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Pediatric Sciences Journal
Published by Universitas Brawijaya
ISSN : 27220427     EISSN : 27221474     DOI : https://doi.org/10.51559/pedscij
Core Subject : Health,
Health Professions Public Health
Pediatric Sciences Journal (PedSciJ) is published by the Medical Faculty of Brawijaya University, Indonesia, as an Open Access & Peer Reviewed Multidisciplinary Journal. The aims and scope of the Journal include pediatric, neonatal healthcare, and perinatology/ The Journal aims to bridge and integrate the intellectual, methodological, and substantive diversity of medical scholarship and to encourage a vigorous dialogue between medical scholars and practitioners. The Journal welcomes contributions that promote the exchange of ideas and rational discourse between practicing educators and medical researchers worldwide. Pediatric Sciences Journal (PedSciJ) publishes peer-reviewed clinical research articles, case reports, serial case reports, systematic reviews, meta-analyses, and letters to the editor twice a year in June and December. Articles published in the Pediatric Sciences Journal (PedSciJ) embrace the full scope of the manuscript related to the health and diseases of infancy, neonates, children, adolescents, and those related to pediatric topics. The Journal also explores legal and ethical issues, neonatal technology, and product development based on COPE. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians, pediatric subspecialists, obstetrics, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists
Arjuna Subject : Kedokteran - Pediatrics, Perinatology, and Child Health
Articles 67 Documents
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Factors affecting stunted growth in children aged 6-24 months in Bawean Island, Indonesia Arini Haq; Luthfiana Eka Sari; Pitra Sekarhandini; Brigitta Ida Resita Vebrianti Corebima
Pediatric Sciences Journal Vol. 2 No. 2 (2021): (Available online 1 December 2021)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (272.087 KB) | DOI: 10.51559/pedscij.v2i2.26

Abstract

Background: Stunted is defined as a condition where body length and height are less than -2 SD of the WHO height-for-age z score. The number of stunted children worldwide reaches 129 million or 23.8% of the population. This study aims to scrutinize the factors affecting stunted growth in children aged 6-24 months old in Sangkapura district, Bawean. Methods: This cross-sectional quantitative study in Bawean island, involving children aged 6-24 months old who came to posyandu for height measurement. The purposive sampling technique was used in the study, in which the samples filled a questionnaire consisting of several questions. The data analyses presented are univariate analysis, Chi-Square, and Binary Regression Analysis. Results: The analysis results showed that the factors affecting stunted growth in toddlers are birth weight (<2500 grams), gestational age (<37 weeks), exclusive breastfeeding, and weaning foods. If the baby’s birth weight is less than 2500 grams, is born before week 37 of pregnancy, does not get exclusive breastfeeding, and is given homemade weaning foods, the possibility of the baby being stunted is 91.5%. Conclusion: Several factors affect stunted growth in children aged 6-24 months old in Bawean island. Children who experience all of the factors mentioned above have a 91.5% possibility of being stunted. Among the other factors, babies not exclusively breastfed are 190,019 times more likely to be stunted.
Screening for congenital hypothyroidism in Malang, East Java in 2020 Irfan Agus Salim; Berlian Ristina Putri; Tiara Afia Rosmalawati; Haryudi Aji Cahyono; Fadhilah Muttaqin
Pediatric Sciences Journal Vol. 2 No. 2 (2021): (Available online 1 December 2021)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (554.036 KB) | DOI: 10.51559/pedscij.v2i2.28

Abstract

Introduction: Congenital hypothyroidism is defined as a state of thyroid hormone deficiency present at birth. Congenital hypothyroidism must be diagnosed immediately because delay in therapy may cause irreversible neurological deficits, such as mental retardation in children. However, this condition can be prevented by screening in newborns so that congenital hypothyroidism can be diagnosed and treated early, and can result in better neurological development. This study aims to determine the congenital hypothyroidism ratio in Malang from March to November 2020. Methods: The descriptive analysis method was used in this research. The subjects were neonates aged 0 – 28 days with a gestational age of 36 weeks and were involving the Health Office in both the Regency and the City of Malang. The data about identity, gender, age at screening, and gestational age were collected. A laboratory screening test was performed by taking a blood sample from the heel or vein for a TSH test. If the result was positive with a TSH value > 20 U/mL, the subject would be recalled for having a confirmation test and referred to a pediatric endocrinologist. Results: There were 2024 (88.34%) subjects were successfully screened from a total of 2291 subjects. The recall rate for congenital hypothyroidism was 1:2024 (0.04%). Conclusion: The ratio of congenital hypothyroidism cases in Malang from March to November 2020 was higher than the global ratio, which was 1:3000. The high rate of congenital hypothyroidism in Malang indicated the need for congenital hypothyroidism screening in newborns.
Case distribution and survival rate in Pediatric Intensive Care Unit (PICU) at Banjarmasin, Indonesia Choirul Anam; Niarsari Anugrahing Putri; Rahmad Ramadhani; Yasmin Musfirah
Pediatric Sciences Journal Vol. 2 No. 2 (2021): (Available online 1 December 2021)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (298.163 KB) | DOI: 10.51559/pedscij.v2i2.29

