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Sasambo Journal of Pharmacy
Published by Universitas Mataram
ISSN : 27232824     EISSN : 27232832     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Sasambo Journal of Pharmacy (p-ISSN: 2723-2824; e-ISSN: 2723-2832) is a scientific journal publishing original articles research in pharmaceutical science. The Journal is managed by the Pharmacy Study Program, Mataram University. Sasambo Journal of Pharmacy receives manuscripts in both English and Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Herbal Medicines, Pharmaceutical Microbiology and Biotechnology, Community Pharmacy, Clinical Pharmacy, and Pharmaceutical Education
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 101 Documents
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Review artikel: validasi metode analisis kafein dalam minuman kemasan menggunakan berbagai instrumen Maesarah, Siti; Permatasari, Lina
Sasambo Journal of Pharmacy Vol. 6 No. 2 (2025): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v6i2.598

Abstract

Caffeine is a central nervous system stimulant that is commonly found in packaged beverages. While moderate consumption provides cognitive and physical benefits, excessive intake may cause adverse health effects, including anxiety disorders, insomnia, cardiovascular diseases, and renal dysfunction. Consequently, accurate and validated analytical methods are essential for determining caffeine levels in commercial beverages. This review evaluates analytical instruments and techniques for caffeine quantification, drawing on national and international studies published between 2015 and 2025. The methods examined include UV-Visible Spectrophotometry, High-Performance Liquid Chromatography (HPLC), Gas Chromatography–Mass Spectrometry (GC–MS), Ultra-Performance Liquid Chromatography (UPLC), and High-Performance Thin-Layer Chromatography (HPTLC). Validation was assessed using parameters such as limit of detection (LOD), limit of quantification (LOQ), precision, accuracy, and linearity. The findings indicate that all methods meet acceptable validation criteria. Among them, UPLC demonstrated the highest sensitivity, while HPTLC provided advantages in speed and operational efficiency. Therefore, the choice of method for caffeine determination should be guided by analytical objectives, laboratory resources, and required sensitivity.
The effect of sodium metabisulfite concentration on the physicochemical stability of an L-Ascorbic Acid face mist formulation Siska Anastasia, Desy; Desnita, Rise; Yuswar, Muhammad Akib; Halim, Clara Maretta
Sasambo Journal of Pharmacy Vol. 6 No. 2 (2025): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v6i2.623

Abstract

Face mist is a cosmetic that is included in skin fresheners, is more practical to use, and has the potential to add antioxidants. Vitamin C is one source of antioxidants. Although water-soluble, vitamin C is an antioxidant that oxidizes readily. Sodium metabisulfite must be added to prevent oxidized vitamin C from becoming unstable. Topical treatments containing 0.01–1.0% sodium metabisulfite act as antioxidants. Therefore, a face mist preparation was made with variations in the concentration of sodium metabisulfite, namely 0.25%, 0.5%, and 1%. This study aims to see an increase in the stability of vitamin C face mist preparations with an increase in the concentration of sodium metabisulfite through physicochemical stability testing under real-time storage conditions for 28 days. The parameters to be observed in the stability test include organoleptic test, pH, specific weight, viscosity, and vitamin C levels. The F1 formula with the smallest concentration of sodium metabisulfite (0.25%) has been able to maintain the stability of vitamin C face mist preparations for 28 days of storage
Telaah: self-care mobile application untuk pencegahan luka diabetes Untari, Eka Kartika
Sasambo Journal of Pharmacy Vol. 6 No. 2 (2025): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v6i2.624

Abstract

Self-care practices and appropriate glycemic management may prevent diabetic ulcer, a complication that has a detrimental effect on patients and their families. Through mobile-health applications, educational initiatives can increase patient awareness and promote the early preventative measures required to minimize complications from diabetes. The purpose of this review of the literature is to investigate research on the development of mobile-health applications for people with diabetes. The articles reviewed were obtained through keyword searches in the PubMed and Google Scholar databases within the last 10 years. According to seven published articles, six applications were created as self-care resources for people with diabetes mellitus. In order to prevent diabetic ulcer, mobile-health applications might assist people with diabetes maintain their independence in self-care routines.
Sugar content evaluation in commercially available lidah kucing pastries: uv-vis spectrophotometric analysis of traditional indonesian confections in pontianak tenggara district Reynaldi, Muhammad Andre; Enggy Erwansani; Hakim, Aditia Rahman; Arif Setiawansyah; Valentina, Febriani; Salsabila, Salwa; Amelia, Nanda; Jaya, Farrel Septian; Agnesia, Agnesia
Sasambo Journal of Pharmacy Vol. 6 No. 2 (2025): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v6i2.632

