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Nur Alim
Program Studi Farmasi, Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Islam Makassar, Makassar
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health

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Skirining fitokimia ekstrak etanol kulit buah sirsak (Annona muricata Linn) dan uji aktivitas antioksidan dengan metode DPPH Nur Alim; Nurul Jummah; Agus Sangka Pratama; Nurdiyanti Nurdiyanti
Sasambo Journal of Pharmacy Vol. 2 No. 2 (2021): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (222.047 KB) | DOI: 10.29303/sjp.v2i2.40

Abstract

Phytochemical screening research on the ethanol extract of soursop (Annona muricata Linn) peel and antioxidant activity was tested using the DPPH method. The purpose of this study was to determine several classes of compounds found in soursop rind and to determine the antioxidant activity of ethanol extract of soursop rind against DPPH free radicals. The results showed ethanol extract of positive soursop fruit skin containing flavonoids, tannins, and terpenoids. of soursop fruit skin extract was carried out by DPPH method results obtained IC50 value of 192.13 µg / mL ± 5.198137 which was categorized as weak.
Phytochemical Screening, Relationship of Total Phenolic with Antioxidant Activity Of Ethanol and Methanol Extracts of Kesambi (Schleichera oleosa (Lour.) Oken) Bark Nur Alim; Tahirah Hasan; Rusman Rusman; Jasmiadi Jasmiadi; Zulfitri Zulfitri
Jurnal Ilmiah Sains Volume 22 Nomor 2, Oktober 2022
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (261.689 KB) | DOI: 10.35799/jis.v22i2.40091

Abstract

Phenolic content has a role in antioxidant activity. The higher the phenolic content of a test sample, the higher the antioxidant activity, which is indicated by a smaller IC50 value. Methanol and 70% ethanol are solvents that have been proven to be widely used to extract total plant phenolic compounds. This study aims to determine the phytochemical content and the relationship of total phenolic content with antioxidant activity of ethanol and methanol extract of Schleichera oleosa (Lour.) Oken) bark using UV-Vis spectrophotometry. Schleichera oleosa (Lour.) Oken was extracted by maceration using 70% ethanol and methanol as solvent. Qualitative analysis of phytochemical compounds using specific reagents, analysis of total phenolic content, and antioxidant activity test using the DPPH method using UV-Vis spectrophotometry at 764 nm and 515 nm, respectively. The results of the qualitative test showed that the ethanol and the methanol extract was positive for alkaloids, flavonoids, and phenolics. The results of the analysis of total phenolic content and antioxidant activity showed that the 70% ethanol extract had a total phenolic content of 7.6829 mg gallic acid equivalent/g with IC50 28.5240 ppm and the methanol extract had a total phenolic content of  9.2057 mg gallic acid equivalent/g with IC50 1.6191 ppm. From these results, it was concluded that the higher the total phenolic content, the higher the antioxidant activity.Keywords: Antioxidant; Schlechera oleosa (Lour.) Oken.; total phenolic Skrining Fitokimia dan Hubungan Kadar Fenolik Total dengan Aktivitas Antioksidan Ekstrak Etanol dan Metanol Kulit Batang Kesambi (Schleichera oleosa (Lour.) Oken)ABSTRAKKadar fenolik memiliki peran terhadap aktivitas antioksidan. Semakin tinggi kadar fenolik suatu sampel uji maka aktivitas antioksidannya juga semakin tinggi, yang ditunjukkan dengan nilai IC50 yang lebih kecil. Pelarut metanol dan etanol 70% merupakan pelarut yang telah terbukti banyak digunakan untuk menarik senyawa fenolik total tanaman.  Penelitian ini bertujuan untuk menentukan kandungan fitokimia, hubungan kadar fenolik total dengan aktivitas antioksidan ekstrak etanol dan ekstrak metanol kulit batang kesambi (Schleichera oleosa (Lour.) Oken) menggunakan spektrofotometri UV-Vis. Kulit batang kesambi (Schleichera oleosa (Lour.) Oken) diekstraksi dengan cara maserasi menggunakan pelarut etanol 70% dan pelarut metanol. Analisis kualitatif senyawa fitokimia menggunakan pereaksi spesifik, analisis kadar fenolik total dan uji aktivitas antioksidan dengan metode DPPH menggunakan spektrofotometri UV-Vis masing-masing pada panjang gelombang 764 nm dan 515 nm. Hasil uji kualitatif menunjukkan bahwa ekstrak etanol dan ekstrak metanol kulit batang kesambi (Schleichera oleosa (Lour.) Oken) positif mengandung alkaloid, flavonoid dan fenolik. Hasil analisis kadar fenolik total dan uji aktivitas antioksidan menunjukkan bahwa ekstrak etanol 70% memiliki kadar fenolik total sebesar 7,6829  mgGAE/g ekstrak dengan nilai IC50 sebesar 28,5240 ppm dan esktrak metanol memiliki kadar fenolik total sebesar 9,2057 mgGAE/g ekstrak dengan nilai IC50 sebesar 1,6191 ppm. Dari hal tersebut disimpulkan bahwa semakin tinggi kadar fenolik total maka semakin tinggi pula aktivitas antioksidannya.Kata kunci: Antioksidan; fenolik total; Schlechera oleosa (Lour.) Oken
Antipyretic Activity of Ethanol Extract from Beligo (Benincasa hispida (Thunb.) Cogn.) Fruit Flesh in Wistar Albino Rats (Rattus norvegicus) Nur Alim; Rusman Hasanuddin; Jasmiadi Jasmiadi; Musdalifah Musdalifah; A. Ihdinal Hagg; Nur Linda
Jurnal Ilmiah Sains Volume 23 Nomor 2, Oktober 2023
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jis.v23i2.48443

