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Ismiarni Komala
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Program Studi Farmasi, Fakultas Ilmu Kesehatan UIN Syarif Hidayatullah Jakarta Jl. Kertamukti No. 5, Pisangan, Ciputat 15412 Tangerang Selatan, Banten, Indonesia Telp: (62-21)74716718 Fax: (62-21) 7404985
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Pharmaceutical And Biomedical Sciences Journal (PBSJ)
Published by Universitas Islam Negeri Syarif Hidayatullah Jakarta
ISSN : 27152979     EISSN : 27156702     DOI : https://doi.org/10.15408/pbsj
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Pharmaceutical and Biomedical Sciences Journal is an official peer-reviewed, open access journal that is managed by the Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia. This journal publishes original research articles, review articles, as well as short communications covering all aspects of Pharmacy, Pharmaceutical dan Biomedical Sciences in both Bahasa Indonesia and English. The journal includes various fields of Pharmacy, pharmaceutical and biomedical sciences such as: Pharmacology and Toxicology, Pharmacokinetics, Community and Clinical Pharmacy, Pharmaceutical Chemistry, Pharmaceutical Biology, Pharmaceutics,Pharmaceutical Technology, Biopharmaceutics, Pharmaceutical Microbiology and Biotechnology, Alternative medicines, Biochemistry& Biomedic.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 155 Documents
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QSAR Analysis and ADMET Prediction of Tamoxifen Derivatives Using LFER Hansch Model Andzar Fikranus Shofa; Rawwdha Luthfi Nur Muhammad; Norma Adityaningsih Prameswari; Sendi Handika Putra; Aisyah Afifah Setiawan; Dhia Salsabila Rizki
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 2 (2025)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i2.49191

Abstract

Tamoxifen is a pharmaceutical compound that can be widely used in the therapeutic regimen for breast cancer, particularly for postmenopausal women. Nevertheless, this clinical efficacy is frequently diminished and limited due to the emergence of drug resistance and heterogeneous therapeutic impacts with different degrees of severity. This has led to the discovery of structurally connected compounds that are more effective than tamoxifen. The current research study describes QSAR modeling and predicting the ADMET parameters of tamoxifen derivatives for the treatment of breast cancer. SPSS software was used for analysis of multiple linear regression and found the pIC50 = -0.059CLogP + 0.759LUMO - 0.011MR + 3.444. Model validation yielded R = 0.921, R² = 0.848 and Q² = 0.651, which suggests high predictability. The most important characteristic being LUMO energy, the second most important descriptor was followed by CLogP and MR. The ADMET prediction showed high intestinal absorption values (HIA > 90%) and satisfactory permeability over skin. Water solubility was impaired but also low. The metabolism of compounds seemed to predominantly occur via CYP3A4 enzyme. However, LD50 values were of acceptable size, ranging from 324 to 3000 mg/kg (within the safety profile). The findings of this work will thus show help in designing anticancer tamoxifen derivative products with the least toxicity. Additional structural optimization is advocated to achieve maximal therapeutic benefit and least toxicity.  
Exploration and Inventory of Ethnobotanical Knowledge of Medicinal Plants in Ternate: Tracing the Traditional Pharmacy Heritage of the Spice Islands Lina Elfita; Hijria Abd Gani; Ismiarni Komala
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 2 (2025)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i2.49235

Abstract

The ethnobotanical wisdom of the Ternate community represents a rich heritage of traditional healing practices that are deeply rooted in the interaction between people and nature. However, the modernization of the healthcare system and cultural shifts have increasingly threatened the continuity of this indigenous knowledge. This study aimed to explore and inventory the ethnobotanical knowledge of medicinal plants traditionally used in the Ternate region as part of an effort to preserve the traditional pharmacy legacy of the Spice Islands. Data were collected through field-observations, semi-structured interviews with traditional healers, local residents, and plant specimen documentation. A purposive sample of 29 traditional healers was recruited for this study, based on their presumed expertise in medicinal plant knowledge. The study identified 70 medicinal plant species belonging to 40 families, which are empirically used to treat common ailments such as fever, digestive disorders, wounds, insomnia, diabetes mellitus, and urinary stones. Leaves were the most frequently used plant part (approximately 64%) followed by roots and barks, with decocting being the dominant preparation method. Several endemic species have demonstrated pharmacological potential, consistent with findings in contemporary scientific literature, indicating promising opportunities for bioprospecting. This research highlights that preserving ethnobotanical knowledge is not merely a cultural duty but also a scientific imperative for sustainable natural product development rooted in Ternate’s local wisdom.
Peran Tenaga Kefarmasian Dalam Pelayanan Penyakit Faringitis Di Apotek Wilayah   X Propinsi Banten Yardi Saibi; Suci Ahda Novitri; Erza Agustia
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 2 (2025)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i2.49343

