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Journal of Science and Technology Research for Pharmacy
Published by Universitas Negeri Semarang
ISSN : -     EISSN : 27760685     DOI : https://doi.org/10.15294/jstrp.v1i2
Core Subject : Science,
Chemistry
Journal of Science and Technology Research for Pharmacy is open access, peer-reviewed journal published by Pharmaceutical Science Study Program, Faculty of Mathematics and Natural Sciences, Universitas Negeri Semarang, Indonesia. The journal publishes only papers describing original findings and review articles of all aspects in developing the field of pharmaceutical science and technology.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 5 Documents
 1 
Search results for , issue "Vol 1 No 2 (2021)" : 5 Documents clear
The Role of Mesenchymal Stem Cell in Controlling Liver Function on Liver Fibrosis Antari, Arini Dewi; Prasetio, Ardi; Nugroho, Baskoro Adi
Journal of Science and Technology Research for Pharmacy Vol 1 No 2 (2021)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v1i2.45699

Abstract

ABSTRACT Background: Liver fibrosis (LF) is the end-stage of liver damage characterized by the increase concentration of SGOT and SGPT. A previous study, revealed that liver transplantation as the most effective therapy for LF has limited availability and remains a major challenge. Mesenchymal stem may control inflammation and regenerate damaged tissue leading to accelerated liver function repair. Aim: The purpose of this study was to determine the optimum doze for MSC administration to recover LF. Method: The research used variations doze of MSCs administration of 1x106 and 2x106. Liver firbosis was induced by twice a week intraperitoneal injection of carbon tetrachloride (CCl4) (Sigma-Aldrich) dissolved with olive oil in 1:1 ratio for eight weeks. The concentration of SGPT SGOT was measured at day 9 post MSC administration. One Way Anova was performed to analyze statictical data. Result: This study showed that there was a significant decrease in SGOT concentration (P < 0,05). P2 group treatment showed the lowest concentration of SGOT among the treatment (Figure B). In the same time, the administration of UC-MSCs reduce SGPT concentration insignificantly (P > 0,05). Conclusion: The transplantation of MSCs ameliorated LF by reducing SGPT and SGOT concentration
Potential of Ginger (Zingiber officinale), as anti-hypercholesterolemia to prevent metabolic syndrome: Systematic Literature Review Melani, Beta; Vikasari, Suci Nar
Journal of Science and Technology Research for Pharmacy Vol 1 No 2 (2021)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v1i2.49573

Abstract

Abstract Background: One of the symptoms of metabolic syndrome is an increase in cholesterol levels in the blood. Ginger (Zingiber officinale) is a herbal plant that has several active compounds that can help improve lipid levels in the blood. Aim: This systematic study was conducted to examine the potential of ginger as an anti-hypercholesterolemia to prevent metabolic syndrome. Methods: The study was conducted on Indonesian-language articles through the Google Scholar Indonesia database. The inclusion criteria used were articles in Indonesian, preclinical and clinical experimental research, and complete articles that were accessible free of charge. Results: The results of the study show that the anti-cholesterol effect of ginger has been proven both preclinically and clinically. To reduce blood cholesterol levels, ginger can be used combined with other herbs. Some of the active ingredients in ginger are phenolic compounds, including gingerols and shogaols. The suspected mechanism of action is to affect the HMG-CoA reductase enzyme by inhibiting the oxidation pathway and as antiinflammation. Conclusion: Ginger has the potential to prevent metabolic syndrome by reducing cholesterol levels in the blood Keywords: Ginger, Zingiber officinale, hypercholesterolemia, metabolic syndrome
The Antibacterial Activity of Acanthus ilicifolius L. n-Hexane Fraction warsinah, warsinah; Wijaya, Triyadi Hendra; Ekowati, Nuraeni
Journal of Science and Technology Research for Pharmacy Vol 1 No 2 (2021)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v1i2.49615

