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Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
ISSN : 2502647X     EISSN : 25031902     DOI : https://doi.org/10.36387/jiis
Core Subject : Health,
Medicine & Pharmacology
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIIS is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 457 Documents
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FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI NANOSPRAY GEL EKSTRAK ETANOL RIMPANG RUMPUT TEKI (Cyperus rotundus) TERHADAP Staphylococcus epidermidis DAN Cutibacterium acnes Ayuningtyas, Nurista Dida; Riskianto; Nayumi Gozal, Eugenia
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2867

Abstract

Acne is a common inflammatory skin condition among teens and adults. Topical treatment with chemical agents often carries the risk of irritation and photosensitization. This has led to the exploration of natural alternatives such as Nutgrass (Cyperus rotundus L.), which possesses antibacterial activity. The objective of this study was to formulate a nanospray gel as a topical delivery system and to test the antibacterial activity of the formulation against S. epidermidis and C. acnes. Cyperus rotundus was extracted via maceration using 96% ethanol; antibacterial activity tests were conducted on both the extract and the formulation. The nanospray gel formulation was prepared with varying extract concentrations: F1 (1%), F2 (2%), and F3 (3%). Subsequently, transmittance tests, physical characterization, and antibacterial activity assessments were performed using the disk diffusion method. The inhibition percentages of the extracts against S. epidermidis and C. acnes at a 35% concentration were 86.14% and 92.11%, respectively. The transmittance test results for the formulations were 94.1%, 53%, and 56%, respectively. Particle size testing of F1 yielded 158.06 ± 4.60 nm with a zeta potential of -40.46 ± 2.1 mV. The antibacterial activity test results for C. acnes in formulations F1–F3 were 1.63 mm, 2.3 mm, and 2.23 mm, respectively. The characteristics of the nanospray formulations met quality standards; however, the antibacterial activity was still weak, necessitating optimization of the extraction process.
PEMANFAATAN ULANG PELEPAH KELAPA SAWIT (Elaeis guineensis) UNTUK APLIKASI BIOMEDIS MELALUI UJI IN VITRO ANTIBAKTERI, ANTIBIOFILM, DAN ANTIOKSIDAN Setiawan, Deni; Hadi, Samsul; Mardiati, Nurul; Wathan, Nashrul; Aulia, Hilma; Najwa, Siti; Ridha, Muhammad Rasyid; Bachri, Moch. Saiful
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2869

Abstract

Elaeis guineensis fronds possess significant pharmacological potential, especially as antibiofilm and antioxidant. Previous studies have shown that E. guineensis contains flavonoids, alkaloids, tannins, and steroids that function as antioxidants. This study aims to examine the pharmacological activity of E. guineensis fronds and their antibiofilm potential. Palm fronds were macerated with aceton for 5 days. Antibacterial evaluation was conducted on four types of bacteria, and antibiofilm assessment was performed on S. aureus and E. coli. Evaluation of E. guineensis extract antioxidant activity was carried out using antioxidant tests (DPPH, FRAP, ABTS). The results of the antibacterial test showed good activity against P. acnes bacteria. The results of the antibiofilm evaluation showed significant and concentration-dependent inhibitory activity at a concentration of 1%, especially in the mid-phase for S. aureus and the maturation phase for E. coli. However, effectiveness decreased in the eradication phase. The antioxidant test showed a value of 63.93 ppm in the ABTS test. E. guineensis extract has shown strong potential as an antibacterial against P. acnes and has potential as an antibiofilm and antioxidant.
UJI EFEKTIVITAS EKSTRAK ETANOL DAUN KASTURI (Mangifera casturi Kosterm) TERHADAP PENURUNAN KADAR ASAM URAT SECARA IN VIVO Mahdi, Nur; Kamaliah, Hajatul; Syaiful, Raisha Hamiddani; Muthia Sari, Okta; Maulana Perdana Putra, Aditya
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2870

