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Mohammad Saifur Rohman
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Heart Science Journal
Published by Universitas Brawijaya
ISSN : 27219976     EISSN : 27219984     DOI : http://dx.doi.org/10.21776/ub.hsj.2020.001.01
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology
HEART SCIENCE is the official open access journal of Brawijaya Cardiovascular Research Center, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia. The journal publishes articles three times per year in January, May, and September. The journal is a peer reviewed publication and accepts articles for publication from across the world. HEART SCIENCE accepts and publishes articles in the English language only. The primary goal of this journal is to publish clinical and basic research relevant to cardiovascular medicine. The journal covers the following topics: clinical cardiology, interventional cardiology, intensive and acute cardiovascular care, vascular diseases, non-invasive cardiology, pediatric cardiology, cardiac nuclear medicine imaging, arrhythmia, cardiac prevention and rehabilitation, and cardiac surgery. Animal studies are also considered for publication in HEART SCIENCE. To serve the interest of both practicing clinicians and researchers, the journal provides platform or forum for research scholars, intellectuals, and cardiologists to reveal their views and research work for dialogue, education, and interaction to the entire world. HEART SCIENCE publishes original research, reviews, brief reports, case reports, case series, editorial, and commentary. HEART SCIENCE also publishes the special issues and abstracts of papers presented at the annual meeting of the Cardiological Society of Malang.
Arjuna Subject : Kedokteran - Cardiology and Cardiovascular Medicine
Articles 302 Documents
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Vascular complications post invasive cardiovascular procedures Newary, Yola; Kurnianingsih, Novi
Heart Science Journal Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Lo
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.04.2

Abstract

Vascular complications following intracoronary or intracardiac surgeries, such as hematoma, pseudoaneurysm, and arteriovenous fistula, significantly contribute to morbidity and occasionally. Furthermore, these complications not only escalate treatment costs but also prolong hospital stays. Several risk factors have been associated with vascular issues post-coronary procedures, including prolonged femoral sheath use, excessive anticoagulation, multiple interventions during a single admission, catheter placement in the superficial or deep femoral artery, larger catheter sizes, and complex procedures such as atherectomy or stent placement. Strategies to mitigate procedural risks, ensure early detection of vascular injuries, and facilitate timely management can prevent long-term disabilities.
Pregnancy in patient with congenitally corrected transposition of the great artery and ventricular septal defect without pulmonary stenosis: A case report Auliya, Faiza Fardha; Bambang Rahardjo; Indrawan, I Wayan Agung
Heart Science Journal Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Lo
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.04.17

Abstract

Background: Transposition of the Great Arteries (TGA) is a congenital heart defect affected by an embryological misalignment between the aorta and pulmonary trunk. Congenitally Corrected Transposition of the Great Arteries (CCTGA) or L-TGA, accounts for less than 1 % of congenital cardiac disease cases. This report presents the case of a pregnant woman with a history of CCTGA who successfully delivered an infant. Case illustration: A 32-year-old woman presented with vaginal bleeding at 30-32 weeks of gestation and a history of CC-TGA. Her medical history included CCTGA, ventricular septal defect (VSD) without pulmonary stenosis, prior molar pregnancy curettage, breech fetal position, moderate acute respiratory distress syndrome (ARDS), and low body mass index (BMI 16.6 kg/m²). She was classified as WHO Cardiac Risk Class IV due to the high risk of maternal mortality. Following corticosteroid administration for fetal lung maturation and multidisciplinary evaluation, a planned cesarean section was performed at 30 weeks. A male infant was delivered, weighing 1,480 grams, measuring 41 cm in length, with Apgar scores of 7 and 9, and a Ballard score of 18. Conclusion: Early risk assessment, multidisciplinary collaboration, and individualized management are pivotal in reducing maternal and fetal morbidity in patients with CC-TGA.
Association between frontal QRS-T angle and thrombus burden in patients with ST-elevation myocardial infarction: A single-center cross-sectional study Azmi, Muhammad; Nasution, Ali Nafiah; Lubis, Hilfan Ade Putra; Siregar, Abdullah Afif; Habib, Faisal; Sitepu, Andika
Heart Science Journal Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Lo
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.04.13

