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Pharmaceutical And Biomedical Sciences Journal (PBSJ)
Published by Universitas Islam Negeri Syarif Hidayatullah Jakarta
ISSN : 27152979     EISSN : 27156702     DOI : https://doi.org/10.15408/pbsj
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Pharmaceutical and Biomedical Sciences Journal is an official peer-reviewed, open access journal that is managed by the Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia. This journal publishes original research articles, review articles, as well as short communications covering all aspects of Pharmacy, Pharmaceutical dan Biomedical Sciences in both Bahasa Indonesia and English. The journal includes various fields of Pharmacy, pharmaceutical and biomedical sciences such as: Pharmacology and Toxicology, Pharmacokinetics, Community and Clinical Pharmacy, Pharmaceutical Chemistry, Pharmaceutical Biology, Pharmaceutics,Pharmaceutical Technology, Biopharmaceutics, Pharmaceutical Microbiology and Biotechnology, Alternative medicines, Biochemistry& Biomedic.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 140 Documents
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Hubungan Antara Tingkat Pengetahuan dan Kepatuhan Penggunaan Obat pada Pasien Tuberkulosis di Salah Satu Puskesmas di Jakarta Pusat Maifitrianti, Maifitrianti; Wiyati, Tuti; Apriliyanti, Netha Apriliyanti
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 1 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i1.38174

Abstract

Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Non-compliance with TB treatment can lead to low cure rates, high mortality rates and increased risk of recurrence. Knowledge is very important for TB patients in order to sensitize patients to be compliant in carrying out treatment. This study aims to determine the relationship between knowledge level and adherence to taking medication in TB patients at the Kemayoran District Health Center for the period July - September 2023. This study used a cross sectional method with purposive sampling technique. Respondents of this study amounted to 108 patients, 105 patients met the inclusion criteria and 3 patients met the exclusion criteria. The level of knowledge was assessed using the knowledge questionnaire and the level of compliance was assessed using the Medication Adherence Rating Scale (MARS-5) questionnaire. The relationship between knowledge and adherence was analyzed using the Spearman Rho test. The results showed that most patients had good knowledge as many as 81 patients (77.1%) and patients were compliant in taking medication as many as 75 patients (71.4%). The results of bivariate analysis showed that the level of knowledge had a significant relationship with adherence to taking medication (p<0.05) with a strong correlation value (r 0.660) and positive direction.
Identifikasi DRPs Pasien Gagal Jantung di rawat Inap RSJPD Harapan Kita Tahun 2023 Islam, Zainul; Sari, Desy Puspita
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 1 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i1.38486

Abstract

Identifikasi Drug Related Problems (DRPs) pada pengobatan sangat penting dalam rangka mengurangi angka morbiditas, mortalitas dan biaya pengobatan. Hal ini akan sangat membantu dalam meningkatkan efektivitas terapi obat terutama pada penyakit yang sifatnya kronis dan membutuhkan pengobatan jangka panjang, salah satunya adalah penyakit gagal jantung. Penelitian ini untuk mendapatkan gambaran jumlah kejadian DRPs pada pasien gagal jantung di rawat inap RSJPD Harapan Kita Maret – Mei 2023. Penelitian deskriptif noneksperimental dengan pengambilan data prospektif dari rekam medik pasien. Sampel sebanyak 81 pasien yang memenuhi kriteria inklusi. Data dianalisis menggunakan PCNE V9.1 tahun 2020. Pasien yang mengalami DRPs sebanyak 72 pasien (88,9%) dan yang tidak mengalami DRPs sebanyak 9 pasien (11,1%). Gambaran DRPs setiap kategori yang terjadi meliputi 7 pasien (8,05%) kejadian obat yang merugikan terjadi, 70 pasien (80,46%) interaksi obat, 9 pasien (10,34%) tidak ada pemberian terapi meskipun ada indikasi yang jelas dan 1 pasien (1,15%) regimen dosis tidak cukup sering. Kejadian DRPs terbanyak terjadi pada interaksi obat dengan angka kejadian moderate sebanyak 60,55%, minor sebanyak 23,59% dan major sebanyak 14,06%. Dengan melihat gambaran tersebut diharapkan dapat meningkatkan monitoring terhadap pasien untuk meminimalisir angka kejadian DRPs.
Pemantauan Kadar Obat Antiepilepsi dalam Darah terhadap Clinical Outcome pada Pasien Epilepsi di RSPAD Gatot Soebroto dengan Pendekatan Farmakokinetika Sari, Dini Permata; Sianipar, Winda Septyani
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 2 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.38924

