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Jurnal Klinik dan Riset Kesehatan (Journal of Clinical and Health Research) Bidang Pendidikan dan Penelitian, RSUD dr. Saiful Anwar Malang Jl. Jaksa Agung No. 2, Kec. Klojen, Malang 65112 Phone/Fax: 0341 – 362101 / 0341 - 369384 Email: jkrisk.rssa@gmail.com
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Jawa timur
INDONESIA
Jurnal Klinik dan Riset Kesehatan
Published by RSUD Dr. Saiful Anwar Malang
ISSN : 28092678     EISSN : 28090039     DOI : https://doi.org/10.11594/jk-risk
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health
Jurnal Klinik dan Riset Kesehatan (JK-RISK) – RSUD dr. Saiful Anwar Malang adalah jurnal open-access resmi yang dikelola oleh tim Penelitian dan Pendidikan Rumah Sakit Umum Daerah dr. Saiful Anwar Malang, Jawa Timur, Indonesia. JK-RISK menerbitkan satu volume yang terdiri atas tiga nomor setiap tahunnya yang diterbitkan pada bulan Oktober, Februari, dan Juni. JK-RISK hanya akan menerbitkan jurnal berbahasa Indonesia. Jurnal Klinik dan Riset Kesehatan – RSUD dr. Saiful Anwar Malang menerbitkan tulisan-tulisan ilmiah hasil penelitian, laporan kasus, tinjauan pustaka dalam bidang kedokteran dan kesehatan yang belum pernah diterbikan di jurnal manapun. Pernyataan kode etik publikasi JK-RISK merupakan pernyataan kode etik yang melibatkan pengelola jurnal, editor, mitra bestari serta penulis dalam proses publikasi jurnal ilmiah. Pernyataan kode etik didasarkan pada Peraturan Kepala LIPI Nomor 5 tahun 2014 tentang Kode Etik Publikasi Ilmiah yang menjunjung tinggi tiga nilai etik dalam publikasi, yaitu (i) Kenetralan, yang berarti terbebas dari pertentangan kepentingan dalam pengelolaan publikasi jurnal; (ii) Keadilan, dengan memberikan kebebasan hak kepengarangan kepada pengarang/penulis; dan (iii) Kejujuran, yang berarti bebas dari duplikasi, fabrikasi, falsifikasi dan plagiarisme (DF2P) dalam publikasi.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 200 Documents
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Plasma cell myeloma: Pendekatan diagnosis dari aspek kliniko-morfologik dan imunofenotipe Angelina, Aina; Retnani, Diah
Jurnal Klinik dan Riset Kesehatan Vol 2 No 2 (2023): Februari 2023
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.02.2.5

Abstract

Plasma cell myeloma (PCM)/Mutiple myeloma (MM) is hematologic malignancy characterized by the proliferation of neoplastic plasma cells of bone marrow. The manifestation of disease include multifocal lytic bone lesions, increased serum or urine M protein, target organ damage, and can present as an extramedullary mass. Extramedullary tumor mass biopsy can show morphology that overlaps with other plasma cell neoplasms or malignant lymphoma, this become a diagnostic challenge especially if the clinical and radiological information is incomplete. End-organ damage attributable to abnormal plasma cell proliferation is known as CRAB consist of hypercalcemia, renal insufficiency, anemia and bone lesions. The clinical spectrum often varies so the diagnosis of PCM requires the integration of clinical, laboratory, imaging, morphology, and immunophenotype data. Histopathological examination of bone marrow biopsy and tumor mass biopsy needs to be confirmed by immunohistochemical examination and clonality tests to establish an accurate diagnosis. This review intends to explain the clinical, morphological and immunophenotypic aspects as well as construct an approach to the diagnosis of PCM.
Insomnia pada Lansia: Tantangan dalam Mendiagnosis dan Pemberian Perawatan Fatma, Siti; Sunarti, Sri
Jurnal Klinik dan Riset Kesehatan Vol 2 No 2 (2023): Februari 2023
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.02.2.6

Abstract

Age – related sleep changes are common symptoms in elderly and are related to various factors including physiologic factor, sleep habits, comorbid diseases, and also drug side effect. Screening for primary sleep disorder, comorbid diseases, and mental diseases such as depression and anxiety are essential. Managing insomnia is challenging because it may require comprehensive assessment to make precise diagnosis and also several treatment needed such as lifestyle changes, controlling comorbid disease, non pharmacological interventions as first line treatment, and then pharmacological interventions regarding efficacy, acceptability tolerability, and adverse events of the drugs.
Investigasi Masalah Gangguan Tidur Terhadap Penyakit Kronik Fatma, Siti
Jurnal Klinik dan Riset Kesehatan Vol 2 No 2 (2023): Februari 2023
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.02.2.1

