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Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Published by Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
ISSN : 2502647X     EISSN : 25031902     DOI : https://doi.org/10.36387/jiis
Core Subject : Health,
Medicine & Pharmacology
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIIS is a forum for the publication of quality and original works that open discussions in the field of pharmacy and health sciences.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 457 Documents
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POTENSI AKAR BURDOCK SEBAGAI BENTUK PROTEKTIF RADIKAL BEBAS PADA SALURAN PERNAPASAN PEROKOK AKTIF STUDY IN-VIVO PADA TIKUS JANTAN Faizal, Imam Agus; Octaviany, Frinsisca; Pangesti, Ira; Puspodewi, Dini; Sa'adah, Arina Lis
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2561

Abstract

Exposure to cigarette smoke is known to trigger oxidative stress and trigger an inflammatory response in lung tissue. Lung organs are highly susceptible to damage due to continuous exposure to pollutants, especially free radicals. This condition has the potential to cause pathological changes in the structure of lung cells. This study aimed to evaluate the difference in histological changes in rat lungs between the group not exposed to conventional cigarette smoke (control group) and the group exposed to cigarette smoke accompanied by the administration of burdock root extract, ethanol solvent, methanol, and vitamin E. Exposure was carried out 7 times for 14 days, using one cigarette for each treatment session. The results of the observation showed that all the groups that received exposure had lung tissue damage. Based on the average histopathological score, the rate of lung damage was grouped as follows: K1 (negative control) of 4.6; K2 (positive control) of 7; P1 (treatment with ethanol) of 5.6; P2 (treatment with methanol) of 8.6; and P3 (treatment with vitamin E) by 6.6. The group with the highest level of damage was P2 (methanol) which fell into the severe damage category, while the lowest level of damage was found in P1 (ethanol), which fell into the light category.
AKTIVITAS TONIKUM EKSTRAK ETANOL 96% BUNGA KAMBANG PUTIH (Plumeria rubra)  PADA MUS MUSCULUS   BALB/c Ulfa, Anna Maria; Purnama Sari, Wahyu Niar Wulan; Soka, Burhanudin Gasim
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2593

Abstract

Tonic is a preparation used to increase physical strength or stamina. White frangipani (Plumeria rubra) is known to have several potentials such as anti-free radicals, antimicrobials, anti-inflammatory, and contains bioactive compounds such as flavonoids, heterocyclic nitrogen bases, and phenolics. This experiment aims to determine the potential tonic activity of white frangipani flowers extracted with 96% ethyl alcohol on BALB/c musculus and the optimum dose. Tonic activity was evaluated using the natural exhaustion method by measuring the swimming time of mice until exhaustion. The musculus used consisted of 5 groups with 5 replications each, each containing 0.5% sodium carboxymethylcellulose as a negative control, caffeine as a positive control, with variations in doses of 100, 200, and 400mg/kgBW. The results of the treatment showed that the ethanol extract of white frangipani flowers significantly increased the swimming time of mice compared to the negative control. Data processing using one-way ANOVA and subsequent Tukey HSD tests showed a p<0.05 result for the negative control, and differences between treatment groups. The optimal dose was obtained with treatment at 400 mg/kg body weight compared to other doses and was close to the dose in the positive control. The conclusion of this experiment is that frangipani flower extract has potential as a tonic.
ANALISIS COST EFFECTIVENESS METHOTREXATE VS LEFLUNOMIDE PADA TERAPI RHEUMATOID ARTHRITIS: NARRATIVE REVIEW DAN IMPLIKASI DI INDONESIA Mardia, Sita Rizky; Gondokesumo, Marisca Evalina; Pratama, Jainuri Erik
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2658

