therefore, anti-inflammatory drugs derived from plants are used. One of the natural medicines used is Dayak onion (Eleutherine palmifolia) because empirically it is widely used by the Dayak and Kutai communities, which has the potential as a medicinal plant with various enormous properties. This study aimed to determine the anti-inflammatory activity of an ethanol extract of Dayak onion bulbs (Eleutherine palmifolia) in carrageenin-induced mice. The test of anti-inflammatory activity was carried out by forming artificial inflammation on the soles of the feet of white mice. The study was conducted on 15 mice, which were divided into 5 groups. The first group as a negative control was given a 0.5% CMC solution. The second group as a positive control was given diclofenac sodium at a dose of 27 mg/ 20 g BW. The third, fourth, and fifth groups were given a dayak onion bulb extract dose of 100 mg /kgBB, 200 mg /kgBB, and 400 mg /kgBB. Based on the measurement of the percent inhibition of inflammation from the 30th minute to the 300th minute, it was found that the average dose of Dayak onion extract 1 (100 mg/KgBB) had the lowest percent inhibition of inflammation, which was 23.064±1.286%, dose 2 was 37.701±2.354%, and dose 3 was 52.324±4.751% and positive control of 76.348±8.702% which has the highest percent of inflammation inhibition. Based on the study, it can be concluded that the ethanol extract of dayak onion bulbs has the best anti-inflammatory activity at dose 3 of 52.324±4.751% in mice induced by carrageenin.
PENILAIAN MIKROBIOLOGIS MENGGUNAKAN METODE TPC DAN MPN SERTA EVALUASI ORAGANOLEPTIK DI OBJEK WISATA ALAM SUMBER GENTONG DESA TIRTOMOYO KABUPATEN MALANG Susanto, Misbahuddin Febrian; Faisal; Syauqi, Ahmad
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 1 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i1.680

Abstract

Waterr irs oner of ther materrirals or erlermernts that maker up ther erarth that allows lirfer to taker placer as irt irs on erarth. Waterr irs userd to merert ther nererds of human lirfer. Oner of ther sourcers of sprirng waterr irn Malang Cirty comers from ther natural tourirsm of ther barrerl sourcer locaterd irn Manglirawan Virllager, Malang Rergerncy. Rerserarch was carrirerd out on ther sprirng waterr sourcer wirth ther airm of obtairnirng mircrobirologircal terst rersults baserd on TPC, MPN and organolerptirc asserssmernt merthods. Thirs  study  users  a quantirtatirver  derscrirptirver  merthod  that  airmsir to derscrirber and merasurer cerrtairn varirablers wirthout manirpulatirng therm whirch airms to irprovirder  a dertairlerd  and  accurater  pircturer  of th er characterrirstircs or condirtirons obserrverd. Ther rersults of ther TPC terst of waterr samplers that haver not berern affercterd by human actirvirty werrer obtairnerd from ther averrager calculatiron of total bacterrira as much as 3.1 x 103 CFU /ml, whirler irn samplers that haver berern affercterd by human actirvirtirers, ther averrager calculatiron of total bacterrira was obtairnerd as much as 1.2 x 104 CFU /ml. MPN terst usirng ErMB merdira Irn orderr to firnd bacterriral colonirers, irncludirng Erscherrirchira colir (Non-fercal), Klerbsirerlla sp and Ernterrobacterr sp. Irn ther Organolerptirc Asserssmernt wirth addirtironal paramerterrs, ther rersults werrer obtairnerd that sampler A was qualirfirerd as cleran waterr suirtabler for consumptiron whirler sampler B dird not merert ther rerquirrermernts. Bercauser ther MPN terst found Erscherrirchira colir / Colirform, irt can ber concluderd that samplers A and B arer not erlirgirbler as waterr that can ber consumerd dirrerctly accordirng  to  ther  Rergulatiron  of ther  Mirnirsterr  of  Heralth  No. 492 /MErNKErS /PErR/IrV /2010 . H owerverr, irbaserd  on ther  addirtiron of Statuter Book of ther Rerpublirc of Irndonersira Numberr 4161 irn ther  irattachmernt  to gov errnmernt  irrergulatiron  No. 82  of 2001 artircler 8 paragraph 1, sampler A, whirch irs ther placer wherrer ther waterr comers out, can  ber ir userd  as a  sourcer  of drirnkirng  waterr  on  ther  condirtironir that irt must go through  ther treratmernt procerss  firrst
EVALUASI INTERAKSI OBAT DALAM SATU LEMBAR RESEP DAN KELENGAPAN DAFTAR TILIK ALERGI OBAT PASIEN RAWAT JALAN RUMAH SAKIT X JAKARTA Chusun, Chusun; Poppy, indrianti; Harun, Alam Nur
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 1 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i1.681