Abstract

The people of South Sulawesi employ beligo as a plant with fever-reducing properties. The utilized part is the flesh of its fruit. The beligo fruit contains fatty acids, flavonoids, phenolics, and steroids that hold promise as antipyretic agents. The study aimed to determine the antipyretic activity of ethanolic extract from beligo fruit flesh on male Wistar rats induced with peptone solution. The research method encompassed maceration extraction using 70% ethanol solvent and antipyretic activity testing using 15 male Wistar rats divided into five treatment groups. Group I served as the negative control and received SODIUM-CMC 1%, groups II, III, and IV received ethanolic extract of beligo fruit flesh at doses of 250 mg/kg BW, 500 mg/kg BW, and 750 mg/kg BW respectively, and group V, the positive control, received paracetamol tablets. Measurements of initial temperature, temperature after induction, and temperature after treatment were taken at 30-minute intervals for 180 minutes. Data were statistically analyzed using a Completely Randomized Design (CRD) and Duncan test. The research findings revealed a fever reduction percentage of 1,57% for group I, 4,03% for group II, 4,28% for group III, 4,45% for group IV, and 5,25% for group V. Data analysis indicated that ethanolic extract of beligo fruit flesh at doses of 250 mg/kg BW, 500 mg/kg BW, and 750 mg/kg BW exhibited significant antipyretic activity (p < 0.05). The ethanolic extract from beligo fruit flesh possesses antipyretic activity in induced Wistar rats, suggesting its potential use as a fever-reducing medication. Keywords: Antipyretic; Benincasa hispida (Thunb.) Cogn; fever
Uji Teratogenik Ekstrak Etanol Biji Beligo (Benincasa Hispida (Thunb.) Cogn.) Pada Mencit Betina (Mus Musculus) Nur Alim; Sri Sulistyawati Anton; Rusman Hasanuddin; Muhammad Ihsan; Ni Ketut Sinarsih
Jurnal Yoga dan Kesehatan Vol 6 No 2 (2023)
Publisher : UHN IGB Sugriwa Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Selama kehamilan, janin dapat mengalami efek yang tidak dikehendaki dari penggunaan obat herbal dan kimia, terutama pada fase embrionik organogenesisTujuan penelitian ini adalah untuk mengetahui bagaimana biji beligo (Benincasa hispida (Thunb.) Cogn.) mempengaruhi mencit betina (Mus musculus). Penelitian ini melibatkan pengujian teratogenik menggunakan 16 ekor mencit sebagai hewan uji dan ekstraksi melalui maserasi dengan pelarut etanol 70%. Hewan-hewan ini dibagi menjadi 4 kelompok. Pada kelompok perlakuan, ada tiga betina dan satu jantan dalam setiap kelompok. Kelompok 1 kontrol negatif diberi Na-CMC 1%, kelompok II, III, IV diberi ekstrak etanol biji beligo dengan dosis masing-masing 140 mg/kgBB, 280 mg/kgBB dan 420 mg/kgBB. Semua kelompok diberikan sediaan selama hari ke-6 sampai ke-15 masa kebuntingan. Hasil penelitian menunjukkan bahwa ekstrak etanol biji beligo memberikan efek penuh pada fetus mencit. Hasilnya menunjukkan bahwa ekstrak etanol biji beligo dengan dosis 140 mg/kgBB, 280 mg/kgBB, dan 420 mg/kgBB tidak memiliki efek teratogenik pada fetus mencit.
Pengukuran omega-3 pada ikan penja (Awaous sp.) asal Polewali Mandar Provinsi Sulawesi Barat Rusman Hasanuddin; Nur Alim; Karnidayanti Karnidayanti
Sasambo Journal of Pharmacy Vol. 4 No. 2 (2023): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v4i2.256

