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Ade Setiadi
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International Journal of Science and Society (IJSOC)
Published by GoAcademica Research and Publishing
ISSN : -     EISSN : 27158780     DOI : https://doi.org/10.54783/ijsoc.v4i1
Core Subject : Science, Social,
Materials Science & Nanotechnology Social Sciences
International Journal of Science and Society (IJSOC) is open access and peer-reviewed journal with e-ISSN (2715-8780), IJSOC is an international journal devoted to the study of science and technology in a social context. It focuses on the way in which advances in science and technology influence society and vice versa. It is a peer-reviewed journal that takes an interdisciplinary perspective, encouraging analyses whose approaches are drawn from a variety of disciplines such as History, Sociology, Economics, Political Science and International Relations, Technology Management, Environmental Studies, Health Science, etc. The journal publishes original full-length research papers in all areas related to Science, Technology, and Society. The topics related to this journal include but are not limited to that. The journal consciously endeavors to combine scholarly perspectives relevant to academic research and policy issues relating to development. Besides research articles, the journal encourages research-based country reports, commentaries, literature reviews, and book reviews.
Arjuna Subject : Ilmu Sosial - Administrasi Publik
Articles 1,285 Documents
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Metabolomics-Driven LC-HRMS Identification and Multi-Target Computational Pharmacology of Shzygium polyanthum Bioactives for Mechanism-Based Precision Management of Type 2 Diabetes Mellitus Said Haikal Alfajar; Urip Harahap; Aminah Dalimunthe; Nur Aira Juwita; Rony Abdi Syahputra
International Journal of Science and Society Vol 8 No 2 (2026): International Journal of Science and Society (IJSOC)
Publisher : GoAcademica Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Type 2 Diabetes Mellitus (T2DM) continues to be a major cause of mortality and metabolic complications in developing nations, highlighting the urgent need for safer and more accessible therapies. Herbal bioactives from Syzygium polyanthum (SYPOL) have gained attention due to their traditional use in managing blood glucose levels. Nevertheless, the molecular mechanisms underlying their antidiabetic effects remain poorly understood. This study employed an integrative in silico approach to evaluate the interactions between SYPOL-derived compounds and ten key protein targets involved in T2DM pathogenesis, including HK2, AKT1, PYGL, INSR, PYGM, IGF1R, PPARG, SLC2A1, MAPK3, and GCK. Ethanolic leaf extracts of SYPOL were analyzed using Liquid Chromatography–High Resolution Mass Spectrometry (LC-HRMS) for phytochemical profiling. Detected compounds were screened for structural availability, toxicity, ADME properties, and compliance with Lipinski's Rule of Five prior to molecular docking. From 9.834 detected phytochemical features, 31 compounds met the selection criteria and were docked against the ten diabetes-related targets. The simulations revealed stable interactions within active site regions, primarily driven by hydrogen bonding and favorable binding energies, suggesting potential modulation of glucose metabolism and insulin signaling pathways. ADME profiling indicated acceptable pharmacokinetic properties, with most compounds satisfying Lipinski's parameters. Toxicity prediction showed a 54.83% probability of nephrotoxicity, emphasizing the importance of safety validation in future studies SYPOL contains multi-target bioactive compounds with potential to regulate glucose homeostasis. This computational analysis provides a mechanistic basis for subsequent experimental research and supports the development of SYPOL-based phytotherapeutics for T2DM management.
The Feasibility and Practicality of a Digital Enrichment Book for News Text Listening Comprehension Oriented toward The Pancasila Student Profile Supported by an AI-Powered Help Page Desyfa Cahya Aina; Subyantoro
International Journal of Science and Society Vol 8 No 2 (2026): International Journal of Science and Society (IJSOC)
Publisher : GoAcademica Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/ijsoc.v8i2.1674

Abstract

Teaching news text listening comprehension in junior high school requires supplementary teaching materials that provide targeted practice, adequate listening materials, and analytical activities that support the strengthening of students’ character. This study aims to describe the feasibility and practicality of a digital enrichment book for news text listening comprehension oriented toward the Pancasila Student Profile, supported by an AI-powered help page. This study employs the Research and Development (R&D) method based on Sugiyono’s model up to the seventh stage, namely product revision following a limited pilot test. Data were collected through media expert validation, content expert validation, student response questionnaires, and product usage observations. Data were analyzed using qualitative and quantitative descriptive methods with percentage calculations. The results indicate that the product achieved a feasibility percentage of 97% from media experts and 97.5% from content experts, placing it in the “highly feasible” category. The practicality results showed a percentage of 90% based on student responses and 89.71% based on product usage observations, placing it in the “highly practical” category. Revisions to the product were made regarding the user guide, internet connection instructions, notes for teachers, content reinforcement, and clarification on the use of the AI-powered Help Page. Thus, the product is suitable and practical for use as supplementary teaching material for learning to listen to news texts and supports the dimensions of critical thinking, independence, and creativity.
Antihyperlipidemic Activity of Kratom Leaves (Mitragyna speciosa) In Vivo and In Silico Sintia Karina Putri; Yuandani; Pipit Pitriani; Said Haikal Alfajar; Rony Abdi Syahputra
International Journal of Science and Society Vol 8 No 2 (2026): International Journal of Science and Society (IJSOC)
Publisher : GoAcademica Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/ijsoc.v8i2.1675