Abstract

Analisis Pengaruh Obesitas pada Derajat Keparahan Pasien Covid-19 Gelombang ke-2 yang Dirawat Inap di RSUD Dr. Saiful Anwar Malang Djajalakasana, Susanthy; Cendani, Wulan; Djajalaksana, Susanthy; Santosa, I
Jurnal Klinik dan Riset Kesehatan Vol 3 No 3 (2024): Edisi Juni
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.03.3.3

Abstract

Background : Based on WHO data, Covid-19 has officially been declared a pandemic because its spread has reached more than 100 infected countries. Several risk factors can affect the severity of Covid-19 patients, one of which is comorbid obesity. The Covid-19 pandemic occurred when the prevalence of overweight/obesity was increasing in almost every country in the world. Chronic inflammation associated with obesity, impaired immune function, and increased expression of ACE 2 contribute to disease severity and worsen clinical outcomes in obese patients with Covid-19 infection. Aim : This study aims to analyse the effect of obesity on the severity of the second wave of Covid-19 patients who were hospitalized at RSUD dr. Saiful Anwar Malang. Methods : This research is an analytic observational study with cross sectional approach. The sample consisted of 46 Covid-19 patients with obesity who were hospitalized at RSUD dr. Saiful Anwar Malng. The data acquired will be analysed using Mann Whitney non-parametric analysis test. Results : In the obese and non-pbese groups, the p-value was 0,042 and the odds ratio was 1,23. In the distribution of age and sex groups, each group obtained a p-value of 0,363 and 0,592. Conclusion : There is a significant difference in obesity among patients, with a 1,23-fold increased risk of experiencing severity compared to those who are not obese. Meanwhile, for the distribution based on age and sex, there was no significant difference, but it tended to have a more critical degree of severity towards men and older age.
Hubungan Rasio Neutrofil Limfosit (RNL) d engan Status Merokok Pada Kanker Paru Indah Sari, Fitri; Setyawan, Ungky; Destyana, Dita
Jurnal Klinik dan Riset Kesehatan Vol 3 No 1 (2023): Edisi Oktober
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.03.1.2

Abstract

Background: The high mortality rate is influenced by several risk factors, one of which is smoking which is currently the main risk factor for lung cancer. NLR and from peripheral whole blood can be evidence of systemic inflammation and cancer prognostic index. Aim: The purpose of this study was to determine the characteristics of lung cancer patients based on age, sex, smoking status and NLR in RSSA Malang and the relationship between RNL and smoking status of lung cancer patients in RSSA Malang Methods: This research method is an analytic observational study using a cross-sectional research design approach. The population of this study were all patients who were diagnosed lung cancer who were treated at RSUD Dr. Saiful Anwar Malang City from January 2021 to March 2022. The sample data is secondary data taken from the medical records of 40 lung cancer patients at RSSA Malang. Results: The results showed that the characteristics of the subjects were dominated by age <60 years where the smoking status was more recorded in this study with a total of 22 with male sex being more dominant than women with a number of 24 and more recorded as smokers. In this study, NLR values ​​>3.53 were more commonly found in lung cancer patients. The mean in smokers has a higher NLR value of 4.821 ± 3.88 while in non-smokers it has a value of 4.253 ± 3.73. Conclusion: There is no significant difference and relationship between NLR values ​​in smokers and non-smokers.
Analisis Perbedaan INR dan D-dimer terhadap Mortalitas pasien COVID-19 di RSUD Dr Saiful Anwar Malang Rakhma, Rakhma; Asyari, Claudia Herda; Choizin, Iin; Rakhma, Sastia
Jurnal Klinik dan Riset Kesehatan Vol 3 No 2 (2024): Edisi Februari
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.03.2.2