Abstract

Omega-3 is an essential fatty acid necessary for human health. It has anti-inflammatory properties, reduces the risk of cardiovascular disease, and is needed for brain development. The three main omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Penja fish is a typical marine biota of Polewali Mandar, West Sulawesi, which is believed to be rich in omega-3. The research aimed to determine the omega-3 content in penja fish (Awaous sp.) from Polewali Mandar, West Sulawesi Province. Penja fish was extracted using the Soxhlet method, and then the fatty acid content was analyzed by GC-MS. The results of this study show that penja fish extract (Awaous sp.) contains omega-3 consisting of 2.64% linolenic acid, 0.94% eicosapentaenoic acid (EPA), and 1.17% docosahexaenoic acid (DHA). The total omega-3 content in penja fish (Awaous sp.) is 4.75%.  
Aphrodisiac Activity of Beligo (Benincasa hispida (Thunb.) Cogn.) Seeds of Ethanol Extract in Mice Alim, Nur; Jasmiadi, Jasmiadi; Nadillah, Nadia; Indrawaty Kadir , Ira; Afirah, Nur
Jurnal Kedokteran Brawijaya Vol. 33 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.02.1

Abstract

Beligo (Benincasa hispida (Thunb.) Cogn.), is empirically used by the people of South Sulawesi-Indonesia as an aphrodisiac. Beligo seeds contain alkaloids, phenolics, flavonoids, and unsaturated fatty acids, which have the potential to act as aphrodisiacs. The primary objective of this research is to determine the aphrodisiac activity of an ethanol extract from beligo seeds in mice.  The procedure entails extraction and aphrodisiac evaluation using introduction, climbing, and coitus test parameters. Aphrodisiac testing was carried out for seven days using 25 mice as experimental animals, divided into five groups. Each group consists of four males and one female. Group I was given Sod. CMC 1% as a negative control; II, III, and IV were given ethanol extracts of beligo seeds at doses of 350mg/kg, 700mg/kg, 1400mg/kg BW, and group V, as a positive control, was given Yohimbine. The results showed that the ethanol extract of beligo seeds at doses of 350mg/kg BW, 700mg/kg BW, and 1400mg/kg BW had aphrodisiac activity (p=0.0001) compared to Sod. CMC 1% based on data on the amount of introduction and climbing. However, based on data on the number of coitus, it showed that the ethanol extract of beligo seeds at doses of 350mg/kg BW (p=0.072) had no aphrodisiac activity, 700mg/kg BW (p=0.007), 1400mg/kg BW (p=0.0001) had aphrodisiac activity compared to Na-CMC 1% and only a dose of 1400 mg/kg BW had the same aphrodisiac activity compared with Yohimbine (p=0.967). It is concluded that the ethanol extract of beligo seeds had aphrodisiac activity.
Antioksidan in vivo buah beligo (Benincasa hispida (Thunb.) Cogn.) berdasarkan penurunan kadar malondialdehid tikus jantan wistar Alim, Nur; Irfayanti, Nur Alfiah; Fajrianti, Siti; Suarni, Suarni; Jannah, Raudatul
Sasambo Journal of Pharmacy Vol. 5 No. 2 (2024): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v5i2.261