Abstract

Glucose content in confectionery products requires careful monitoring due to its association with serious health conditions including obesity, diabetes, and cardiovascular disease. This study examined glucose levels in three lidah kucing cookie samples from Pontianak Tenggara district retailers to assess nutritional variability in these traditional Indonesian confections. The research employed a dual analytical approach combining qualitative and quantitative methods. Initial screening utilized Fehling and Benedict reagent tests to confirm glucose presence, followed by precise quantitative analysis using the Nelson-Somogyi method with UV-visible spectrophotometry. The quantitative protocol involved standard solution preparation, calibration curve development, optimal wavelength determination, and triplicate sample measurements to ensure analytical reliability. Qualitative testing confirmed glucose presence in all three samples through positive Fehling and Benedict reactions. Quantitative analysis revealed significant concentration variations among products. Sample A contained 0.227 percent glucose, Sample B demonstrated substantially higher levels at 0.993 percent, while Sample C showed minimal glucose content at 0.004 percent. These results indicate considerable variability in glucose concentrations across commercially available lidah kucing products within the study area. The investigation successfully established glucose presence in all examined samples while documenting substantial differences in glucose concentrations among similar commercial products. These findings highlight the importance of analytical monitoring in traditional confectionery items and demonstrate significant nutritional variation among comparable products in local markets. The results provide essential baseline data for consumer awareness and potential regulatory considerations regarding glucose content in traditional Indonesian baked goods, supporting informed dietary choices and public health initiatives.
Antidiabetic activity test of mangrove leaf extract (Rhizophora mucronata) from west lombok regency using the oral glucose tolerance test method Amran Halim; Raisya Hasina; Lina Permatasari
Sasambo Journal of Pharmacy Vol. 7 No. 1 (2026): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v7i1.641

Abstract

Black mangrove (Rhizophora mucronata) is recognized as a natural ingredient with potential antidiabetic properties due to the presence of active compounds such as flavonoids, alkaloids, and tannins. Conventional antidiabetic drugs like metformin often cause side effects, highlighting the need for safer, natural alternatives. The safety of Rhizophora mucronata leaves has been demonstrated through acute toxicological studies. This study aimed to evaluate the antidiabetic activity of Rhizophora mucronata leaf ethanol extract and determine the most effective dose. Unlike previous studies that used maceration and methanol as solvent, this research employed a sonication method with 96% ethanol solvent and collected leaf samples from the Cemare area, West Lombok, to reflect local conditions. Twenty-five mice were divided into five groups: negative control (0.5% Na CMC), positive control (metformin 500 mg/kg body weight), and three test groups receiving extract doses of 62.5; 125; and 250 mg/kg body weight. The first blood sample was taken to measure fasting blood glucose, followed by induction with a 50% glucose solution, and another blood sample was taken after 30 minutes. Then, the test solutions were administered, and blood glucose levels were measured at 30, 45, 60, 90, and 120 minutes post-administration. Blood glucose data were analyzed using SPSS version 25 with One Way ANOVA, Post Hoc Tukey, and Paired Sample T-Test. The results showed that doses of 125 mg/kg and 250 mg/kg body weight significantly reduced blood glucose levels (p<0.05), identifying these as the optimal doses. These findings support the potential of Rhizophora mucronata as a safe, natural antidiabetic therapy.
Evaluasi Pengaruh Metformin Terhadap Kadar Testosteron Pada Pasien Pria Dengan Diabetes Melitus Tipe 2 (DMT2): Pre-Posttest Design Maiyeni Sabrina; Sally Khoirunisa
Sasambo Journal of Pharmacy Vol. 7 No. 1 (2026): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v7i1.676

