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Mohammad Saifur Rohman
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Department of Cardiology and Vascular Medicine, Dr. Saiful Anwar General Hospital, 3rd Floor CVCU Jl. Jaksa Agung Suprapto No. 2, Malang, Indonesia
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Heart Science Journal
Published by Universitas Brawijaya
ISSN : 27219976     EISSN : 27219984     DOI : http://dx.doi.org/10.21776/ub.hsj.2020.001.01
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology
HEART SCIENCE is the official open access journal of Brawijaya Cardiovascular Research Center, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia. The journal publishes articles three times per year in January, May, and September. The journal is a peer reviewed publication and accepts articles for publication from across the world. HEART SCIENCE accepts and publishes articles in the English language only. The primary goal of this journal is to publish clinical and basic research relevant to cardiovascular medicine. The journal covers the following topics: clinical cardiology, interventional cardiology, intensive and acute cardiovascular care, vascular diseases, non-invasive cardiology, pediatric cardiology, cardiac nuclear medicine imaging, arrhythmia, cardiac prevention and rehabilitation, and cardiac surgery. Animal studies are also considered for publication in HEART SCIENCE. To serve the interest of both practicing clinicians and researchers, the journal provides platform or forum for research scholars, intellectuals, and cardiologists to reveal their views and research work for dialogue, education, and interaction to the entire world. HEART SCIENCE publishes original research, reviews, brief reports, case reports, case series, editorial, and commentary. HEART SCIENCE also publishes the special issues and abstracts of papers presented at the annual meeting of the Cardiological Society of Malang.
Arjuna Subject : Kedokteran - Cardiology and Cardiovascular Medicine
Articles 302 Documents
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Predictive value of GRACE and APACHE-II scores on mortality in acute coronary syndrome patients admitted to CVCU Prasetya, Indra; Hakim, Dennis Ievan; Anjarwani, Setyasih
Heart Science Journal Vol. 6 No. 3 (2025): Advancements in Cardiac Imaging : Unlocking New Perspectives on the Heart Visua
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.03.16

Abstract

BACKGROUND: Acute coronary syndrome (ACS) is correlated with elevated death and fatality rates. The Global Registry of Acute Coronary Events (GRACE) score is frequently employed for risk stratification in ACS. Nevertheless, intensive care physicians frequently utilize more comprehensive and general prognostic judgments derived from critically ill individuals, one of which is the Acute Physiology and Chronic Health Evaluation II (APACHE-II) score. OBJECTIVES: To compare the effectiveness of the score compared to APACHE-II score in predicting cardiovascular care unit () mortality. METHODS: A Retrospective cohort study was carried out at a single center, utilizing data from ACS patients admitted to the CVCU of RSUD Dr. Saiful Anwar Malang from 2021 to 2023. Both GRACE and APACHE-II scores were computed at the initial admission to hospital. The discriminative capability was computed using the area under the curve (AUC), and calibration was verified by the Hosmer-Lemeshow (HL) test. Multivariate logistic regression was performed to ascertain independent determinants of death. RESULTS: CONCLUSION: APACHE-II exhibited enhanced efficacy in predicting CVCU mortality in ACS patients, and both scoring systems continue to serve as valuable instruments.                
Redefining cardiovascular risk stratification: The evolving role of coronary CTA Kamila, Putri Annisa
Heart Science Journal Vol. 6 No. 3 (2025): Advancements in Cardiac Imaging : Unlocking New Perspectives on the Heart Visua
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.03.1

