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Pharmaceutical And Biomedical Sciences Journal (PBSJ)
Published by Universitas Islam Negeri Syarif Hidayatullah Jakarta
ISSN : 27152979     EISSN : 27156702     DOI : https://doi.org/10.15408/pbsj
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Pharmaceutical and Biomedical Sciences Journal is an official peer-reviewed, open access journal that is managed by the Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia. This journal publishes original research articles, review articles, as well as short communications covering all aspects of Pharmacy, Pharmaceutical dan Biomedical Sciences in both Bahasa Indonesia and English. The journal includes various fields of Pharmacy, pharmaceutical and biomedical sciences such as: Pharmacology and Toxicology, Pharmacokinetics, Community and Clinical Pharmacy, Pharmaceutical Chemistry, Pharmaceutical Biology, Pharmaceutics,Pharmaceutical Technology, Biopharmaceutics, Pharmaceutical Microbiology and Biotechnology, Alternative medicines, Biochemistry& Biomedic.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 168 Documents
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Hydrating Balm Serum Minyak Cendana (Santalum album L.) dan Minyak Zaitun (Olea europaea) untuk Meningkatkan Kelembapan Kulit Vica Aspadiah; Astrid Indalifiany; Suryani Suryani; Nur Illiyyin Akib; Rahmat Muliadi; Wa Ode Sitti Aminah Basri
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 8 No. 1 (2026)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v8i1.49347

Abstract

Dry skin is associated with barrier dysfunction and decreased hydration of the stratum corneum. Santalum album and Olea europaea contain bioactive compounds that function as emollients and occlusives. A serum balm formulation with a high concentration of active ingredients has the potential to effectively restore skin moisture. This study aimed to determine the optimal composition of a serum balm formula, identify the physical characteristics and stability of the formulation using the cycling test method, and evaluate the moisturizing effectiveness of a serum balm containing sandalwood oil and olive oil. The method involved formulating a serum balm with varying concentrations of sandalwood oil as the active ingredient, followed by evaluation of physical characteristics including organoleptic properties, pH, homogeneity, spreadability, and adhesiveness. Stability testing was conducted using the cycling test method by storing the preparation at 4°C for 24 hours and then transferring it to room temperature (25°C) for another 24 hours. The effectiveness test was performed using an in vitro occlusivity method. The results showed that the serum balm formulations were homogeneously distributed, had a pH of approximately 5, spreadability of 3.2–3.6 cm, and adhesiveness ranging from 9–22 seconds. The physical stability test indicated that the formulations met the required standards, and the moisturizing effectiveness ranged from 30–62%. In conclusion, the most optimal formula was F5 with 10% sandalwood oil, as it demonstrated the highest moisturizing activity at 61.095% before the cycling test and 54.965% after the cycling test, while also fulfilling the required physical characteristics.
Pendekatan Molecular Docking dalam Metode Penemuan Obat Berbasis Struktur: Sebuah Tinjauan Adha Dastu Illahi; Tifany Maulida Candra
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 8 No. 1 (2026)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v8i1.50146

Abstract

Molecular docking is one of the most widely used computational techniques in computer-aided drug design (CADD) for predicting ligand binding modes and relative binding affinities toward target proteins. Although binding affinity is frequently used to evaluate docking performance, the success of molecular docking cannot be determined by a single parameter. Instead, predictive accuracy depends on the integration of multiple interrelated methodological factors. This review discusses the fundamental principles, methodologies, validation strategies, and interpretation of molecular docking in the context of structure-based drug discovery. The topics covered include protein structure quality, conformational search algorithms, scoring functions, docking workflows, and protein–ligand interaction analysis. This review highlights that the accuracy of molecular docking relies on the integration of all methodological stages, from protein structure selection to validation and result interpretation. It provides a comprehensive overview of molecular docking as an effective tool for initial screening and hypothesis generation in structure-based drug discovery prior to further validation using molecular dynamics simulations and experimental studies.
Enhancing Dissolution of Febuxostat: Novel Febuxostat–Syringic Acid Multicomponent Crystals via Liquid-Assisted Grinding Gita Sri Fitri; Lili Fitriani; Erizal Zaini; Adhitya Jessica
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 8 No. 1 (2026)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v8i1.50282

