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Anna Safitri
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Research Center for Smart Molecule of Natural Genetics Resources (SMONAGENES) office: 2nd floor MIPA Building, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Jl. Veteran Malang, East Java, Indonesia – 65145
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JSMARTech : Journal of Smart Bioprospecting and Technology
Published by Universitas Brawijaya
ISSN : 26860805     EISSN : 27147894     DOI : https://doi.org/10.21776/ub.jsmartech.2020.001.02.
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience
JSMARTech : Journal of Smart Bioprospecting and Technology (p-ISSN: 2686-0805, e-ISSN : 2714-7894) is an Open Access Scientific Journal published by Research Center of Smart Molecule and Natural Genetics Resources (SMONAGENES), Universitas Brawijaya, Malang, East Java, Indonesia, since 2019. It is a journal covering of bioprospecting, biochemical, biotechnology, bioinformatics, natural product, pharmaceuticals, biomedical, genetics engineering, nutrigenomic, and nanotechnology. The journal publishes a manuscript written in English for original research papers, short communications, and review articles. The paper published in this journal implies that the work described has not been, and will not be published elsewhere, except in abstract, as part of a lecture, review or academic thesis.
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 77 Documents
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EFFECTIVENESS OF USING TRICHODERMA VIRIDE AS BIOSORBENT FOR REMAZOL BRILLIANT PURPLE IN BATIK WASTEWATER TREATMENT Safitri, Anna; Febrianti, Wiwin Dwi; Rahmaniah, Galuh
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 1, No 2 (2020)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (309.634 KB) | DOI: 10.21776/ub.jsmartech.2020.001.02.4

Abstract

Synthetic dyes used in the batik industry cause negative impacts to the environment. One type of synthetic dyes used in batik industry is remazol brilliant violet. This synthetic dye is reactive, carcinogenic, and non-biodegradable. Therefore, a strategy to degrade this synthetic dye is needed. In this study, the potential application of Trichoderma viride for biosorption of remazol brilliant violet (RBZ) in batik wastewater was investigated. The current work aimed on determination of the optimum biosorption conditions, including pH, contact time, and  RBZ concentration. Biosorption of RBZ were carried out at pH 4 to 9; with contact times of 12, 24, 30, 36, and 42 h, with concentrations of dye solutions were 40, 60, 70, 80, and 90 mg/L. Results showed that the optimum biosorption of RBZ was obtained at pH 4, for 30 h, and optimum concentration of RBZ at 60 mg/L, with the RBZ absorbed was 79.27%. The FTIR analysis suggested that RBZ biosorption changed the chemical functional groups in the T. viride. The FTIR spectra revealed that the biomolecules that are affected during the process of biosorption were mainly lipids and proteins, and slightly from nucleic acids and carbohydrates.
THE USE OF YELLOW KEPOK BANANA PEEL EXTRACT (MUSA PARADISIACA L. VAR BLUGGOE) AS AN ANTIBACTERIAL FOR CHRONIC PERIODONTITIS CAUSED BY PORPHYROMONAS GINGIVALIS Sutanti, Viranda; Destyawati, Arum Anugrah
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 1, No 1 (2019)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.015 KB) | DOI: 10.21776/ub.jsmartech.2019.001.01.4

Abstract

Chronic periodontitis is the most common periodontal disease, and Porphyromonas gingivalis is its dominant causative microorganism. Yellow kepok banana peel (Musa Paradisiaca L. Var. Bluggoe) contains flavonoids, alkaloids, tannins, saponins and triterpenoids that can inhibit and kill Porphyromonas gingivalis. Purpose:  To reveal the antibacterial effectiveness of yellow kepok banana peel extract against Porphyromonas gingivalis. Method: This is true experimental research employing the post-test only control group approach. Preliminary research was conducted to determine the concentration of the sample group, 6 treatment groups (5%, 7.5%, 10%, 12.5%, 15%, 17.5%), and 2 control groups were involved. Yellow kepok banana peel extract was obtained through the maceration method using methanol as a solvent. The antibacterial activity was identified using the tube dilution method. Data analysis was conducted through the Kruskal Wallis test, the Mann Whitney test, and the Spearman correlation test. Result: Minimum Inhibitory Concentration (MIC) is obtained at a concentration of 10%, while the Minimum Bactericidal Concentration (MBC) is obtained at a concentration of 17.5%. The test results of tube turbidity statistics indicated that there were significant differences in each extract concentration and there was a relationship between the concentration variables and the turbidity of the tubes. The statistical test results of the colony growth revealed that there were significant differences in each extract concentration and there was a relationship between the concentration variables and the growth of bacterial colonies. Conclusion: Yellow kepok banana peel extract (Musa paradisiaca L. var. Bluggoe) is effective to use as antibacterial for chronic periodontitis caused by Porphyromonas gingivalis.
Front Matter JSMARTech, October 2020, Vol. 2 No.1 Safitri, Anna; Sari, Dewi Ratih Tirto
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 1 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2020.002.01.0

