cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Rachmat Hidayat
Contact Email
dr.rachmat.hidayat@gmail.com
Phone
+6281949581088
Journal Mail Official
indonesian.medical.reviews@gmail.com
Editorial Address
Jl. Sirna Raga no 99, 8 Ilir, Ilir Timur 3, Palembang
Location
Kota palembang,
Sumatera selatan
INDONESIA
Open Access Indonesian Journal of Medical Reviews
Published by HM Publisher
ISSN : -     EISSN : 28076257     DOI : https://doi.org/10.37275/oaijmr
Core Subject : Health,
Health Professions Medicine & Pharmacology
Open Access Indonesian Journal of Medical Reviews (OAIJMR) is a bi-monthly, international, peer-review, and open access journal dedicated to various disciplines of medicine, biology and life sciences. The journal publishes all type of review articles, narrative review, meta-analysis, systematic review, mini-reviews and book review.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 193 Documents
 5   6   7   8   9 
Nerve Function Examination as a Screening for Prevention of Disability in Morbus Hansen at Kelet General Hospital, Central Java: A Case Report Teguh Prihastomo; Wahyu Tri Sudaryanto
Open Access Indonesian Journal of Medical Reviews Vol. 2 No. 6 (2022): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v2i6.247

Abstract

Disability in leprosy or Morbus Hansen can be prevented by early diagnosis and regular and accurate treatment with multi-drug treatment. This study aimed to describe the examination of nerve function in preventing leprosy disability. In this case, a man, 21 years old, has a history of diagnosis of Morbus Hansen multibacillary type since five years ago. There are deformities in both hands and feet with red bumps. On neurological examination, there was anesthesia in hand with paralysis of the finger muscles causing claw hand. No reduction in muscle mass was seen. The patient found it difficult to move his left hand, especially on the 4th and 5th fingers. The range of motion (ROM) of the 4th and 5th fingers was limited. Examination of nerve function begins by palpating the auricular magnus, radial, ulnar, peroneus communis, and posterior tibial nerves. Motor and sensory examinations were carried out by examining the strength of the facial muscles, finger muscles, and wrist muscles. For the lower limbs, examine the muscles of the ankles and toes. In conclusion, early examination of disability and exercise therapy can help prevent disability and keep the condition of disability from getting worse.
Analysis of Molecular Docking Chemical Content of Lime (Citrus aurantiifolia (Christm.) Swingle) Against Diabetes Mellitus Therapy Targets and Prediction of Pharmacokinetic Profiles and Toxicity Kadar Ismah; Supriyadi
Open Access Indonesian Journal of Medical Reviews Vol. 2 No. 6 (2022): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v2i6.259

Abstract

Diabetes mellitus drugs currently available are sulfonylureas, biguanides, thiazolidines, and alpha glucoside inhibitors which are widely used to control hyperglycemia. These drugs cannot prevent complications of diabetes, and these drugs should not be used continuously because it causes undesirable pathological conditions. The essential oil in lime peel is rich in phenolics, especially flavonoids, which can prevent oxidative stress. This research was carried out computationally to determine the affinity of the compound mechanism in lime, pharmacokinetic profile, and toxicity of the chemical content of lime which is thought to have antihyperglycemic activity using chemoinformatics studies. The hardware used is an Asus laptop X441UB-GA502T Intel Core I5 – 8250 DDR 4 4GB HD 1TB VGA mix 110 2GB screen 14 "DVD-RW WIN 10 ORI. The software used is PLANTS (PROTEIN-LIGAND ANT SYSTEM), YASARA, Marvin sketch, Swisstargetprediction, SwissADME, and Toxtree. All compounds in lime were most active against the target protein PPARγ with an average value of -78.0092, while the positive control value of thiazolidinediones was -90.3393. The highest inhibitory affinity of the compound contained in lime was hesperidin with the target protein DPP-4 of -113.614, higher than the positive control sitagliptin with an inhibitory affinity value of -107.591. Hesperidin absorption in the digestive tract is low, the topology polar surface area (TPSA) value is 234.29Å2, and low polarity and high lipophilicity. There are unexpected heterocyclic compounds, so it becomes a warning against the potential for genotoxic carcinogenicity, namely oxygen element "o".
Prostate Cancer and DNA Genes Repair: What Should an Oncologist Know? – A Narrative Review Fernando Santos de Azevedo; Lanúscia Morais de Santana Sá; Uirá Maíra de Resende; Augusto Ribeiro Gabriel; Elisângela de Paula Silveira Lacerda
Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 1 (2023): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v3i1.267