Abstract

Diabetes melitus tipe 2 (DMT2) pada pria kerap disertai penurunan kadar testosteron. Metformin merupakan terapi lini pertama yang efektif mengendalikan glukosa darah, tetapi pengaruhnya terhadap hormon testosteron masih menjadi perdebatan. Penelitian ini bertujuan mengevaluasi pengaruh dosis metformin, usia, perubahan indeks massa tubuh (IMT), serta kadar gula darah sewaktu (GDS) terhadap perubahan kadar testosteron pada pasien pria dengan DMT2. Metode yang digunakan adalah desain pre–post dengan pendekatan kuantitatif analitik pada 79 pasien pria yang menjalani terapi metformin. Data yang dikumpulkan meliputi dosis obat, usia, IMT, GDS, dan kadar testosteron total sebelum serta sesudah terapi. Analisis statistik dilakukan menggunakan uji korelasi Pearson, Spearman, Mann-Whitney, dan regresi linear berganda. Hasil menunjukkan adanya perbedaan bermakna kadar testosteron antara kelompok dosis metformin <1500 mg/hari dan ≥1500 mg/hari (p=0,016). Perubahan GDS memiliki hubungan sangat kuat dengan perubahan testosteron (r=0,773; p<0,001), sedangkan perubahan IMT menunjukkan hubungan sedang (ρ=0,458; p<0,001). Analisis regresi mengidentifikasi perubahan GDS sebagai faktor paling dominan, diikuti oleh IMT, sementara usia dan dosis metformin tidak signifikan. Disimpulkan bahwa penurunan GDS berasosiasi dengan penurunan testosteron, yang kemungkinan berkaitan dengan pengaruh metformin terhadap proses steroidogenesis.
Computational intelligence in cell-penetrating peptide discovery: emerging paradigms and predictive frameworks Ebrahim Sadaqa; Muhammad Ikhlas Arsul; Nurul Hidayati; Arif Setiawansyah
Sasambo Journal of Pharmacy Vol. 7 No. 1 (2026): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v7i1.677

Abstract

Researchers are increasingly fascinated by cell penetrating peptides (CPPs) owing to their ability to deliver biomolecules within cells. This unique capability makes CPPs an incredibly valuable asset in fields such as drug delivery, gene therapy and imaging where precision is paramount. However, the design and prediction of CPPs with optimal attributes and augmented cellular uptake still pose a challenge. With this literature review piece, we hope to shed light on significant progress that has been made within the field of in silico prediction techniques for CPPs. In particular our focus lies on discussing how these methodologies can assist with discovering and optimizing promising CPP candidates more efficiently. To accomplish this goal respectfully and comprehensively, we will examine computational methods like machine learning algorithms, sequence-based techniques, and structure-based modeling. These techniques employ large-scale databases, extensive peptide libraries, and advanced algorithms to scrutinize peptide properties, predict CPP activity, and optimize CPP sequences. Within this analysis, we find a significant emphasis placed on integrating physicochemical features, sequence motifs, and structural information into predictive models relating to CPP development. These factors are essential to predicting successful peptide uptake within cells while presenting various challenges during this process. Furthermore, the review highlights considerable strides in silico prediction techniques for CPPs, demonstrating great promise in accelerating their identification for further development. Incorporating computational tools and experimental validation holds tremendous promise in facilitating the design of CPPs with enhanced properties, thus advancing the field of intracellular delivery and therapeutics.
Antioxidant activity and formulation evaluation of Morinda citrifolia L.leaf ethanol extract nanoparticles incorporated into moisturizing gel Eriska Agustin; Ranti Ayu Anjelina; Yola Yernianti
Sasambo Journal of Pharmacy Vol. 7 No. 1 (2026): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v7i1.679