Abstract

The aim is to ascertain the in vivo antioxidant activity of beligo fruit flesh ethanol extract based on the measurement of malondialdehyde levels in Wistar male rats generated by used frying oil. The procedure involves macerating 70% ethanol to extract the flesh from beligo fruit and assessing the in vivo antioxidant activity by measuring the amounts of malondialdehyde in fifty Wistar male rats split into 5 groups. Group V received vitamin C at a dose of 27 mg/kgBW, and groups II, III, and IV received an ethanol extract of beligo fruit flesh at 100, 200, and 400 mg/kg BW. Group I received 1% Na-CMC as a negative control. Using a UV-Vis spectrophotometer, malondialdehyde levels were determined using the TBARS test. Statistical data analysis by a Completely Randomized Design (CRD) and an Honestly Significant Difference (HSD) follow-up test. Malondialdehyde levels decreased in Group I (19.16%), Group II (78.70%), Group III (82.86%), Group IV (87.76%), and Group V (90.23%) according to the study's findings. The study findings demonstrated the antioxidant potential of beligo fruit flesh ethanol extract at doses of 100 mg, 200 mg/kg BW (p<0.05), and 400 mg/kg BW (p<0.01) in lowering malondialdehyde levels in Wistar male rats.
Aktivitas Antibakteri Ekstrak Etanol Daging Buah Beligo (Benincasa hispida (Thunb.) Cogn.) terhadap Escherichia coli dan Staphylococcus aureus Hasanuddin, Rusman; Alim, Nur; Jasmiadi; Fauzan, Ahmad
Jurnal Novem Medika Farmasi Vol. 1 No. 3: Volume 1 Issue 3
Publisher : Program Studi Farmasi, Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59638/junomefar.v1i3.527

Abstract

Antibacterial is a compound that can be used to inhibit or kill bacteria. Ethanol extract of Beligo fruit flesh [Benincasa hispida (Thunb.) Cogn.)] contains flavanoid compounds that can be used as antibacterials. The purpose of this research was to determine the antibacterial activity of the ethanol extract of beligo fruit flesh [Benincasa hispida (Thunb.) Cogn.)] against bacteria Escherichia coli and Staphylococcus aureus. Research methods include macerated extraction using 70% ethanol and testing antibacterial activity against bacteria Escherichia coli and Staphylococcus aureus with diffusion methods using disc paper. The result obtained using concentration of 12,8%; 25,6%; 51,2% each had an inhibitory diamter of 7,34 mm; 8,97 mm; 12,12 mm for Staphyloccous aureus bacteria while the inhibitory diamter is 6,45 mm; 7,33 mm; 9,91 mm for Escherichia coli bacteria. The conclusion of this research is that the ethanol extract of Beligo fruit flesh has antibacterial activity against Escherichia coli and Staphylococcus aureus.
Aktivitas Antipiretik Ekstrak Etanol Daun Beligo (Benincasa hispida (Thunb.) Cogn.) Pada Tikus Alim, Nur; Jasmiadi; sulastri, dewi; pratama, Agus sangka
Jurnal Novem Medika Farmasi Vol. 1 No. 2: volume 1 Issue 2
Publisher : Program Studi Farmasi, Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59638/junomefar.v1i2.610