Abstract

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Molecular Docking Study of Active Compounds in Amaranthus tricolor Leaves as High Mobility Group Box 1 (HMGB1) Inhibitor in Breast Cancer Ardiana, Rachmawati; Khasanah, Dewi Uswatun; Permatasari, Diah; Adianingsih, Oktavia Rahayu
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 1 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2020.002.01.28

Abstract

Breast cancer shows the proliferation of malignant epithelial cells that limit the ducts and lobes of the breast. If this process is not controlled, it will cause lumps that can then spread to other parts of the body and cause death. High-mobility group box protein 1 (HMGB1) has been reported to play roles in promoting cell survival of breast cancer cells. The inhibition of HMGB1 could be a reasonable target for the treatment of breast cancer. Amaranthus tricolor has been found could reduce the viability of breast cancer cells. In this study, we aim to predict the ability of the active compounds in Amaranthus tricolor leaves to inhibit the HMGB1 through molecular docking study. The molecular docking was conducted by using the PyRx software. This study shows that the four active compounds in Amaranthus tricolor leaves, namely isorhamnetin, routine, myricetin, and quercetin, have the smallest bond energy, indicating that the four compounds are the most stable and have the highest potency as HMGB1 inhibitor.
Ocular changes –cataract and retinal lesion- in Spontaneously Diabetic Torii (SDT) fatty rats, an obese type 2 diabetic model Maekawa, Tatsuya; Nakamura, Sanae; Miyajima, Katsuhiro; Uno, Kinuko; Yamaguchi, Ayane; Mandai, Kouhei; Gotoh, Takayuki; Shinohara, Masami; Shinozaki, Yuichi; Sasase, Tomohiko; Fatchiyah, Fatchiyah; Ohta, Takeshi
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 2 (2021)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2021.002.02.81

Abstract

Cataract and retinopathy remain the preventable cause of blindness worldwide, and many pharmacological strategies have been proposed for the treatment of these eye diseases. Animal models play an important role in understanding the pathophysiological features of eye disease and developing for a new therapy. In this study, we investigated the development of cataract and retinal lesion with diabetes using an obese type 2 diabetic models SDT fatty rat. Macroscopic analysis in eyes was performed from 16 to 24 weeks of age and histological analysis was performed at 24 weeks of age. As a result, the lens cloudiness was observed from 19 weeks of age and the degree of the cloudiness was more progressed until 24 weeks of age. Histopathological findings, such as degeneration of lens fiber and shortening and irregular arrangement of cone and rod in retinal tissue, were observed at 24 weeks of age. In conclusion, SDT fatty rats may be useful to understand the pathological features in diabetic cataract and retinopathy develop a new therapy for the disease.
Histopathological Profile of Therapeutic Doses of Mango Mistletoe Methanolic Extract (MMME) in Cardiac of Hypertensive Rats (DOCA-Salt) Hakimah, Annisatul Anis; Sjakoer, Nour Athiroh Abdoes; Mubarakati, Nurul Jadid
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 2 (2021)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2021.002.02.48

Abstract

This study determined the effect of Mango mistletoe Methanolic Extract (MMME) on the cardiac's histopathological profile of hypertensive rats (DOCA-Salt) treated. The MMME was treated on fifty rats for 14 days, divided into five treatments: negative control, positive control, doses 50, 100, and 200 mg/kg BW with five replications. One-way ANOVA analysis was used, namely JAMOVI with version 1.1.9.0, and for cell calculation, diameter using the IMAGE J application. Results showed that there were no significant differences in the histopathological profile of the cardiac in hypertensive rats (DOCA-Salt) treated with MMME for 14 days on the diameter of the heart muscle cells between the control (+) and control groups (-), treatments 1, 2, and 3. This is evidenced by the analysis of p-value> 0.05, namely 0.187 millimeters. Therefore, we concluded that MMME does not affect the diameter of heart/cardiac organ muscle cells. However, there was a significant difference in the amount of necrosis in the cardiac of hypertensive rats between control (+) and control (-) groups, treatments 1, 2, and 3. Based on the results, MMME reduces the number of necrosis in the heart/cardiac organ. 
Community Empowerment Through 2nd Generation Tempeh Innovation Towards a Food Organized Village Raharjo, Sentot Joko; Fidyasari, Ambar
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 1 (2020)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2020.002.01.43

Abstract

Tempeh is one of Indonesia's traditional foods. Currently proposed to be a world cultural heritage in UNESCO. Tempeh cannot last long, so it takes innovation that can increase the economic value of tempeh itself. The main objective of this empowerment program is to optimize the potential of “UKM” (Small and Medium Industries) in the food sector for tempeh craftsmen and reduce the losses of tempeh craftsmen for those whose tempeh is not sold. The target partner of this community assistance program is the “UKM” group Tempeh Village in Beji Village, Junrejo, Batu City who has been economically productive as Tempeh craftsmen. The method used is Asset Based Communities Development (ABCD), where the community service focuses on assets owned by the community as the main basis for program development. The efforts carried out are assistance to SMEs to deliver material on the nutritional value of 2nd generation tempeh, workshops and 2nd generation tempe making practices, entrepreneur assistance and evaluation. This innovation is expected to be a solution to the unsold tempeh problem. This assistance was carried out for 3 months. The output of this empowerment activity is in the form of material modules, 2nd generation tempeh products, understanding of the nutritional value concept of second generation tempeh and digital marketing media plans.
In Silico Study: Potential Prediction of Curcuma longa And Cymbopogon citratus Essential Oil As Lipoxygenase Inhibitor Bare, Yohanes; Indahsari, Lilin Ika Nur; Sari, Dewi Ratih Tirto; Watuguly, Theopilus
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 2 (2021)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2021.002.02.75