Abstract

Coronary computed tomography angiography (CCTA) has evolved far beyond its initial role as an anatomical imaging modality. Today, it serves as a versatile, multiparametric tool for cardiovascular risk assessment. This progress has been driven by advances in plaque characterization, non-invasive functional assessment, coronary inflammation imaging, and artificial intelligence (AI). CCTA enables clinicians not only to detect obstructive coronary artery disease but also to evaluate total plaque burden and high-risk plaque characteristics, such as low-attenuation components and positive remodeling. The addition of fractional flow reserve derived from CCTA (FFR-CT) offers myocardial ischemia assessment without the need for invasive testing. More recently, the perivascular fat attenuation index (FAI) has emerged as a promising marker of coronary inflammation, highlighting patients who may have residual inflammatory risk despite non-obstructive disease. AI-driven tools, including models like AI-QCTISCHEMIA, now allow for automated and accurate plaque analysis and ischemia prediction. The advent of photon-counting detector CT (PCD-CT) complements these advancements by improving spatial resolution and visualization of vulnerable plaque. These developments are reshaping the role of CCTA in clinical practice—from a diagnostic test to an integrated platform for individualized cardiovascular prevention and management.
Supplement Issue : Indonesian Acute Coronary Syndrome Summit in Conjunction with Asia Primary Angioplasty Congress (APAC) 2025 APAC
Heart Science Journal Vol. 6 No. Suppl_July (2025): Supplement Issue : Indonesian Acute Coronary Syndrome Summit in Conjun
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.Suppl_A2025.1

Abstract

This supplementary issue contains the abstracts presented at the Indonesian Acute Coronary Syndrome Summit in Conjunction with Asia Primary Angioplasty Congress (APAC) 2025 held on July 25th-26th 2025. The abstracts are grouped into three categories: Review Article, Original Article, and Case Report.
Impact of physical exercise on short physical performance battery as the performance indicator of elderly in community setting: A meta-analysis of randomized controlled trials Syafiqul Umam, Mohammad; Mardya Rakhmadhan, Iraky; Soenarti, Sri
Heart Science Journal Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Lo
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.04.6

Abstract

BACKGROUND: Age-related physical decline affects daily activities and increases health risks in the elderly. Tailored exercise programs are essential for improving functional well-being, necessitating robust evaluations to confirm their efficacy. OBJECTIVES: The aim of this study is to present a comprehensive review of the influence of physical activity on the Short Physical Performance Battery (SPPB) as a performance metric within the elderly population. METHODS: In April 2024, an extensive investigation was carried out by reviewing literature obtained from reputable databases like PUBMED and COCHRANE. The study focused on interventions related to physical exercise for older adults, with a specific emphasis on utilizing the SPPB to gauge their effects on physical functionality. RESULTS: The analysis of six selected papers revealed a positive enhancement in performance following interventions that involved physical exercise. These interventions fell into three main categories: Vivifrail-based exercise, group-based exercise, and telemedicine-guided exercise. The statistical analysis indicated significant improvements (95% CI: 0.2861 to 0.9077; p Egger: 0.973, Q(5) = 156.3870, p < 0.0001, tau² = 0.1423, I² = 96.8826%). CONCLUSION: In conclusion, the findings suggest that tailored physical training regimes have the potential to improve physical capabilities among the elderly cohort. This highlights the importance of integrating such exercise routines into their daily schedules to promote overall health and functional performance.
Cardiovascular side effects and toxicity of lithium usage in adults: A systematic review of case reports and observational studies Rahmi, Koyuki Atifa; Khotimah, Husnul; Rohman, Mohammad Saifur
Heart Science Journal Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Lo
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.04.7

Abstract

BACKGROUND: Lithium is a first-line treatment for Bipolar Affective Disorder, but it has a narrow therapeutic range and has been shown to have cardiovascular side effects. This study aimed to compile the cases of lithium-induced cardiovascular abnormalities and the pathological mechanisms behind those effects. OBJECTIVES: To conduct a systematic review of case reports in adult patients who experienced cardiovascular side effects of lithium in the last 11 years. METHODS: The PRISMA method was followed to search PubMed, Wiley Online Library, ResearchGate, Springer, Semantic Scholar, and Google Scholar databases for articles from January 2013 to June 2024 using combinations of 'lithium,' 'cardiac,' 'cardiovascular,' 'side effect,' 'patient,' and 'case.' Case reports and observational studies concerning lithium use were identified for cardiovascular side effects. RESULTS: Reported cardiovascular side effects of lithium included ECG abnormalities (N=31), myocarditis (N=1), cardiomyopathies (N=4), cardiac tamponade (N=1), thrombosis (N=1), and pulmonary hypertension (N=1). Lithium causes cardiovascular abnormalities via sodium channel blockage, interference with cardiac pacemaker cells, increased serum catecholamines and serotonin, disruption of thyroid gland functions, and induction of nephrogenic diabetes insipidus, leading to hemodynamic imbalance. CONCLUSION: Lithium precipitates cardiac side effects and toxicity through direct interference with the cardiac conduction system, disruption of metabolic hormones, and multi-organ interactions.
Navigating pulmonary hypertension: Echocardiography insight into right ventricular function and dynamics Rahmawati, Novi; Yogibuana, Valerinna
Heart Science Journal Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Lo
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.04.4