Abstract

Beligo merupakan tanaman yang dipercaya oleh masyarakat Indonesia sebagai obat demam. Penelitian tentang buah beligo sebagai obat demam telah banyak dilakukan. Namun, pada daun belum dilakukan sehingga pada penelitian ini dilakukan uji aktivitas antipiretik ekstrak etanol daun beligo (Benincasa hispida (Thunb.) Cogn.) pada tikus putih (Rattus norvegicus). Tujuan penelitian ini untuk mengetahui aktivitas antipiretik ekstrak etanol daun beligo pada tikus putih. Metode penelitian ini meliputi ekstraksi dan pengujian antipiretik dengan metode design pre post test with control group. Ekstraksi dilakukan secara maserasi dengan pelarut etanol 70%. Pengujian antipiretik yaitu tikus putih sebanyak 15 ekor dibagi menjadi 5 kelompok perlakuan. Kelompok I kontrol negatif diberi Na-CMC 1%, kelompok II kontrol positif diberi paracetamol, kelompok III, IV dan V diberi ekstak etanol daun beligo dosis 250 mg/kg BB, 500 mg/kg BB dan 750 mg/kg BB yang diinduksi pepton 5%, dilakukan pengukuran suhu awal, suhu setelah induksi dan suhu setelah perlakuan setiap 30 menit selama 180 menit. Hasil penelitian dianalisis secara statistik menggunakan Rancangan Acak Lengkap (RAL) dan uji Duncan yang menunjukkan bahwa ekstrak etanol daun beligo dosis 250 mg/kg BB, 500 mg/kg BB dan 750 mg/kg BB memiliki aktivitas antipiretik secara signifikan (p<0,05) yang tidak berbeda nyata dengan kontrol positif tablet paracetamol.
Perbandingan Aktivitas Antioksidan Ekstrak Etanol Daun Awar-Awar (Ficus septica burm) dengan Asam Askorbat Menggunakan Metode DPPH Alim, Nur; Hasan, Tahirah; Musdalifah; Abidin, Araf Asraf
Jurnal Novem Medika Farmasi Vol. 1 No. 3: Volume 1 Issue 3
Publisher : Program Studi Farmasi, Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59638/junomefar.v1i3.663

Abstract

Daun awar-awar diketahui memiliki kandungan senyawa alkaloid, flavonoid, saponin dan tanin yang berpotensi sebagai antioksidan Penelitian perbandingan aktivitas antioksidan ekstrak etanol daun awar-awar (Ficus septica Burm) dengan askorbat menggunakan metode DPPH telah dilakukan. Penelitian ini bertujuan untuk menentukan aktivitas antioksidan ekstrak etanol daun awar-awar (Ficus septica Burm) dibandingkan dengan asam askorbat menggunakan metode DPPH. Metode penelitian meliputi ekstraksi dengan cara maserasi menggunakan pelarut etanol 70% dilanjutkan dengan uji aktivitas antioksidan menggunakan metode DPPH dengan baku pembanding asam askorbat. Aktivitas antioksidan terhadap radikal DPPH dianalisis menggunakan spektorofotometer UV-Vis pada panjang gelombang maksimum 515 nm. Hasil uji aktivitas antioksidan ekstrak etanol daun awar-awar diperoleh nilai IC50 sebesar 199, 2853 μg/mL dan kemampuan aktivitas antioksidannya 0,0138 dibandingkan aktivitas antioksidan asam askorbat IC50 2,7595 μg/mL.Kesimpulan penelitian menunjukkan bahwa ekstrak etanol awar-awar memiliki potensi sebagai antioksidan alami
Co-Authors A. Ihdinal Hagg Abidin, Araf Asraf Afirah, Nur Agus Sangka Pratama Ahmad Fauzan Emilina Jafar Fajrianti, Siti Hasanuddin, Rusman Indrawaty Kadir , Ira Jasmiadi Jasmiadi Jasmiadi Jasmiadi, Jasmiadi Jumrah Sudirman Karnidayanti Karnidayanti Muhammad Ihsan Musdalifah Musdalifah Musdalifah Mustaina Nadillah, Nadia Ni Ketut Sinarsih Nur Alfiah Irfayanti Nur Linda Nurdiyanti Nurdiyanti Nurul Jummah Pratama, Agus Sangka Rahma, Tarisa Jabal raudatul jannah Sri Sulistyawati Anton Suarni Suarni Sulastri, Dewi Tahirah Hasan Zulfitri Zulfitri