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Erina Yatmasari
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Oceana Biomedicina Journal
Published by Universitas Hang Tuah
ISSN : -     EISSN : 26140519     DOI : https://doi.org/10.30649/obj
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
Oceana Biomedicina Journal is an open access journal of health and medicine. Specifically, the journal focuses on marine medicine, hyperbaric medicine and health, medicine on ships, harbor health, maritime and coastal health, medicolegal studies related to ships, ports and districts, maritime/coastal communities and fishermen, epidemiological aspects of diseases, disabilities and disorders that occur on ships and affect boat workers, ports and maritime zones, coastal areas, fishermen communities and their families, including pharmacological and non-pharmacological prevention and treatment management policies; and miscellanous.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 51 Documents
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The Infection of Vibrio parahaemolyticus in Shrimp and Human Rian Ka Praja; Dwi Putri Safnurbaiti
Denta Journal Kedokteran Gigi Vol 1 No 1 (2018): Oceana Biomedicina Journal Vol 1 Issue (No) 1 January-June 2018
Publisher : Universitas Hang Tuah

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Abstract

Vibrio parahaemolyticus is an aquatic zoonotic agent that can threaten human and aquaculture animal health. Humans can be infected by consuming contaminated raw seafood or wound-related infections. Generally infection of V. parahemolyticus is orally transmitted and causes gastroenteritis in humans while in aquaculture animals especially shrimp can cause Acute Hepatopancreatic Necrosis Disease (AHPND) or Early Mortality Syndrome (EMS) with a very high mortality rate and cause economic losses. Shrimp species susceptible to infection are Litopenaeus vannamei, Penaeus monodon, and P. chinensis. V. parahaemolyticus produces several toxins in human disease such as thermostable direct hemolysin (TDH), TDH-related haemolysin (TRH), and thermolabile hemolysin (TLH). Meanwhile, Photorabdus insect-related (Pir) toxins consisting of PirAvp and PirBvp are the toxins associated with AHPND in shrimp. The genes that encode the toxin are used as targets to diagnose V. parahaemolyticuspathogens molecularly. Until now the treatment of V. parahaemolyticus infection is using antibiotics and fluid therapy, but there were V. parahaemolyticus isolates from aquaculture that have been resistant to antibiotics so that the use of antibiotics in aquaculture must be controlled and the use of alternative therapy are very important to be developed to control V. parahaemolyticus infection.
Ethanolic Extract of The Graptophyllum Pictum Griff Leaves to Male White Rat Setya Enti Rikomah; Gina Lestrari; Juwita Winanti
Denta Journal Kedokteran Gigi Vol 1 No 1 (2018): Oceana Biomedicina Journal Vol 1 Issue (No) 1 January-June 2018
Publisher : Universitas Hang Tuah

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Abstract

Utilization of plants as traditional medicinal are still always be used by people in Indonesian. Especially in rural areas that still rich with variety of plants. Plants of black pudding leaves (Graptophyllum pictum Griff) are one that efficacious for treating various of diseases. The content of flavonoid in the black pudding leaves have antipyretic effect, analgesic and anti-inflammatory. This research aims to find out whether the black pudding leaves have antipyretic effect or not. This research used the induction method of vaccineDPT-Hb 0.022 / 20 gr a white rat as stimulant fever. Positive control with paracetamol 1.3 mg / 20 gram a white rat, negative control with Na CMC 0.5 ml / 20 grams a white rat, first extract test of black pudding leaves 0.8 mg / 20 gram a white rat, second extract test of black pudding leaves 1.6 / 20 gram a white rat, and third extract test of black pudding leaves 3.2 / 20 gram a white rat. The results of research showed that ethanol extract of black pudding leaves if it’s looked from statistic result of SPSS 16 program , it doesn’t show out of any effect as antipyretic effect because the significant value is P> 0.05.
ANALISIS BIAYA DAN NILAI UTILITAS PASIEN HEMODIALISA YANG DIBERIKAN TERAPI SEVELAMER KARBONAT Dwi Putri Safnurbaiti; Tri Murti Andayani; Fredie Irijanto
Denta Journal Kedokteran Gigi Vol 1 No 2 (2018): Oceana Biomedicina Journal Volume 1 Issue (No) 2 July - December 2018
Publisher : Universitas Hang Tuah

