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Pharmaceutical And Biomedical Sciences Journal (PBSJ)
Published by Universitas Islam Negeri Syarif Hidayatullah Jakarta
ISSN : 27152979     EISSN : 27156702     DOI : https://doi.org/10.15408/pbsj
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Pharmaceutical and Biomedical Sciences Journal is an official peer-reviewed, open access journal that is managed by the Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia. This journal publishes original research articles, review articles, as well as short communications covering all aspects of Pharmacy, Pharmaceutical dan Biomedical Sciences in both Bahasa Indonesia and English. The journal includes various fields of Pharmacy, pharmaceutical and biomedical sciences such as: Pharmacology and Toxicology, Pharmacokinetics, Community and Clinical Pharmacy, Pharmaceutical Chemistry, Pharmaceutical Biology, Pharmaceutics,Pharmaceutical Technology, Biopharmaceutics, Pharmaceutical Microbiology and Biotechnology, Alternative medicines, Biochemistry& Biomedic.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 8 Documents
 1 
Search results for , issue "Vol 5, No 1 (2023)" : 8 Documents clear
Review: Potensi Resin Kemenyan (Styrax benzoin) dan Senyawa Aktifnya Dalam Pengobatan Penyakit Erlia Anggrainy Sianipar
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 1 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i1.30202

Abstract

Studies on drug discovery from natural ingredients are important to determine the pharmacological effects of the compound’s content so that it can be used to treat diseases. Kemenyan (Styrax benzoin) resin has been widely used by the local community for various purposes, including medicine. This review article aims to provide a comprehensive view of the potency of Kemenyan resin and its active compounds so that they could be used and developed to treat diseases in the future. The method used was based on searching for scientific literature in national and international journals. The results showed that the Kemenyan resin contains active compounds, including cinnamic acid, benzoic acid, benzaldehyde, benzyl benzoate, vanillin, styrene, styracin, coniferyl benzoate, benziresinol resin, resinotannol, sterols, phthalic acid, and sumaresorcinol. These compounds are known to have various pharmacological effects, including antibacterial, anesthetic, anti-inflammatory, antispasmodic, antimutagenic, fungicidal, herbicidal, tyrosinase inhibitory, and LDL synthesis inhibitory effects. Based on these studies, it can be concluded that the Kemenyan resin has great potential for the treatment of various diseases.
Kualitas hidup ODHA di Klinik VCT RSUD Raden Mattaher Jambi Chytra Bertdiana Ersa; Najmiatul Fitria; Dedy Almasdy
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 1 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i1.32264

Abstract

Implementasi terapi Antiretroviral (ARV) dikatakan berhasil apabila kualitas hidup Orang dengan HIV/AIDS (ODHA) menjadi lebih baik (Wu, 2000). Tujuan penelitian ini adalah untuk memberikan gambaran tentang kualitas hidup ODHA di Klinik VCT RSUD Raden Mattaher Jambi berdasarkan lama penggunaan terapi ARV dan rejimen yang digunakan. Penelitian ini dilakukan secara prospektif mulai Januari hingga April 2023 di klinik VCT RSUD Raden Mattaher Jambi. Kami mengumpulkan data dari pasien klinik VCT RSUD Raden Mattaher Jambi yang memenuhi kriteria inkllusi dan eksklusi sebagai responden. Kuesioner terstruktur, instrument EQ-5D-5L dan EQ-VAS digunakan sebagai instrumen pengumpulan data. Data dianalisis menggunakan Uji Mann Whitney, Kruskall Wallis, Korelasi Spearman. Dari 349 populasi ODHA usia dewasa (≥ 18 tahun) yang terdata di klinik VCT RSUD Raden Mattaher Jambi, 152 (43,55%) diantaranya bersedia menjadi Responden penelitian dan sejumlah 143 (94%) dari total sampel yang dapat dianalisis. Hasil penelitian ini menunjukkan secara sosiodemografi tidak terdapat perbedaan bermakna nilai kualitas hidup pada variabel usia, jenis kelamin, domisili, pekerjaan, pendidikan dan status pernikahan (p<0,05) akan tetapi terdapat perbedaan bermakna nilai kualitas hidup pada faktor resiko penularan dan ada tidaknya penyakit lain (p<0,05). Ditemukan perbedaan bermakna nilai kualitas hidup pada lama penggunaan terapi ARV dimana kelompok responden yang menggunakan terapi ARV ≤ 2 tahun memiliki perbedaan bermakna dibandingkan dengan responden yang telah menggunakan terapi ARV >2 tahun (p<0,05). Tidak terdapat perbedaan bermakna pada kelompok yang menggunakan terapi ARV >2 – 5 tahun,  >5 – 10 tahun maupun > 10 tahun (p>0,05). Tidak ada perbedaan nilai kualitas hidup secara bermakna pada 8 kelompok rejimen terapi ARV (p>0,05). Analisis korelasi menunjukkan terdapat hubungan positif antara nilai UEQ-5D dan UEQ-VAS dengan dengan tingkat cukup (koefisien korelasi 0,348). 
Korelasi Tingkat Pengetahuan Terhadap Keberhasilan Terapi Pasien Hipertensi di Puskemas Tuti Wiyati; Vera Rahayu; Septianita Hastuti
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 1 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i1.30231

