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Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
ISSN : 2502647X     EISSN : 25031902     DOI : https://doi.org/10.36387/jiis
Core Subject : Health,
Medicine & Pharmacology
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIIS is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 429 Documents
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ANTIDIABETES DAN PROFIL HISTOPATOLOGI SEL BETA PANKREAS PADA MENCIT MODEL INDUKSI STREPTOZOTOSIN EKSTRAK ETANOL DAUN RENGGAK (Amomum dealbatum L.) Mislamah; Mislamah, Mislamah; Amalia, Ananda Ayu Amalia; Firma, Firma Amelia Kusuma; Abdul, Abdul Rahman Wahid; Safwan
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2131

Abstract

antidiabetic effects because their flavonoid levels are higher than the fruit. This study aims to determine the antidiabetic activity of ethanol extract of renggak leaves (EEDR), the optimal dose and the histopathological profile of the mouse pankreas. To determine its antidiabetic activity, a pre-test (initial blood sugar level before STZ induction) and post-test (after STZ induction) were carried out on the blood sugar levels of mice. A total of 36 male white mice were divided into 6 groups, namely normal group, negative group (Na-CMC 0.5%), positive group (Metformin 500 mg), EEDR group at doses of 240, 300, and 360 mg/kgBW.. Test results LSD posthoc showed that there was a mean difference between treatment groups with significant antidiabetic activity (p value <0.05). The ethanol extract group of renggak leaves was dosed at 240 mg/kgBW. The histopathological profile of the pankreas in each group showed extensive necrosis, the islets of Langerhans and inch tubules were difficult to distinguish, the cells looked degenerative with incomplete cytoplasm and degenerative nuclei.
OPTIMASI FORMULA FAST DISINTEGRATING TABLET EKSTRAK DAUN JAMBU BIJI (Psidium guajava L.) DENGAN KOMBINASI BAHAN PENGIKAT POLIVINILPIROLIDON DAN PENGHANCURSODIUM STARCH GLYCOLATE Setiyadi, Gunawan; Ihsani, Salsabila
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2276

Abstract

Guava leaves (Psidium guajava L.) can be used as an antidiarrheal with the presence of tannin compounds in them. One way to obtain the benefits of guava leaves is to develop them in practical and easy-to-use preparations such as Fast Disintegrating Tablets (FDT) which are very useful for pediatric and geriatric patients who have difficulty swallowing whole tablets. In addition, FDT has a faster onset of action than regular tablets. This study aims to determine the effect of the combination of Sodium Starch Glycolate (SSG) as a disintegrant and polyvinylpyrrolidone (PVP) as a binder and the optimum concentration of the combination of both that provide good physical properties of guava leaf FDT. This study was conducted using a simplex lattice experimental design. The components of the guava leaf FDT formula that were optimized were PVP and SSG, while the response used for formula optimization was the physical properties of the tablet, namely weight uniformity, hardness, fragility, and tablet disintegration time. In this study, the manufacture of guava leaf FDT was carried out using the wet granulation method. The results showed that the optimum formula was obtained at a ratio of PVP 2.947% and SSG 9.553% with a desirability value of 0.622 which resulted in a weight uniformity (coefficient of variation) of 1.20%, a hardness of 4.55 kg, a friability of 1.68%, and a disintegration time of 124.78 seconds. Verification of the predicted response of the optimum formula showed that the optimization process could predict the response well.
KEAMANAN PENGGUNAAN OBAT PADA KEHAMILAN DI RUMAH SAKIT SWASTA YOGYAKARTA Sari, Chynthia Pradiftha; Hanifah, Suci; Febrianti, Yosi; Sari, Azmi Fahma; Dwirahmania, Pipit
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2485