Abstract

Introduction: Epidemiological studies about case distribution and survival in PICU is important to do. Knowledge of these epidemiological studies can assist in decision-making to improve patient quality of care. So far there is no data about the case distribution and survival rate of the patients in the PICU in Banjarmasin, Indonesia. This study aims to provide an overview of case distribution and survival rates of patients treated at the PICU of Ulin Hospital Banjarmasin. Methods: A retrospective study was conducted at the PICU of Ulin Hospital Banjarmasin. Data was taken from patients’ records from January 2017 to December 2018. Results: A total of 202 patients were admitted to the PICU, males 109 and females 93. The mortality rate was 17% with a survival rate, 83% with a mean length of stay of 10 days. The most common patient diagnosis was pneumonia 23%, meningoencephalitis 10%, and dengue shock syndrome 6%. The system commonly involved was respiratory system 26%, central nervous system 17%, and infection 13%. The median length of stay for overall admission was 9 days with a mean of 10 days. The cardiovascular and respiratory systems tend to have lower survival rates, 78%, and 79% respectively. Conclusions: This study shows that respiratory, neurological, and infectious diseases are the most common diseases that cause children to be admitted to the PICU. The mortality rate in this study was 17% with a mean length of stay of 10 days. It is necessary to focus on medical facilities and interventions to reduce respiratory-related mortality.
Relationship of Epidermal Growth Factor (EGF) and Insulin-Like Growth Factor-1 (IGF-1) levels in breast milk colostrum with the occurrence of necrotizing enterocolitis in neonates Anik Puryatni; Prasetya Ismail; Fireka Juniantika; Bayu Kurniawan
Pediatric Sciences Journal Vol. 2 No. 2 (2021): (Available online 1 December 2021)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (366.636 KB) | DOI: 10.51559/pedscij.v2i2.30

Abstract

Background: Colostrum contains various bioactive compounds that have various roles and potentials in preventing the occurrence of necrotizing enterocolitis (NEC). EGF and IGF-1 are growth factors found in breast milk colostrum in the form of polypeptides that play a role in regulating and stimulating cell proliferation and differentiation processes. The purpose of this study was to determine the relationship between EGF and IGF-1 levels in breast milk colostrum with the occurrence of NEC in neonates. Methods: This analytical observational study was conducted at Saiful Anwar Hospital Malang during June-August 2019 on mothers and neonates who were breastfed. Maternal colostrum was collected at 72 hours postpartum, while NEC incidence in infants was determined prospectively. EGF and IGF-1 levels in colostrum were examined using the ELISA method. The data were processed by SPSS 21 program and analyzed using Spearman’s test and logistic regression. Results: 24 mother and baby pair samples were included in the study. The mean level of EGF in maternal colostrum was 466±304 ng/ml, and the mean level of IGF-1 was 1.99±0.96 ng/ml with no significant difference in levels based on gestational age. There is a strong negative correlation between the levels of EGF (r = -0.630; p=0.001) and IGF-1 (r = -0.646; p=0.001) on the occurrence of NEC. With the regression test, there was no significant effect between the levels of IGF-1 (p=0.995) and EGF (p=0.997) on NEC occurrence. Conclusion: EGF and IGF-1 levels have a significant relationship to the occurrence of NEC. The higher levels of EGF and IGF-1 contained in breast milk colostrum reduced the incidence of necrotizing enterocolitis in neonates.
Correlation between leukocyte count and hemoglobin with the incidence of febrile seizures at RSUD Abdul Wahab Sjahranie Samarinda Muhammad Harbiyan Acikdin; Annisa Muhyi; Vera Madonna Lumban Toruan
Pediatric Sciences Journal Vol. 3 No. 1 (2022): (Available online 1 June 2022)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v3i1.31

