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All Journal Pharmaceutical And Biomedical Sciences Journal (PBSJ) Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Putri Agustina
Universitas Buana Perjuangan Karawang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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Formulasi Sediaan Sampo Antiketombe Ekstrak Etanol Daun Jambu Air (Syzygium aqueum (Burm.f.) Alston) Neni Sri Gunarti; Himyatul Hidayah; Bintang Larasati; Putri Agustina
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 5, No 1 (2023)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i1.29851

Abstract

Syzygium aqueum (Burm.f) Alston) leaves have many ingredients that are beneficial to health, one of which is as an antifungal for fungi that cause anti dandruff. To optimize this content, an anti dandruff shampoo formulation was made with the active ingredient ethanol extract of Syzygium aqueum (Burm.f) Alston leaves against Malassezia furfur. The purpose of this study was to determine the effect of extract concentration on the quality of the preparation and to find out which formula had the best antidandruff activity. The research method used was quasi experimental. The results of the phytochemical screening of the ethanol extract of Syzygium aqueum positively contained alkaloids, flavonoids, saponins, tannins, quinones and steroids. The Minimum Inhibitory Concentration showed inhibitory activity at a concentration of 1.56% using the well diffusion method. In the preparation activity test on F1; F2; and F3 with an extract concentration of 1.5%; 2% and 2.5% showed the potential as a very strong anti-dandruff category with an average inhibition zone diameter of 23.41±1.60 mm; 28.11±3.66 mm and 30.21±0.92 mm. The results of the evaluation of the physical properties of the preparation are in the form of a viscous semi-liquid, with a distinctive aromatic odor with a white to brownish green color with an average pH of 5.28±0.02 ; 6.16±0.01 ; 6.18±0.00 and 6.23 ± 0.01 with an average viscosity of 3550.3±38.88 cPs ; 3279±68.94 cPs ; 2656.6±33.29 cPs and 2568.6±108.14 cPs and foam height of 23.11±1.57 mm ; 31.76±1.95mm ; 43.03±0.77 mm and 49.06±1.37 mm, which means that the results of the physical evaluation of the preparations met the criteria. From the research that has been done, it can be seen that F3 with an extract concentration of 2.5% showed the best anti-dandruff activity.
Integrasi Parameter Spesifik, Nonspesifik, dan Penapisan Fitokimia Sebagai Sidik Mutu Ekstrak n-Heksana Daun Begonia × erythrophylla Herincq Lia Fikayuniar; Putri Agustina; Farhamzah Farhamzah; Delika Syalomita; Diany Astuti
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 4 (2026): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i4.2405

Abstract

Begonia × erythrophylla Herincq is an ornamental plant with potential as a source of secondary metabolites; however, information on the standardization of its non-polar extract remains limited. This study aimed to establish the quality profile of the n-hexane extract of Begonia × erythrophylla Herincq  leaves based on specific and non-specific parameters and phytochemical screening. An experimental study was conducted using successive maceration of 317 g of powdered leaves. The extract was evaluated for yield, organoleptic properties, water- and ethanol-soluble extractive values, loss on drying, specific gravity, ash values, and secondary metabolite groups. Extraction produced 37.0 g of extract with a yield of 11.67%. The extract was thick, dark green, homogeneous, and had a characteristic odor. Phytochemical screening indicated the presence of alkaloids, flavonoids, tannins, polyphenols, steroids, and monoterpenoids/sesquiterpenoids, whereas quinones and saponins were not detected. The water- and ethanol-soluble extractive values were 0.1137 ± 0.0401% and 0.2119 ± 0.0095%, respectively. Loss on drying was 0.0106 ± 0.0017%, specific gravity was 0.8802 ± 0.0029 g/mL, total ash was 0.5543 ± 0.0434%, water-soluble ash was 0.4859 ± 0.0405%, and acid-insoluble ash was 0.4845 ± 0.0229%. Overall, the ethanol-soluble extractive value, loss on drying, specific gravity, and ash parameters were relatively consistent, whereas the water-soluble extractive value showed considerable variation. These findings provide a preliminary standardization profile for the n-hexane extract of Begonia × erythrophylla Herincq leaves. However, the water-soluble extractive value and relationships among ash parameters require verification before being established as quality specifications for herbal raw materials.
Co-Authors Bintang Larasati Delika Syalomita Diany Astuti Farhamzah Fikayuniar, Lia Gunarti, Neni Sri Himyatul Hidayah