Abstract

Gout is a non-communicable disease whose prevalence continues to increase, particularly among the elderly. The treatment using medicinal plants has become widely known to the public, one of which involves kasturi leaves, which are known to contain flavonoids, alkaloids, and tannins that are potentially effective as antihyperuricemic agents. This study aimed to evaluate the effectiveness of extract of kasturi leaves in reducing uric acid levels in Mus musculus. The research employed a true experimental design with a pre-and post-test control group approach. A total of 25 mice were divided into five groups: a negative control group (Na-CMC 1%), a positive control group (allopurinol), and three treatment groups with extract doses of 3 mg/kgBW, 6 mg/kgBW, and 9 mg/kgBW. Hyperuricemia was induced using chicken liver for 7 days. Afterward, the extract was administered for another 7 days, and uric acid levels were measured before and after treatment using the Glucometer tool. The data were analyzed using ANOVA. The results showed that dose 1st reduced uric acid by 21.56%, dose 2nd by 27.15%, and dose 3th by 38.88%. Based on these findings, the ethanol extract of casturi leaves was proven effective in lowering uric acid levels and comparable to allopurinol. Statistically, dose III had a significantly different effect from the negative control and was not significantly different from allopurinol (p> 0.05). It can be concluded that the ethanol extract of casturi leaves at a dose of 9 mg/gBW has the most effective antihyperuricemic activity. The calculated ED50 value was 13.20 mg/gBW.
POTENSI KOMBINASI EKSTRAK ETANOL DAUN DADAP SEREP (Erythrina subumbrans) DAN PEGAGAN (Centella asiatica) DALAM MENURUNKAN RISIKO DISFUNGSI ENDOTEL PADA TIKUS DENGAN DIET TINGGI FRUKTOSA Kaniawati, Marita; Sulaeman, Agus; Nurfazri Istiqomah, Aulia; Efraim Lian, Kevin
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2875

Abstract

Fructose has long been known as a sugar additive or sweetener, commonly found in soft drinks, pastries, and other processed foods. High levels of added sugar in the daily diet increase the risk of various metabolic disorders, including insulin resistance. Insulin resistance can lead to impaired endothelial function (endothelial dysfunction), which can lead to impaired vasodilation responses. Endothelial dysfunction can lead to an increased risk of cardiovascular diseases such as atherosclerosis, coronary heart disease (CHD), hypertension, and other vascular diseases. The aim of this study was to identify the potential of a combination of dadap serep (Erythrina subumbrans) and pegagan (Centella asiatica) to reduce the risk of endothelial dysfunction (as measured by nitric oxide (NO) levels) triggered by high fructose consumption. This research method is an in vivo experimental preventive using 36 rats divided into normal group, induction group, comparison group of curcumin 9 mg/kgBW, test group 1 EEPDS 50:100 mg/kgBW, test group 2 EEPDS 100:100 mg/kgBW and test group 3 EEPDS 100:50 mg/kgBW. Measurement of NO levels using the Griess method, while insulin resistance examination was carried out using the insulin tolerance test method. The results showed that the combination group of EEPDS 100:50 mg/kgBW was the group that showed the most optimal effect in maintaining endothelial function and had the best insulin sensitivity. The conclusion of this study shows that the combination of EEPDS 100:50 mg/kgBW is effective in maintaining insulin sensitivity and maintaining endothelial function in rats.
POTENSI ANTIATEROGENIK KOMBINASI EKSTRAK ETANOL RIMPANG KUNYIT DAN DAUN PEGAGAN DALAM MENURUNKAN RISIKO PENYAKIT KARDIOVASKULAR PADA MODEL HEWAN TIKUS OBES Lestari, Kharina Septi; Istiqomah, Aulia Nurfazri; Farihah, Ai Siti; Ramadhan, Dika Azhar; Kaniawati, Marita; Sulaeman, Agus
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2882

Abstract

Obesity is a major risk factor for atherosclerosis and cardiovascular disease, characterized by dyslipidemia and oxidative stress. This study aimed to evaluate the anti-atherogenic effects of a combination of ethanol extracts of turmeric rhizome (Curcuma longa) and gotu kola leaves (Centella asiatica) in obese–hyperlipidemic rats.  Male rats were divided into seven groups: normal, induction, comparator (orlistat 10.8 mg/kgBW), and treatment groups receiving single and combined extracts (ERK, EDP, ERKDP 200:100, ERKDP 100:200 mg/kgBW). Obesity and hyperlipidemia were induced using a high-fat and fructose diet for 60 days. Parameters measured included body weight, lipid profile (TG, HDL, LDL, total cholesterol), Atherogenic Index of Plasma (AIP), and aortic histology. The induction group showed significant increases in body weight, triglycerides, LDL, and AIP (P<0.05). All treatment groups significantly improved lipid profiles and reduced AIP compared to the induction group. The ERKDP 100:200 mg/kgBW combination showed the most optimal effect, with a 51.83% reduction in LDL, a 54.60% decrease in AIP, and a 146% increase in HDL. Histological analysis also demonstrated reduced foam cell formation and improved aortic structure in this group. In conclusion, the combination of turmeric and gotu kola extracts, particularly at a dose of 100:200 mg/kgBW, exhibits significant anti-atherogenic potential through lipid profile improvement, AIP reduction, and vascular protection.
PEMANTAUAN PROSES EKSTRAKSI Curcuma xanthorrhiza Roxb. DENGAN METODE REFRAKTOMETRI DAN GRAVIMETRI Pattymahu, Charlyna Veronika Puspitasari; Kusumawati, Idha; Isadiartuti, Dewi
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2910