Abstract

BACKGROUND: ST-Elevation Myocardial Infarction (STEMI) is one of the leading causes of global morbidity and mortality, with burden of thrombus as an influential factor of clinical outcomes. OBJECTIVES: The purpose of this study was to evaluate the relationship between frontal QRS-T (fQRST) angle and thrombus burden in STEMI patients. METHODS: A cross-sectional study was carried out at Haji Adam Malik General Hospital, Medan, between January 2024 and July 2024. STEMI patients who underwent coronary angiography were included. The fQRST angle was measured using a 12-lead electrocardiogram (ECG), the thrombus burden was graded according to the Thrombolysis in Myocardial Infarction (TIMI) grading system. Statistical analysis included Spearman's correlation and Receiver Operating Characteristic (ROC) curve analysis. RESULTS: 108 STEMI patients were included in the study. The fQRST angle was strongly positively correlated with thrombus burden (r = 0.61–0.80, p < 0.05). Patients with more thrombus burden had larger fQRST angles compared to patients with less thrombus burden. Additionally, diabetes mellitus and symptom delay exceeding 12 hours were highly correlated with higher thrombus burden (p < 0.05), whereas infarct-related artery (IRA) location was not significantly associated (p > 0.05). ROC curve demonstrated that the fQRST angle had an AUC of 0.88 (p = 0.001) At the optimal cut-off value of 61°, the sensitivity and specificity were 88.3% and 87.5% (95% CI of 88.5%–98.2).
Patient-reported perceptions of life quality and longevity in chronic heart failure Lubis, Ahmad Feriansyah; Lubis, Anggia Chairuddin; Andra, Cut Aryfa; Raynaldo, Abdul Halim; Ardini, Tengku Winda; Haykal, Teuku Bob; Sarastri, Yuke
Heart Science Journal Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Lo
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.04.9

Abstract

BACKGROUND: Although heart failure therapy has advanced, many patients still experience functional limitations, which impact their quality of life. OBJECTIVES: To explore the factors influencing heart failure patients' preferences for quality of life and longevity. METHODS: This cross-sectional study was conducted at Adam Malik Hospital, Medan, Indonesia. The study was conducted from April 2023 to October 2023. A total of 143 chronic heart failure patients were included using purposive sampling. Data were collected through interviews and the EuroQol five-dimension five-level questionnaire, EuroQol visual analogue scale, and the Time Trade-Off method. Statistical analysis was performed using multivariate logistic regression. RESULTS: Of the 143 patients, 66.4% preferred quality of life over longevity, and 47.3% were willing to trade two years of their lives for a better quality of life. The main factors associated with this preference were heart failure with reduced ejection fraction (OR: 3.554; 95% CI: 1.373 - 9.198; p: 0.009), diabetes mellitus (OR: 2.705; 95% CI: 1.108 - 6.602; p: 0.029), and lower visual analog scale scores (OR: 0.889; 95% CI: 0.848 - 0.932; p: 0.000). Our results also showed that patients in the longevity group had better ejection fractions, fewer rehospitalizations, and were less likely to have diabetes mellitus or chronic kidney failure compared to the quality of life group. CONCLUSION: The majority of heart failure patients choose quality of life over longevity, and this may be influenced by symptom burden and rehospitalization history. These findings emphasize the importance of patient-centered therapy focusing on symptom management and psychosocial support.
Correlation between iron profile and severity of coronary artery lesion in patients with non-ST segment elevation myocardial infarction Syarifuddin, Fairuz; Andika Sitepu; Abdullah Afif Siregar; Zulfikri Mukhtar; Cut Aryfa Andra; Teuku Bob Haykal; Harris Hasan
Heart Science Journal Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Lo
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.04.12

Abstract

BACKGROUND: Excessive iron has been shown to increase the atherosclerosis process through the help of non-transferrin-bound iron (NTBI). OBJECTIVE: This study aimed to ascertain the association between iron profile and the severity of coronary artery lesions in patients with acute non-ST segment elevation myocardial infarction (NSTEMI).  METHOD: This observational analytical study with a cross-sectional design was conducted from February to September 2024 at Adam Malik General Hospital. NSTEMI patients planned for coronary angiography were examined for iron profile, including serum iron, total iron binding capacity (TIBC), and transferrin saturation. Coronary artery lesion severity was evaluated using the synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score.  RESULTS: This study involved 72 subjects. The results showed there were no correlations between serum iron levels and SYNTAX scores (p = 0.891) and transferrin saturation with SYNTAX scores (p = 0.545). Nevertheless, TIBC and SYNTAX score were negatively correlated (p = 0.004) with a weak correlation coefficient (r = -0.334).  CONCLUSION: TIBC levels are inversely correlated with the severity of coronary artery lesions. However, transferrin saturation and serum iron have not been shown to correlate with the severity of coronary artery lesions.
Challenging diagnostic for open artery ischemia Akbar, Akita Rukmana; Rahimah, Anna Fuji
Heart Science Journal Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Lo
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.04.3