Abstract

The use of antiepileptic drugs requires monitoring of blood drug levels because antiepileptics are drugs with a narrow therapeutic index. This study was conducted to determine the relationship between the accuracy of blood antiepileptic drug levels and clinical outcomes in epilepsy patients at RSPAD Gatot Soebroto using a pharmacokinetic approach. This study is an analytical observational study with a retrospective cross-sectional study of epilepsy patients using antiepileptic drugs from January 2023 to January 2024 at RSPAD Gatot Soebroto Jakarta. The results of this study showed that the most antiepileptic drug was valproic acid (38.55%). Of the 32 patients using valproic acid, there were 22 uses of valproic acid below the therapeutic range (<50 mg/L), 10 uses of valproic acid within the therapeutic range (50–100 mg/L). Of the 22 uses of phenytoin, there were 4 uses of phenytoin below the therapeutic range (<10 mg/L), 17 uses of phenytoin within the therapeutic range (10–20 mg/L), and 1 use of phenytoin above the therapeutic range (>20 mg/L). Of the 10 uses of carbamazepine, 1 use of carbamazepine was below the therapeutic range (<4 mg/L), and 9 uses of carbamazepine were within the therapeutic range (4-12 mg/L). Of the 4 uses of levetiracetam, there were 4 uses of levetiracetam below the therapeutic range (12-46 mg/L), and 1 use of oxcarbazepine had a therapeutic range below the therapeutic range (3-35 mg/L). In clinical outcomes within 6 months, 18.07% of patients experienced seizures after receiving antiepileptic drug therapy, and 81.93% of patients experienced seizure-free for up to 6 months. The conclusion of this study is that a p-value of >0.05 is obtained, which means that there is no relationship between clinical outcomes and the accuracy of antiepileptic drug levels in the blood of epilepsy patients. This is because there are other pharmacokinetic parameters that cannot be predicted, so it is necessary to monitor antiepileptic drug levels directly on patients to improve the desired clinical outcomes.
Efektivitas Ekstrak Daun Pepaya (Carica papaya L.) sebagai Wound Healing Menggunakan Ikan Zebra Danio rerio Hamilton, 1822 Yang Diinduksi Hiperglikemia sebagai Model Aini, Falihah Nur; Elfita, Lina; Fitriana, Narti
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 1 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i1.38957

Abstract

Papaya leaves are known to have antidiabetic and wound-healing activities because they contain flavonoids, alkaloids, tannins, and saponins. Tests of the activity of papaya leaf extract in mouse models have been widely conducted. In this study, the wound healing activity of papaya leaves was carried out using zebrafish as a model, because of their ability to regenerate and 70% similarity to human glucose metabolism. This study aimed to analyze the potential of zebrafish as a model for healing diabetic wounds using 96% ethanol extract from papaya leaves. Zebrafish were divided into six groups, namely normal control, negative control, positive, and papaya leaf extract 125, 187.5, and 250 ppm. The parameters observed were a decrease in blood sugar levels, regeneration of the zebrafish caudal fin, and survival rate of the fish. The results showed that there was an effect of administering papaya leaf extract at doses of 125, 187.5, and 250 ppm respectively to reduce blood sugar levels by an average of 42.67; 44.33; and 72 mg/dL, an increase in fin length of 1; 1.3; 1 mm, and survival rate with a percentage of 91%, 91%, 64%. It was concluded that zebrafish could be used as a test model for diabetic wound healing. Apart from that, the use of 96% ethanol extract from papaya leaves affects the healing of diabetic wounds. Of the 3 doses given with 96% ethanol extract of papaya leaves, the best dose for healing diabetic wounds was 187.5 ppm.
Studi In Silico Senyawa Kimia Zingiber Montanum J.König sebagai Antidiabetes terhadap Reseptor α-Glukosidase Eltriya, Ninu; Adelina, Rosa; Komala, Ismiarni
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 2 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.39136

Abstract

Diabetes Mellitus (DM) is a metabolic disorder resulting from the impaired secretion of insulin, glucagon, and other hormones, leading to elevated blood sugar levels. Bangle (Zingiber montanum) is recognized for its potent antidiabetic compounds. This study sought to evaluate the potential and interaction of chemical compounds from bangle on the α-glucosidase receptor as an antidiabetic using molecular docking studies. The molecular docking analyses were conducted using Autodock Vina software and Biovia Discovery Studio Visualizer for 2D and 3D visualization. Fifteen chemical compounds from the bangle plant were subjected to molecular docking studies against the α-glucosidase receptor, with the comparative ligand acarbose. Results indicated that acarbose demonstrated a bond energy (ΔGbind) of -6.9 cal/mol. Conversely, six test compounds, including cassumunarin A (-7.7 kcal/mol), cassumunarin B (-7.5 kcal/mol), cassumunarin C (-8.0 kcal/mol), cassumunin A (-7.0 kcal/mol), cassumunin C (-7.0 kcal/mol), and banglenol A (-6.9 kcal/mol), exhibited lower binding energy than acarbose, signifying a more stable bond conformation and a stronger effect. These compounds formed hydrogen bonds with the amino acids Asp327, Asp203, Arg526, and Asp542, hydrophobic bonds with Tyr299, Thr406, and Phe575, and electrostatic bonds with Asp327, Asp203, Met444, and Asp542. In conclusion, this research indicates that several chemical compounds from the rhizome of bangle have the potential to interact with the α-glucosidase receptor as antidiabetic agents.
Aktivitas Antijamur Ekstrak Biji Kopi Hijau Robusta (Coffea canephora) Terhadap Candida albicans. Situmorang, Ing Mayfa Br; Salsadila, Putri; Maulidayanti, Sharfina; Tanjung, Asbar
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 2 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.39149

