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Yolanda Handayani
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Respiratory Science
Published by Perhimpunan Dokter Paru Indonesia
ISSN : -     EISSN : 27471306     DOI : https://doi.org/10.36497/respirsci.v1i3.17
Core Subject : Health,
Health Professions Medicine & Pharmacology
Focuses on original article reviews and case reports in pulmonary and critical care medicine Scope: 1. Asthma 2. Chronic Obstructive Pulmonary Disease (COPD) 3. Lung Physiology and Sleep-Related Disorder 4. Lung Infection 5. Thoracic Oncology 6. Interstitial Lung Disease 7. Environmental Lung Disease 8. Tobacco Control 9. Occupational Pulmonary Disease 10. Pulmonary Intervention and Emergency Medicine 11. Respiratory critical care 12. Respiratory immunology and biomolecular
Arjuna Subject : Kedokteran - Kedokteran Paru dan Pernafasan
Articles 6 Documents
 1 
Search results for , issue "Vol. 6 No. 1 (2025): Respiratory Science" : 6 Documents clear
Dry Pleuroscopy as a Diagnostic Tool for Lung Cancer with Minimal Pleural Effusion Putra, Muhammad Ryan Adi; Aniwidyaningsih, Wahju; Martini, Ni Putu Laksmi Ananda
Respiratory Science Vol. 6 No. 1 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v6i1.178

Abstract

Dry pleuroscopy is a minimally invasive procedure used to evaluate and manage pleural conditions, particularly in cases of minimal pleural effusion (mini-PE) or dry pleural dissemination (DPD). This procedure involves the induction of artificial pneumothorax to create a workspace, allowing for direct access to the pleura without relying on a significant pleural effusion, unlike wet pleuroscopy. The key advantages of dry pleuroscopy include the elimination of the need for general anesthesia, mechanical ventilation, or specialized operating rooms, thereby reducing the risk of complications and associated costs. With a sensitivity of 94.4% and a specificity of 92.8%, dry pleuroscopy is highly effective for diagnosing lung cancer and pleural metastases in cases of minimal effusion. It also aids in lung cancer staging, minimizing the need for invasive procedures like lobectomy in complex cases. Artificial pneumothorax is a key step in dry pleuroscopy. It can be achieved through blunt dissection, optical trocars, or specialized tools such as the Boutin needle or Veress cannula. Ultrasound (USG) guidance further enhances procedural accuracy and safety by reducing complications. Dry pleuroscopy provides a safe, effective, and cost-efficient diagnostic and therapeutic solution, making it preferable to methods such as video-assisted thoracoscopic surgery (VATS), especially in patients unfit for invasive procedures.
Factors Associated with Delayed 2-Month Sputum Smear Conversion in MDR-TB Patients Treated with All-Oral Regimen at Persahabatan Hospital Sitinjak, Sahat Anugerah Immanuel; Harfiani, Erna; Tjang, Yanto Sandy; Muktamiroh, Hikmah; Sutarto, Riyadi
Respiratory Science Vol. 6 No. 1 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v6i1.183

Abstract

Background: The emergence of multidrug-resistant tuberculosis (MDR-TB) presents significant challenges in achieving treatment success. Sputum conversion time, an essential indicator of treatment progress, varies among patients and may be influenced by demographic and clinical factors. This study aimed to identify factors associated with sputum conversion time in MDR-TB patients treated with all-oral regimens at Persahabatan Hospital during the 2021–2022 period. Method: This retrospective cohort study analyzed data from 154 MDR-TB patients treated with all-oral regimens at Persahabatan Hospital. Patients were categorized by sputum conversion time (≤2 months or >2 months). Independent variables included age, sex, diabetes mellitus, anemia, previous TB treatment, pulmonary cavitation, education level, marital status, and initial sputum AFB results. Inclusion criteria were primary pulmonary MDR-TB patients confirmed via sputum culture, aged ≥20 years, and treated per Indonesian national guidelines. Logistic regression analyses identified significant factors. Results: Among the nine factors studied, four significantly influenced sputum conversion time: elderly age, anemia, pulmonary cavitation, and initial sputum AFB results. Older age (≥60 years) was protective against delayed conversion, while anemia, pulmonary cavitation, and higher initial sputum AFB results were associated with prolonged conversion times. Conclusion: Factors such as anemia, pulmonary cavitation, and initial sputum results are associated with delayed sputum conversion, with elderly age as a protective factor against delayed sputum conversion.
Navigating Airway Dilemmas in Massive Lung Abscess: A Case Report of Risking Rupture to Save Ventilation Putri, Nurul Hazi; Fauzi, Zarfiardy Aska; Ananda, Pratama
Respiratory Science Vol. 6 No. 1 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v6i1.185

Abstract

Background: Lung abscess is a necrotizing infection with cavitary lesions and air fluid levels, most often from aspiration, hematogenous spread, or bronchial obstruction. Despite better antibiotics, large abscesses remain difficult to manage, especially with respiratory failure and altered consciousness. Case: A 49-year-old woman with uncontrolled hypertension who presented with progressive shortness of breath, cough, and fever. On admission to the Respiratory Intensive Care Unit (RICU), the patient appeared acutely ill, with a Glasgow Coma Scale of E4M6V4 and signs of systemic inflammation, hypoalbuminemia, and elevated D-dimer. Chest imaging revealed a large cavitary lesion in the left lower lobe (9.4 × 12.5 × 12.4 cm) with segmental atelectasis. PaO₂/FiO₂ ratio was 210, indicating mild oxygenation impairment. Blood cultures yielded Staphylococcus haemolyticus. Due to declining consciousness and respiratory effort, the patient underwent endotracheal intubation with lung-protective ventilation. A chest tube was placed, draining 300 mL of purulent fluid. The patient improved clinically and radiographically and was discharged, with successful extubation and recovery over ten days. Discussion: This case shows that managing a massive lung abscess in a critically ill patient demands individualized, multidisciplinary decisions that balance airway protection, infection control, and procedural safety, using head-up RSI with minimal-pressure ventilation and early cuff inflation, strict lung-protective settings, and timely chest-tube drainage. Stabilization was achieved despite a negative sputum culture and Staphylococcus haemolyticus bacteremia, in the context of complicating comorbidities. Conclusion: Timely intubation and individualized drainage strategies using a multidisciplinary approach are essential in managing large pulmonary abscesses in critically ill patients.
Hematologic and Non-Hematologic Side Effects in Lung Cancer Patients Post Chemotherapy at Arifin Achmad General Hospital Oinike, Irene; Munir, Sri Melati
Respiratory Science Vol. 6 No. 1 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v6i1.186

