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Yolanda Handayani
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INDONESIA
Respiratory Science
Published by Perhimpunan Dokter Paru Indonesia
ISSN : -     EISSN : 27471306     DOI : https://doi.org/10.36497/respirsci.v1i3.17
Core Subject : Health,
Health Professions Medicine & Pharmacology
Focuses on original article reviews and case reports in pulmonary and critical care medicine Scope: 1. Asthma 2. Chronic Obstructive Pulmonary Disease (COPD) 3. Lung Physiology and Sleep-Related Disorder 4. Lung Infection 5. Thoracic Oncology 6. Interstitial Lung Disease 7. Environmental Lung Disease 8. Tobacco Control 9. Occupational Pulmonary Disease 10. Pulmonary Intervention and Emergency Medicine 11. Respiratory critical care 12. Respiratory immunology and biomolecular
Arjuna Subject : Kedokteran - Kedokteran Paru dan Pernafasan
Articles 6 Documents
 1 
Search results for , issue "Vol. 5 No. 1 (2024): Respiratory Science" : 6 Documents clear
Correlation Between Changes in NLR Value and RECIST among Lung Cancer Patients at Saiful Anwar Malang Hospital Kristianto, Fransiskus; Setyawan, Ungky Agus; Erawati, Dini Rachma
Respiratory Science Vol. 5 No. 1 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v5i1.141

Abstract

Background: In practice, clinicians use Response Evaluation Criteria in Solid Tumors (RECIST) to decide the progressivity of lung tumors. Besides RECIST, there is an inflammatory marker called Neutrophil to Lymphocyte Ratio (NLR), which has prognostic value in cancer patients. Many previous studies have shown that NLR can predict the prognosis because inflammation in cancer patients is part of the tumor progressivity.  Therefore, the changes in NLR value have the potency to be one of the ways to decide the progressivity of tumors in lung cancer patients. Method: This cross-sectional study was conducted to see whether there is a correlation between RECIST and NLR in 95 lung cancer patients at Saiful Anwar Hospital whose data were taken from January 2022 to May 2023. The variable will be tested using the chi-square test to see the correlation and the logistic regression method to obtain the odds ratio. Results: There is a significant correlation between changes in NLR and RECIST with P=0.041.  Through Logistic Regression Analysis, the value of the odds ratio is 2.46 (CI 95%=1.03-5.94).  In the group with progressive RECIST, the average NLR value after therapy was higher than the average NLR value after therapy in the non-progressive group. Conclusion: This study concludes that changes in NLR value have the potency to help the determination process of lung cancer progressivity as RECIST does.
The Relationship of Serum Zinc Levels and Clinicopathological Characteristics in Individuals with Lung Cancer Haryati, Haryati; Eko Prasetyo, Nugroho; R. Simarmata, Eviriana; Parhusip, Mual Bobby Enrico; Arganita, Fidya Rahmadhany; Humaira, Adhwa
Respiratory Science Vol. 5 No. 1 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v5i1.143

Abstract

Background: Lung cancer is one of the main contributors to malignancy and leads to the patient's death. The immune system, genetics, and inflammation affect lung cancer progression. Zinc (Zn) is an essential mineral; a Zn deficiency increases the tumor suppressor's expression, damaging deoxyribonucleic acid (DNA) repair ability in tumor growth. The study focused on establishing a relationship between serum Zn levels and lung cancer patients' clinicopathologic characteristics. Method: Thirty-five patients diagnosed with lung cancer were part of the study. The study collected clinicopathological data and serum Zn levels at the initial diagnosis. Serum Zn insufficiency is characterized by a below 80 μg/dL serum Zn level. Results: The median Zn level in our study was 65 μg/dL (range=56.5-73 μg/dL). Serum Zn deficiency was observed in 91.4% of patients, particularly those who had a smoking history, advanced stage, or had hypoalbuminemia. The low-level group exhibited significantly lower albumin concentrations (3.06 g/dL vs. 3.66 g/dL; P=0.024) than the normal group. Conclusion: Most patients with lung cancer at initial diagnosis had a deficiency in Serum Zn, which was associated with hypoalbuminemia.
Profile of Risk Factors for Venous Thromboembolism (VTE) in Acute COPD Exacerbations at Kolonel Abundjani Bangko Regional Hospital Mutmainnah, Yaumi; Lindra, Derallah Ansusa
Respiratory Science Vol. 5 No. 1 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v5i1.151

Abstract

Background: Acute exacerbation of COPD is characterized by dyspnea and/or cough with worsening sputum production for <14 days. Patients with acute exacerbations of COPD are at increased risk of vascular events, including venous thromboembolism (VTE). VTE risk factor assessment can be carried out using a scoring system to estimate the risk of a patient experiencing VTE before further examination is conducted. Method: This study used a cross-sectional approach. Research subjects were selected from patients diagnosed with acute exacerbation of COPD at Kolonel Abundjani Bangko Regional Hospital from November 2023 to January 2024. Patient data were extracted from medical records, and then patients who were compatible with the inclusion criteria were interviewed using the Wells and Padua criteria. Univariate analysis was conducted to assess the characteristics of VTE risk in acute exacerbation of COPD. Bivariate analysis was utilized to determine the correlation between the exacerbation of COPD and VTE risk using the chi-square test.   Results: A total of 20 cases of acute exacerbation of COPD were identified from November 2023 to January 2024. Based on Wells's criteria, as many as 18 patients (90%) were not at risk of developing VTE. Based on Padua criteria, 13 patients (65%) were at low risk and 7 patients (7%) were at high risk of developing VTE. The most common patient characteristics based on the scoring system are an increase in heart rate >100x according to the Wells criteria and the presence of acute infections or rheumatological disorders, which represent the Padua criteria. There is no correlation between acute exacerbation of COPD and VTE risk scoring.   Conclusion: The majority of patients with acute exacerbation of COPD are not at risk of developing VTE. There is no correlation between acute exacerbation of COPD and the risk of VTE.
Obesity Hypoventilation Syndrome (Pickwickian Syndrome): A Literature Review Ramadhan, Alfin Ridha; Betcy, Betcy; Aurora, Ruth Grace; Prasenohadi, Prasenohadi; Alatas, Mohamad Fahmi
Respiratory Science Vol. 5 No. 1 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v5i1.155