Abstract

Gout is a chronic inflammatory disease characterized by the deposition of monosodium urate crystals in the joints, and its global prevalence continues to increase. Febuxostat, a selective xanthine oxidase inhibitor, serves as an alternative therapy for patients who cannot tolerate allopurinol. Although effective, its clinical performance is limited by very low aqueous solubility and slow dissolution due to its Biopharmaceutics Classification System (BCS) Class II characteristics. Enhancing its solubility is therefore essential to improve oral absorption. This study aimed to prepare and characterize a febuxostat–syringic acid multicomponent crystal using the liquid-assisted grinding (LAG) method and to evaluate its impact on dissolution behavior. Multicomponent crystals were prepared using various molar ratios and optimized based on differential scanning calorimetry (DSC) results. Further characterization was conducted using powder X-ray diffraction (PXRD), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Dissolution studies were conducted with three replicates (n=3) in phosphate–citrate buffer pH 5.5 containing 1% sodium lauryl sulfate followed by HPLC analysis. The formation of a multicomponent crystal was evidenced by a reduced melting point and decreased peak intensity, along with distinct diffraction patterns indicating lower crystallinity compared to the febuxostat and syringic acid components. FTIR analysis revealed shifts in the absorption of wave numbers, while SEM showed smaller and rougher particles, indicating improved wettability. Statistical analysis using one-way ANOVA showed that the febuxostat–syringic acid multicomponent crystal demonstrated significantly enhanced dissolution (99.21% at 60 minutes) compared with pure febuxostat (76.00% at 60 minutes) (p < 0.05). The febuxostat–syringic acid multicomponent crystal prepared via the LAG method improved the physicochemical characteristics and dissolution performance of febuxostat. This approach provides a potential strategy to enhance the bioavailability of poorly soluble BCS Class II drugs.
Formation of Silver Nanoparticles Using Phyllantus buxifolius Leaf Extract and Its Antioxidant Activity Dini Hanifa; Purnawan Pontana Putra; Akmal Djamaan; Marta Aulia Zahra; Maharani Auliasanrah Siregar
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 8 No. 1 (2026)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v8i1.50647

Abstract

Green synthesis is an approach for producing silver nanoparticles (AgNPs) that more popular because the use of bioreductor, making it safer and more eco-friendly. The use of Phyllanthus buxifolius as a source of reducing and stabilizing agents in the formation of AgNPs and its contribution to antioxidant activity is still limited. Therefore, this study aims to synthesize AgNPs using P. buxifolius leaf extract and evaluate its antioxidant activity. The leaves of P. buxifolius were extracted using ethanol in a 1:10 ratio through maceration, then followed by solvent evaporation using a rotary evaporator. AgNO3 was mixed with a 10% P. buxifolius leaf extract solution. The UV-Vis spectrum was analyzed at wavelengths ranging from 400 to 800 nm. Particle size, morphology, functional groups, and crystal structure of AgNPs were characterized. Antioxidant activity was assessed using the DPPH method to determine the IC50, with ascorbic acid as the reference standard. To confirmed the formation of silver nanoparticles, a color change from colorless to brown were observed. These nanoparticles exhibited a Surface Plasmon Resonance (SPR) peak at 420 nm, were non-spherical with the particle size around 50 nm, and showed a crystalline structure. Additionally, the silver nanoparticles synthesized with P. buxifolius extract demonstrated comparable antioxidant activity to standard ascorbic acid, indicating their potential to be developed as antioxidant agents for health and therapeutic uses.
Antioxidant and Cytotoxic Evaluation of Garcinia dioica Blume Stem Bark Extracts Vivi Anggia., M.Farm; Hendri Aldrat; Arsha Waniza Rusdi
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 8 No. 1 (2026)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v8i1.50813

Abstract

Garcinia dioica Blume, locally known as asam kandis, is a member of the Garcinia genus, which is recognized as an important source of xanthones, a class of polyphenolic compounds associated with diverse biological activities. Previous studies have demonstrated that xanthones possess antioxidant, anti-inflammatory, antimicrobial, and cytotoxic properties. The present study aimed to evaluate the antioxidant and cytotoxic activities of G. dioica stem bark extracts. The antioxidant analyzes with DPPH method and the cytotoxic activities with BSLT method. Asam kandis stems were extracted in stages with hexane, ethyl acetate, and ethanol. All extracts exhibited very strong antioxidant activity compared to vitamin C, with an IC50 of 3.86. The 96% ethanol extract showed the highest activity (IC₅₀ 10.59 ppm; AAI 1.89), followed by n-hexane and ethyl acetate extracts with IC50 of 12.96 and 20.04 ppm. The cytotoxic activity of ethyl acetate was proven to provide significant results, followed by ethanol and hexane extracts with LC50 of 30.50 ppm, 37.68 ppm, and 59.10 ppm, respectively. These results indicate that the bark of Garcinia dioica exhibits significant antioxidant and cytotoxic activity, suggesting its potential for further research as a source of anticancer compounds.
Optimization of Fermentation Time Enhances the Antioxidant and Antiinflammatory Activities of Tea Kombucha Cascara from Pagar Alam Robusta Coffee (Coffea canephora) Eka Putri; Lina Elfita; Hendri Adrat; Fathul Majidi; Fadhlika Putri Vihanda; Aulia Amira; Zulaila Hunafa
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 8 No. 1 (2026)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v8i1.51260

