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Marcellino Rudyanto
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Department Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Airlangga Surabaya, Kampus C, Mulyorejo, Surabaya-60115, East Java, Indonesia
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Berkala Ilmiah Kimia Farmasi
Published by Universitas Airlangga
ISSN : 23028270     EISSN : 28081048     DOI : http://dx.doi.org/10.20473/bikfar.v8i2.31763
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology
to facilitate interaction, discussion, and updating of research ideas in the fields of pharmacy, Pharmaceutical Chemistry, Medicinal Chemistry, Drug Development, Organic synthesis, Analytical chemistry, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Nutraceutical / functional foods.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Farmakologi
Articles 5 Documents
 1 
Search results for , issue "Vol. 10 No. 1 (2023): June" : 5 Documents clear
Identification of Paracetamol and Caffeine in Jamu Powders Simultaneously Using TLC-Densitometry Wahyuningsih, Etik; Isnaeni, Isnaeni; Asri Darmawati; Annisa Kartika Sari
Berkala Ilmiah Kimia Farmasi Vol. 10 No. 1 (2023): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v10i1.44242

Abstract

Paracetamol and caffeine were chemical compounds suspected to be illegally added to traditional herbs claimed as rheumatics drugs. Identification of paracetamol and caffeine was conducted on five samples of jamu powder obtained from the Depot Jamu in Surabaya. This study aimed to simultaneously identify paracetamol and caffeine commonly found in traditional medicine, one of which was jamu powder, using thin-layer chromatography densitometry (TLC-Densitometry). Evaluation of the presence of paracetamol and caffeine in the product of jamu was performed by thin-layer chromatography with silica gel GF254 and chloroform-ethyl acetate (1:1) as the stationary and mobile phases, respectively. The spots on the TLC plate were detected using a UV light at 254 nm, and the areas were measured by a Camag TLC scanner. The TLC profile demonstrated good separation of paracetamol, caffeine, and other substances contained in the products. The retardation factors (Rf) of paracetamol and caffeine were 0,42 and 0,26, with detection limits of 0,0125 µg/spot and 0,05 µg/spot, respectively. The simultaneous identification of caffeine and paracetamol using thin-layer chromatography densitometry revealed that none of the five samples were detected to contain paracetamol and caffeine. Keywords:  Simultaneously, Identification, Paracetamol, Caffeine, Jamu Powder, TLC- Densitometry
Improving the Bioavailability of Curcumin in Curcuma heyneana by Preparing Solid Dispersion Sudjarwo, Sudjarwo; Bobsaid, Jihan; Windianto, Farhan Rizqi; Rizkyah, Chaerini; Shaffiqa, Nurul; Putra, Anggara Satria; Jaelani, Mochammad Iqbal; Zulfah, Yasmin; Nareswari, Andwynanda Bhadra; Fridayanti S, Septia Indah; Devitri, Nabilah Apsari; Yakub, Nikolas; Putri, Yushalluuna Bekti Pasuka; Widyowati, Retno
Berkala Ilmiah Kimia Farmasi Vol. 10 No. 1 (2023): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v10i1.44546

Abstract

Curcuma heyneana or Temu Giring contained curcumin which had anti-aging potential and was traditionally used as a body scrub. This potential comes from the active ingredient (curcumin) which could prevent premature aging with its activity as an antioxidant, inhibitor of the tyrosinase enzyme, and inhibitor of the collagenase enzyme so that it can prevent hyperpigmentation and inhibited the breakdown of collagen which can have an impact on skin aging. Oral dosage forms for anti-aging had started to be found on the market and were becoming a trend because of their convenient use. However, it is known that curcumin as an active ingredient of Temu Giring, had poor solubility and bioavailability. The bioavailability of curcumin was low when administered orally due to its low absorption and its stability which decreased significantly when the pH was above 7. This study was a literature review of national and international literature databases which aimed to determine the potential for increasing the bioavailability of curcumin using solid dispersion techniques. The results obtained indicated that making Temu Giring extract tablets containing curcumin using the solid dispersion method could increase the bioavailability of curcumin by overcoming the poor solubility, permeability, absorption and stability of curcumin. By designing the Temu Giring extract using a solid dispersion method, the curcumin could be completely dissolved and absorbed when released into the stomach. Keywords:  Curcuma heyneana, Temu Giring, Anti Aging, Tablet, Curcuminoid, Antioxidant, Solid Dispersion
Molecular Docking Study of Ferulic Acid Analog Compounds as Lung Antifibrotic at TGF-β1 Receptors Pebrianti, Denayu; Ekowati, Juni; Ainurrizma, Dhea Ananda
Berkala Ilmiah Kimia Farmasi Vol. 10 No. 1 (2023): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v10i1.45430