Abstract

Obesity hypoventilation syndrome (OHS), also known as Pickwickian syndrome, is a respiratory disorder characterized by reduced alveolar ventilation and elevated daytime carbon dioxide levels, primarily associated with obesity. If untreated, OHS can progress to pulmonary hypertension (PH) and ultimately heart failure. The exact prevalence of OHS in the general population remains unclear, but studies estimate it to range from 8% to 12.3%, increasing with obesity prevalence. This review discusses the diagnostic criteria for OHS, the utility of the STOP-Bang questionnaire in screening, and advances in understanding the pathophysiology and management of OHS, focusing on heart failure with preserved ejection fraction (HFpEF). Accurate diagnosis of OHS is critical and requires a thorough approach involving an extensive patient medical history and physical examination to differentiate OHS from obstructive sleep apnea (OSA). Key diagnostic tests include serum bicarbonate levels and arterial blood gas (ABG) analysis, to confirm the hypercapnia and identify the severity of hypoventilation. Given the rising prevalence of obesity worldwide and the serious complications associated with untreated OHS, early and accurate identification of OHS is essential, as it can prevent the progression to severe pulmonary hypertension (PH) and the subsequent development of heart failure (HF).
Physical Medicine and Rehabilitation Management in Patients with Long COVID-19 and Thymoma-associated Myasthenia Gravis: A Case Report Tambunan, Tresia Fransiska Ulianna; Nathania, Eugene; Putryanti, Rimnauli Deasy Putryanti; Tifany, Elisabeth Pauline; Kurnain, Dave Nicander
Respiratory Science Vol. 5 No. 1 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v5i1.156

Abstract

Background: Myasthenia gravis is an autoimmune disease that causes muscle weakness and fatigue due to antibodies attacking the acetylcholine receptor. In patients with MG, fatigue can be worsened by concurrent long COVID, leading to further deterioration of cardiorespiratory function. Case: A 44-year-old woman with long COVID syndrome and thymoma-associated myasthenia was given an exercise program that aimed to overcome fatigue so that the patient could carry out her role as a housewife, and to prepare for thymectomy surgery. Before exercise, patients were educated to take pyridostigmine 1 hour earlier. During exercise, the patient was monitored to prevent excessive fatigue. At the end of the training session, the patient was asked to observe for signs of exacerbation until the next training session. Discussion: Pulmonary rehabilitation (PR) can be beneficial for patients with thymoma-associated MG and long COVID-19, but it requires special strategies. PR typically starts with light weights and gradually increases in intensity. It has been shown to improve fatigue and cardiorespiratory endurance, as indicated by a successful 6-minute walk test after 4 weeks of training intervention. Conclusion: Pulmonary rehabilitation plays an important role in increasing cardiorespiratory endurance and functional capacity for surgery preparation. The provision of pulmonary rehabilitation programs must be tailor-made according to the patient's functional ability and underlying disease to achieve optimal goals.
The Relationship between Particulate Matter and Length of Exposure to Respiratory Complaints and Lung Function Disorder among Brick Craftsmen in Aceh Besar Dianova, Sri; Febriansyah, TM.; Yanti, Budi; Andayani, Novita; Yusuf, Nurrahmah; Kurniawan, Ferry Dwi; Salawati, Liza
Respiratory Science Vol. 5 No. 1 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v5i1.161

Abstract

Background: Brick craftsmen are heavily exposed to particulate matter (PM) from brick burning, possibly contributing to respiratory complaints. The research aims to evaluate the association between PM levels, duration of exposure, respiratory complaints, and lung function disorders among brick craftsmen in Aceh Besar. Method: The research method is observational analytic with a cross-sectional design. It was conducted in September 2023 on 68 respondents to assess lung function using spirometry and PM levels using the Air Quality Monitor. Results: The data analysis revealed restrictive types of lung function disorders (47.1%), 75% of participants had worked for more than three years with working hours ≥8 hours/day (100%), the most frequent respiratory complaint was coughing (23.5%) and shortness of breath (13.2%), and the dominant type of work was brick molding (67.6%) rather than burning (32.4%). The PM2.5 index in the brick manufacturing area is classified as very dangerous (100%), while the PM10 index is identified as very unsafe (55.6%) and very dangerous (44.4%). The correlation analysis revealed a significant connection between PM2.5 as well as PM10 and lung function impairments (values of P=0.002 and 0.012, respectively). There was a significant correlation between work periods and lung function impairments (P=0.037). Multivariate analysis showed that a working term of 1-3 years was strongly linked with lung function disorder (FEV1) among brick craftsmen in Aceh Besar (P=0.026). Conclusion: This study showed that PM exposure was significantly associated with impaired lung function but not with respiratory complaints. Furthermore, a long working period is significantly associated with respiratory symptoms, especially for workers with 1-3 years, and is associated with impaired lung function in brick artisans in Aceh Besar.

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