Abstract

Ischemic heart disease has traditionally been linked to obstructive coronary artery disease. However, a significant subset of patients presents with ischemic symptoms despite having non-obstructive coronary arteries—a condition termed Open Artery Ischemia (OAI). This encompasses entities like ANOCA(angina with no obstructive coronary arteries), INOCA(ischemia with nonobstructive coronary arteries), and MINOCA(myocardial infarction with nonobstructive coronary arteries), which challenge conventional diagnostic paradigms.​ Patients with OAI often experience persistent chest discomfort and demonstrable ischemia, yet their angiograms reveal no significant epicardial blockage. These individuals, frequently women in midlife, endure considerable morbidity, including diminished quality of life and recurrent hospitalizations. Underlying mechanisms such as microvascular dysfunction, vasospasm, and systemic inflammation contribute to their symptoms.​ This review aims to elucidate the clinical features, pathophysiological mechanisms, and diagnostic challenges of OAI. By highlighting the importance of advanced diagnostic tools and a patient-centered approach, we advocate for increased awareness and better management strategies for this often-overlooked condition.
Low-tech, high-value: Electrocardiographic markers of left ventricular dysfunction in non-ischemic cardiomyopathy Ghosh, Soumik; Tandon, Arjun; Kulshreshtha, Srashti; Kumar A, Lava; Amit, Kumar; Agrawal, Vikas
Heart Science Journal Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Lo
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.04.14

Abstract

Background: Electrocardiography (ECG) is a widely accessible, cost-effective diagnostic tool, particularly valuable in resource-limited settings where echocardiography is unavailable. Identifying ECG parameters that reflect left ventricular (LV) systolic dysfunction could enable earlier detection and intervention in patients with non-ischemic cardiomyopathy (NICM). Objectives: To evaluate the correlation between ECG parameters—QTc duration, QRS duration, morphology, voltage, and axis—and left ventricular ejection fraction (LVEF) in NICM patients with reduced ejection fraction (REF), and to assess their potential as surrogate markers of LV systolic function. Methods: A cross-sectional study was conducted on 140 NICM patients (LVEF ≤40%) confirmed by echocardiography and angiography. Clinical, biochemical, and ECG data were collected. Pearson’s correlation and ANOVA were used to assess associations between ECG variables, mitral regurgitation (MR) severity, hemoglobin levels, and LVEF. Results: QTc duration showed a significant inverse correlation with LVEF (r = –0.428, p = 0.001). Hemoglobin levels were positively correlated with LVEF (r = 0.175, p = 0.039). The presence of mitral regurgitation was associated with lower LVEF (p = 0.029), with a trend toward further decline as severity increased. Conclusions: Prolonged QTc was strongly associated with reduced LVEF in patients with non-ischemic cardiomyopathy. As ECG is inexpensive and widely available, QTc may provide a simple surrogate marker to aid in identifying LV dysfunction, especially in resource-limited settings. Larger prospective studies with outcome data are needed to validate its prognostic role. 
Endovascular coil embolization for accessory veins in dialysis AVF: A pioneering case series from Saiful Anwar Hospital, Malang Fahmi, Hanim Isyfi; Kurnianingsih, Novi
Heart Science Journal Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Lo
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.04.15

