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Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
ISSN : 2502647X     EISSN : 25031902     DOI : https://doi.org/10.36387/jiis
Core Subject : Health,
Medicine & Pharmacology
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIIS is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 457 Documents
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Overview of Community Knowledge on Hepatitis C Disease in the Pulo Gebang Public Housing Area, Cakung, East Jakarta Elisya, Yetri; Aulia, Septi Nurul; Junaedi; KA , Nanang
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2970

Abstract

Hepatitis C is a virus infection of the liver that can lead to severe complications, including cirrhosis and hepatocellular carcinoma. Despite the existence of established principles, there remains a prevalence of erroneous comprehension within the populace regarding this subject. The possession of knowledge by the general population is of paramount importance in the efforts to prevent and control hepatitis C. The objective of this study is to ascertain the level of knowledge of the residents of Pulo Gebang Residential Complex in Cakung, Jakarta Timur, with regard to hepatitis C. The nature of the research is quantitative descriptive, with a quota sampling technique employed to determine the sample size. The total number of respondents included in the study was 96. The collection of data was achieved through the utilisation of a questionnaire. The findings indicate that the majority of respondents are female (76%), aged between 18 and 59 years (83.3%), have a secondary education (50.1%), and are not employed (56.2%). The level of knowledge of the respondents was categorised as follows: 47.9% of respondents demonstrated a satisfactory level of knowledge, 33.3% demonstrated an adequate level of knowledge, and 18.8% demonstrated an insufficient level of knowledge. Nevertheless, a misperception remains regarding the manner of transmission and the existence of a vaccine. It is imperative that education on the subject is sustained in order to enhance public awareness and understanding of hepatitis C.
POTENSI ANTI-INFLAMASI DAN KADAR FLAVONOID TOTAL EKSTRAK ETIL ASETAT DAUN KOKANG (Lepisanthes amoena) YANG DIEVALUASI DENGAN METODE INHIBISI DENATURASI PROTEIN Fadlilaturrahmah; Arnida; Khairunnisa, Amalia; Normaidah; Arini, Mifthah Dwi
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2973

Abstract

Kokang (Lepisanthes amoena) is an endemic plant from Kalimantan traditionally used by the Dayak Tunjung community for skincare and wound treatment. Empirically, its leaves accelerate healing of skin problems such as acne scars and wounds within approximately two weeks. This research aimed to determine the total flavonoid content and evaluate the anti-inflammatory potential of the ethyl acetate extract of L. amoena leaves using the protein denaturation inhibition assay. The total flavonoid content was quantified spectrophotometrically using the aluminum chloride method, expressed as quercetin equivalents (QE). Anti-inflammatory activity was assessed by measuring the inhibition of protein denaturation, with sodium diclofenac as a positive control, and IC₅₀ values were calculated to compare activity levels. The results showed that the yield of the ethyl acetate extract of L. amoena leaves was 1.77%, with a total flavonoid content of 143.496 mg QE/g extract, and that it exhibited strong anti-inflammatory activity with an IC₅₀ value of 16.759 ppm. These findings scientifically support the traditional use of L. amoena leaves as an anti-inflammatory and wound-healing agent, highlighting their potential development for herbal or cosmeceutical formulations.
KAJIAN SUHU REAKSI TERHADAP POLA SUBSTITUSI DAN HASIL SINTESIS DERIVAT KUERSETIN Aini, Nur; Fauzi, Muhammad; Su’aida, Nily
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2976

Abstract

Quercetin is a flavonoid compound with various pharmacological activities but has limited solubility and stability. The derivatization synthesis of quercetin through acylation with benzoyl chloride was carried out at temperatures of 25°C, 40°C, and 60°C using acetone as the solvent and pyridine as the catalyst. The reflux reaction for 12 hours produced mono-benzoylation characterized by Thin Layer Chromatography (TLC), column chromatography, as well as UV-Vis and IR spectra confirming the presence of benzoyl groups on quercetin. The 60°C temperature resulted in multi-benzoylation substitution, indicated by two carbonyl bands at 1785.00 cm⁻¹ and 1742.36 cm⁻¹, along with the highest yield of 88%. Controlling the reaction temperature can direct a more selective substitution pattern and improve the efficiency of quercetin derivatization. Higher temperatures accelerate the reaction rate and promote multi-substitution, potentially affecting the biological activity of the product.
OPTIMASI FASE GERAK PADA KLT DAN IDENTIFIKASI METABOLIT SEKUNDER Ipomoea pes-caprae Hidayat, Lalu Husnul; Murti, Yosi Bayu; Yuniarti, Nunung; Riski, Akhmad
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2995