Abstract

Obesity and hyperlipidemia are metabolic problems that can trigger various comorbid diseases. Kratom leaves (Mitragyna speciosa) are one of the herbal-based medicines containing alkaloid compounds that have the potential to improve lipid profiles. This study aims to analyze the antihyperlipidemic activity of kratom leaves in vivo and in silico. Extraction of kratom leaves was carried out by maceration using 96% ethanol (1:10 w/v) for 3 days, then concentrated using a rotary evaporator. Compound identification was performed using LC-MS/MS. The in vivo study was conducted on rats (n=6 per group) for 14 days, including a negative control, positive control, and three treatment groups with doses of kratom leaf extract of 100, 300, and 500 mg/kg BW. The parameters assessed included body weight, LDL cholesterol, HDL cholesterol, triglycerides, and total cholesterol, as well as molecular docking using PyRx. The results showed that kratom leaf extract at doses of 100, 300, and 500 mg/kg BW exhibited significant antihyperlipidemic activity compared to the negative control (p<0.05), characterized by reductions in triglyceride, total cholesterol, and LDL levels, as well as an increase in HDL and a decrease in body weight. The 500 mg/kg BW dose showed the best pharmacological effect compared to the 100 mg/kg BW and 300 mg/kg BW doses (p<0.05). The docking results confirmed strong binding affinities between kratom leaf alkaloids and the therapeutic target HMG-CoA. Thus, kratom leaf alkaloids have the potential to be developed as antihyperlipidemic agents through inhibition of the HMG-CoA reductase enzyme.
Integration of Molecular Factors Influencing VCAM-1 Expression in Vascular Inflammation and Atherosclerosis: A Narrative Review Nur Asini; Taufik Indrajaya; Irfannuddin; Siti Sarahdeaz Fazzaura Putri
International Journal of Science and Society Vol 8 No 2 (2026): International Journal of Science and Society (IJSOC)
Publisher : GoAcademica Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/ijsoc.v8i2.1676

Abstract

Vascular Cell Adhesion Molecule-1 (VCAM-1) is a vascular adhesion molecule that plays a crucial role in vascular inflammation, endothelial dysfunction, and the development of atherosclerosis. Increased VCAM-1 expression occurs in response to various inflammatory stimuli and cellular stressors that involve the activation of specific molecular signaling pathways. Various factors such as chronic inflammation, oxidative stress, activation of the Nuclear Factor-kappa B (NF-κB) pathway, the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway, obesity, leptin resistance, genetic factors, and changes in vascular hemodynamics are known to contribute to increased VCAM-1 expression. This study aims to analyze various factors that influence VCAM-1 changes molecularly using a narrative review method. Article searches were conducted through the PubMed, Scopus, and Google Scholar databases using the keywords "VCAM-1", "NF-κB", "oxidative stress", "LEPR", "leptin resistance", "endothelial dysfunction", and "atherosclerosis". The articles used were published between 2020 and 2026, relevant to the research topic, and available in full text. The review results indicate that NF-κB activation is the primary mechanism of VCAM-1 elevation triggered by pro-inflammatory cytokines, increased reactive oxygen species (ROS), leptin resistance, and LEPR activation via the JAK-STAT pathway. Furthermore, genetic factors such as LEPR polymorphisms and epigenetic mechanisms also contribute to increased vascular inflammation and VCAM-1 expression. Thus, VCAM-1 has great potential as a biomarker of vascular inflammation and a therapeutic target in cardiovascular disease, particularly atherosclerosis.
Management of Gingival Enlargement in Patient with Fixed Orthodontic Appliances in Undiagnosed Type-2 Diabetic Patient: A Case Report Evelyn Christina Muliyanto; R. A. Eka Yunanthi; Jovan Amadeo Muliyanto
International Journal of Science and Society Vol 7 No 2 (2025): International Journal of Science and Society (IJSOC)
Publisher : GoAcademica Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/ijsoc.v7i2.1677

Abstract

Gingival enlargement (GE) is a common periodontal condition that may result from inflammatory processes, medications, hormonal changes, or systemic diseases, including diabetes mellitus, which has a well-established bidirectional relationship with periodontal health. This case report aims to describe the clinical effectiveness of conventional gingivectomy in the management of gingival enlargement in an orthodontic patient with previously undiagnosed type 2 diabetes mellitus. A 37-year-old female undergoing fixed orthodontic treatment for two years presented with a complaint of gingival swelling in the mandibular anterior region accompanied by frequent bleeding during tooth brushing for approximately one year. The patient denied persistent pain, prolonged bleeding, or any known systemic disease. Clinical examination revealed localized gingival enlargement, most prominent around tooth 33, with the presence of plaque and calculus accumulation. The enlarged gingival tissue covered nearly half of the clinical crown, corresponding to a gingival overgrowth index score of 2, contributing to plaque retention and aesthetic concerns. Further assessment revealed a random blood glucose level of 272 mg/dL, indicating uncontrolled type 2 diabetes mellitus, while blood pressure was within normal limits. Following medical management and stabilization of blood glucose levels, conventional scalpel gingivectomy and gingivoplasty were performed to remove excess gingival tissue, restore normal gingival contours, reduce plaque-retentive areas, support ongoing orthodontic treatment, and improve aesthetics. Postoperative evaluation demonstrated satisfactory healing and improvement in gingival morphology and oral hygiene maintenance. This case highlights that conventional gingivectomy is an effective treatment modality for gingival enlargement when appropriately indicated and underscores the importance of identifying and controlling underlying systemic conditions, particularly diabetes mellitus, to achieve favorable periodontal and surgical outcomes.

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