Abstract

Pregnancy is a special physiological condition in which the use of medication is often unavoidable. However, the risks of teratogenicity and drug safety require careful evaluation to minimize risks to both mother and fetus. This study aims to evaluate the safety of drug use based on FDA (Food and Drug Administration) categories in pregnant inpatients at a private hospital in Yogyakarta. The study uses a descriptive observational method with a cross- sectional design, analyzing 141 inpatient medical records from 2022. The analyzed data includes patient demographics, diagnoses, drug safety, and dosages. Inclusion criteria were pregnant inpatients treated with or without pregnancy emergencies; exclusion criteria were patients giving birth or experiencing abortion. Descriptive results (using Microsoft Excel) showed most pregnant inpatients were aged 20-35 years (80.14%), hospitalized during the first trimester (49.65%), had no comorbidities (90.07%), no emergency pregnancy conditions (82.27%), and a length of stay under 4 days (72.34%). The most common diagnosis was hyperemesis gravidarum (41.84%), with predominant use of multivitamins (16.18%) and antiemetics (14.91%). The safety of drugs in inpatients was categorized as A (18.80%), B (34.34%), C (36.86%), D (2.26%), and N (6.77%), with appropriate dosage usage (96,30%). The study concludes that drug use was dominated by category C, and no use of category X drugs was found. The most used drugs were folic acid multivitamins and iron supplements for increasing blood levels.
KORELASI EFEKTIVITAS ANTIOKSIDAN EKSTRAK BUNGA MAWAR (Rosa damascena MILL.) DAN LIMBAH AIR BUNGA MAWAR (Rose water) SEBAGAI POTENSI TABIR SURYA Weni , Dewi; Sakti Purwanto, Diyan; Weni Sari, Dewi; Tanafasa, Diana; Nurkharimah, Vivin
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2505

Abstract

Roses (Rosa damascena Mill) are a commodity with economic value that has the potential to be a source of natural antioxidants. Further research related to the active compounds found in rose flower extract and waste water that can potentially be used as sunscreen for human skin health in accordance with standards by showing appropriate tests. The process begins with extraction, phytochemical screening, TLC, determination of antioxidant levels, SPF values, and continues with the manufacture of sunscreen gel  with  physical gel testing. The results showed that the antioxidant content in rose flower extract was 47.82 ± 0.09 µg/ml, which is classified as very strong, while rose flower water waste had an antioxidant content of 58.78 ± 0.10*µg/ml, which is classified as strong. Meanwhile, rose flower extract has an SPF value of 34.64 ± 0.08, and rose flower waste has an SPF value of 36.84 ± 0.05, which falls into the ultra-protection category, meaning the highest level of protection and does not cause tanning. There is a correlation between antioxidants and SPF that can be used in making rose flower sunscreen gel preparations and has physical tests that comply with the requirements.
PENGARUH KONSELING ASUHAN KEFARMASIAN PADA RESPONDEN DIABETES MELLITUS II UNTUK PENINGKATAN KEPATUHAN MINUM OBAT DALAM PENGENDALIAN GLUKOSA DARAH DI RUMAH SAKIT SIDOARJO Priyono, Tridoso Sapto Agus; Siswidiasari, Arifani; Wati, Henni
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2510

Abstract

The purpose of the study was to determine the compliance and glucose levels of patients DM II and the effect of counseling pharmaceutical care on compliance and glucose levels of patients DM II Outpatient at Sidoarjo hospital with a sample of 47 patients. The research method is quantitative with descriptive analysis techniques, related of counseling pharmaceutical care on adherence and glucose levels of patients DM II and the relationship between adherence and glucose levels of patients DM II. The compliance is obtained from the results of the questionnaire, while glucose levels are obtained from measurements before and after counseling using univariate tests with descriptive techniques to see a description of the characteristics of patients DM II and bivariate tests are carried out with normality tests and correlation tests. The results was a significant effect of providing counseling pharmaceutical care on compliance and glucose levels of patients DM II. The provision of counseling pharmaceutical care can significantly reduce the glucose levels of patients DM II, and obtained a value of p = 0.000. The average fasting glucose level of patients was 190.98 ± 74.85, while after counseling, it dropped to 73.79 ± 97.48, and the patient's glucose level 2 hours after eating was 250.70 ± 92.36 while after counseling, the average patient's glucose level 2 hours after eating decreased to 218.47 ± 113.21. The conclusion of the study is that counseling pharmaceutical care can improve compliance and reduce the glucose levels of outpatients DM II at the Sidoarjo hospital.
EVALUASI STABILITAS FISIKO-KIMIA DAN UJI HEDONIS GEL PEMBERSIH WAJAH ANTIPOLUTAN BUNGA ROSELLA UNGU Fitri, Hidayah Anisa; Hidayah Anisa, Fitri; Rahman, Fikri Nur; Falahdin, Fadita Iza; Fitriyani
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2536

