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International Archives of Medical Sciences and Public Health
Published by Yayasan Pena Cendekia Insani
ISSN : 2798561X     EISSN : 27985172     DOI : -
Core Subject : Religion, Health, Social,
Religion Environmental Science Health Professions Medicine & Pharmacology Public Health
Journal considers submissions on any aspect of the health field across age groups and settings, these include: Capacity in public health systems and workforce Dentistry Environmental health Environmental Science Health Economic and Policy Studies Health law and ethics Health Professions Maternal and child health Medical Science Midwifes Nursing Public health nutrition Public health practice and impact Reproductive health Islamic and health
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 183 Documents
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TOPICAL MORINGA OLEIFERA GEL AND FIBROBLAST/COLLAGEN CHANGES IN A DIABETIC RAT BURN-WOUND MODEL: A PILOT IN VIVO-IN SILICO STUDY TARGETING TGF-BETAR1 Anggeria, Elis; Yunus, Muhammad; Damanik, Derma Wani
International Archives of Medical Sciences and Public Health Vol. 7 No. 1 (2026): International Archives of Medical Sciences and Public Health
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v7i1.1570

Abstract

Diabetic wounds remain a major clinical challenge, as persistent hyperglycemia disrupts fibroblast function and matrix remodeling, delaying healing. Transforming Growth Factor-beta 1 (TGF-beta1) is a key regulator of fibroblast proliferation and collagen synthesis during repair. This pilot study explored Moringa oleifera gel's wound-healing effects using an integrated in vivo in silico approach, generating hypotheses about its mechanism via the TGF-beta1 pathway. Twenty-five streptozotocin-induced diabetic Wistar rats with partial-thickness (Grade II) burn wounds were randomized to 0.5% Na-CMC (negative control), Bioplacenton (positive control), or M. oleifera gel (5%, 10%, or 15%) once daily for 14 days. Because histomorphometric analysis used only two animals per group (n = 2/group), fibroblast and collagen outcomes are reported descriptively as preliminary, pilot-stage observations. The 15% gel group showed descriptively higher mean fibroblast counts than the negative control (110.0 pm 9.9 vs. 54.5 pm 4.9 cells/3 HPF) and higher collagen coverage (score 3, about 80%) than untreated wounds (score 2, about 20%). Molecular docking showed quercetin, a major M. oleifera constituent, has favorable predicted affinity (-9.6 kcal/mol) toward TGF-betaR1's ATP-binding pocket; this is hypothesis-generating only. These preliminary findings suggest topical M. oleifera gel may warrant further investigation as a candidate adjunctive therapy for diabetic wound management.
ANTIBACTERIAL ACTIVITY OF JACKFRUIT LEAF (Artocarpus heterophyllus L.) EXTRACT SCRUB PREPARATION AGAINST Staphylococcus aureus Maulita Saraswati; Fika Quba Mayada; Gigih Kenanga Sari
International Archives of Medical Sciences and Public Health Vol. 7 No. 1 (2026): International Archives of Medical Sciences and Public Health
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v7i1.1578

Abstract

Jackfruit leaves (Artocarpus heterophyllus L.) were extracted by maceration with 96% ethanol, yielding a 7.03% yield. Jackfruit leaves contain compounds including alkaloids, flavonoids, saponins, tannins, and steroids. Based on the secondary metabolic content, jackfruit leaves have antibacterial activity. The use of secondary metabolites as antibacterials requires ease of use, so in this study jackfruit leaf extract was made into a scrub preparation. This scrub preparation was tested for antibacterial activity against Staphylococcus aureus bacteria using the well method with variations in jackfruit leaf extract concentrations of F0 without extract, FI 1%; FII 3%; FIII 5%; positive control clindamycin. The results of the inhibition of Staphylococcus aureus bacteria obtained FI of 11.23 mm; FII 11.48 mm; FIII 12.39 mm; Positive control 30.44 mm and F0 10.86 mm. Based on the results of the bacterial inhibition test, which was replicated three times, a statistical test was subsequently conducted using the SPSS software. The statistical analysis employed a One-Way ANOVA test, with the following results the significance value was 0.000 < 0.05, indicating that the means are different, where the variation in extract concentration influences the diameter inhibition test of the scrub preparation. These results indicate that FIII with an extract concentration of 5% showed better inhibitory power than other formulas but was not yet able to match the inhibitory power of the positive control clindamycin.
FACTORS ASSOCIATED WITH UNCONTROLLED BLOOD PRESSURE AMONG THE COMMUNITY OF OLDER ADULTS WITH HYPERTENSION AT PUSKESMAS DESA LALANG, MEDAN: A CROSS- SECTIONAL STUDY Purba, Dahlia; Br. Tarigan, Ratnasari Putri; Lina Rizki
International Archives of Medical Sciences and Public Health Vol. 7 No. 1 (2026): International Archives of Medical Sciences and Public Health
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v7i1.1617

Abstract

Uncontrolled blood pressure remains a concern among older adults with hypertension. This study analyzed factors associated with uncontrolled blood pressure. An analytical cross-sectional study was conducted in the Puskesmas Desa Lalang working area, Medan, from September to November 2025, involving 116 older adults with hypertension recruited using purposive sampling. Data were collected using the SQ-FFQ, MMAS-8, and IPAQ-SF; blood pressure was measured using an aneroid sphygmomanometer. Chi-square and multivariable logistic regression analyses were performed (p < 0.05). Of 116 participants, 65 (56.0%) had uncontrolled and 51 (44.0%) controlled blood pressure. Age > 65 years (AOR = 12.87; 95% CI: 8.09-33.47; p < 0.001), high salt in-take (AOR = 11.78; 95% CI: 5.34-18.71; p < 0.001), and medication non-adherence (AOR = 9.84; 95% CI: 7.64-14.74; p < 0.001) were associated with uncontrolled blood pressure. Older age, high salt intake, and medication non-adherence were associated with uncontrolled blood pressure. Primary healthcare should prioritize monitoring, salt reduction, and medication adherence.

Page 19 of 19 | Total Record : 183

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