Abstract

Pulmonary hypertension (PH) is a pathophysiological disorder characterized by pulmonary vascular remodeling and dysfunction, which may arise in various clinical contexts, particularly in association with cardiovascular and respiratory diseases. PH is characterized by a mean pulmonary arterial pressure (mPAP) exceeding 20 mmHg at rest as determined by hemodynamic assessment via right heart catheterization (RHC), which remains the gold standard for diagnosis. Transthoracic echocardiography (TTE) is recommended as a non-invasive screening tool for the initial evaluation of individuals presenting with symptoms, risk factors, or clinical suspicion of PH. Echocardiography enables the identification of pulmonary hypertension by assessing right ventricular (RV) dysfunction and increased RV pressure overload. A comprehensive assessment of the RV’s dimensions and function is essential in all individuals with PH, given that mortality in PH is correlated with the severity of RV dysfunction. While RHC remains the definitive diagnostic modality for PH, echocardiography provides a valuable, widely available, and non-invasive alternative for estimating pulmonary artery pressures, assessing RV function, and stratifying disease severity, in alignment with current guidelines from the European Society of Cardiology (ESC) and the European Respiratory Society (ERS).
The effectiveness of supervised exercise training regarding NT-pro BNP level as a prognostic value among patients with congenital heart disease-related to pulmonary hypertension Setyowati, Danti Utami; Martini, Heny; Prasetya, Indra
Heart Science Journal Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Lo
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.04.5

Abstract

Congenital heart disease-related to pulmonary hypertension (CHD-PH) constitutes a significant subset of related Pulmonary Hypertension (PH), representing around 11% of all PH patients. Considering the emergence of novel medicines and enhanced patient outcomes in PH, it continues to be a life-shortening condition, and the time frame before diagnosis has not altered. Current strategies to enhance outcomes emphasize on early diagnosis and a treatment methodology designed to put individuals with PH into a low-risk category for one-year mortality. The N-terminal prohormone of BNP (NT-pro BNP) is secreted by cardiomyocytes in reaction to mechanical strain and wall stress. An increased concentration of NT-pro BNP is included in some PH risk stratification methods and screening protocols. The initial recommendation to restrict physical exertion in individuals with PH was based on its adverse impact on their clinical status. But clinicians have recently concentrated on the significance of physical exercise in those with PH. Consistent physical activity can enhance functional capacity, elevate quality of life (QoL), and increase prognosis and life expectancy as well. This literature review seeks to consolidate research about the impact of physical activity on NT-ProBNP levels in individuals with CHD-PH.  
Effects of exercise training on C-reactive protein (CRP) levels and 6-minute walk distance: A preliminary study Aziz, Indra Jabbar; Martini, Heny; Anna Fuji Rahimah; Valerinna Yogibuana; Cholid Tri Tjahjono
Heart Science Journal Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Lo
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.04.11

