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Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
ISSN : 2502647X     EISSN : 25031902     DOI : https://doi.org/10.36387/jiis
Core Subject : Health,
Medicine & Pharmacology
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIIS is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 429 Documents
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ANALISIS BIAYA MEDIS LANGSUNG PASIEN RAWAT INAP BEDAH UROLOGI DI RSUD KOTA YOGYAKARTA Supadmi, Woro; Kristina, Susi Ari Kristina; Feangi, Yanti Fitriani; Supadmi, Woro Supadmi; Basuki, Adriyanto Rochmad; Kristina, Susi Ari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2657

Abstract

Urological surgical procedures, such as urolithiasis and benign prostatic hyperplasia (BPH), continue to increase with high recurrence rates. Limited treatment facilities and the risk of antibiotic resistance can affect the cost burden. This study aims to determine the alignment of direct medical costs with INA-CBG’s claim rates and to identify variables influencing total direct medical costs. The study employs an observational approach with a retrospective design. Samples were selected using purposive sampling with inclusion criteria. Data were collected from electronic medical records and financial reports. Direct medical costs were calculated based on all cost components using a hospital perspective approach. Data analysis used univariate, bivariate, and multivariate tests. The average total direct medical costs for urology patients were Rp 9,962,325 ± Rp 1,699,707.79, while the INA-CBG’s claim rates were Rp 9,600,328 ± Rp 1,853,291.26. There were differences in direct medical costs based on age (p-value 0.024), care class (p-value 0.035), and length of stay (LOS) (p-value 0.000). Regression analysis shows that LOS and care class have a statistically significant impact on total direct medical costs (p-value < 0.05). There is a difference between the actual costs borne by the hospital and the INA-CBG’s claim rates.
PENGARUH PENGERING AEROSIL DAN KROSPOVIDON TERHADAP KARAKTERISTIK FISIK SOLID-SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM KURKUMIN Wahyuningsih, Iis; Kyllingga, Muhammad Rhapis
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2664

Abstract

Curcumin belongs to BCS II with low solubility but high permeability. In previous studies, a curcumin SNEDDS formulation was developed with a curcumin concentration of 7 mg/mL, VCO (11%), Tween 80 (65.66%), and PEG 400 (23.34%); however, this formulation had the drawback of being incompatible with capsule shells. The objective of this study was to formulate and characterise solid SNEDDS curcumin using aerosil and crospovidone as drying agents. The S-SNEDDS formulation was prepared using the absorption-to-solid carrier method with aerosil and crospovidone as drying agents, followed by characterisation using parameters such as clarity, emulsification time, static angle test, bulk density, tapped density, Carr’s index, Hausner ratio, and droplet measurement. The resulting S-SNEDDS curcumin formulations contained 0.5 g of aerosil drying agent per mL and 3 g of crospovidone. The formulations exhibited the following characteristics: clarity of 96.28±0.00% and 95.35±0.01%, emulsification time of 52.58±0.75 seconds for aerosil in AGF and 56.14±0.42 seconds in distilled water, while crospovidone yielded 48.63±1. 84 seconds and 50.58±0.45 seconds, angle of repose 19.77±2.03º and 41.41±3.35º, bulk density and tapped density 0.56±0.00 and 0.63±0.01 for aerosil, and 0.50±0.00 and 0.57±0. 01 for crospovidone, Carr’s index and Hausner ratio 11.33±2.08% and 1.13±0.03 for aerosil, and 12.66±2.51% and 1.15±0.03 for crospovidone, with droplet sizes of 77.08 nm and 198.2 nm. Aerosil-dried S-SNEDDS produced granules with better characteristics.
PERAN INDEKS MASSA TUBUH TERHADAP KADAR TESTOSTERON PADA PRIA DIABETES MELITUS TIPE 2 DENGAN TERAPI METFORMIN Sabrina, Maiyeni; Lukas, Stefanus
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2721

Abstract

Type 2 diabetes mellitus (T2DM) is a metabolic disorder often accompanied by decreased testosterone levels in men. Metformin is effective in lowering blood glucose, but its impact on testosterone remains controversial.To evaluate the effects of metformin dose, age, and changes in body mass index (BMI) on testosterone levels in men with T2DM. A pre–post study was conducted on 79 male T2DM patients receiving metformin. Data included metformin dose, age, BMI, and testosterone levels before and after therapy. Spearman correlation and multiple linear regression were used for analysis. Changes in BMI showed a strong correlation (ρ = 0.608; p = 0.000) and metformin dose showed a moderate correlation (ρ = 0.564; p = 0.000) with changes in testosterone. Regression analysis identified BMI as the dominant factor (β = 0.523; p = 0.009), while age was not significant (p > 0.05). This study provides simultaneous analysis of metformin dose, BMI, and age using a pre–post design. A unique finding was that BMI reduction was followed by decreased testosterone levels, contrasting with most international studies. Changes in BMI were the most dominant factor influencing testosterone levels in men with T2DM receiving metformin.
IMPETIGO KONTAGIOSA BERAT PADA ANAK DENGAN ATOPI: LAPORAN KASUS DENGAN TINJAUAN FARMAKOLOGI Adelia Hanarizky Kurniasari; Dwiana Savitri
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2785