Abstract

https://docs.google.com/document/d/1ia1-repmtPyigOvKg4lqXogtL4Rl0h1P/edit?usp=sharing&ouid=117864675563898028088&rtpof=true&sd=true
Comparative Phytochemical Evaluation of Indonesian Single-Origin Arabica Coffees: Caffeine, Total Phenolic Content, and DPPH Antioxidant Activity Ahmad Dzaky Mualim; Fitria Puspita
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 8 No. 1 (2026)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v8i1.51354

Abstract

Coffee (Coffea arabica) is a globally significant commodity, and Indonesia's diverse archipelagic geography produces beans with distinct origin-associated characteristics. Although the antioxidant properties of coffee are well-documented, the influence of specific geographical origins on its secondary metabolites is less understood. This study aims to investigate the variations in Total Phenolic Content (TPC), caffeine concentration, and antioxidant activity (IC50) across eight prominent Indonesian single-origin Arabica coffees: Aceh Gayo, Ciwidey, Papua Wamena, Bali Kintamani, Kerinci, Toraja, Bajawa, and Temanggung. Utilizing standardized medium-roast samples and ethanolic extraction, the phytochemical profiles were quantified and statistically analyzed via one-way ANOVA and linear regression. The results revealed significant variations (p < 0.001) across all measured parameters based on geographical origin. High-altitude coffees, specifically from Ciwidey and Papua, exhibited the highest TPC (up to 42.72 mg GAE/g) and the most potent antioxidant activity (IC50 of 40.15 ppm and 44.90 ppm, respectively). Conversely, Temanggung coffee, cultivated at lower elevations with nutrient-rich volcanic soil, demonstrated the highest caffeine concentration (1.31%) but the lowest TPC and antioxidant capacity. A strong linear correlation (R2 = 0.793) between TPC and antioxidant activity confirms that phenolic compounds are the primary drivers of radical scavenging efficacy. Ultimately, this study demonstrates that geographical origin significantly shapes the chemical profile and antioxidant capacity of Indonesian Arabica coffees, providing a practical scientific framework for origin authentication and quality evaluation.
Evaluasi Penggunaan Antibiotik pada Pasien Pneumonia Komunitas Menggunakan Metode Gyssens Dwi Aulia Zahra; Rezlie Bellatasie; Putri Ramadhani; Widya Kardela; Wulan Panduwi Melasari; Hendri Satria Kamal Uyun
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 8 No. 1 (2026)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v8i1.51659

Abstract

Pneumonia is an infection of the lower respiratory tract that remains a significant cause of morbidity and mortality globally, including in Indonesia. Irrational antibiotic use among pneumonia patients can promote the development of antibiotic resistance, elevate treatment expenses, and adversely affect clinical outcomes. This study aims to evaluate the rationality of antibiotic use among patients with community-acquired pneumonia in the internal medicine inpatient ward of a government hospital in Padang City, West Sumatra, using the Gyssens method. This study employed a descriptive, observational, cross-sectional design from January to March 2025. A total of 29 patients were selected based on the inclusion criteria. The most commonly prescribed antibiotics were third-generation cephalosporins (especially ceftriaxone and cefixime), macrolides (azithromycin), and fluoroquinolones (levofloxacin). The results showed that 18 patients (62.07%) used antibiotics rationally (category 0), while 11 patients (37.93%) used antibiotics irrationally in categories IIIa (17.24%), IIa (17.24%), and I (3.45%). There still needs to be better monitoring of antibiotic use by healthcare workers to improve the accuracy of antibiotic choices for patients.

Page 17 of 17 | Total Record : 168

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