Abstract

  Background: The optimal vascular access for hemodialysis is an arteriovenous fistula (AVF), yet the failure rates range from 30% to 40%. Accessory veins modify blood flow, contributing to 40% of early failures. The treatment for stenosis is clearly established, whereas accessory vein treatment is not. Case Illustration: Two cases of endovascular coil embolization for accessory vein obliteration were performed at Saiful Anwar Hospital, Malang. The first case involved a 47-year-old female with late arteriovenous fistula failure, which was fixed with a percutaneous transluminal angioplasty and coil embolization. The second case involved a 58-year-old male with early radiocephalic arteriovenous fistula failure, which was also treated with a percutaneous transluminal angioplasty and coil embolization. Both procedures achieved complete elimination of the accessory vein and showed no signs of retrograde flow. The first and second cases have different onsets of early and late failure. Both patients required PTA and coil embolization simultaneously. Conclusion: Endovascular coil embolization is a safe and effective technique for occluding accessory veins in AVF, which helps improve their function in both early and late failures and shows higher success rates.
Factors that influence the clinical and technical success of venoplasty in patients with central venous stenosis at Saiful Anwar hospital Kurnianingsih, Novi; Akbar, Akita Rukmana
Heart Science Journal Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Lo
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.04.8

Abstract

Background: Central venous stenosis (CVS) is a common complication in long-term hemodialysis patients, particularly those with a history of central venous catheterization. Percutaneous transluminal venoplasty is the primary treatment modality; however, its success varies depending on anatomical and procedural factors. Objectives: This study aimed to evaluate the procedural success of venoplasty in CVS patients and to identify anatomical and procedural factors associated with wire-crossing failure and residual stenosis of less than 30%. Materials and Methods: A retrospective study was conducted involving 55 patients with CVS who underwent venoplasty at Dr. Saiful Anwar General Hospital, Malang, between 2021 and 2025. Data collected included patient demographics, lesion characteristics, and procedural variables. Data were analyzed using SPSS version 27. Descriptive statistics were used to summarize baseline characteristics. Chi-square or Fisher’s exact tests were used for bivariate analysis, followed by multivariate logistic regression to determine independent predictors of procedural success. Results: Wire crossing was successfully achieved in 76.4% of cases, while balloon venoplasty resulted in residual stenosis <30% in 74.5% of patients. Multivariate analysis revealed that total occlusion (OR 1.619; 95% CI: 1.243–2.109; p = 0.001), presence of venous collaterals (OR 1.429; 95% CI: 0.974–2.094; p = 0.048), and vessel tortuosity (OR 2.237; 95% CI: 1.258–3.978; p = 0.000) were significantly associated with wire-crossing failure. Clinical success (residual stenosis <30%) was significantly associated with non-total occlusion (OR 1.542; 95% CI: 1.164–2.043; p = 0.014) and absence of vessel tortuosity (OR 2.610; 95% CI: 1.362–5.001; p = 0.000). No significant associations were found between procedural outcomes and factors such as wire type, balloon pressure, or puncture technique. Conclusion: Anatomical characteristics—including total occlusion, vessel tortuosity, and collateral formation—are the key determinants of venoplasty success in patients with CVS, outweighing the influence of procedural variables. Comprehensive anatomical assessment prior to intervention is essential to optimize procedural outcomes.
Local anesthetic systemic toxicity (LAST) during pacemaker implantation through persistent left superior vena cava (PLSVC) Sunu Budhi Raharjo; Gadistya Novitri Adinda; Dony Yugo Hermanto; Indira Aura Balqis; Dicky Armein Hanafy
Heart Science Journal Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Lo
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.04.18

Abstract

BACKGROUND: Local anesthesia is considered safe and commonly used in the pacemaker implantation procedure. However, it carries a risk of local anesthetic systemic toxicity (LAST). Although rare, LAST occurrence can be fatal. CASE PRESENTATIONS: We reported a case of a 69-year-old woman with fatigue and dizziness. The patient's ECG indicates atrial fibrillation with total AV block. Pacemaker implantation was performed under local anesthesia. Within minutes of lidocaine injection, the patient developed a seizure followed by cardiac arrest. Immediate administration of intravenous midazolam and cardiopulmonary resuscitation was done, resulting in the patient's stability. A permanent pacemaker was successfully implanted using a modified hand-shaped stylet to accommodate the presence of a persistent left superior vena cava (PLSVC). Brain computed tomography scan showed only mild brain atrophy. No clinical symptoms were documented during the outpatient visit after discharge. CONCLUSIONS: Local anesthetic systemic toxicity during pacemaker implantation is a rare but potentially catastrophic. Prompt recognition of its signs and appropriate management are crucial. In this case, a persistent left superior vena cava posed additional challenges to the pacemaker implantation.

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