Abstract

Prostate cancer is a very prevalent disease in men, especially in Western countries. The treatment of this neoplasm, both localized and locally advanced, is based on the clinical risk analysis (Gleason, tumor size, PSA, and other factors) and is founded on surgery and/or radiotherapy with or without androgen blockade with a GnRH analog (hormone gonadotropin releaser). However, in patients who invariably progress to a metastatic disease scenario, the tumors may present a heterogeneous behavior, depending on whether or not they are sensitive to androgen blockade therapy. Due to the poor prognosis of the metastatic castration-resistant scenario, current research carried out in the molecular biology and genetics field has identified several gene alterations associated with the development of prostate cancer, which correlate with clinical risk, therapeutic predictive responses, and prognosis. Among the associated gene alterations, the genes of the DNA repair pathway are correlated with diseases that present: a higher risk of recurrence; early metastasis; worse cancer-specific survival; familial risk, and predictive responses to new targeted therapies. Therefore, the breast cancer susceptibility genes, BRCA1 and BRCA2 (and other variants), present in the DNA repair machinery are being investigated to provide more (and better) therapeutic options for the treatment of the disease in the advanced scenario. This review was aimed to describe the malignant prostate disease, especially with regard to DNA repair mechanisms, genomic analysis of prostate cancer, predictive and prognostic implications, as well as on the development of poly-(ADP-ribose) polymerase (PARP) inhibitors, synthetic lethality mechanisms, and BRCAness phenomenon.
Characteristics of Laryngomalacia Patients at Department of Otorhinolaryngology-Head and Neck Surgery Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Period 2021-2022 Fatharani Azka Toer; Puspa Zuleika; Adelien; Lisa Apri Yanti; Fiona Widyasari
Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 1 (2023): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v3i1.273

Abstract

Laryngomalacia is a congenital laryngeal disorder that is commonly found as a cause of stridor in infants and children. This disorder causes the collapse of the structures in the larynx resulting in impaired breathing and eating conditions in patients. This study aimed to present the characteristics of laryngomalacia patients at the Department of Otorhinolaryngology-Head and Neck Surgery (ORL-HNS) Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, period 2021-2022. This was a descriptive observational study that used medical record data as secondary data and primary data in the form of questionnaires in the medical record section and ORL-HNS at Dr. Mohammad Hoesin General Hospital, Palembang, period 2021-2022. Data evaluated included age, gender, clinical symptoms, classification based on Olney distribution, degree of severity, comorbid factors, and therapy. This study showed that most patients were in the age group 3-12 months (52.9%). More were found in males (73.5%). The most common clinical symptoms were eating disorders (51.4%). The most common classification is type 1 (52.9%). Most patients come with a mild degree of severity (61.8%). The most common comorbid factors were neurological diseases (35.1%). The type of medical therapy was given to the majority of patients (94.1%).
Risk Factors for Progressive Chronic Kidney Disease in Children with Idiopathic Nephrotic Syndrome at Dr. Mohammad Hoesin General Hospital Palembang Mirza Gifari Maulana; Eka Intan Fitriana; Phey Liana; Hertanti Indah Lestari; Dalilah
Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 1 (2023): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v3i1.274

