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Indian Journal of Forensic Medicine & Toxicology
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Articles 5,497 Documents
Post-mortem Gross Detection of Early Myocardial Infarction using Triphenyl Tetrazolium Chloride Test Ali Ayad Abdulridha; Saad Kadhim Kareem
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16778

Abstract

Background: Ischemic heart disease is the leading cause of mortality in the world. More than 17 millionpeople die each year as a result of myocardial infarctions. Post-mortem histochemical detection of earlymyocardial infarction using 2,3,5-Triphenyl Tetrazolium Chloride (TTC) technique is based on the factthat ischemic myocardial cells lose their membrane integrity and release dehydrogenase enzyme into theblood stream, resulting in decrease or total depletion of these enzymes within the necrotic areas of themyocardium, and so, after immersion in TTC solution, enzyme depleted necrotic myocardium will notretain TTC dye and therefore appears as pale/yellow areas. Materials and Methods: This prospectivepostmortem study was conducted at Medicolegal Directorate in Baghdad city during the period fromMarch 2020 to December 2020. Myocardial specimens were isolated from 75 cases of sudden natural deathand were subjected to 1% TTC solution staining for gross assessment, and subsequently, tissue samples weretaken from suspected areas, processed and stained with H&E for histopathological evaluation and detectionof a possible acute myocardial infarction. Results: The mean age of studied cases was 50.3 ±12.57 years,ranging from 18 to 78 years, median age was 53 years. Males constituted the majority of cases (80%). Caseswere predominantly within 40-59 years age group (58%). The postmortem interval was ranging from 2 to17 hours (mean= 8.6 ±3.6 hours). After immersion in 1% TTC solution, 45 myocardial specimens showedmacroscopic pale/yellow areas which were indicative of acute myocardial infarcts within the ventricularwall, while histopathological examination of specimens revealed features of acute myocardial infarction(AMI) in 62 specimens. TTC stain was found to have a diagnostic sensitivity of 69.4% and specificity of76.9% in postmortem detection of AMI. Conclusion: The TTC technique allows identification of earlymyocardial necrosis. It’s practical, reliable and valid method that promises to be of considerable value. Itcan be used together with histopathology for postmortem detection of visually unapparent acute myocardialinfarcts.
Fetal and Maternal Plasma Thyroid Hormone’s Levelsin the Guinea Pigs ALwan Ali Fadil; AL-Souz Mohammed Abdul Hadi Khalil; TareqHafdhiAbdtawfeeq Al-Khayat
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16780

Abstract

Background: All available data indicate that the thyroid of the guinea pig fetus is capable of functioningindependently of that of the mother . Therefor fetal thyroid function is necessary for normal growth in utero.Intrauterine adaptation to the outside environment is important mechanism via which fetus increases thechance to thrive after birth. Aim and Objective of this work to assess the plasma level of thyroxin (T4) andTriiodothyronine (T3) through most period of pregnancy in fetal and maternal guinea pigs. Materials andMethods: Blood samples collected from 51pregnant guinea pigsand their fetuses(93), by the Cobase 411device produced by, Roche com. and it works with technology Electro, Plasma T4 and T3 were measured byChemiLuminescence immune-assay. Results: Fetal plasma Thyroxin (T4) concentration was greater thanthat of the mother between Results 50 and 62 days of gestation while fetal plasma T3 concentration was lessthan that of the mother throughout gestation. In fetalguinea pig the reciprocal relationship between pituitaryand thyroid is established at approximately day 34-35 of gestation. Conclusion: Theresults indicated thatthe fetal pituitary–thyroid system (PTS) is functioning at a relatively high level than that of the maternal,starting few days beforethe second half of pregnancy .Thyroid hormones are important for fetal growth andmaturation event.
Effect of Different Drugs on Diuretic Resistance Indices in Patients with Renal Impairment Using Intravenous Furosemide Alyaa Abdalrazaq Abass; Ali Mohammed Hadi; Jubran K. Hassan
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16781

Abstract

Chronic kidney disease is a medical condition defined as a reduction in kidney function, made known byglomerular filtration rate of a less than 60 mL/min per 1·73 m², or signs of kidney impairment (albuminuria),or both for at least three months period, nevertheless of the original cause.Diuretic resistance in the edematous patient is defined as a clinical state in which diuretic response isdiminished or lost before the therapeutic goal of relief from edema has been reached.This study aims to find the effect of different drugs on kidney functionindices and the relationship of usingthese drugs with the development or improvement of diuretic resistance.The study is a cross-sectional observational study. It was carried out at Al-Hussein-Teaching Hospital inThi-Qar. Nasiriya. Data from 104 patients were collected and analyzed using different statistical methods.The results showed that there was a different odd of effects of the drugs commonly used to patients withCKD due to other comorbidities on diuretic resistance indices. There was a significant increase in the bodyweight and decline in serum urea in patients already with edema when they used calcium ampoule. Serumurea was not affected by any of the other studied drugs. There were two drugs affected positively on serumcreatinine, which are clopidogrel and heparin. Albuminuria was highly improved in patients receivingaspirin and atorvastatin. Clopidogrel significantly increased GFR in these patients.
Assessment of Relationship between Ectopic Pregnancy and Assisted Reproductive Technology in Baghdad City Alyaa Khazaal Neamah; Wisam Mashaan Muttaleb
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16784