Abstract

Impetigo is a superficial pyoderma caused by bacterial infection confined to the epidermis and is highly contagious, particularly among children under five years of age. It presents in two forms: bullous and non-bullous (contagious) impetigo. Severe cases in children with atopic dermatitis are rarely reported, although atopy increases susceptibility to infection due to impaired skin barrier function and alterations in the skin microbiome. The patient was hospitalized for five days under daily clinical observation and laboratory monitoring. Treatment included intravenous ampicillin–sulbactam, systemic dexamethasone, a topical fusidic acid–betamethasone combination, and 0.9% NaCl compresses were applied to the lesions. A two-year-old girl with a history of atopy presented with extensive, foul-smelling yellowish pus covering the entire scalp, accompanied by severe pruritus and pain. Yellow-brown crusted impetigo lesions were also observed across the body. Laboratory evaluation revealed mild leukocytosis with neutrophil predominance, and Gram staining demonstrated numerous Gram-positive cocci (+++). The therapeutic strategy aimed to control infection, suppress inflammation, and accelerate healing through a rational pharmacotherapeutic approach in accordance with CDC (2025) and IDSA (2014) guidelines. Dosage, duration, and adverse effects were collaboratively monitored by physicians and clinical pharmacists, accompanied by family education on hygiene and skin care to prevent recurrence. After five days of treatment, significant clinical improvement was observed, including reduced exudate, crusting, and pruritus. This report highlights the importance of comprehensive and collaborative pharmacotherapeutic approach and identification of recurrence risk factors in severe contagious impetigo with atopy to optimize treatment outcomes and patient quality of life.
KARAKTERISTIK PARAMETER SPESIFIK DAN NON SPESIFIK DAUN KRATOM (Mitragyna speciosa Korh.) ASAL KALIMANTAN SELATAN Febrianti, Dwi Rizki; Wahyuono, Subagus; Fakhrudin, Nanang; Riski, Akhmad; Kumalasari, Eka; Normilawati; Niah, Rakhmadhan; Mar'uf, Muhammad
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2786

Abstract

Standardization is a process of fulfilling the requirements for raw materials of traditional medicine, aimed at ensuring and maintaining safety, consistent quality, and efficacy. Kratom leaves (Mitragyna speciosa) are a traditional medicinal plant found in the interior regions of Kalimantan. This plant functions as a source of energy due to its stimulant properties. This study aims to determine the standardization of kratom leaf extract simplicia, including both specific and non-specific parameters. The extraction method used in this study was maceration with ethanol. The results showed that the scientific name of kratom leaves is Mitragyna speciosa. The standardization of kratom leaf simplicia powder includes parameters such as loss on drying, total ash, water-insoluble ash, acid-insoluble ash, total microbial count (ALT), total yeast and mold count (AKK), and heavy metal contamination, with the following results: 9.5%; 5.51%; 3.58%; 0.39%; 6.9 × 10² cfu/g; >3.0 × 10³ cfu/g; <0.001 mg/kg. Meanwhile, the standardization of kratom leaf extract includes ash content and heavy metal contamination, with results of 6.06% and <0.001 mg/kg, respectively. The active compounds contained in the kratom leaf simplicia and extract are alkaloids, flavonoids, and tannins.
EKSPLORASI HAMBATAN KEPATUHAN PENGOBATAN PASIEN DIABETES MELITUS DI PUSKESMAS: STUDI KUALITATIF Alfian, Riza; Fawwazi, Muhammad Hafizh Abiyyu Fathin; Faqih, Muhammad; Adikusuma, Wirawan
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2789

Abstract

Medication adherence is a crucial factor in the successful management of diabetes mellitus, yet many studies show that adherence remains low and is shaped by multidimensional influences. This study aimed to explore barriers to medication adherence among patients with diabetes mellitus in primary health centers (Puskesmas) using the WHO five-domain adherence framework. A qualitative descriptive-exploratory design was applied. Data were collected through in-depth interviews with ten patients undergoing routine treatment at Puskesmas in Banjarmasin City, recruited through purposive sampling. Thematic analysis was performed guided by the WHO adherence model. Five major themes emerged. Social and economic factors included limited transportation costs, distance to the health center, and lack of family support. Health system and provider factors involved brief consultations, insufficient patient education, and long queues. Condition-related factors comprised the absence of immediate symptoms, fatigue from chronic illness, comorbidities, and psychological distress. Therapy-related factors included complex regimens, side effects, and discontinuation of therapy without consultation. Patient-related factors were characterized by forgetfulness, reliance on alternative medicine, fluctuating motivation, and feelings of boredom. These findings highlight that adherence barriers are multidimensional and result from the interaction of individual, social, and system-level determinants. Addressing adherence requires holistic and continuous interventions at the primary care level, with emphasis on patient education, family involvement, and strengthening the role of healthcare providers.
COST UTILITY ANALYSIS PADA PASIEN DIABETES MELLITUS TIPE 2: INTEGRASI GULA DARAH, KOMORBIDITAS, BIAYA DAN KUALITAS HIDUP DALAM PENGAMBILAN KEPUTUSAN KLINIS Ilahi, Fitrah Shafran; Nordin; Faqih, Muhammad; Yumassik, Abdul Mahmud; Mellyani H.S, Ananda
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2796