Abstract

Background Mortality rates increase among those with intermediate to high-risk pulmonary arterial hypertension, demonstrating the importance of improved diagnostic methods, treatment algorithms, and the development of new approaches to therapy for severely ill patients. Inflammation contributes to pulmonary hypertension progression, and exercise has been shown to suppress this process. Objective This study evaluated the relationship and differences between CRP levels and functional capacity after a 12-week exercise training program. Methods A clinical prospective cohort preliminary study was conducted with 26 consecutive patients who had already received pulmonary hypertension treatment and were enrolled in the LET-SHINE registry. Patients were divided into two groups: one control group (PH therapy only) and one treatment group (receiving adjuvant physical exercise). The study was conducted for 12 weeks, 6MWT and CRP tests were performed both before and after the study. Result This study found that the majority of cases were ASD, consistent with the fact that ASD is the most common congenital heart defect. The analysis of C-reactive protein levels showed non-significant changes in both groups after 12 weeks. The treatment group exhibited a modest reduction from 0.8 ± 2.4 mg/dl to 0.5 ± 1.0 mg/dl (p=0.514), while the control group maintained stable levels, ranging from 0.7 ± 1.0 mg/dl to 0.7 ± 0.8 mg/dl (p=0.166). An intergroup comparison revealed a non-significant greater mean decrease in the treatment group (-0.3 ± 1.5 mg/dl vs -0.1 ± 0.2 mg/dl, p=0.514). There was no significant correlation between the reduction in CRP levels and improvements in 6MWT distance in either the treatment group (correlation coefficient: -0.367, p=0.240) or the control group (correlation coefficient: 0.021, p=0.948). Conclusion This study showed that exercise training had no statistically significant impact on C-reactive protein levels, indicating a limited effect on systemic inflammation. No significant correlation was found between decreases in CRP levels and improvements in 6MWT distance in either the treatment or control groups.        
Impact of supervised physical activity as adjunctive therapy on functional capacity and NT-pro BNP in patients with negative-reactivity test pulmonary hypertension related to congenital heart disease patient in Saiful Anwar Hospital Malang : A preliminary study Setyowati, Danti Utami; Martini, Heny; Prasetya, Indra; Tjahjono, Cholid Tri; Yogibuana, Valerinna
Heart Science Journal Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Lo
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.04.10

Abstract

Background: Appropriate levels of physical activity (PhA) provide health benefits to patients with chronic diseases, including patients with pulmonary hypertension-related to congenital heart disease (CHD-PH), representing around 4-10% of all PH patients. Objective: The purpose of this analysis was to determine the benefits and effectiveness of PhA as an additional therapy to optimal medication vs. control group on the functional capacity and N-terminal prohormone of B-type natriuretic peptide (NT-pro BNP) in patients with inoperable CHD-PH. Methods: A clinical preliminary study was conducted with 26 consecutive patients in stable condition before the study. Each patient was educated about the benefits of PhA and efficacy parameters of the six-minute walking distance (6MWD) and NT-Pro BNP levels have been evaluated at baseline and after 12 weeks. Results: The study included participants aged 33 ± 11 years, 84% of whom were female. All patients tolerated PhA without severe adverse events. Patients significantly improved the mean 6MWD compared to baseline by 382.9 ± 64.7 (p=0,000) and 318.3 ± 74 (p=0,041) meters after 12 weeks (training vs. control group). Ln NT-pro BNP improved significantly in the training group (p=0,002). There were no differences at week 12 in the delta 6MWD and NT-pro BNP levels, with all P values >0,05. Likewise, there is no correlation between the two variables Conclusions: PhA as an add-on to medical therapy may enhance work capacity and other prognostic relevant parameters in patients with inoperable CHD-PH. However, further larger, multi-center randomized controlled trials, is warranted to validate these preliminary findings
A rare case of reel syndrome: The unexpected permanent pacemaker event Irmansyah, Yos Akbar; Irnizarifka
Heart Science Journal Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Lo
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.04.16

Abstract

BACKGROUND: "Reel syndrome" is a rare complication that occurs after implantation, affecting up to 1.7% of patients with large generator pockets. This condition generally manifests 4–6 weeks post-implantation. CASE ILLUSTRATION: A 64-year-old woman presented unexpectedly with exertional dyspnea and mild fatigue over the past two days. She has a history of pacemaker installation from one month ago. The ECG demonstrated loss of capture, and pacemaker interrogation showed increased capture thresholds with normal impedance. A chest X-ray revealed a ventricular lead coil encircling the generator with lead dislodgment. Reel syndrome is defined by the torsion of the pulse generator along its transverse axis, leading to the coiling of the pacemaker leads around it, which typically protects both the generator and the leads from damage. Symptoms remain asymptomatic until lead dysfunction occurs due to lead malposition. We suggest appropriate diagnostic assessments, such as chest X-rays and ECGs, for prompt identification. The older population has been recognized as a considerable risk factor for this "event." CONCLUSION: Upon confirmation, reel syndromes require immediate intervention. Effective implantation techniques and information for patients and caregivers are essential in alleviating these issues.

Page 27 of 31 | Total Record : 302

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