Abstract

An evaluation of a cosmetic product containing natural ingredients is important to determine its stability and shelf life. This study aims to evaluate the physicochemical aspects and acceptance of Facial Wash Gel Purple Roselle Flower to asess the quality, effectiveness, safety and acceptance of the product after optimization development. The stability evaluation was carried out by cycle testing methods and accelerated stability testing for its physical (viscosity, pH and dispersal power) and chemical aspect. The chemical aspect determined Total Flavonoid Contents (TFC) using UV-Vis spectrophotometry methods. The data were analyzed statistically using the SPSS program using two-tailed T-Test model for cycle test data and paired T-Test sample for accelerated stability test. The product acceptance evaluation was conducted using hedonistic test. Based on the data , it can be concluded that the optimum formula could still maintain its physical stability in cycle tests and accelerated physico-chemical stability tests. Although there was syneresis and pH increasing (P<0.05) during the test but they were not significantly affected organoleptic and TFC in products (P>0.05). All the physical parameters were still met the requirements of facial cleansing gel. The results of the hedonistic test showed that all panelists liked color, smell, texture, clean and coarse sensations and did not give dryness and irritation after use. However, all panelists rather like the foam characteristics that did not meet expectations. It was likely caused by the panelists' personal perception, experience and understanding of foam in a cleaning product.
PENGARUH PERBEDAAN JENIS PELARUT TERHADAP KADAR FLAVONOID TOTAL BATANG KECOMBRANG (Etlingera elatior) Adini, Syilvi; Syilvi Adini; Sofi Nurmay Stiani; Yusransyah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2546

Abstract

Kecombrang stem (Etlingera elatior) contains flavonoid compounds and can be used as a medicine, an antibacterial, and an antioxidant. Several factors influence the extraction compounds in plants, one of which is the type of solvent. This study aimed to determine the effect of different solvents on the total flavonoid content in kecombrang stems. Kecombrang stems were extracted using methanol, 70% ethanol, and 96% ethanol. Qualitative flavonoid analysis was carried out using color reagents and thin-layer chromatography (TLC), and quantitative analysis was carried out using a UV-Vis spectrophotometer. The results of the qualitative flavonoid test showed that all kecombrang stem extracts were positive for flavonoids, indicated by a color change to yellow-orange, and the TLC results showed that all extracts were positive for flavonoids, indicated by light blue fluorescence under UV light 366 nm, with an Rf value range of 0.62-0.66. The results of determining total flavonoid levels in methanol extract were 12.14 mgQE/g, 70% ethanol was 13.55 mgQE/g, and 96% ethanol was 21.77 mgQE/g. One-way ANOVA statistical analysis showed that differences in solvent types significantly affected the total flavonoid levels of kecombrang stems, with a p value <0.05. The highest flavonoid levels in kecombrang stems were found in 96% ethanol extract.
EVALUASI IMPLEMENTASI KEBIJAKAN STANDAR PELAYANAN KEFARMASIAN DI PUSKESMAS WILAYAH PERIFER KOTA SAMARINDA Abdissalam, Erfan; Rahman, Fikri Difa Auliyah; Hanifa, Deasy Nur Chairin; Ghozali, Muhammad Thesa; Susanto, Yugo
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2568