Abstract

Type 2 Diabetes Mellitus (T2DM) is one of the most prevalent chronic diseases in Indonesia and imposes a significant burden on healthcare costs. This study aimed to perform a Cost Utility Analysis (CUA) among T2DM patients by integrating blood glucose levels, comorbidities, direct medical costs, and quality of life. The research applied a cross-sectional design with prospective data collection using a convenience sampling technique. Quality of life was measured using the EQ-5D-5L questionnaire, while blood glucose levels, comorbidities, and direct medical costs were obtained from hospital medical records. Data analysis included descriptive statistics, Chi-Square tests, Logistic Regression analysis, and calculation of the utility index. The results showed that 38% of patients had good quality of life and 62% had poor quality of life, with an average utility index score of 0.5175. Random blood glucose levels of ≥200 mg/dL were found in 56% of respondents, while 44% had levels <200 mg/dL. Comorbidities were present in 52% of patients, while 48% had none. The median direct medical cost was IDR 425,500, with 62% categorized as high-cost and 38% as low-cost. Bivariate analysis revealed significant relationships between comorbidities, blood glucose levels, and direct medical costs with quality of life (p < 0.05). However, multivariate analysis showed that only blood glucose levels remained significant (p = 0.006). In conclusion, the overall quality of life of T2DM patients was generally poor, and blood glucose control was identified as the most influential independent factor affecting quality of life.
HUBUNGAN KOMPLEKSITAS REGIMEN PENGOBATAN DENGAN KEPATUHAN PENGOBATAN PASIEN DIABETES MELITUS TIPE 2 DI POLI PENYAKIT DALAM RSUD SULTAN SURIANSYAH BANJARMASIN Faqih, Muhammad; Alfian, Riza; Yumassik, Abdul Mahmud; Ilahi, Fitrah Shafran; Nordin, Nordin
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2810

Abstract

Diabetes Mellitus (DM) is a chronic disease that requires prevention and treatment to reduce the various consequences associated with poor glycemic control. Diabetes mellitus treatment aims to control blood sugar levels within normal limits, improve the patient's quality of life, and prevent complications. One factor contributing to non-adherence to treatment in diabetes mellitus patients is the complexity of the medication regimen. This study aimed to examine the level of medication regimen complexity, medication adherence, and the relationship between medication regimen complexity and medication adherence in type 2 diabetes mellitus patients at the Internal Medicine Clinic of Sultan Suriansyah Hospital, Banjarmasin. This study used a cross-sectional design. Data were collected from August to September 2024, with 155 samples used in this study. The sampling method used a consecutive sampling technique. Medication regimen complexity (MRCI) data were obtained from prescriptions, while medication adherence data were collected using the Adherence to Refill Medication Scale (ARMS) questionnaire. The results of this study showed that the complexity of the patient's regimen was dominated by medications with a moderate level of complexity (75%, 48.4%). The results showed that the medication adherence rate was 61% of patients (39.4%). The correlation test showed an insignificant relationship between the complexity of the medication regimen and medication adherence, with a p value > 0.05 (0.139). Based on the research results, it can be concluded that the complexity of the medication regimen is not the main factor causing non-compliance in diabetes mellitus patients.
STANDARDISASI KULIT PISANG KEPOK (Musa paradisiaca L) SEBAGAI ALTERNATIF PENYEMBUH LUKA Ariani, Novia; Kumalasari, Eka; Fawwazi, Muhammad Hafizh Abiyyu Fathin; Nayandra, Faizah; Purnomo, Dimas Kalinggo; Rahayu, Mirenne Anik Sri
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2814

Abstract

Kepok banana peel (Musa paradisiaca) is an agricultural waste with great potential to be utilized as a raw material for traditional medicine. Several studies have demonstrated that kepok banana peel contains bioactive compounds that act as antioxidants, antibacterial agents, and accelerate the wound healing process. Standardization of the simplicia and extract is necessary to ensure quality, safety, and consistency of its effectiveness as a phytopharmaceutical. This study aims to standardize kepok banana peel through both specific and non-specific parameters. The extraction method employed in this research was sonication using ethanol as a solvent. The results showed that kepok banana peel contains active compounds such as alkaloids, flavonoids, and saponins. Standardization tests on the simplicia powder of kepok banana peel included determination of water content, total ash, acid-insoluble ash, ethanol-soluble extract, water-soluble extract, total plate count (TPC), yeast and mold count (YMC), and heavy metal contamination, with the following results: 10.34%; 9%; 2.25%; 0.06%; 6.91%; 10.26%; >3.0 × 10³ cfu/g; 5.7 × 10³; <0.001 mg/kg, respectively. Meanwhile, the standardization results for the kepok banana peel extract were as follows: 9.57%; 11.19%; 0.07%; 0.26%; 21.68%; 22.53%; 4.6 × 10³ cfu/g; 8.2 × 10³; <0.001 mg/kg.

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