Abstract

Abstrak Pendahuluan: Pada Juli 2022, COVID-19 menginfeksi 565 juta orang, dengan 6,3 juta kasus kematian di seluruh dunia. Hubungan parameter laboratorium dengan waktu kematian dan komorbiditas belum banyak diteliti. Studi ini untuk mengetahui perbedaan INR dan D-dimer terhadap mortalitas pasien COVID-19 di RSUD Dr Saiful Anwar Malang. Metode: Studi kohort retrospektif dilakukan pada April 2020-September 2021, total 229 subjek COVID-19 terdiagnosis swab PCR. Analisis data berupa waktu kematian sejak masuk rumah sakit terbagi menjadi <7 hari dan >7 hari, data laboratorium, data komorbiditas dan tanpa komorbiditas. Uji data dengan Chi Square untuk data kategorik, serta Mann-Whitney, dan Kruskall Wallis untuk data numerik. Hasil: Pada subjek tanpa komorbiditas, kadar D-Dimer signifikan lebih tinggi pada subjek dengan waktu kematian >7 hari dibanding <7 hari. Pada subjek dengan waktu kematian <7 hari, kadar PT dan INR signifikan lebih tinggi pada subjek dengan komorbiditas dibanding tanpa komorbiditas. Pada subjek dengan waktu kematian >7 hari, kadar D-Dimer dan feritin signifikan lebih rendah pada subjek dengan komorbiditas dibanding tanpa komorbiditas. Secara keseluruhan, kadar INR ditemukan signifikan lebih tinggi pada subjek dengan komorbiditas dibanding subjek tanpa komorbiditas (p<0.05). Pembahasan: Pada tahap awal COVID-19, dapat terjadi hiperfibrinolisis lokal pada parenkim paru, dan hipofibrinolisis sistemik. Hal ini berujung pada peningkatan D-dimer tanpa diikuti pemanjangan parameter perdarahan, hal ini sesuai dengan subjek waktu kematian <7 hari tanpa komorbiditas. Selain itu, terjadi perubahan kondisi hiperkoagulabel menjadi hiperfibrinolisis akibat konsumsi faktor koagulan yang berlebihan, mengakibatkan meningkatnya PT dan INR pada kondisi COVID-19 yang berat. Kesimpulan: Secara keseluruhan ditemukan bahwa kadar INR signifikan lebih tinggi pada subjek dengan komorbiditas dibanding tanpa komorbiditas, serta D-dimer pada subjek dengan waktu kematian >7 hari tanpa komorbiditas signifikan lebih tinggi dibanding kelompok subjek lain.
Tantangan Untuk Mengobati Hipoglikemia Bagi Pasien Lanjut Usia Diabetes Dalam Praktek Klinis Sehari-hari Rochmah, Izzah; Erwan, Nabila; Mumtaza, Hilya
Jurnal Klinik dan Riset Kesehatan Vol 2 No 3 (2023): Edisi Juni
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.02.3.7

Abstract

Background: Hypoglycemia is an acute complication that often occurs in daily clinical practice. The incidence of hypoglycemia is increased, one of which is by age factors and the use of insulin. Case Presentation: A 66-years old Indonesian woman with obesity (BMI=35.2 kg/m2) came to Emergency Department (ED) with decreased of consciousness due to a skipped meal after a prandial insulin injection with errors in calculating insulin dose. She had Diabetes Mellitus type 2 since 10 years ago and got insulin prescription since last year. The random blood sugar (RBG) was 27 mg/dl. Patient was administered intravenous D40% 75ml and the symptoms was improved. Patient was diagnosed this patient with severe hypoglycemia. During hospitalization, patient’s blood sugar had fluctuation in 2 days consecutive mornings and began to stable in day 3 on ward. When the patient discharged, we prescribed 24U basal insulin given before bed if the RBG level >200mg/dl. Discussion: In older population, the neuroglycopenic symptoms, such as lethargy, dizziness, and delirium appear in higher BG level than the autonomic symptoms. The disproportion of demand and supply of blood glucose in the brain causes the neuroglycopenic symptoms. In addition, those signs are also likely to be misinterpreted as signs of stroke, dementia, or vision problems. This cycle of misidiagnosed and the tendency of neuroglypenic symptoms lead the older population into hypoglycemia unawareness. Conclusion: Hypoglycemia unawareness is one of the warning signs of the severity of Diabetes Mellitus type 2 caused by multiple factors which has high prevalence in the elderly. Therefore, particular management is needed in this population by selecting the suitable glucose-lowering agent considering individualized patient preferences rather than focusing on the glycemic target.
Cerebral Salt Wasting Syndrome pada Pasien dengan Infark Serebri : Sebuah Laporan Kasus Hapsari, Aulia; Prakoso, Budi
Jurnal Klinik dan Riset Kesehatan Vol 2 No 3 (2023): Edisi Juni
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.02.3.8