Abstract

Abstract: Inflammation is the human body response by the injure as a results the inflammation will release LOX. To curve the conditions we use the bioactive from the nature are essential oil from Curcuma longa and Cymbopogon citratus because has a potential has pharmacologist activity. The purpose of this research to investigate the role essential oil from Curcuma longa and Cymbopogon citratus through LOX gene. Several chemical substances, including 3,7-dimethyl-1,3,6-octatriene, camphor, eugenol, curzerene and isoborneol were retrivied from PubChem database. The PyRx 0.8 was used to minimize and convert the sdf file to pdb format file of ligands. Those compounds were predicted their interaction using STITCH online server. Ligands and protein were docked by HEX Cuda 8.0.0 program, 3D and 2D views were evaluated using Discovery studio ver.19.0.0 and LigPlot+ ver 2.2, respectively. We found fourteen amino acid residues from LOX which bound the chemical compounds. Those interaction was supported by hydrogen bond with variety energy binding. To sum up, the essential oil from Curcuma longa and Cymbopogon citratus has a potential function as inhibitor LOX by inhibiting fourteen active side of the LOX gene. 
Effects of Mango Mistletoe (Dendrophthoe pentandra L. Miq) Extracts on Brain in Hypertensive Rats Treated with Deoxycorticosterone Acetate (DOCA)-Salt Saputri, Syntia Diyah Hayu Ria; Sjakoer, Nour Athiroh Abdoes; Mubarakati, Nurul Jadid
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 2 (2021)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2021.002.02.55

Abstract

Mango mistletoe (Dendrophthoe pentandra) is a plant that has the potential as a medicinal plant. Mango mistletoe is reported to contain the flavonoids quercetin, mesoinositol, rutin, and tannins. Hypertension as a non-communicable disease is a very serious health problem experienced by people in developing countries. Hypertension can be caused by high ROS (reactive oxygen species) which can inhibit oxygen flow to the heart and brain. Antioxidants can reduce the risk of hypertension. Damage to the brain due to hypertension is manifest in the white matter area. This study aimed to see how the histopathological profile of the brain in hypertensive rats (DOCA-Salt) which were given mango mistletoe methanolic extract (MMME) by experimental method. The number of tested animals was 25 male Wistar rats divided into 5 groups, each group contained 5 rats, they were negative control (Control-) as normotension, positive control (Control+) as inducer, and the treatment group with the provision of MMME at a dose of 50 mg / kgBW, 100 mg / kgBW, and 200 mg / kgBW. Data were analyzed using JAMOVI 1.1.9.0. Based on the results of the study showed that the difference in significant values between all groups was p<0.05. So, that giving EMBM to male rat significantly can decrease the number of cell necrosis and affect the width of the white matter area of the brain. The three dose variations did not show a significant difference, so this effect was controlled by the MMME dose of 50 mg / KgBW which was the optimum dose in reducing the amount of cell necrosis in the white matter area of the male Wistar rat brain.
Screening of COVID-19 Using Rapid Test Before Gastrointestinal Procedures; Experience in a Limited Resource Hospital Yusuf, Fauzi; Maghfirah, Desi; Muhsin, Muhsin
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 1 (2020)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2020.002.01.35

Abstract

Corona Virus Disease 2019 (COVID-19) is an emerging disease announced by World Health Organization (WHO) as a pandemic disease since March 2020. Several international guidelines suggested use of reverse transcriptase polymerase chain reaction (RT-PCR) test as screening tool before starting gastrointestinal (GI) procedures. Although RT-PCR is a gold standard, it has limitation as it is expensive and requires special expertise therefore difficult to implement in limited resource hospitals. Due to lack of RT-PCR tests available and in accordance with Indonesian government regulation, thirty patients in a tertiary referred hospital in Banda Aceh were screened with rapid test antigen and antibody for COVID-19 before underwent emergency and urgency GI procedures such as endoscopy, colonoscopy and abdominal ultrasonography. Several laboratory parameters and chest X-ray in all patients were assessed. All health care workers in procedure room were also tested with rapid antigen 1 week after the procedures. The study showed that laboratory parameters and chest X-ray were relatively normal for all patients. All procedures were conducted safely and leave no new COVID-19 case amongst health care workers. In conclusion, rapid test can be used in hospitals with limited resources, although RT-PCR test is still needed to confirm COVID-19 cases. Safe GI procedures can still be performed in limited resource hospital, although the possibility for disease transmission is still high. A modified guideline is needed in these hospitals in order to conduct safe GI procedures.

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