Abstract

Pharmaceutical services in Community Health Centers play an essential role in ensuring rational drug use and quality of health services. The government has set standards for pharmaceutical services through Ministerial Regulation No. 74 of 2016 and Ministerial Regulation No. 26 of 2020. However, implementation has not been optimal in several areas, especially with difficult access. The purpose of this study was to observe the implementation of pharmaceutical service standard policies in Community Health Centers in the peripheral area of ​​Samarinda City, East Kalimantan. This study used a mixed method approach with data collection techniques through observation with questionnaire instruments, in-depth interviews, and document reviews. The results of the study showed that pharmaceutical preparation management activities had been carried out very well (94-100%) based on applicable standards. Meanwhile, the implementation of clinical pharmacy services showed variations in achievement among the health centres. Several activities such as prescription assessment and counselling have been optimal, but other indicators such as monitoring of drug side effects, evaluation of drug use, and inpatient visit activities have not been running optimally. In conclusion, the implementation of pharmaceutical services at the Health Centers in the peripheral area of ​​Samarinda City has mostly been following standard policies, especially in the aspect of managing pharmaceutical preparations and disposable medical materials. However, strengthening of clinical pharmacy services is still needed to optimize the role of pharmacists in comprehensive pharmaceutical services.
TINJAUAN SISTEMATIS EFEKTIVITAS LAYANAN TELEFARMASI OLEH APOTEKER TERHADAP HASIL KLINIS DAN KEPUASAN PASIEN Rahman, Abdur; Adji, Adji Prayitno Setiadi; Yosi, Yosi Irawati Wibowo
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2570

Abstract

Telepharmacy is a rapidly expanding form of remote pharmaceutical care, especially since the COVID-19 pandemic, aimed at improving access to and the quality of pharmaceutical services. Despite its widespread implementation, the effectiveness of this service remains a topic of debate. Therefore, this study aims to evaluate the types and effectiveness of telepharmacy services provided by pharmacists through a systematic review. This study employed a systematic review approach following the PRISMA 2020 guidelines. Data sources were obtained from PubMed and Oxford Journal databases using relevant keywords such as ‘effectivity,’ ‘effectiveness,’ and ‘telepharmacy.’ The process involved study identification, screening, quality assessment, and data extraction, resulting in 24 articles that met the inclusion criteria. Telepharmacy services identified across the studies were categorized into four main types: 1) remote pharmacist consultation (n=10), 2) drug information provision (n=7), 3) therapeutic drug monitoring (n=5), and 4) electronic medication dispensing (n=2). Evaluation of telepharmacy effectiveness demonstrated significant improvements in several aspects, including: 1) clinical outcomes (6 out of 9 studies; p = 0.019–0.048), 2) patient satisfaction (3 out of 4 studies; p = 0.018–0.041), 3) medication adherence (12 out of 15 studies; p = 0.002–0.040), and 4) cost efficiency (all 4 studies; p = 0.021–0.048). The findings of this systematic review indicate that telepharmacy services are generally effective in improving patient clinical outcomes, patient satisfaction with services, medication adherence, and treatment cost efficiency.
PENGARUH EFEKTIVITAS PENGGUNAAN SISTEM INFORMASI TUBERKULOSIS (SITB) TERHADAP KETERSEDIAAN LOGISTIK PADA PUSKESMAS DI KABUPATEN JEMBER Suhaemi, Iim; Iim Suhaemi, Iim; Rahem, Abdul; Nita, Yunita
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2576

Abstract

The Tuberculosis Information System (SITB) is a strategic platform for optimizing TB logistics management in primary health facilities, but its use is still not optimal. This study aims to analyze the effectiveness of SITB usage and its impact on the availability of TB logistics in community health centers in Jember Regency. This study used a cross-sectional design involving 30 community health centers from July to December 2024. Variables examined included technology, management, and organizational components affecting SITB system impact. The effectiveness of SITB was evaluated using the HOT (Human-Organization-Technology) - Fit model, the relationship between components is analyzed using the Spearman rank test. The results show, despite SITB implementation since 2020, logistics availability remained inequitable is still empthy beyond the standard in primary healthcare (> 4%), but Non- antituberculosis logistic have overstocked with an average availability of more than 5 months in quarterly periode (> 150%). Correlation analysis revealed that information quality and user satisfaction significantly influenced system impact (p < 0,05). In conclusion, SITB implementation has not ensured equitable TB logistics availability across community health centers in Jember Regency, where in the used of SITB, information quality and user satisfaction are key factors influencing system impact.

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