Abstract

Background: Lung cancer is the second-highest cause of malignancy in the world, with a prevalence of 11.4% of all types of cancer. The majority of lung cancer patients are diagnosed at an advanced stage; therefore, chemotherapy acts as palliative therapy without curative therapy options. Chemotherapy drugs have various side effects, both hematologic and non-hematologic. Thus, monitoring side effects should be notable to improve the quality of life for patients with lung cancer undergoing chemotherapy. Method: This research was a descriptive study with a total sampling data collection technique. Samples were collected for 6 months according to the inclusion criteria, and the results were presented in the form of a distribution table. Results: During August 2023 to January 2024, 29 lung cancer patients met the inclusion criteria at Arifin Achmad General Hospital. Of these 29 patients, 25 (86.21%) were men and 4 (13.79%) were women. The hematologic side effects were observed in 16 (55.17%) patients, while non-hematologic side effects were found in 18 (62.07%) patients. The most common hematologic side effect is anemia, and the most common non-hematologic side effect is gastrointestinal disorders. Conclusion: The chemotherapy regimen used for lung cancer patients caused both hematologic and non-hematologic side effects. The non-hematologic side effects were more common than the hematologic.
Optimizing Early Recognition and Management of Sepsis Secondary to Pneumonia: A Literature Review Adhyaksa, I Wayan Pande
Respiratory Science Vol. 6 No. 1 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v6i1.187

Abstract

Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, frequently complicates pneumonia, a leading global cause of morbidity and mortality. This review synthesizes current evidence on optimizing early recognition and management of sepsis secondary to pneumonia, highlighting critical diagnostic and therapeutic strategies. Streptococcus pneumoniae remains the predominant pathogen in community-acquired pneumonia (CAP), though antimicrobial resistance and atypical organisms pose growing challenges. Key risk factors include comorbidities (e.g., renal/liver disease, diabetes), immunosuppression, and socioeconomic determinants. Early diagnosis combines clinical assessment (e.g., SOFA, qSOFA scores) with biomarkers like procalcitonin, lactate, and neutrophil-to-lymphocyte ratio (NLR). Innovative tools, such as AI-driven analysis of blood count data, show promise for rapid sepsis detection. The cornerstone of management is the "1-hour bundle": immediate broad-spectrum antibiotics (tailored to local resistance patterns), fluid resuscitation with crystalloids, and vasopressors for refractory hypotension. Antibiotic selection must account for pathogen profiles, with macrolides or fluoroquinolones recommended for severe CAP. Fluid balance is critical to avoid pulmonary edema, while organ support (e.g., mechanical ventilation) is often required for respiratory failure. Despite therapeutic advances, sepsis mortality remains high (24–65% in Indonesia), driven by delays in treatment and comorbid conditions. Survivors frequently face long-term physical and cognitive impairments, necessitating comprehensive rehabilitation. Future efforts should prioritize rapid diagnostics, personalized therapy, and post-sepsis care to improve outcomes. This review underscores the importance of early, protocol-driven interventions to mitigate the global burden of sepsis complicating pneumonia.
Association Between Factory Workers’ Profile with Chest X-ray Finding and Spirometry at Industrial Company of X Wijaya, Dewi; Esha, Indi; Adrianison, Adrianison; Simatupang, Elvando Tunggul Mauliate; Amarudin, Amarudin
Respiratory Science Vol. 6 No. 1 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v6i1.198

Abstract

Background: Factory workers are a group at high risk of developing occupational lung abnormalities. Continuous exposure to dust, smoke, or gas particles during work processes may lead to progressive lung damage. Chest X-ray and spirometry are essential diagnostic tools for assessing both structural and functional lung changes, allowing early detection and prevention of occupational lung disability, especially among workers exposed to airborne pollutants. Method: This analytical observational study employed a cross-sectional design to analyze the association between factory workers’ profiles and chest X-ray and spirometry findings. Lung function was assessed using spirometry parameters, including Forced Vital Capacity (FVC), Forced Expiratory Volume in one second (FEV₁), and FEV₁/FVC ratio to identify restrictive or obstructive patterns. Data were collected using total sampling during periodic health examinations and analyzed with SPSS version 26.0. Descriptive statistics were used to summarize characteristics, while inferential analysis using Chi-square or Fisher’s exact tests was conducted to determine associations between categorical variables, with a significance level set at P<0.05. Results: A total of 260 factory workers participated, most with ≤5 years of work experience (60.76%). Comorbidities were significantly associated with both chest X-ray findings and lung function (P=0.034 and P=0.004). Smoking history and length of work also showed significant relationships with lung function (P=0.027 and P=0.019). Conclusion: There is a significant association between smoking history and length of work with changes in lung function. Meanwhile, comorbidities have a significant association with lung structure and lung function. Periodic evaluation using spirometry and chest X-ray is essential for early detection and prevention of occupational lung abnormalities among factory workers.

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