Abstract

Pulmonary fibrosis was one of the conditions that occurred in Post-COVID Syndrome patients. Development of specific treatment as an agent to treat pulmonary fibrosis was still ongoing. Ferulic acid was a compound that had a potential lung antifibrotic agent through the inhibition of TGF-β1-mediated signaling. Molecular docking studies using the AutoDock Tools program version 1.5.7 were conducted on ferulic acid and its analogs to determine the activity of compounds as antifibrotic. Furthermore, the interaction of the compounds with the receptor was visualized using the Discovery Studio 2021 program. The results showed that ferulic acid and its analogs had lower free energy than Pirfenidone, which was a standard lung antifibrotic drug. 4-Benzoyloxy-3-methoxycinnamic acid was the compound that had the greatest activity. The group that contributed to the ligand-receptor interaction was the aromatic group with π interaction. Keywords:  Molecular Docking, AutoDock, Antifibrotic, TGF-β1, Ferulic Acid
Evaluation of Oral Preparations of Vitamin E as Antioxidant Using DPPH Method (Diphenyl picrylhydrazyl) Broto Anung Laksono; Nawal Ariqoh Rif'at; Tsabitah ‘Afiy Arsyah; Erlisa Alya Hanifah; Evi Wiela Astuti; Happy Rizki Rakhmawati; Clarisa Dian Cahyani; Hanun Najwa; Ariesta Yusuf Adyatama; Dena Septiyani; Zabrina Izatti Rachman; Agda Rismafuri Mukti Kirana; Achmad Toto Purnomo; Retno Sari
Berkala Ilmiah Kimia Farmasi Vol. 10 No. 1 (2023): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v10i1.47115

Abstract

This article aimed to evaluate the activity of Vitamin E as an antioxidant in oral pharmaceutical preparations. Vitamin E was an essential nutrient soluble in fat that had the pharmacological effect as an antioxidant. Vitamin E consisted of α, β, γ, δ-tocopherol and α, β, γ, δ-tocotrienol. The activity of Vitamin E was observed for its ability to inhibit reduction using the DPPH method. The antioxidant activity was calculated as an inhibition concentration of 50% (IC50), which was the concentration of a sample that could reduce 50% of DPPH. It was known that IC50 of Vitamin E was very strong with a value of 42,86%. Based on the article review, it could be concluded that the activity of Vitamin E as an antioxidant in oral pharmaceutical preparations was very high and strong. Keywords:  Vitamin E, Alpha-Tocopherol, Antioxidant, Activity, IC50, Oral Pharmaceutical Preparations
Determination of Queercetin Content in Preparation of Powder Extract of Starfruit Leaves (Averrhoa bilimbi L.) by Tlc-Densitometry Sudjarwo, Sudjarwo; Zulfiyah Emaz; Amirudin Prawita
Berkala Ilmiah Kimia Farmasi Vol. 10 No. 1 (2023): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v10i1.51432

Abstract

Quercetin was a flavonoid from Averrhoa bilimbi Linn. which had a variety of potential therapeutic uses. Therefore, this research was needed to determine the quercetin content in Averrhoa bilimbi L.’s extract powder. Method validation was performed to ensure that an analytical method met the criteria and requirements of a good analysis method. Method validation used was the first category with parameters of selectivity, linearity, accuracy, and precision. The content of quercetin in Averrhoa bilimbi L.’s leaf was small, which required the parameters of Limit of Detection (LOD) and Limit of Quantitation (LOQ). The analysis method was by TLC-Densitometry with Silica gel 60 F254, eluent of toluene: ethyl acetate: formic acid (7:3:1) as the mobile phase with a resolution of 1,67 and 1,60, respectively. The results showed a linear regression of y = 8122,4899 x + 1181,9943 (r: 0,9976; Vxo 4,88%). The accuracy was 90,2% (w/w) ± 5,89; the coefficient of variation of precision was 1,35%; LOD and LOQ were 0,0064 µg, and 0,0215 µg, respectively. The determination result showed that quercetin content in the leaf extract in ethanol of Averrhoa bilimbi L. was 0,58% (w/w) ± 0,04, and the determination of quercetin from 4,0 g extract powder of Averrhoa bilimbi L. leaf showed that the average content of quercetin was 6,05 ± 0,09 mg. Keywords:  Quercetin, Extract Powder, Averrhoa bilimbi L, TLC-Densitometry

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