Abstract

Skin is continuously exposed to environmental stressors such as ultraviolet radiation and pollution, which trigger the formation of reactive oxygen species (ROS) leading to oxidative stress, premature aging, and skin damage. Therefore, the development of topical antioxidant formulations from natural sources has become increasingly important. This study aimed to develop nanoparticles of Morinda citrifolia L. leaf ethanol extract and incorporate them into a moisturizing gel, followed by evaluation of their physicochemical properties and antioxidant activity. The extract was prepared by maceration using 96% ethanol, while nanoparticles were synthesized using the ionic gelation method with chitosan and sodium tripolyphosphate. Particle size, polydispersity index, morphology, and antioxidant activity (DPPH method) were evaluated. The nanoparticles exhibited sizes below 200 nm with a uniform distribution (PDI< 0.3). The optimized formulation showed the smallest particle size (FIII=77.5±6.36 nm) and good stability. Antioxidant activity increased after nanoparticle formulation, with IC₅₀ values decreasing from 182.4±2.26 ppm (extract) to 145.4±6.89 ppm (FIII), indicating moderate activity. The gel formulations showed good physical stability and acceptable viscosity, although pH values were below the ideal skin range. The moisturizing test demonstrated significant improvement in skin hydration. In conclusion, nanoparticle incorporation enhanced antioxidant and moisturizing performance, indicating potential for topical applications.
Evaluation of drug use in rheumatoid arthritis patients at the outpatient installation of Dr. H. Abdul Moeloek Bandar Lampung Regional Hospital Dewi Suci S. Riadi; Nurul Irna Windari; Gayatri Simanullang
Sasambo Journal of Pharmacy Vol. 7 No. 1 (2026): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v7i1.467

Abstract

Rheumatoid Arthritis (RA) is an autoimmune disease characterized by the main symptoms of pain, swelling, stiffness in the joints and joint inflammation. Joint pain in RA can reduce quality of life and can interfere with work and social activities. This study aims to determine the characteristics of rheumatoid arthritis patients and analyze the evaluation of drug use in rheumatoid arthritis patients in the outpatient installation of RSUD Dr. H. Abdul Moeloek Bandar Lampung. This research is non-experimental in nature using data collection techniques in the form of purpose sampling. The patient population studied was aged ≥ 18 years with a minimum sample size of 65 patients. The results of research regarding the characteristics of rheumatoid arthritis patients in the outpatient installation of RSUD Dr. H. Abdul Moeloek Bandar Lampung showed that RA patients were dominated by age 40-50 years as much as 35% with female gender as much as 86.15%, and consuming methotrexate as much as 78% with the most symptoms being pain as much as 97% and accompanied by hypertension as comorbidities were 12.3%. Evaluation of drug use in rheumatoid arthritis patients in the outpatient installation of Dr. H. Abdul Moeloek Bandar Lampung Hospital obtained rationality results of 9.2% irrational and 90.8% rational with categories of appropriate indications of 100%, appropriate drugs of 100%, appropriate dosage of 90.7%, and appropriate patients of 100%.
Evaluasi kejadian interaksi obat antihipertensi pada pasien rawat jalan di klinik x kota Palembang Hairun Niza; Abu Rachman; Dini Afriliza; Satra Yunola; Helni Anggraini
Sasambo Journal of Pharmacy Vol. 7 No. 1 (2026): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v7i1.519

Abstract

Data World Health Organization (WHO) menunjukkan bahwa pada tahun 2023, 1,28 miliar orang dewasa berusia 30 hingga 79 tahun di seluruh dunia mengalami hipertensi, hipertensi merupakan peningkatan tekanan darah >140/>90 mmHg. Hipertensi terapi secara farmakologi membutuhkan pengobatan tunggal atau kombinasi jika terdapat komplikasi maka juga membutuhkan beberapa macam obat untuk terapinya. Risiko interaksi obat meningkat jika pasien mengonsumsi lebih dari dua jenis obat sekaligus. Tujuan penelitian ini adalah untuk melihat potensi terjadinya interaksi obat di Klinik X Kota Palembang. Metode penelitian secara retrospektif dengan tehnik pengumpalan purposive sampling dengan alat bantu resep dan rekam medik pasien. Hasil penelitian menunjukkan karateristik responden usia >56 tahun dengan jenis kelamin laki-laki terbanyak, terdapat interaksi obat antihipertensi yaitu sebanyak 37 potensi terjadinya interaksi obat terutama penggunaan amlodipine dengan obat obat lain. Kesimpulan terdapatnya interaksi obat pada pasien rawat jalan di Klinik X Kota Palembang. Interaksi minor sebesar 2.7%, moderat 94.65 dan mayor 2.7%.

Page 10 of 11 | Total Record : 101

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