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with substantial clinical and economic burden. Methotrexate (MTX) is recommended as first-line therapy, whereas leflunomide (LEF) is used as an alternative or adjunctive treatment in specific clinical circumstances. This review aims to analyze the comparison between LEF and MTX from the perspectives of clinical efficacy, health economic assumptions, and their relevance within Indonesia’s National Health Insurance system (Jaminan Kesehatan Nasional, JKN). A narrative review methodology was employed, synthesizing international and national clinical and pharmacoeconomic studies published between 1999 and 2024. The findings indicate that the clinical effectiveness of LEF and MTX is generally comparable; however, most economic models developed in high-income countries rely on cost structures, utility values, and willingness-to-pay (WTP) thresholds that limit their transferability to the Indonesian context. Within the JKN framework, which emphasizes cost containment and budget efficiency, MTX remains the most cost-effective first-line therapy due to its low generic price and adequate clinical effectiveness. LEF retains a role as an alternative or sequential therapy and may be considered an intermediate strategy prior to escalation to substantially more expensive biologic agents. Significant local evidence gaps persist, particularly regarding long-term economic models based on national data, incremental cost-effectiveness ratio (ICER) analyses, and budget impact evaluations within the BPJS system. The development of pharmacoeconomic models grounded in the national payer perspective is therefore essential to support more context-specific and sustainable policy decision-making.
PEMBUATAN, UJI FISIKOKIMIA DAN UJI STABILITAS MINYAK KELAPA (Cocos nucifera L.) RENDAH FREE FATTY ACIDS (FFA) DARI LIMBAH KULIT BUAH KELAPA (TESTA) Sairi, Ahmad; Liandhajani, Liandhajani; Iqbal, Muhammad; Triyandi, Ramadhan; Yudha Asmara, Donny
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2781

Abstract

Coconut (Cocos nucifera L.) is an important commodity for Indonesia’s economy, with testa (coconut seed coat) waste commonly found in traditional markets. A survey in Bandar Lampung revealed daily testa waste production of 13.5–18.0 kg. This study aimed to explore the potential of coconut testa oil through extraction and esterification processes. Extraction was performed using a fat extractor E-500 with n-hexane solvent at heating levels 2, 5, and 8, followed by esterification. The results showed that testa oil contained 1.36% free fatty acids (FFA). Physicochemical analysis using GC-MS demonstrated identical chromatogram peaks between testa oil and Brc oil, with saturated fatty acids bound as triglycerides. The unsaturated fatty acid content in testa oil (0.28%) was slightly higher than in Brc oil (0.27%). Accelerated Shelf Life Test (ASLT) predicted a shelf life of four months for testa oil. In conclusion, coconut testa oil has potential as a vegetable oil source with physicochemical characteristics comparable to Brc oil, although its unsaturated fatty acid content remains relatively low.
PENGARUH EKSTRAK BATANG AKAR KUNING (Arcangelisia flava (L.) Merr.) TERHADAP AKTIVITAS SEKSUAL MENCIT JANTAN (Mus musculus) SECARA IN VIVO Istiqamah, Farida; Sandhori, Fajar Jamaluddin; Ainah, Nur; Amalia, Senya Puteri; Lestari, Desy Ayu
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2799

Abstract

Disfungsi seksual merupakan masalah umum di kalangan banyak orang dewasa dan dapat diobati dengan mengonsumsi obat herbal. Salah satu tanaman yang berpotensi sebagai afrodisiak adalah Akar Kuning (Arcangelisia flava (L.) Merr.). Penelitian ini bertujuan untuk menentukan aktivitas afrodisiak ekstrak etanol 70% dari Akar Kuning (Arcangelisia flava (L.) Merr.) menggunakan uji in vivo. Penelitian ini menggunakan uji perilaku seksual mencit jantan pendekatan, menunggangi , dan kawin. Jumlah mencit percobaan adalah 25 pasang (25 mencit jantan dan 25 mencit betina) yang dibagi menjadi lima kelompok. Kelompok I (suspensi CMC-Na), kelompok II, III, dan IV masing-masing menggunakan ekstrak etanol 70% akar kuning (150 mg/kgBB, 200 mg/kgBB, dan 250 mg/kgBB), dan kelompok V (sildenafil 0,13 mg/20g BB tikus). Pengamatan dilakukan selama satu hari menggunakan kotak libidometer yang dilengkapi dengan CCTV, kipas angin, dan lampu merah. Data dianalisis menggunakan SPSS versi 25. Berdasarkan hasil, kelompok IV (250 mg/kgBB) merupakan dosis paling optimal karena menghasilkan efek afrodisiak tertinggi pada semua parameter dibandingkan dengan kelompok II (150 mg/kgBB) dan kelompok III (200 mg/kgBB). Berdasarkan hasil penelitian ini, dapat disimpulkan bahwa ekstrak etanol 70% akar kuning (Arcangelisia flava (L.) Merr.) dapat meningkatkan efek afrodisiak.
POTENSI AKTIVITAS ANTIOKSIDAN DAN PENETAPAN KADAR FENOLIK TOTAL EKSTRAK DAUN KRATOM (Mitragyna speciosa Korth.) MENGGUNAKAN VARIASI PELARUT Riski, Akhmad; Nanang Fakhrudin; Agung Endro Nugroho; Rakhmadhan Niah; Lalu Husnul Hidayat
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2802