Abstract

Objectives: To find out the relationship between assisted reproductive technology,Some demographics characteristic and ectopic pregnancy among women with ectopic pregnancyMethodology: A descriptive study was applied to assess the relationship between ectopic pregnancy andAssisted Reproductive Technology among purposive sample of (60) women aged between (20-43) yearsold attended the hospitals in Baghdad city. Results: The study show that the most woman in the age group(32-37) years old, was primary school graduate, most of them have no gravidity, were treated with assistedreproductive technology previously for (5-12) month, Clomiphene citrate (clomid) is used in the rate (50%),suffering from lower abdominal pain and Darker or brown vaginal spotting. Conclusions: The studyconcluded that there is significant relationship between the use of Clomiphene citrate (clomid) and ectopicpregnancy and the most benefit treatment for ectopic pregnancy is methotrexate. Recommendations: Thestudy recommended a furthers study on ovulation induction, training program about the effect of ovulationinduction especially (clomid) on women health
Evaluating the Safety of Non-Steroidal Anti-inflammatory Drugs use in Asthmatic Patients: A Systematic, Critical Review of Literature Amanj Baker Kurdi
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16785

Abstract

Background: Evidence suggest avoidance of Non-steroidal anti-inflammatory drugs (NSAID) in aspirinintolerantasthmatics due to the risk of triggering exacerbation attack; however, evidence around avoidingNSAIDs in all other asthmatic patients are unclear. This study aimed to evaluate the evidence surroundingthe safety of using NSAIDs, including selective COX-2 inhibitors, among asthmatic patients.Methods: A systematic review used Medline (OVID), Scopus and Embasefrom January-2008 toJanuary-2019. Inclusion criteria includedEnglish, and human studies that evaluated the use of NSAID inasthmatics. Data was screened/extracted using a pre-designed data extraction form using Covidence®,thenwere critically appraised.Conclusion: Of the 49 identified studies,eight were eligible. Prevalence of NSAID-induced asthmaexacerbation was 9%(95%CI:6.0–12.0%)-9.9% (95%CI:9.4-10.5%). Asthmatics who were aspirin/NSAIDintolerant had 37% higher risk of hospitalisation compared to tolerant patients (RR:1.37; 95%CI:1.12–1.67).Use of COX-2 inhibitors showed non-significant associations with worsening respiratory symptoms/exacerbation. Only low-quality evidence was found for the safety of topical NSAID. NSAIDs-inducedrespiratory reactions/symptoms is relatively uncommon with the majority of asthmatic patients couldtolerate NSAIDs therapy. Asthmatic patients who suffer from aspirin-induced asthma or NSAIDsexacerbatedrespiratory disease (NSAIDs intolerant) should be avoided NSAIDs prescribing but could besafely prescribed selective COX-2 inhibitors as an alternative.
Pt Kereta Api Indonesia (Persero) Strategy in Facing Corona Virus Disease-19 Pandemic Ambar Mutiara; Djoko Suhardjanto; Yeni Priatna Sari
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16786

Abstract

The purpose of this research is to study and find out the strategies implemented by KAI in dealing with theimpact of the Covid-19 pandemic on KAI’s performance. The method of analysis in this study is a qualitativedescriptive method by analyzing all the data related to the topic being studied, which is then presentedwith fairly comprehensive and comprehensive arguments. The results showed that the very fast growth inthe last ten years is KAI’s performance that should be appreciated. However, the Covid-19 pandemic is areminder that economic development (profit) must be accompanied by the principles of sustainability andenvironmental and social concerns. The current situation in the impact of the Covid-19 Pandemic is veryunfavorable for achieving revenue targets for passenger and freight transport. KAI has carried out variousstrategies in dealing with the impact of the Covid-19 pandemic. Several things that have been done by KAIin dealing with the impact of the Covid-19 pandemic include: 1. Protecting passengers and employees ofKAI by prioritizing health through the Covid-19 prevention protocol; 2. Maintain company liquidity bypreparing several scenarios, if the pandemic ends in June, August or December; 3. Perform cost efficiency(operational expenditure) and reduced investment (capital expenditure) to balance the potential decline inincome.
Novelty Predictor ZnO Nano practical for Cancer Treatment Anmar Hameed Bloh; Hassan Khuder Naji; Antesar Rheem Obead
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16787