Abstract

Background: Hyponatremia is a common problem in hospitals, especially among patients suffering from central nervous system disorders., it is frequently caused by SIADH (Syndrome Inappropriate Antidiuretic Hormone) and CSWS (cerebral salt wasting syndrome). Case Report: A 71-year-old woman presented with complaints of not being conscious for 12 hours before the admission and a history of slipped and hit her head on the floor three days prior to admission. The patient has a history of hypertension and is currently taking 5 mg of amlodipine. With severe hyponatremia, the patient appeared dehydrated and had a urine output of 3000cc/day. The patient was diagnosed with CSWS and was given hypertonic saline and steroids. Patients respond positively to the therapy, as evidenced by regular increases in serum sodium levels and regain of consciousness. Discussion: CSWS is a hyponatremia and dehydration condition caused by a head injury, cerebral infarction, or other neurological disorders. The cause of CSWS is influenced by natriuretic peptides, which are released not only in conditions of heart failure but also in conditions of central nervous damage. Conclusion: In this case report, a 71-year-old woman with CSWS caused by a cerebral infarction responded favourably to hypertonic saline and steroid therapy. In order to provide holistic and comprehensive therapy, the condition of hyponatremia must be defined for the main cause, notably SIADH or CSWS, which is obtained from the history taking to supporting examinations.
Pasien COVID-19 dengan Cedera Hati Sedang dan Sindrom Gangguan Pernapasan Akut (ARDS) Anjarwati, Dwi; Putri, Rifka; Rizqi, Damar
Jurnal Klinik dan Riset Kesehatan Vol 3 No 1 (2023): Edisi Oktober
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.03.1.7

Abstract

Pendahuluan: Penyakit coronavirus 2019 (COVID-19) masih berlangsung. Beberapa data menunjukkan bahwa penyakit ini menyerang berbagai organ, terutama pada kasus yang parah dan kritis. Kerusakan hati dan ARDS merupakan komplikasi yang sering terjadi pada pasien COVID-19. Tujuan penulisan makalah ini adalah untuk melaporkan dan mendiskusikan terapi pada kasus-kasus yang ditemukan oleh penulis sehingga diharapkan dapat bermanfaat secara klinis. Ilustrasi kasus: Laki-laki 35 tahun dengan hasil swab nasofaring positif COVID-19 dengan kerusakan hati dan ARDS. Pasien mendapatkan protokol terapi standar pada saat perawatan di rumah sakit, plasma konvalesen 3 kolf dan terapi setelah perawatan di rumah sakit. Pasien telah membaik. Diskusi: Menekan hiperaktivasi sitokin merupakan target utama dalam terapi COVID-19 agar tidak berkembang menjadi stadium yang lebih parah. Pemilihan favipiravir, colchicine, dexamethasone, UDCA, dan vitamin D adalah terapi yang menargetkan mekanisme ini. Kesimpulan: Pasien dengan gejala berat hingga kritis berisiko mengalami kondisi yang lebih buruk bahkan kematian. Mengatasi hiperaktivasi sitokin merupakan target utama terapi kasus COVID-19, sehingga pemilihan obat yang digunakan didasarkan pada mekanisme patogenesis tersebut. Selain itu, pemberian terapi suportif lainnya juga perlu diperhatikan untuk penatalaksanaan yang lebih optimal.
Penelitian Retrospektif Profil Klinikopatologi Tumor Kelenjar Liur di Instalasi Patologi Anatomi RSUD Dr. Saiful Anwar Malang Periode Tahun 2017-2021 Lukman Firmansyah, Muhammad; Fadli, Muhammad; Retnani, Diah
Jurnal Klinik dan Riset Kesehatan Vol 3 No 1 (2023): Edisi Oktober
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.03.1.3

Abstract

Abstract Background: Cases of salivary gland tumors are relatively rare. There are not many data that explain the prevalence of salivary gland tumor incidence in Indonesia. Objective: This study aims to determine the clinicopathological profile of salivary gland tumors based on case incidence, age, gender, location and histopathological subtype at the Anatomical Pathology Installation of Dr. Saiful Anwar Hospital Malang in 2017-2021. Methods: This research is a quantitative descriptive study. Data was collected from medical records from 2017 to 2021 at the Anatomical Pathology Installation of Saiful Anwar Hospital, Malang. All subjects in this study were all clinical data of patients with tumor located salivary gland (parotid, submandibular, sublingual/cavum oris). Results and Discussion: There were 162 cases of salivary gland tumors from 2017-2021, malignant neoplasm 57 (35%), benign neoplasm 60 (37%) and non neoplasm 45 (28%). The distribution of the incidence of cases per year is not the same and does not always increase. There was a relationship between the increase in cases of malignancy with increasing age. There is no relationship between increasing cases of salivary gland tumors and malignancy with gender. The most common locations for salivary gland tumors and malignant neoplasm in parotid gland. The most malignant neoplasm is mucoepidermoid carcinoma 11 (19.2%), the most benign neoplasm is pleomorphic adenoma 38 (63.3%), the most non-neoplastic cases is inflammation and abscess 34 (75.5%). Conclusion: Salivary gland tumors are rare cases. Cases of malignancy increase in adults and the elderly. The most common location in the parotid gland with the most cases of malignant neoplasm is mucoepidermoid carcinoma and the most benign neoplasms is pleomorphic adenoma. Keywords: Salivary gland tumor, histopathology.

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