Abstract

Kratom (Mitragyna speciosa) is a medicinal plant native to Southeast Asia that contains a wide range of secondary metabolites. The characteristics of medicinal plant extracts are strongly influenced by the type of solvent used during the extraction process, particularly with respect to phenolic compounds that play a key role in antioxidant activity. This study aimed to evaluate the antioxidant activity and total phenolic content of Mitragyna speciosa leaf extracts obtained using solvents with different degrees of polarity. Kratom leaves were extracted with water using the decoction method, as well as with 70% and 90% ethanol using the maceration method. Total phenolic content was determined by Spectrophotometer UV–Vis employing the Folin–Ciocalteu reagent with gallic acid as the standard, while antioxidant activity was assessed based on IC₅₀ values using the DPPH assay. The results showed that the total phenolic content of the water, 70% ethanol, and 90% ethanol extracts was 81.27 ± 0.13, 93.85 ± 0.07, and 99.21 ± 0.07 mg GAE/g extract, respectively. Antioxidant activity analysis revealed IC₅₀ values of 64.71 µg/mL for the water extract (strong antioxidant), 35.52 µg/mL for the 70% ethanol extract (very strong antioxidant), and 35.12 µg/mL for the 90% ethanol extract (very strong antioxidant). Based on these findings, the 90% ethanol extract exhibited the highest total phenolic content and the most potent antioxidant activity, indicating its potential for development as a natural antioxidant source derived from kratom leaves.
IDENTIFIKASI TURUNAN ASAM KARBOKSILAT AKAR Acalypha indica SEBAGAI KANDIDAT INHIBITOR GFAT MELALUI LC-HRMS DAN STUDI IN SILICO Arviani; K. Salimi, Yuszda; Bialangi, Nurhayati; Chandra Lakasan, Ahmad; Nur Rahman, Zifran
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2828

Abstract

Diabetes mellitus remains a major global health challenge, prompting the exploration of natural products as sources of safer antidiabetic agents. This study aimed to identify bioactive compounds from the roots of Acalypha indica and evaluate their potential as inhibitors of glutamine–fructose-6-phosphate amidotransferase (GFAT), an enzyme involved in glucose metabolism. Compound profiling was conducted using liquid chromatography–high resolution mass spectrometry (LC-HRMS), while the inhibitory potential against GFAT was assessed through in silico docking. This integrated approach has not been previously reported. Metabolite profiling using LC-HRMS tentatively identified thirteen carboxylic acid derivatives, including hydroxycinnamic acid, gluconic acid, trans-aconitic acid, and glucoheptonic acid. molecular docking analysis revealed strong binding affinities of several compounds toward GFAT.  Glucoheptonic acid exhibited the lowest binding energy (−8.0 kcal/mol), followed by xylaric acid A (−7.9 kcal/mol) and trans-aconitic acid (−7.5 kcal/mol). These compounds interacted with key active-site residues Gln421, Ser420, Ser422, and Lys675, suggesting a potential enzyme inhibition mechanism. In silico pharmacokinetic analysis indicated that 2-hexylpentanedioic acid exhibited favorable ADME properties, with high gastrointestinal absorption, no major inhibition of CYP450, and low predicted acute toxicity risk. These findings highlight Acalypha indica roots as a promising source of bioactive carboxylic acid derivatives, with glucoheptonic acid emerging as the most promising candidate for further in vitro evaluation as a GFAT inhibitor
FORMULASI DAN KARAKTERISASI NANO FITOSOM ANTIDIABETES DARI EKSTRAK ETANOL BUAH MENGKUDU (Morinda Citrifolia L.) DENGAN METODE HIDRASI LAPIS TIPIS Rosyada, Amrina; Noval; Yulia Hastika, Febby; Budi, Setia; Febrianti, Dwi Rizki
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2848