Abstract

Background: Recently, with the high prevalence of diarrhoea caused by bacterial infection, the usage of antibiotics has increased. Antibiotic overuse might lead to several side effects and resistance, suggesting the development of an alternate antibacterial agent. A mangrove plant, Acanthus Illinois, contained triterpenoid, which has antibacterial properties. Aim: This study aimed to evaluate the antibacterial effect of the Acanthus Illinois n-hexane fraction against Escherichia coli and Shigella dysenteriae. Method: The Acanthus Illinois was fraction using n-Hexane, identification of secondary metabolite compound using GC-MS, and evaluation of antibacterial activity against Escherichia coli and Shigella dysenteriae under paper disc methods. This study was designed using a fully randomized design (CRD) with concentrations of fractions 1%, 2%, and 4%. The GC-MS results were compared to the WILEY 9 library and analysed. A prism graph was used to measure the inhibition zone of antibacterial activity. Result: The n-hexane fraction yield is 3.3% and contains sesquiterpene compounds (trans (beta.)-caryophyllene, alpha humulene, naphthalene decahedron-4A-methyl), terpenoid alcohol (3,7,11,15-tetramethyl -2-hexadecane-1-ol), and fatty acids (hexadecanoic acid methyl ester. Acanthus Illinois n-hexane fraction has antibacterial activity against Escherichia coli and Shigella dysenteriae in a dose-dependent manner. Conclusion: The n-hexane fraction of leaves Acanthus ilicifolius contains sesquiterpene, alcohol terpenoids, and fatty, and has antibacterial activity against Escherichia coli and Shigella dysenteriae
Total Phenolic, Total Flavonoid Content and in vitro Sun Protection Factor test of Arabica Coffee Leaves Extract (Coffea arabica L) Fatmawati, Sofia; Sjahid, Landyyun Rahmawan; Utami, Nadiyya Maulida; Kartini, Kartini
Journal of Science and Technology Research for Pharmacy Vol 1 No 2 (2021)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v1i2.51374

Abstract

Background: Arabica coffee leaf (Coffea arabica L.) is a well-known plant by the Indonesian people because it has many benefits apart from being a drink. Coffee leaves are known to have good antioxidant activity. The use of antioxidants in sunscreen preparations can prevent various diseases caused by UV radiation from UV rays’ sunlight. Aim: This study aims to determine the phenol content, the flavonoid content and the value of Sun Protection Factor (SPF) from differences between solvent extracts of arabica coffee leaves (Coffea arabica L.). Method: The extraction method used was maceration with solvents: 70% ethanol, 96% ethanol and methanol. Determination of phenol content was carried out using the Folin ciocalteu method. Determination of flavonoid content was done by the AlCl3 method. SPF value is based on the Mansur equation from absorbance scanning using UV Spectrophotometry. Result: The results obtained were the highest phenol and flavonoid content is in the methanolic extract of arabica coffee namely 62.371 ± 0.47 mgGAE/g and 8.6707 ± 0.04 mgQE/g. In the SPF test, the highest value was obtained from 70% ethanol extract of 5.0593 ± 1.28 at 100 ppm extract concentration with intermediate protection category. Conclusion: Arabica coffee leaves have the potential as an active ingredient in herbal sunscreens
Alpinia galanga Extract Inhibits MCF-7/HER2+ Cells by Inducing Apoptosis Ibrahim, Sugeng
Journal of Science and Technology Research for Pharmacy Vol 1 No 2 (2021)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v1i2.51512

Abstract

Background: Cancer is a disease caused by abnormal growth of body tissue cells. Cancer treatment strategy by induce apoptosis and inhibit proliferation. Aim: This research aims to examine the anticancer effect of Alpinia galanga extract on MCF-7/HER2+ breast cancer cells. Method: The MTT Assay cytotoxic test was carried out to determine the growth inhibitory activity. Apoptotic assay to determine the activity of compounds in apoptosis, as well as through a structural approach utilizing various virtual platforms to monitor its activity. Result: Based on the MTT assay Alpinia galanga extract possessed cytotoxic effect in dose-dependent manner with IC50 value of 330.79 μg/mL. The extract induces apoptosis of MCF-7 cells up to 25.56%. Conclusion: It can be concluded that Alpinia galanga extract demonstrated cytotoxic activity toward MCF-7/HER2+ breast through apoptosis induction. This extract had an opportunity to be developed as a potential anticancer agent to overcome breast cancer diseases.

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