Abstract

Nephrotic syndrome (NS) is a kidney disease that is often found in children. NS can cause infectious and non-infectious complications, such as upper respiratory tract infections, urinary tract infections, edema, acute kidney injury (AKI), and hypertension. This study aimed to determine the risk factors of age, gender, nutritional status, hypertension, hematuria, AKI, hyperfiltration, and steroid sensitivity to the progression of chronic kidney disease (CKD) in children with the initial idiopathic NS in the pediatric ward of Dr. Mohammad Hoesin General Hospital Palembang. This study was an analytic observational study with a cross-sectional design. A total of 72 secondary data of research subjects were included in this study. Risk factor analysis was carried out with the help of SPSS version 24 software in univariate, bivariate, and multivariate ways. The most common risk factor for children with the initial idiopathic NS is age ≥10 years, males and females gender obtained the same number, and the nutritional status of obesity, hematuria, AKI, and hyperfiltration have quite low rates. However, hypertension and SRNS have high rates in children with initial idiopathic NS. In conclusion, hypertension and hyperfiltration are risk factors that play a role in initiating the progression of idiopathic NS to CKD in the pediatric ward of Dr. Mohammad Hoesin General Hospital, Palembang.
Vitamin D and Its Role in Modulating Immune System: A Narrative Literature Review Chaula Putri Rizkia
Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 1 (2023): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v3i1.282

Abstract

Vitamin D is recognized for its pivotal role in maintaining calcium-phosphorus homeostasis and regulating bone metabolism. The beneficial effects of vitamin D on the protective function of the immune system are seen in the innate immune system. It increases the production of defensin β2 and cathelicidin by macrophages, monocytes, and keratinocytes in response to infection. Cathelicidin is produced by neutrophils, macrophages, and cells lining epithelial surfaces such as skin, respiratory, and digestive tracts. Recent research showed that vitamin D exerts potent immunomodulatory effects by modulating the innate and adaptive immune systems. This led to the recognition of various disease conditions associated with vitamin D deficiency. This narrative review aimed to describe the molecular mechanisms for the vitamin D immunomodulatory effect.
Antioxidant Activity of Leucaena leucocephala Lmk.de Wit. N-Hexane Fraction Ricka Islamiyati; Yanulia Handayani; Kadar Ismah; Gendis Purno Yudanti; Heni Setyoningsih; Sri Fitrianingsih
Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 1 (2023): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v3i1.286

Abstract

Antioxidants are chemical compounds that can neutralize free radical agents. These compounds work by donating electrons to achieve a stable form, thereby inhibiting the oxidative mechanisms that cause degenerative disease. Lamtoro seeds contain many active compounds that can be used as a source of natural antioxidants and antibacterials. This study aimed to determine the antioxidant effect of the n-hexane fraction of lamtoro seeds (Leucaena leucocephala Lmk. de Wit.). This study is an in vitro experimental study. The object of study was the n-hexane fraction of lamtoro seeds, where antioxidant activity was examined using the DPPH method. Analysis was performed using a UV-Vis spectrophotometer. The n-hexane fraction contained a total flavonoid content of 9.224% and had antioxidant activity with an lC50 value of 67.94 ppm. In conclusion, the n-hexane fraction of lamtoro seeds (Leucaena leucocephala Lmk.de Wit.) has strong antioxidant activity.
Phytochemicals; Targeted-Based Therapeutic Approaches for Pigmentation Disorders Sana Ullah; Rabbia Shoaib; Siyar Khan; Aalia Masood
Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 2 (2023): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v3i2.287

Abstract

Skin pigmentation disorders refer to conditions that affect the color of the skin due to alterations in the production or distribution of melanin, the pigment responsible for skin color. The development of skin pigmentation is a complex process involving various signaling pathways, including the melanin synthesis pathway, the cyclic AMP pathway, and the Wnt signaling pathway. Dysregulation of these pathways can lead to the development of skin pigmentation disorders. Phytotherapeutic approaches have been increasingly studied as a potential treatment for skin pigmentation disorders. This literature review aimed to describe the basic mechanism of melanogenesis, various pathways involved in melanin formation, and certain diseases and their treatment through plant extracts. Plant extracts containing bioactive compounds such as flavonoids, phenolic acids, and tannins have been shown to have anti-pigmentary effects through various mechanisms, including inhibition of tyrosinase activity, reduction of melanin synthesis, and modulation of melanogenesis-related signaling pathways. Skin pigmentation disorders are complex and multifactorial conditions that can significantly impact a person's quality of life. Targeting the signaling pathways involved in pigmentation regulation, particularly through phytotherapeutic approaches, represents a promising avenue for the development of new therapies for these disorders.
Mechanisms of Cellular Adaptation and Change: A Narrative Literature Review Rachmat Hidayat; Catherine
Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 2 (2023): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v3i2.298