Abstract

Pharyngitis, or sore throat inflammation, is a disease generally caused by a virus and can heal on its own within a few days. However, symptoms such as pain when swallowing can cause discomfort for patients. Patients often come to the pharmacy to get medication without first consulting a doctor. The purpose of this study was to determine the role of pharmacists in region X in Banten province in providing pharmaceutical services to patients who come with complaints of sore throat. This study is a cross-sectional study using a survey method. Data collection methods were carried out using two methods, the first is participatory observation where researchers and observers acted as patients visiting selected pharmacies by conveying the complaints in question based on the scenario created. The second method was conducting interviews with pharmaceutical personnel at pharmacies in one of the selected areas who met the specified inclusion and exclusion criteria. The results of the study showed that in the patient simulation method: methyl prednisolone was the most frequently prescribed drug (52%), followed by lozenges containing dequalinium chloride (32%), the most frequently asked questions by pharmaceutical personnel when assessing patients were the symptoms experienced (63%) followed by the patient's age (53%). Meanwhile, in the interview method, lozenges containing dequalinium chloride were the most frequently prescribed medication (78%), followed by methylprednisolone (46%). The most frequently asked questions during patient assessment were the patient's age (98%), followed by the duration of symptoms experienced (96%). The drug's usage information was the most frequently conveyed information in both methods. The patient assessment process and drug information provided to patients in the interview method were better than in the simulated patient method. In general, pharmaceutical services provided by pharmacists to patients with sore throat problems are still not optimal and need to be improved
Quantitative Evaluation of Antibiotic Utilization Using the ATC/DDD and DU90% Methods and Length of Hospital Stay Among Pediatric and Adult Pneumonia Patients in Bima Jihan Istiqomah; Azrifitria; Marvel
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 2 (2025)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i2.49345

Abstract

The primary treatment modality for pneumonia is antibiotic therapy, yet improper use can accelerate bacterial resistance and diminish therapeutic effectiveness. The study aims to evaluate the patterns of antibiotic utilization among hospitalized pediatric and adult patients with pneumonia in a hospital in Bima City, as well as to examine the factors influencing the length of hospital stay during the period of January to August 2020. The evaluation employed the WHO ATC/DDD methodology combined with DU 90% analysis using a descriptive cross-sectional design. Data were obtained retrospectively from medical records, and total sampling. A total of 95 patients met the inclusion criteria, representing all age categories with complete and legible documentation. Quantitative analysis showed that the total antibiotic consumption in pediatric patients reached 39.27 DDD per 100 patient-days, while in adult patients it reached 121.26 DDD per 100 patient-days. Ceftriaxone was the antibiotic with the highest DDD value in pediatric patients and  adult patients, with 19.53 and 98.00 DDD/100 patient-days respectively. In the pediatric group, antibiotics within the DU 90 percent segment comprised ceftriaxone, gentamicin, cefotaxime, and azithromycin, whereas in adults, the DU 90 percent segment included ceftriaxone and azithromycin. A total of 97.6 percent of prescriptions were aligned with the hospital formulary. The bivariate analysis indicates that the presence of comorbidities is significantly associated with the length of hospital stay among pneumonia patients (p < 0.05). Meanwhile, patient age and nutritional status did not show a significant association (p > 0.05). Overall, the findings demonstrate a predominance of ceftriaxone use in the management of pneumonia in the hospital. These results highlight the importance of ongoing quantitative surveillance to monitor prescribing trends, and support implementation of antimicrobial stewardship programs to minimize resistance risk and maintain optimal therapeutic outcomes. Keywords: Antibiotic use; Antimicrobial Stewardship Program; ATC/DDD; Ceftriaxone; DU 90%; Pneumonia
Korelasi Pengetahuan dengan Perilaku Pasien dalam Penggunaan NSAIDs untuk Swamedikasi Nyeri di Apotek Zainul Islam; Lulu Isra Safira
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 2 (2025)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i2.49682

Abstract

The use of drugs for self-medication without proper knowledge and behavior can have a negative impact. This study explores the relationship between knowledge and behavior of patients self-medicating for pain at Serang City pharmacies. This study adopted cross-sectional research and sampling using purposive sampling. The level of knowledge and behavior was assessed using a questionnaire. This study included a total of 222 respondents (age 18-59 years) who were using non-steroidal anti-inflammatory drugs (NSAIDs) for pain and had taken them for the previous 3 months. The analysis of the relationship between knowledge and behavior was measured using the Spearman rho test. The results of showed a sufficient level of knowledge of the respondents (59.9%) with responsible behavior (57.2%). Spearman rho correlation test showed that there is a significant relationship between knowledge and behavior with a fairly strong correlation value (r = 0.715) in a positive direction. The higher the knowledge in self-medication, the better the behavior will be.

Page 16 of 16 | Total Record : 155

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