Abstract

Rapid in-process control (IPC) is essential in the extraction of Curcuma xanthorrhiza Roxb. rhizomes to ensure quality consistency. Refractometry based on Total Soluble Solids (TSS) offers an efficient IPC alternative; however, its quantitative validity relative to gravimetric yield in hydroalcoholic matrices requires systematic verification. This study aimed to evaluate the correlation between TSS profiles (°Brix) and total solids yield during the stepwise ultrasound-assisted extraction (UAE) of C. xanthorrhiza rhizomes using 70% ethanol. Extraction was performed using a sonicator bath (40 kHz, 120 W) in a stepwise manner (E1-E12) with sampling intervals every 30 minutes up to 360 minutes. Physicochemical parameters were monitored via TSS values (°Brix) and compared with gravimetric total solids determination. The relationship between variables was analyzed using Spearman correlation and linear regression. The analysis demonstrated a strong Spearman correlation between °Brix values and yield (ρ = 0.984; p < 0.001). The linear regression model showed high predictive accuracy with an R² of 0.986, and low error rates (MAE = 0.09% and RMSE = 0.14%). A stable plateau phase was reached at stages E9-E12, achieving a maximum yield of 8.31% at a TSS value of 9.00 °Brix. The refractometric method is a valid, rapid, and reliable IPC tool for monitoring the ultrasonic extraction of C. xanthorrhiza, providing real-time yield estimation comparable to the conventional gravimetric method.
ANALYSIS OF RISK FACTORS AND TREATMENT PHASES ON THE SEVERITY OF HEPATOTOXICITY DUE TO ANTI-TUBERCULOSIS DRUGS Isnani, Nazhipah; hadi, Samsul; Sandi, Dita Aulia Dwi; Rahmatullah, Satrio Wibowo; Adikusuma, Wirawan; Saksono, Reni Yustiati; Auralia, Najma; Maulida, Khelda; Setiawan, Feri
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2911

Abstract

Hepatotoxicity caused by anti-tuberculosis drugs (OAT) is one of the adverse effects of tuberculosis therapy and may lead to liver dysfunction. This study aimed to analyze the relationship between age, gender, and treatment phase with the severity of OAT induced hepatotoxicity, as well as to assess factors influencing the increase in hepatotoxicity grade. This research employed a retrospective cross-sectional design and was conducted at Ulin Regional Hospital Banjarmasin using a total sampling method involving 45 tuberculosis patients. Secondary data were obtained from medical records of TB patients in 2024–2025. The results showed that 62.2% of patients were under 60 years old and 37.8% were over 60 years old. Male patients accounted for 75.6%, while females accounted for 24.4%. The distribution of hepatotoxicity grades was 40% normal, 28.9% grade 1, 20% grade 2, and 11.1% grade 3. Based on the treatment phase, 91.1% of patients were in the intensive phase and 8.9% were in the continuation phase. The Chi square test revealed no significant association between age, gender, or treatment phase and the severity of hepatotoxicity.
IMMUNOSTIMULANT EFFECTS OF PROPOLIS: A study of cytokine production Putri, Mutiara Sani Demira; Fitriani, Hannie; Syukri, Yandi; Ramadani, Arba Pramundita
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2926