Abstract

Injury to cells and the surrounding environment, called the extracellular matrix, triggers injury to tissues and organs. Although a normal cell is limited by narrow boundaries of structure and function, it is capable of adapting to biological demands or stress to maintain a steady state called homeostasis. Adaptation is a reversible, structural, or functional response to normal or physiological conditions and adverse or pathological conditions. This review aimed to describe the mechanism of cellular adaptation in the human body. Cells adapt to the environment to escape and protect against injury. Adaptation of the cell, be it normal or injured, this condition lies somewhere between these two conditions. The most significant adaptive changes in cells include atrophy (decreased cell size), hypertrophy (increased cell size), hyperplasia (increased cell number), and metaplasia (reversible replacement of one mature cell for another less mature cell or change in phenotype). Dysplasia (a disorder of cellular growth) is not considered a true cellular adaptation but rather an atypical hyperplasia. In conclusion, cellular adaptation is a central and common part of many disease conditions.
The Role of Natural Physical, Mechanical, and Biochemical Barriers as Innate Immunity: A Narrative Literature Review Septi Purnamasari; Rachmat Hidayat
Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 2 (2023): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v3i2.299

Abstract

The specialized epithelial outer layer, including the skin and mucosal surfaces, is relatively resistant to most environmental hazards and resistant to infection by disease-causing microorganisms. This literature review aimed to describe the role of natural physical, mechanical, and biochemical barriers in innate immunity. The physical barrier that protects against damage and infection consists of closely related epithelial cells, including the skin and the sheet membranes that line the digestive tract, genitourinary, and breathing. The epithelial surface also provides a biochemical barrier by synthesizing and secreting substances intended to trap or destroy microorganisms (chemicals derived from the epithelium). Mucus, sweat, saliva, tears, and earwax are examples of biochemical secretions that can trap and kill potential disease-causing microorganisms. Microorganisms in the microbiome do not usually cause disease, although some are opportunistic in that they can cause disease if the integrity of the body surface is compromised or the individual's immune or inflammatory systems are damaged. In conclusion, natural barriers include physical, mechanical, and biochemical on the surface of the body and are present from birth to prevent damage by substances in the environment and prevent infection by pathogenic microorganisms.

Page 7 of 20 | Total Record : 193

 5   6   7   8   9 

Filter by Year

2021 2025


Reset
Filter By Issues
All Issue Vol. 5 No. 6 (2025): Open Access Indonesian Journal of Medical Reviews Vol. 5 No. 5 (2025): Open Access Indonesian Journal of Medical Reviews Vol. 5 No. 4 (2025): Open Access Indonesian Journal of Medical Reviews Vol. 5 No. 3 (2025): Open Access Indonesian Journal of Medical Reviews Vol. 5 No. 2 (2025): Open Access Indonesian Journal of Medical Reviews Vol. 5 No. 1 (2025): Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 6 (2024): Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 5 (2024): Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 4 (2024): Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 3 (2024): Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 2 (2024): Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 1 (2024): Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 6 (2023): Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 5 (2023): Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 4 (2023): Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 3 (2023): Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 2 (2023): Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 1 (2023): Open Access Indonesian Journal of Medical Reviews Vol. 2 No. 6 (2022): Open Access Indonesian Journal of Medical Reviews Vol. 2 No. 5 (2022): Open Access Indonesian Journal of Medical Reviews Vol. 2 No. 4 (2022): Open Access Indonesian Journal of Medical Reviews Vol. 2 No. 3 (2022): Open Access Indonesian Journal of Medical Reviews Vol. 2 No. 2 (2022): Open Access Indonesian Journal of Medical Reviews Vol. 2 No. 1 (2022): Open Access Indonesian Journal of Medical Reviews Vol. 1 No. 6 (2021): Open Access Indonesian Journal of Medical Reviews Vol. 1 No. 5 (2021): Open Access Indonesian Journal of Medical Reviews Vol. 1 No. 4 (2021): Open Access Indonesian Journal of Medical Reviews Vol. 1 No. 3 (2021): Open Access Indonesian Journal of Medical Reviews Vol. 1 No. 2 (2021): Open Access Indonesian Journal of Medical Reviews Vol. 1 No. 1 (2021): Open Access Indonesian Journal of Medical Reviews More Issue