Abstract

Clinical pharmacy services are direct services provided by pharmacists to patients in order to improve therapeutic outcomes and minimize the risk of side effects because the aim of using drugs is for patient safety. One of the clinical pharmacy services provided is assessment and prescription services which must be in accordance with clinical requirements, including the absence of drug interactions and patient allergy records. Based on clinical significance, the severity of drug interactions is classified into three, namely Major, Moderate and Minor. This research uses descriptive methods with retrospective data. The population in this study was all outpatient prescription sheets served from 1 October to 31 December 2023. Sampling used simple random sampling and determining the sample size using the Slovin formula so that the sample used was 460 prescription sheets. Identify drug interactions in one prescription sheet using the Drug Interaction Checker application (Drugbank.com). Results The research showed that of the 460 prescriptions examined, 301 prescriptions had the potential for drug interactions (65.4%), and 320 prescriptions (69.6%) completed the drug allergy checklist. The highest level of drug interactions was at moderate severity, namely 102 prescriptions (33.9%), and minor at 88 prescriptions (29.2%), and the lowest at major severity was 15 prescriptions (5%). If we look at the drug items in one prescription sheet, it can be concluded that there are 506 incidents with the highest level of severity at moderate level, namely 254 incidents (50.2%), which should be avoided in combination or only used in special circumstances and with close monitoring of health workers. While there were 219 minor interactions (43.3%); and major 33 events (6.5%), where this drug combination should not have been given.
FORMULASI DAN EVALUASI SEDIAAN LOTION KOMBINASI EKSTRAK KULIT PISANG (Musa paradisaca L.) DENGAN EKSTRAK KULIT PIR (Pyrus pyrifolia) Hashary, A Rufaidah; Baso, Fajrul Fhalaq; Wulan, Riska
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 2 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i2.688

Abstract

Skin is the largest organ in the body, skin damage affects health and appearance, one of the causes of skin damage is free radicals due to ultraviolet radiation. That's why it's important to provide extra protection by using moisturizer or skin cream. The use of lotion that contains antioxidants is good for the skin, one of which is banana peel extract (Musa paradisiaca L) with pear peel extract (Pyrus pyrifolia). This research aims to formulate banana peel extract (Musa paradisiaca L) and a combination of pear peel extract (Pyrus pyrifolia) in formulating and evaluating the physical quality of the preparation. The method used is the experimental method, the extraction process is by maceration using 96% ethanol then a lotion is made from a combination of banana peel extract (Musa paradisiaca L) with pear peel extract (Pyrus pyrifolia) with respective concentrations of FI (1:2), FII (1:1), FIII (2:1), K+ (“M” lotion), and K- (non extract). Preparation testing includes organoleptic tests, homogeneity tests, pH tests, spreadability tests, and moisture tests. From the general observation results, the preparations have a characteristic extract smell, are semi-solid, brownish white in color, have a pH of 8, all preparations are homogeneous, with an average spreadability of 7.1 cm and an average humidity of 45.0.
HUBUNGAN KEPATUHAN PASIEN DALAM PENGGUNAAN OBAT ANTIHIPERTENSI DENGAN HEALTH BELIEF MODEL DI POLI JANTUNG RSUD DR HARDJONO PONOROGO Andari, Susilowati; Rakhmawati, Erna Agung; Handayani, Tatik; Hidayah, Zulfah Nurul
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 2 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i2.698

Abstract

Hypertension is a condition where there is an increase in blood pressure. chronically because the heart pumps blood more strongly to meet the body's needs. The Health Belief Model is the first theory in the health sector that focuses on an individual's belief or perception of an illness. The aim of this study was to determine the relationship between compliance of hypertensive patients in using antihypertensive drugs with health belief model at the heart clinic of RSUD Dr. Hardjono Ponorogo. The method used is observational analytical instruments using questionnaires that have been tested for validity and reliability. The sample in this study was hypertensive patients at the heart clinic of RSUD Dr. Hardjono Ponorogo in April 2024 who met the inclusion criteria. The data results were analyzed using the Spearman method with SPSS. The results of the study show that the health belief model has a relationship with medication adherence in hypertensive patients. Significant value. obtained is 0.000 and the correlation coefficient (r) is 0.660. In conclusion, the health belief model and compliance behavior variables. have a unidirectional and strong relationship.
FORMULASI DAN EVALUASI KRIM VITAMIN E DENGAN VARIASI EMOLIEN Pritaningtyas, Nazifa Wulan; Putri, Alayya Adistia; Manik, Adelia Margareta; Gintoro, Atilla Dian Dewanti; Elsandi, Elsa; Febrianto, Yahya
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 2 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i2.702

Abstract

Skin health and aesthetics are becoming a major focus in modern society’s lifestyle, with issues such as dehydration, premature aging, and hyperpigmentation due to UV exposure and pollution. The skin, as the largest organ, requires protection from the harmful effects of sunlight, and the use of sunscreen and skincare products containing vitamin E is becoming increasingly important. This study aims to explore the formulation of vitamin E cream with various emollients to improve product quality and effectiveness. The methodology used includes the creation of cream formulas and evaluation through organoleptic, homogeneity, pH, spreadability, viscosity, and preference tests. The results showed that all three cream formulas met the established standards, with appropriate pH and good homogeneity. The preference test showed varying preferences, providing insight into the development of innovative skincare products. This study is expected to provide solutions for consumers who want effective and environmentally friendly skincare products
ANALISIS KANDUNGAN MINERAL (KALSIUM, KALIUM,FOSFOR) PADA KULIT PISANG KEPOK DAN PISANG AMBONDENGAN METODE MPAES Mauli, Mauli Handa Yani; Nofita; Husein, Saddam
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 1 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i1.705