Abstract

Acne is a disease that can be caused by bacteria, one of which is Staphylococcus epidermidis. Acne can be treated with active compounds derived from natural ingredients such as cucumbers and tomatoes. Gel masks peel off. This study aims to determine the average diameter of the inhibition zone, the difference in the average diameter of the inhibition zone, and the antibacterial activity of the peel-off from a mixture of cucumber (Cucumis sativus) and tomato  (Solanum lycopersicum) with a concentration of 5%, 10 %, 15%, 20% against  Staphylococcus epidermidis. This experimental study uses a Completely Randomized Design (CRD) consisting of one factor and 6 levels. The results showed that the average diameter of the inhibition zone of the anti-acne peel-off gel mask preparation of cucumber and tomato extracts against Staphylococcus epidermidis at a concentration of 5%, 10%, 15% and 20% were 16.38 mm, respectively. ; 24.88 mm; 29.88 mm and 34.88 mm. There was a significant difference in the average diameter of the inhibition zone of the peel off mixture of cucumber and tomato extracts with a concentration of 5%, 10%, 15%, and 20%; against Staphylococcus epidermidis. gel mask preparation peels off from a mixture of cucumber and tomato extracts against Staphylococcus epidermidis at a concentration of 5%, 10% concentration, 15% concentration and 20% concentration, namely strong, very strong, very strong and very strong.   Keywords: staphylococcus epidermidis, gel mask peel-off, cucumber, tomato
Formulasi dan Karakterisasi Nanopartikel Ekstrak Biji Carica (Carica pubescens) dengan Variasi Konsentrasi Kitosan menggunakan Metode Gelasi Ionik Luhurningtyas, Fania Putri; Damayanti, Prashinta Nita; Astyamalia, Suzan; Kemila, Mir-a; Novitasari, Evi
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 2 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.39161

Abstract

Carica seeds (Carica pubescens) contain alkaloid, saponin, and flavonoid compounds, which have pharmacological activities such as antibacterial, anti-inflammatory, immunomodulatory, and antihyperlipidemic properties, but their bioavailability is low. Nanotechnology has significantly advanced in drug delivery systems because it can enhance absorption in the gastrointestinal tract, allowing entry into the bloodstream. This study aims to create and evaluate the characteristics of carica seed extract nanoparticles with varying concentrations of chitosan. The carica seed extract was obtained using the maceration method with 70% ethanol as the solvent. The Carica seed extract was then formulated into nanoparticles using the ionic gelation method with varying concentrations of chitosan: NaTPP, specifically formulas FA (0.3:1), FB (0.2:1), and FC (0.1:1). The resulting nanoparticle colloids were characterized for particle size, polydispersity index (PDI), percent transmittance (%T), and specific functional groups. The results showed that the particle sizes for formulas FA, FB, and FC were 243.7 nm, 47.96 nm, and 116.6 nm, respectively. The PDI values for formulas FA, FB, and FC were 0.378, 0.357, and 0.52, respectively. The percent transmittance for all three formulas ranged from 99.5% to 99.6%. The characterization of functional groups indicated interactions between the carica seed extract, chitosan, and NaTPP, with the presence of OH, N-H, aliphatic CH, P=O, and PO3 groups. These interactions were observed based on the shift in wavenumbers in the FTIR results for each sample. All carica seed nanoparticle formulas showed particle sizes within the nanometer range (<1000 nm), polydispersity indices less than 1, percent transmittance close to 100%, and specific functional groups indicating interactions between the extract and the coating polymer. Formula FB was the optimal formula, with the smallest nanoparticle size (<100 nm), a PDI value of <0.5, and a percent transmittance of >99%.
Studi In Silico Senyawa Bioaktif pada Daun Yakon (Smallanthus sonchifolius), Kayu Secang (Caesalpinia sappan L.), Daun Salam (Syzygium polyanthum) Sebagai Antidiabetes Mekanisme Kerja Inhibitor SGLT-2 Prasetyo, Andri Prasetyo; Mumpuni, Esti; Rahmadhani, Sekar Harsti; Amin, Saeful
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 2 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.39508