Abstract

Ipomoea pes-caprae (L.) R.Br traditionally used to treat pain, skin infections, inflammation, and rheumatic disorders. In vitro studies also reported antioxidant, anti-inflammatory, and antimicrobial potential activities obtained from secondary metabolites such as flavonoids, tannins, terpenoids, steroids, saponins, and alkaloids contained in Ipomoea pes-caprae. The purpose of this study is to optimize the mobile phase and identify secondary metabolite compounds of Ipomoea pes-caprae. The analysis used thin layer chromatography (TLC) in identifying compounds responsible for providing antioxidant activity with a spray reagent in the form of DPPH. The results showed the ideal of mobile phase, namely Chloroform: Ethyl Acetate: Methanol: Formic Acid (2: 7: 0.5: 0.5). Ethanol extract of 96% leaves has antioxidant activity with a DPPH spray reaction than ethyl acetate and N-hexane extracts. The metabolite profiles in samples with various specific reagents include the group of polyphenols, alkaloids and flavonoid compounds. Based on the results of the descriptive analysis, it was shown that the most dominant group of flavonoid compounds from ethanol extract was 96% of Ipomoea pes-caprae leaves, so it had a strong correlation with antioxidant activity.
PREDIKTOR INDEPENDEN PERPANJANGAN INTERVAL QTc PADA PASIEN TUBERKULOSIS RESISTAN OBAT (TB-RO) Andryanto, M. Hasan; Soedarsono Soedarsono; Amelia Lorensia; Umi Fatmawati
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.3002

Abstract

Drug-resistant tuberculosis (DR-TB) remains a global health challenge with suboptimal treatment success rates. Long-term treatment regimens in DR-TB patients may lead to cardiotoxic adverse effects, including QTc interval prolongation, which increases the risk of fatal arrhythmias such as torsades de pointes. This study aimed to analyze the independent predictors of QTc interval prolongation in patients with DR-TB receiving long-term treatment regimens. A retrospective cohort study was conducted at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, from January 2021 to December 2023. A total of 100 eligible DR-TB patients were included. QTc prolongation was defined as ≥ 450 ms in males and ≥ 470 ms in females using Bazett’s or Fridericia’s correction. Bivariate analysis was performed using the Mann–Whitney test and chi-square or Fisher’s exact. Multivariate logistic regression analysis was subsequently conducted to identify independent predictors of QTc interval prolongation. The results showed that 60% of patients experienced QTc interval prolongation. Multivariate analysis revealed that age ≥ 60 years (adjusted OR 6.94; 95% CI 1.34–35.98; p = 0.021) and diabetes mellitus (adjusted OR 8.76; 95% CI 2.99–25.68; p < 0.001) were independent predictors of QTc interval prolongation in patients with DR-TB receiving long-term treatment regimens. Diabetes mellitus was identified as the strongest independent risk factor in this study. These findings highlight the importance of cardiometabolic risk stratification and more intensive electrocardiography (ECG) monitoring in patients with these risk factors to improve treatment safety.
UJI AKTIVITAS ANTI JAMUR SEDIAAN SERUM EKSTRAK ETANOL DAUN PACAR (Impatiens balsamina L.) TERHADAP JAMUR Candida albicans SECARA IN VITRO Kusharyanti, Indri; Pratiwi, Liza; Anjani, Ayu Paramitha
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.3009

Abstract

The normal flora on the scalp that can cause dandruff when excess oil is produced is Candida albicans. Chemical antifungal treatments for dandruff often cause side effects such as hair loss and headaches. Garden balsam leaves, which contain antifungal compounds like flavonoids, saponins, and alkaloids, can be extracted and formulated into hair serum as a natural alternative. This study aims to analyze the physical properties of the extract and serum from water henna leaves and evaluate their antifungal activity against Candida albicans. The evaluation involved physical property tests and in vitro disc diffusion using 2% ketoconazole shampoo as a positive control and serum without extract as a negative control. Tested concentrations were 1%, 3%, and 5%. Standardization of the extract showed a thick, dark brown liquid with a characteristic odor, a yield of 36.66%, water-soluble extract content of 78.66%, ethanol-soluble extract content of 70.09%, and moisture content of 2.51%. The serum showed increased color intensity, spreadability (4.63–5.3 cm), adhesiveness (3.49–41.91 seconds), pH (5.74–8.78), and viscosity (1016.6–1417.6 cPs). No inhibition zones were observed in the extract, serum, or negative control, while the positive control showed a strong inhibition zone of 46.03 mm.
FORMULASI SEDIAAN SABUN PADAT FRAKSI ETIL ASETAT DAUN JERUK PURUT (Citrus hystrix) SEBAGAI ANTIMIKROBA Kalalo, Tasya Kensy; Yamlean, Paulina V.Y; Abdullah, Surya Sumantri
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.3010

Abstract

The kaffir lime plant (Citrus hystrix) contains flavonoids, alkaloids, saponins, steroids, terpenoids, and tannins, which have antimicrobial activity. This study aims to determine whether the solid soap formulation of the ethyl acetate fraction of kaffir lime leaves possesses antimicrobial activity and to find the optimum concentration for this effect. The research employed an experimental laboratory method. Extraction and fractionation were conducted using various solvents, followed by antimicrobial activity testing. The results showed that the ethyl acetate fraction exhibited the strongest antibacterial activity with an inhibition zone of 16 mm against Staphylococcus aureus, while there was no inhibition zone against Candida albicans. Solid soap formulations were made with concentration variations of 0%, 1%, 3%, and 5%, all meeting physical evaluation requirements. Antimicrobial testing of the solid soap against Staphylococcus aureus showed the highest antibacterial activity with an inhibition zone of 10.5 mm at a 5% concentration. It can be concluded that all solid soap formulations of the ethyl acetate fraction of kaffir lime leaves demonstrated antimicrobial activity against Staphylococcus aureus, with the highest activity at a 5% concentration, resulting in a 10.5 mm inhibition zone.

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