Abstract

Banana is one of the most abundant horticultural commodities in Indonesia. Apart from the fruit, banana peels have great potential to be utilized because they contain various minerals that are beneficial to the body, such as calcium, potassium, and phosphorus. However, the utilization of banana peels is still very low because they are often considered as waste. This study aims to analyze the mineral content of kepok and ambon banana peels using the Microwave Plasma Atomic Emission Spectroscopy (MPAES) method. The study was conducted qualitatively and quantitatively. Qualitative analysis involved flame test and precipitation reaction to detect the presence of minerals, while quantitative analysis used MPAES instrument to measure mineral content. Qualitative results showed that kepok and ambon banana peels contained calcium, potassium and phosphorus. Quantitatively, kepok banana peels have an average calcium content of 2,568.7 mg/kg, potassium 5,237.6 mg/kg, and phosphorus 429.13 mg/kg. Ambon banana peel contains an average of 2,095.3 mg/kg calcium, 4,216.3 mg/kg potassium, and 177.43 mg/kg phosphorus. Differences in mineral content were analyzed using Paired sample T-Test and Wilxocon which showed significant differences in calcium and phosphorus levels between the two types of banana peels, while potassium levels showed no significant differences. The results of this study indicate the potential of banana peels as a source of minerals for nutritional supplements and pharmaceutical products. Utilization of banana peels can support organic waste management and increase the added value of banana production.
ANALISIS CEMARAN LOGAM TIMBAL (PB) DALAM SEDIAAN KOSMETIK EYELINER PENSIL DAN LIPSTIK BERBAGAI MERK YANG BEREDAR DI MARKETPLACE MENGGUNAKAN SPEKTROFOTOMETER SERAPAN ATOM (SSA) Aisha, Audyra Zahra; Dewi, Cinta Amalia Kurnia; Cahyadi, Doni Nur; Nugraheni, Estiningtyas; Amaris, Eugenia; Maharani, Laila; Maisyaroh, Ratih; Faizah, Riris Fityatun Nur; Hariyani, Hariyani
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 2 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.vol7i2.720

Abstract

Cosmetic preparations come into direct contact with the outside of the body (skin), so the product must be safe from various contaminants. In cosmetic preparations, heavy metal lead is intentionally added to give the impression of a shiny and bright colour; in addition, lead contamination contained in cosmetic products can come from raw materials or equipment in the production process. This study aims to analyze the content of heavy metal lead (Pb) in cosmetic preparations of eyeliner pencil and lipstick from various brands, validate the analysis method, and evaluate the assessment of the maximum limit of heavy metal lead in cosmetic preparations based on the Regulation of the Head of the Food and Drug Supervisory Agency of the Republic of Indonesia Number 16 of 2024 concerning Contamination Limits in Cosmetics. The analysis method used is the Atomic Absorption Spectrophotometer (AAS) instrument. Sample preparation was carried out using the wet destruction method, the procedure was carried out by mixing concentrated HNO₃ and HCl in a ratio of 1:3. The results of the analysis using the Atomic Absorption Spectrophotometer (AAS) instrument showed that the highest lead content in the eyeliner pencil sample was 7.8823 ± 0.4075 mg/Kg; and in the lipstick sample was 118.5490 ± 0.6479 mg/Kg. Based on the results of the study, it can be concluded that the three cosmetic products of eyeliner pencil of various brands have met the requirements of BPOM RI No. 16 of 2024, while of the three samples of lipstick cosmetic preparations, there was one sample that did not meet the requirements for lead content in cosmetic preparations based on BPOM RI No. 16 of 2024.
HUBUNGAN TINGKAT PENGETAHUAN DAN PROFESI TENAGA KEFARMASIAN TENTANG BEYOND USE DATE (BUD) OBAT PADA PUSKESMAS WILAYAH KOTA BANDA ACEH Aulianshah, Vonna; Dewi, Desri Fitria; Pamudi, Berwi Fazri; Rasidah, Rasidah
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 2 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i2.721

Abstract

Basically, the determination of the Beyond Use Date (BUD) is included in the drug information service where the implementation of drug information services is the obligation of pharmacy personnel. Beyond Use Date (BUD) of a drug is the time limit for the use of a drug product after it has been formulated or prepared or after the primary packaging has been opened or damaged. The purpose of this study is to find out the relationship between the level of knowledge and profession of pharmaceutical personnel about drug BUD at the Banda Aceh City Health Center. This study is a descriptive analysis with a cross-sectional design to relate the research variables, namely the level of knowledge and profession of health workers, based on their level of education. The sample in this study is pharmacy personnel, including pharmacists and pharmaceutical technical personnel totaling 39 responders. The measuring tool used is a questionnaire. The results of the study showed that the level of knowledge of respondents was generally in the good category. Through statistical tests, significant results > 0.05 were obtained, which showed that there was no relationship between the level of knowledge and profession of pharmaceutical personnel at health centers in the Banda Aceh area.

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