Abstract

Knowledge can affect the success of therapeutic outcomes in hypertensive patients. Blood pressure must be controlled to prevent risk factors for other cardiovascular diseases. The purpose of this study was to analyze the relationship between knowledge of patients with hypertension and the success of therapy outcomes that showed controlled blood pressure. This observational cross-sectional study was conducted from March to June 2021 at Tangerang District Health Centers. A sample of 85 outpatients with hypertension was administered the HK-LS questionnaire to measure their level of knowledge, while the results of therapeutic outcomes were measured using blood pressure. The results showed that 60% of patients had intermediate knowledge and only 28.24% of the subjects had well-controlled blood pressure. There was a correlation between knowledge and therapy outcomes (p<0.05) with coef. correlation was -0.336, means a weak and inverse correlation. Comorbidity and sex were significantly correlated with knowledge (p<0,05). The level of knowledge needs to be improved to decrease the number of comorbidities or risk of complications to raise the goal of therapy. 
Kajian Penerapan Cara Pembuatan Obat Tradisional yang Baik pada Industri Ekstrak Bahan Alam di Indonesia Purnama Dwi Tistiyanto; Sukrasno Sukrasno; Budiastuti Budiastuti; Lydia Prima
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 1 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i1.32090

Abstract

 Good Manufacturing Practices for Traditional Medicine (GMP for TM) must be applied by Traditional Medicine Businesses in Indonesia, namely Traditional Medicine Small Businesses (TMSB), Traditional Medicine Micro Businesses (TMMB), Traditional Medicine Industry (TMI) and Active Traditional Medicine Ingredients Industries (ATMII), to ensure the quality of the products produced. At the end of 2021, the Indonesian FDA established the most recent GMP for TM standards, which follow the PIC / PE 009-015 standard that must be applied by TMI and ATMII, with an appendix related to GMP for Active Ingredients Traditional Medicine (ATMI) for ATMII. This study aims to determine the GMP profile for TM implementation, specifically in 17 ATMII in Indonesia, and to provide recommendations to the Indonesian FDA in supervising and assisting ATMII. The method was carried out by creating a list of questions from 17 aspects of GMP for Active Ingredients TM, including aspects of product development and technology transfer, to be filled out independently by 17 IEBA, followed by verification and assessment of compliance with the implementation of GMP for TM with the conclusion of the assessment results of the categories are very good, good, sufficient, and poor. According to the findings of the current GMP for TM application, 6 ATMII (35.3%) received a very good assessment result, 6 ATMII (35.3%) received a good assessment result, 3 ATMII (17.6%) received sufficient assessment results, and 2 ATMII (11.8%) received poor assessment results. The current GMP for TM implementation by ATMII that requires attention are Contract Manufacturers (Including Laboratories), product development and technology transfer, personnel, quality control, and validation, whose average level of fulfilment is still less than 80%. These aspects are critical because they significantly influence the consistency of the quality.
Efek Ekstrak Etanol 70% Daun Kemangi Ocimum americanum L.) Terhadap Perbaikan Sel Spermatogenik Tikus Sprague-Dawley Jantan Azrifitria Azrifitria; Eka Putri
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 1 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i1.27787

Abstract

Kemangi is a strong aromatic herb with aphrodisiac activity. The content of secondary metabolites that are antioxidants in kemangi are thought to be able to overcome fertility disorders due to the work of free radicals.  The aim of this study was to screen for phytochemicals and to analyze the activity of 70% ethanol extract of kemangi leaves (Ocimum americanum L.) on the repair of spermatogenic cells in male sprague-dawley rats exposed to lead. The results of phytochemical screening showed that the basil leaf extract was positive for alkaloids, flavonoids, tannins, and saponins. The results of administration of 70% ethanol extract of kemangi leaves at a dose of 50 mg/KgBW, 100 mg/KgBW, and 200 mg/KgBW in rats that had been induced by lead acetate increased the diameter of the seminiferous tubules, the number of pachytene cells, and round spermatid cells compared to the negative control but not significantly different (p > 0.05). The highest increase in all parameters of the spermatogenic cell repair test was given the kemangi leaves extract at a dose of 200 mg/KgBW.
Aplikasi Natural Deep Eutectic Solvent (NADES) sebagai Green Solvent pada Ekstraksi Kafein dan Katekin dari Limbah Kulit Kopi Fitria Puspita; Isna Nurhidayati; Bella Mellisani; Fajar Amelia Rachmawati Putri; Anton Restu Prihadi
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 1 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i1.32256