Abstract

Zinc oxide nanoparticles (ZnO NPs) are used to increasing the number of industrial products such as rubber,paint, coating, and cosmetic and one of the most popular metal oxide nanoparticles in biological applications.The ZnO NPs have become exceptional biochemistry , trade and industry, and less poisonousness. Inbiomedicine the ZnO NPs have been appeared a encouraging possible, specially in the playing field ofanticancer and antiseptic grounds, which are included by their effective capability to initiate additional ofreactive oxygen species (ROS) creation, produce the zinc ions, and the cell apoptosis have been induce.Furthermore, to keep the structural integrity of insulin is well known zinc. Consequently, the ZnO NPshave been efficiently technologically advanced designed for antidiabetic drug . The ZnO NPs appearanceexceptional luminescent material goods in addition have straight them into one of the chief applicants for bioimaging. Now, in the biomedical fields the synthesis of ZnO NPs for facilitating of future research progressand focusing in biomedical fields will be helpful.
Comparative Study Thymol Oil and Some Gel Face Washing on Resistance Propionibacterium Acnes Mais E.Ahmed; Jenan A.Ghafil; Walaa Najim
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16788

Abstract

Acne is elevated of skin secretion with hyperkeratosis causing Propionibacterium acnes. The goal of studywas to assess the anti-inflammatory, and antibacterial potential of Thymol oil compare Gel face ,and is themain bacterium involved in the acne. The unpredictable use of antibiotics for the treatment of acne may endup within the advancement of bacterial resistance.
Primary Prevention Program of Obesity among Primary School Children Amina Mohamed Ismail; Hanaa Abdel Hakeem Ahmed; Frial Fouad Malika
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16789

Abstract

Background: Childhood obesity is a serious medical condition that affects children and adolescents. It’sparticularly troubling because the extra pounds often start children on the path to health problems thatwere once considered adult problems: diabetes, high blood pressure and high cholesterol. Aim of theStudy: assess the effect of primary prevention program of obesity among primary school children through:assessing knowledge & practices of primary school children related to obesity, Designing, implementingprimary prevention program of obesity among primary school children, evaluating the effectiveness ofprimary prevention program on knowledge & practices related to obesity among primary school children.Subjects and Methods: Setting: The study was conducted in four primary governmental school of El-Salamcity , Cairo governorate including: (El Hussien, Osman Ben Afan, Atef El Sadat and Gamal Abdel Naser).Size: the sample composed of 144 primary school children chosen randomly through multistage sampling .Tools: Different tools were used for data collection of study and it was written in simple language to suit theunderstanding level of the studied primary school children First tool: Structured interviewing questionnaire,second tool: Anthropometric Measurements , physical assessment sheet Results: clarified that only fewpercentage of primary school children had good Knowledge preprogram while this improved to more thanone third post program implementation related to their total knowledge about childhood obesity , there washighly statistically significant difference in post-program compared to pre-program according to their totalpractice related to childhood obesity. Conclusions: primary school children improved their knowledge andpractice regarding childhood obesity after program implementation. Recommendation: primary preventionprogram must be provided for all primary school children to prevent childhood obesity risks.
Neuroprotective Effect of Moringa Oleifera Extract on Acetamiprid Induced Neurotoxicity and Apoptosis in Albino Rats Amr A. Abdallah; Marwa A. Ibrahim; Eman A. Ibrahim; Hossam El Din H. Abdelhafez; Naglaa F. Mahmoud
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16790

Abstract

Acetamiprid (ACMP) can cause neurotoxicity and induces neuronal apoptosis. The ameliorative effects ofMoringa Oleifera (MO) seed extract against the neurotoxicity induced by ACMP in adult male albino ratswere investigated. Forty male albino rats were divided into 4 equal groups. The first group served as a control,the second group administered ACMP 26.8mg/kg b.w. (representing 1/10 LD50) by gavage. The third groupwas given combination of ACMP 26.8 mg/kg b.w. and MO seed extract 150 mg/kg b.w. the fourth group wasgiven MO extract only 150 mg/kg b.w. for 28 consecutive days. Results proved the efficacy of MO extractas a neuroprotective agent through the reduction of the oxidant parameter malondialdhyde (MDA) contentby 26.9%, significant increase of reduced glutathione content (GSH) by 21.4%, and elevation of catalase(CAT) and superoxide dismutase (SOD) activities by (62.2% and 40.8%) respectively, compared to ACMPintoxicated group. Consequently, gene expression analysis for Bax and NBN genes was downregulatedby 54.5% and 36.3% respectively in MO treated rats (group III) compared with ACMP intoxicated group.Moreover, restoration of the pathological tissue injuries was noticed. In conclusion, MO proved to be aneffective neuroprotective and anti-apoptotic agent against ACMP-induced toxicity.