Abstract

Background: Febrile seizures occur at the age of 6 months to 5 years, ranging from 2-5% of cases in children. The sign when the body is fighting infection is the process that occurs, the presence of infection in the body causes a change in the leukocyte count, and high fever can trigger a decrease in hemoglobin. This study aims to determine the relationship between leukocytes and hemoglobin with the incidence of febrile seizures in children. Methods: This research is analytic observational with a cross-sectional design. The research data was taken from medical records at Abdul Wahab Sjahranie Hospital Samarinda with a purposive sampling method. The study sample was children aged 6 months to 5 years who had febrile seizures and fever without seizures and met the inclusion and exclusion criteria. Statistical analysis of this study used the chi-square test. Results: The chi-square test results were obtained on hemoglobin and leukocyte count with the incidence of febrile seizures with a p-value on the number of leukocytes (p=0.032) and hemoglobin (p=0.019). Conclusion: There is a significant relationship between the number of leukocytes and hemoglobin with the incidence of febrile seizures in children.
Correlation of cell apoptosis index and hematology profile in children with acute myeloblastic leukemia with chemotherapy induction Arief Rahman; Susanto Nugroho; Sony Wicaksono
Pediatric Sciences Journal Vol. 3 No. 1 (2022): (Available online 1 June 2022)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v3i1.32

Abstract

Background: Acute myeloblastic leukemia (AML) is one of the most prevalent pediatric neoplasms, with a poor prognosis and high risk of relapse. Response to induction of chemotherapy and complication occurrence are crucial in the AML patient's outcome. Chemotherapy can induce apoptosis in a cancer cell and the blood cell as a side effect that can cause severe complications. This study aims to evaluate the cell apoptosis index and its correlation with hematologic profile (hemoglobin, leucocyte, thrombocyte, absolute neutrophile count/ANC) between induction chemotherapy administration. Methods: Observational study was performed on children with AML who will undergo induction chemotherapy. The cell apoptosis index and the hematologic profile were evaluated before and after induction chemotherapy. The data was then analyzed to compare the cell apoptosis index and its correlation with the hematologic profile. Result: The mean age of the subjects was 13.6 years old, similar to previous epidemiologic studies, which showed the main incidence at 15 years old. There was a significant increase in cell apoptosis index (p=0.014) and a significant decrease in hemoglobin level (p=0.031) and ANC (p=0.05). The cell apoptosis index had a significantly strong negative correlation with all hematologic profiles. Conclusion: Cell apoptosis index increased after induction chemotherapy in pediatric AML and correlated with the hematologic profile.
The relation between vitamin D, calcium, and phosphor in growth retardation of child with chronic kidney disease Radwika Swastanti Wijaya; Ariani; Krisni Subandiyah
Pediatric Sciences Journal Vol. 3 No. 1 (2022): (Available online 1 June 2022)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v3i1.13

Abstract

Background: Growth retardation was a complication in chronic kidney disease (CKD). It is a condition that a child can not achieve linear potential growth. Fifty percent of children with CKD will have a height below the third percentile. The causes of growth disorders in CKD are multifactorial. Electrolyte hemostasis (calcium and phosphorus) and lack of vitamin D play a role in growth in children with CKD. The aim of this study was to determine the relationship between growth problems in children with chronic kidney disease and the correlation with vitamin D, calcium, and phosphorus. Method: This study was a retrospective observational analytical study design. The research subjects were taken from medical records from Saiful Anwar General Hospital in Malang from January 1st to December 2019. 68 pediatric patients aged 2 – 18 years old were diagnosed with chronic kidney disease, divided into 2 groups (with growth retardation and normal stature). Data were analyzed using SPSS v.26 for windows. Results: There was significant correlation between low vitamin D levels and growth retardation (p = 0.005), and significant correlation between calcium levels (p = 0.026) and phosphor levels (p = 0.222) and the incidence of growth retardation. Levels of vitamin D, calcium, and phosphor have a positive correlation with growth retardation 0.427, 0.277, dan 0.300 (p<0.05). Path analysis found a significant direct relationship between vitamin D on growth retardation (β = 0.358, p = 0.002) and had a greater effect when compared to the indirect relationship between vitamin D and growth retardation mediated by calcium and phosphorus. Conclusion: there is a correlation between vitamin D, calcium, and phosphorus with growth retardation in children with chronic kidney disease.
Association of vitamin D and phosphor levels with growth retardation in children with chronic kidney disease Ariani; Subandiyah Krisni; Hutabarat Priscilla Yoella
Pediatric Sciences Journal Vol. 3 No. 1 (2022): (Available online 1 June 2022)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v3i1.34