Abstract

Various studies have been conducted to support green industry by developing green solvents to replace organic solvents that are generally toxic, volatile, and harmful to human health and the environment. Environmentally friendly solvents that have been successfully developed in the 21st century are eutectic solvents and natural deep eutectic solvents (NADES). NADES can be formed from primary metabolites such as amino acids, organic acids, sugars, or choline derivatives, and has a high ability to extract polar, non-polar compounds, and several other secondary metabolites. The amount of waste generated from the process of separating coffee from its seeds is abundant but has not been used optimally. Coffee husk waste has the potential to be used as a food product because it contains many active substances, especially phenolic compounds such as caffeine and catechins. In this study, an NADES solvent based on choline chloride-proline (1:1) was successfully synthesized and used to extract phenolic compounds from coffee husk waste in the form of caffeine and catechins. The results of the HPLC analysis showed that the levels of caffeine and catechins extracted were 14.5 ppm and 61 ppm, respectively. Based on these results, caffeine and catechins in coffee skin waste were successfully extracted using NADES based on choline chloride – proline (1:1). 
Formulasi Sediaan Sampo Antiketombe Ekstrak Etanol Daun Jambu Air (Syzygium aqueum (Burm.f.) Alston) Neni Sri Gunarti; Himyatul Hidayah; Bintang Larasati; Putri Agustina
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 1 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i1.29851

Abstract

Syzygium aqueum (Burm.f) Alston) leaves have many ingredients that are beneficial to health, one of which is as an antifungal for fungi that cause anti dandruff. To optimize this content, an anti dandruff shampoo formulation was made with the active ingredient ethanol extract of Syzygium aqueum (Burm.f) Alston leaves against Malassezia furfur. The purpose of this study was to determine the effect of extract concentration on the quality of the preparation and to find out which formula had the best antidandruff activity. The research method used was quasi experimental. The results of the phytochemical screening of the ethanol extract of Syzygium aqueum positively contained alkaloids, flavonoids, saponins, tannins, quinones and steroids. The Minimum Inhibitory Concentration showed inhibitory activity at a concentration of 1.56% using the well diffusion method. In the preparation activity test on F1; F2; and F3 with an extract concentration of 1.5%; 2% and 2.5% showed the potential as a very strong anti-dandruff category with an average inhibition zone diameter of 23.41±1.60 mm; 28.11±3.66 mm and 30.21±0.92 mm. The results of the evaluation of the physical properties of the preparation are in the form of a viscous semi-liquid, with a distinctive aromatic odor with a white to brownish green color with an average pH of 5.28±0.02 ; 6.16±0.01 ; 6.18±0.00 and 6.23 ± 0.01 with an average viscosity of 3550.3±38.88 cPs ; 3279±68.94 cPs ; 2656.6±33.29 cPs and 2568.6±108.14 cPs and foam height of 23.11±1.57 mm ; 31.76±1.95mm ; 43.03±0.77 mm and 49.06±1.37 mm, which means that the results of the physical evaluation of the preparations met the criteria. From the research that has been done, it can be seen that F3 with an extract concentration of 2.5% showed the best anti-dandruff activity.
Penggunaan Tumbuhan Obat Sebagai Penunjang Kesehatan pada Masyarakat Betawi Hendri Aldrat; Winda Trya Wulandari; Mita Restinia
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 1 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i1.32588

Abstract

Changes in land use from rice fields and plantations to residential areas, offices, and trading complexes will certainly result in changes in the biodiversity of the environment of the inhabitants of the capital city of Jakarta, including the Betawi community. The scarcity of certain species due to land conversion also affects people’s ethnobotanical knowledge. This study aimed to explore how the Betawi people, with the rapid flow of urbanization, use medicinal plants around them. A total of 25 respondents of the selected Betawi ethnicity were interviewed about the use of medicinal plants. Purposive sampling and snowball sampling were used. The data obtained from the respondents were collected and compared using triangulation techniques with previously published ethnobotanical reports. The results showed that as many as 61 species from 36 families were used by the Betawi people to support their health. Ginger, lemongrass, and jatropha are the most widely used plants. The most widely used species belong to the Zingiberaceae family. The most commonly used part is the leaves (55%), the most common processing method is boiling (48%), the most common way to administer the medicine is by drinking (49%), and as much as 61% of medicinal plants are used in the home. In conclusion, the Betawi people still maintain the tradition of using herbal medicine amidst the high rate of urbanization in the capital city of Jakarta. Furthermore, it is necessary to conduct further experiments in the laboratory to validate the safety, efficacy, and identification of the active ingredients in these plants. 

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