Abstract

Propolis is a natural substance derived from bee resin and has long been used in traditional medicine because of its diverse bioactive compounds, especially flavonoids. This study aims to assess the immunostimulant effects of propolis on cytokine expression based on existing scientific research. A narrative review was conducted by collecting literature from PubMed, ScienceDirect, and Google Scholar. Initially, 48 articles were identified, and 15 articles that met the inclusion criteria were further analyzed. The results show that propolis has immunomodulatory activity through multiple mechanisms, including inhibiting the NF-κB pathway, reducing COX-2 expression, and suppressing nitric oxide (NO) production. Propolis also boosts macrophage activation, promotes phagocytosis, and increases the expression of pro-inflammatory cytokines such as IL-1β, IL-6, IL-2, and IFN-γ. However, under excessive inflammatory conditions, propolis decreases pro-inflammatory cytokine expression, indicating an adaptive immunoregulatory response. In conclusion, propolis has strong potential as a natural immunostimulant that works contextually according to the host’s immunological status and may be developed as a future herbal therapeutic agent.
ANALISIS HOMA TERHADAP RESISTENSI INSULIN DAN FUNGSISEL β PANKREAS PADA TIKUS WISTAR (Rattus norvegicus) MODEL DIABETES ALOKSAN SETELAH PEMBERIAN EKSTRAK BONGGOLNANAS (Ananas comosus (L.) Merr.) Arif, Muhammad Azka Azkiya; Yosha Putri Wahyuni; Isniani Ramadhani; Cut Fauziah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2939

Abstract

Diabetes mellitus refers to a metabolic condition characterized by resistance to insulin and abnormalities in pancreatic β-cell function. Pineapple core (Ananas comosus (L.) Merr.) is known to contain bioactive compounds with potential effects on glucose also insulin metabolism. This research aimed to analyze insulin sensitivity using HOMA-IR also HOMA-β in alloxan-induced diabetic Wistar rats (Rattus norvegicus) following administration of pineapple core (Ananas comosus (L.) Merr.) extract. This study employed an experimental laboratory design with a posttest-only control group. Male Wistar rats were induced with alloxan and divided into a control groups and treatment groups receiving graded doses of pineapple core (Ananas comosus (L.) Merr.) extract. Fasting blood glucose levels were measured using a glucometer, while plasma insulin levels were determined using the ELISA method. HOMA-IR and HOMA-β values were calculated to asses insulin sensitivity also pancreatic β- cell function. The results showed a significant difference in HOMA-IR and HOMA- β values between the negative control group and the high dose treatment group (100%) (treatment 3), with a p-value of 0.034. Pineapple core (Ananas comosus (L.) Merr.) extract has the potential to enhance pancreatic β-cell function and significantly improve insulin resistance based on HOMA-IR also HOMA-β parameters in alloxan-induced diabetic Wistar rats.
IDENTIFIKASI SENYAWA YANG BERPOTENSI SEBAGAI ANTIDIABETES PADA EKSTRAK ETANOL 30% DAUN KUMIS KUCING (Orthosiphon aristatus) HASIL KULTUR JARINGAN DAN BUDIDAYA Farhan; Syamsudin; Farayamuda, Fahrauk; Dewi Yuliana, Nancy
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2949

Abstract

Orthosiphon aristatus ( cat's whiskers ) is traditional medicinal plant that contains many secondary metabolite compound such as flavonoids, phenolics acids, and diterpene derivatives and can be used to treat metabolic disorder including inflammation , urinary tract disorders and diabetes. This study aims to compare the secondary metabolite profile of 30% ethanol extract of cat's whiskers leaves from tissue culture and conventional cultivation. Extraction was carried out using Ultrasonic Assisted Extraction (UAE) method and the compounds were identified using Liquid Chromatography–High Resolution Mass Spectrometry (LC-HRMS). The analysis results showed that there were 5 types of dominant compounds in the tissue culture extract, including rosmarinic acid (20.46%), malic acid (6.34%), quinic acid (5.52%), chicoric acid (4.52%), and vanillylmandelic acid (3.4%). The cultivated extract contained rosmarinic acid (11.36%), malic acid (4.7%), ferulic acid (9.46%), vanillylmandelic acid (4.95%), and methylmalonic acid (4.15%). The compounds epigallocatechin gallate (EGCG), isoquercetin, quercitrin, and carmine were only detected in tissue culture. These results indicate that tissue culture techniques can influence the biosynthesis and accumulation of certain secondary metabolites in plants, thus potentially being used to produce high-quality raw materials in the development of phytopharmaka products.

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