Abstract

Introduction: Growth retardation is a complication often found in children with chronic kidney disease (CKD). Growth retardation is characterized by the failure to reach a child's potential linear growth height. Fifty percent of children with CKD will have a height below the third percentile. The causes of growth retardation in CKD are multifactorial. One of them is the electrolyte balance of phosphorus and lack of vitamin D levels which play a role in the linear growth disorders of children with CKD. This study aims to determine the relationship between vitamin D and phosphorus levels on growth retardation in children with chronic kidney disease. Methods: This observational retrospective analytic study was conducted at the Polyclinic and Inpatient Room of the Department of Pediatrics in Saiful Anwar General Hospital, Malang from June 1, 2021 to September 2021. There were 68 subjects, divided into 2 groups: patients with CKD with growth retardation and without growth retardation, age ranging from 2 -18 years. Univariate test is used to describe the frequency distribution of each variable. The Chi-Square test used determines the correlation of each variable, the Spearman correlation test to see the strength of the relationship between the variables of vitamin D and phosphorus on growth retardation. The significance level and confidence interval were P<0.05 and 95%, respectively. Data were analyzed using SPSS v.26 for windows. Result: We found a correlation between vitamin D levels in patients with chronic kidney disease and growth retardation (P=0.005), as well as a correlation between phosphorus levels in patients with chronic kidney disease and growth retardation (p=0.022).Vitamin D and phosphorus had a correlation coefficients of 0.427, and 0.300 to growth retardation (p<0.05). We also found a significant direct correlation between vitamin D and growth retardation (β= 0.358, p=0.002), which shows a greater effect than the indirect relationship between vitamin D and phosphorus-mediated growth retardation. Conclusion: There is a significant corr between vitamin D level and phosphorus on growth retardation in children with chronic kidney disease.
Global climate change issues, natural disasters and their impact on Indonesian children Kurniawan Taufiq Kadafi; Dimas Dwi Saputro; Martinus M. Leman; Aslinar; Badai Buana Nasution; Dimas Tri Anantyo; Niken Wahyu Puspaningtyas; Fathy Zuandy Pohan; I Nyoman Arie Purwana; Muhammad Reza; Jaya Ariheryanto Effendy; Yogi Prawira; Piprim Basarah Yanuarso,
Pediatric Sciences Journal Vol. 3 No. 1 (2022): (Available online 1 June 2022)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v3i1.35

Abstract

Climate change that contributes to the destruction of the earth is one of the impacts of human behavior. One example of damage to the earth due to human behavior is global warming. One of the effects of global warming is the melting of permafrost. Melting of glaciers due to global warming will result in an isostatic rebound phenomenon, where melting glaciers will cause the weight of the earth's crust to decrease and it is easy to move and bounce, resulting in the movement of earth faults and increased activity in the magma chamber (increased seismic activity). The big impact is the occurrence of natural disasters that not only occur in parts of the world where glaciers melt but in other parts of the world far from where glaciers melt. Natural disasters that can occur are earthquakes, volcanic eruptions, tsunamis, and landslides. Global warming will also have an impact on the emergence of disease outbreaks. Indonesia is the meeting place of three major tectonic plates in the world, namely the Eurasian plate, the Indo-Australian plate and the Pacific plate. In addition, Indonesia is also located in the Pacific ring of fire, making Indonesia an area with high volcanic activity and seismic activity. Climate change will increase the risk of disasters in Indonesia. The long experience of the Indonesian people in dealing with natural disasters that often occur should be used as a strategy to prevent and reduce the impact of disasters in the future.
Pericardial effusion in status epilepticus and global developmental delay one-year-old patient with co-exist of atrial septal defect: a case report Pradhika Perdana Sakti; Ariani
Pediatric Sciences Journal Vol. 3 No. 2 (2022): Available online : 1 December 2022
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v3i2.33

Abstract

Introduction: Atrial septal defect (ASD) is one of the most common types of congenital heart disease (CHD) and occurs due to spectrum closure failure during the intrauterine period. ASD is generally asymptomatic, but it can affect patients from various aspects. Case presentation: A 1-year-old 4-month-old girl was referred with a major complaint of shortness of breath as early as 6 days before hospital admission. The dullness accompanied by a fever disappears, as convulsions, pallor and vomiting. On physical examination, a positive result in pathological reflex was found in a decrease in consciousness, epicantal fold, conjunctiva and pale skin, and edema of the left limb. The patient was examined for echocardiography and found the presence of moderate primum ASD with a left to the right pyre, mild tricuspid regurgitation with the possibility of pulmonary hypertension, and effusion pericardium with the collapse of the right atrium. In the laboratory results show the presence of normochromic normocytic anemia, leukocytosis, mild hyponatremia, hypokalemia, hypocalcemia, hypophosphatemia, increased PCT, increased SGOT / SGPT, PT elongation, a decreased of free T4 and increase in TSH, IgG CMV (+), IgG toxoplasma (+), IgG HSV-1 (+), IgG HSV-2 (+), and IgG Rubella (+). The patient is given treated at the PICU and provided with the help of ventilation, antibiotics, antipyretics, anticonvulsants, inotropic, and sympathomimetic agents. On the ninth day of care, the patient experienced cardiac arrest. RJP was performed, but the patient did not have ROSC and was pronounced dead. Conclusion: ASD affects the patient's condition as well as the patient's survival both directly and indirectly. There is a link between ASD and developmental disorders, pericardial effusion and patient mortality. It is necessary to conduct a comprehensive evaluation and management of patients with ASD.

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