Abstract

Diabetes melitus adalah penyakit metabolik yang ditandai dengan hiperglikemia dimana pankreas tidak memproduksi cukup insulin atau tubuh tidak dapat menggunakan insulin secara efektif. Daun yakon, kayu secang dan daun salam memiliki beberapa yang berpotensi sebagai antidiabetes, namun belum diketahui senyawa spesifik mana yang terlibat dalam mekanisme inhibitor SGLT-2. Penelitian ini bertujuan untuk menganalisis potensi senyawa bioaktif yang terkandung dalam Daun yakon, kayu secang dan daun salam dalam menghambat enzim SGLT-2 secara in silico. Data senyawa aktif didapatkan dari laman PubChem. Kristal struktur dari Structure of human SGLT2-MAP17 complex bound with empagliflozin didapatkan dari Protein Data Bank dengan PDB ID: 7VSI. Molecular docking menggunakan Molegro Virtual Docker dan simulasi molecular dynamic menggunakan YASARA Dynamics. Hasil molecular docking didapatkan 4 senyawa memiliki nilai rerank score lebih negative dari senyawa pembanding (empagliflozi). Hasil visualisasi menunjukan residu asam amino yang berperan penting ialah PHE 98 dan VAL 157. Hasil molecular dynamics menunjukan kompleks ligan memiliki kestabilan ikatan paling baik dan stabil dari ligan uji lainnya. Dihasilkan senyawa yang stabil, yaitu 3,4-Dicaffeoyquinic acid.
Optimization Parameters of Natural Deep Eutectic Solvent Based on Choline Chloride and Fructose for Extraction of Polyphenol from Jotang (Spilanthes acmella) Stem Putri, Fajar Amelia Rachmawati; Maimulyanti, Askal; Nurhidayati, Isna; Mellisani, Bella; Widarsih, R. Wiwi; Puspita, Fitria; Prihadi, Anton Restu
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 1 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i1.39583

Abstract

Natural deep eutectic solvents (NADES) have become popular as an environmentally benign alternative to conventional solvents for extracting natural compounds. In this current research, choline chloride was employed as a hydrogen bond acceptor (HBA) and was mixed with fructose which had the role of a hydrogen bond donor (HBD) to construct NADES. This extracting agent was deployed to separate the polyphenolic compounds from the stem of Jotang (Spilanthes acmella) under prime conditions. The extracted polyphenol was subsequently calculated based on the Folin-Ciocalteu method using gallic acid as the standard solution by UV-Vis spectrophotometer at 760 nm. Corresponding to the research outcomes, the most gainful states of extraction were achieved at a sample weight-to-NADES volume ratio of 1:50, a period of extracting process of 60 min, water content of 20%, and a stirring speed of 80 rpm. The optimized parameters were conceived as the most gainful because they exhibited the most prominent level of polyphenol were described as follows: ratio of sample weight-to-NADES volume and extraction time showed polyphenol content of 25.13 mg GAE/g each, while the others, stirring speed and water content revealed the polyphenol concentration of 25.75 mg GAE/g respectively.
Comparative Utility of Doxorubicin, Cyclophosphamide, and Docetaxel in Breast Cancer Treatment in West Sumatera. Fitria, Najmiatul; Nur Rahmadani, Intan; Permatasari, Dita; Handayani, Fitri
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 2 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.40914

Abstract

The large number of breast cancer cases in Indonesia and the high cost of treatment cause the need for utility analysis. West Sumatra province ranks second with the highest prevalence of breast cancer in Indonesia. This study aimed to determine the quality of life of breast cancer patients at the national referral hospital Dr. M. Djamil, West Sumatra, who underwent chemotherapy. This study used a cross-sectional design from January to April 2024. Data collection was done prospectively by filling out questionnaires at the Chemotherapy Unit. Utility value was obtained from filling out a questionnaire with the EQ-5D-5L instrument. Data were analyzed using the Mann-Whitney and Kruskal-Wallis tests. The data obtained was 47 respondents who received Doxorubicin and Cyclophosphamide chemotherapy regimen (24 respondents) and a Docetaxel chemotherapy regimen (23 respondents), all of whom met the inclusion criteria in this study. The average utility value obtained for the doxorubicin and cyclophosphamide regimes is 0.637, and the average utility value for the docetaxel regimen is 0.704. Age did not affect utility (p>0.05), while recent education, occupation, and patient origin affected utility (p<0.05). Both regimens provided similar perceived quality of life and overall health status as measured by utility and VAS scores, suggesting comparable patient-reported quality of life outcomes between these chemotherapy treatments.

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