Abstract

Diabetes mellitus causes high blood sugar levels due to pancreatic metabolic disorders. Noni fruit (Morinda Citrifolia L.) with xeronine content is used. This study created a New Drug Delivery System (NDDS) based on nanophytosomes to overcome blood glucose metabolism problems. Nanophytosomes encapsulate active substances from plant extracts (phytoconstituents) with lipids or phospholipids such as phosphatidylcholine for easier absorption and use. This study examined the formulation results and the effects of cholesterol on noni fruit extract nanophytosomes. This study used a quasi-experimental design, one group posttest. Thin film hydration was used to create nanophytosomes with different cholesterol contents from noni fruit extract. The research formula meets the requirements with particle size results of 271.3-501.3 nm (p-0.24), polydispersity index of 0.614-1.902 nm (p-0.947), zeta potential -10.8 - (-21.7) mv (p-0.998), adsorption efficiency of 70.83%-92.66% (p-1.000), and non-spherical surface morphology. The evaluation results show that F2 with a cholesterol concentration of 1.5 g is a good formula because it has an adsorption efficiency of 92.66% and a fine particle size.
ANALISIS BIAYA PADA PASIEN GANGGUAN HORMON TIROID DI RUMAH SAKIT PUSAT ANGKATAN LAUT DR. RAMELAN SURABAYA Nabila, Muthma'innatun; Nita, Yunita; Libriansyah; Lestiono; Ridwan, Achmad
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2854

Abstract

Thyroid hormone disorders, such as hyperthyroidism and hypothyroidism, are common endocrine diseases that impose a considerable economic burden. This study aimed to analyze the components of treatment costs among outpatients with thyroid hormone disorders at RSPAL Dr. Ramelan Surabaya and to examine the relationship between patient characteristics and total treatment costs. A cross-sectional design was employed from both patient and hospital perspectives, involving 86 outpatients during the period of May to July 2025. Data on direct medical costs were obtained from the hospital billing system and out-of-pocket expenses through patient interviews, while direct non-medical and indirect costs were collected through structured interviews. The results showed that most patients were female (69 patients; 80.23%) with a mean age of 42 years, and hyperthyroidism was the most common diagnosis (n=54). The total annual cost reached IDR 1,618,002,478, with an average of IDR 18,813,982 per patient. Direct medical costs represented the largest component, with laboratory examinations accounting for the highest expenditure (an average of IDR 8,245,814 per patient per year). Statistical analysis revealed significant associations between age (p=0.007) and BPJS insurance class (p=0.049) with direct medical costs, employment status (p=0.025) with direct non-medical costs, and both age (p=0.014) and employment status (p=0.000) with indirect costs. In conclusion, the treatment costs of thyroid disorders are predominantly driven by direct medical expenses, with variations influenced by age and insurance class.
KARAKTERISASI FISIK LIP BALM DENGAN EKSTRAK BIJI KURMA SEBAGAI ANTIOKSIDAN DAN PEWARNA ALAMI BUNGA BATAVIA Alfian, Muhammad; Hasanudin, Muhammad Nurul; Nisa, Askina Khoirun; Irawan , Hisba Cahyani
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2857

Abstract

The growing demand for cosmetics within the community has spurred innovation in the use of herbal ingredients. Lip balm is one such cosmetic product that can benefit from the incorporation of natural components, including antioxidant compounds and natural dyes. This study aims to formulate a lip balm by integrating date seed extract as an antioxidant and batavia flower extract as a natural dye. The extraction process utilizes the maceration method with 96% ethanol as the solvent, followed by assessing the antioxidant activity through the DPPH method. Variations in the concentration of batavia flower extract in the lip balm formulation are set at 1.2%, 2.5%, and 3.7%, with a fixed date seed extract concentration of 2.5%. The evaluation of the lip balm's quality includes organoleptic tests, homogeneity tests, melting temperature tests, and pH tests. The antioxidant activity test on date seed extract yielded an IC50 value of 30.92 ppm, indicating a classification of strong antioxidant activity. The results for the three lip balm formulations exhibited consistent characteristics, including a pink color, a semi-solid consistency, a pH level range 6.5–6.7, and a melting point within the recommended range (52–57°C). In conclusion, the lip balm formulation incorporating date seed extract and batavia flower extract meets acceptable physical parameters for a lip balm product.

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