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Abstract

Sevelamer karbonat merupakan alternatif lain sebagai terapi pengikat fosfat yang diberikan kepada pasien hemodialisa selain CaCO3. Sevelamer karbonat dapat menurunkan kadar fosfat, mengurangi kejadian kalsifikasi vaskular dan mortalitas yang secara langsung berdampak pada perbaikan kualitas hidup pasien hemodialisa, namun harga sevelamer karbonat lebih mahal dibandingkan dengan CaCO3. Penelitian ini bertujuan untuk mengetahui gambaran biaya yang diperlukan untuk terapi sevelamer karbonat dan nilai utilitas pasien hemodialisa yang menggunakan terapi sevelamer karbonat di RS UGM Yogyakarta.Penelitian dilakukan secara prospektif selama 8 minggu di RS UGM Yogyakarta pada bulan Oktober-November 2016. Desain penelitian adalah quasi eksperimental dengan “pretest posttest design with control group”. Kelompok eksperimental adalah sevelamer karbonat dan kontrol adalah CaCO3. Pengukuran health related quality of life(HRQOL) pasien hemodialisa salah satunya dengan mengukur utilitas pasien hemodialisa dengan kuesioner EQ-5D-5L pada awal (pre) dan akhir (post) penelitian. Analisis biaya dilihat berdasarkan perspektif rumah sakit dengan menghitung total direct medical cost.Jumlah total responden dalam penelitian ini adalah 37 pasien yang terdiri atas 16 pasien kelompok eksperimental dan 21 pasien kelompok kontrol. Rata-rata biaya yang diperlukan pasien hemodialisa dengan sevelamer karbonat untuk menangani kondisi gangguan mineral dan tulang adalah sebesar Rp 2.999.188,75±167.920,75 per pasien selama 8 minggu terapi. Nilai utilitas dan skor EQ-5D VAS baseline pasien hemodialisa yang diberikan sevelamer karbonat adalah masing-masing 0,91±0,13 dan 75,93±9,34, dan di akhir penelitian (posttes) terdapat perubahan nilai utilitas dan skor EQ-5D VAS sebesar 0,93±0,08 dan 77,44±11,12. Hasil uji statistik menunjukkan bahwa perubahan nilai utilitas dan skor EQ-5D VAS pasien hemodialisa yang diberikan sevelamer karbonat antara awal (pre) dan akhir penelitian (posttes) adalah menunjukkan tidak berbeda bermakna (p>0,05).
Empirical Antibiotic Therapy Assessment of Patients diagnosed with Sepsis in Intermediate Care Ward of Internal Medicine Department of Dr. Soetomo General Hospital according to Gyssens Method Ronald Pratama Adiwinoto
Denta Journal Kedokteran Gigi Vol 1 No 2 (2018): Oceana Biomedicina Journal Volume 1 Issue (No) 2 July - December 2018
Publisher : Universitas Hang Tuah

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Abstract

Rational empirical antimicrobial therapy is an important component of sepsis patient management. This study aimed to assess the rationality of empirical antimicrobial therapy in patients diagnosed with sepsis admitted in intermediate care ward of internal medicine department (RPI) of Dr. Soetomo General Hospital from January 2016 to July 2017. Medical records of 91 patients diagnosed with sepsis were collected and studied retrospectively in period from July 2017 to November 2017. 91 (85.05%) medical records from 107 sepsis patients were evaluated. Cultures and antimicrobial sensitivity tests were carried out in 21 (23.07%) patients. 14 patients yielded positive culture results, 9 of which were MDRO positive with ESBL as resistant marker. Empirical antibiotic therapies for these patients were reviewed according to Gyssens method.73 (80.2%) of 91 patients were deemed receiving appropriate empirical antibiotic therapies. Ceftriaxone IV injection as monotherapy or combination therapy were the most common empirical antibiotic therapies (82 in 91 patients, 90.1%), despite local microbiologic flora and antibiogram show most pathogens were resistant to ceftriaxone. Mortality rate in this study was high, 92.3% (84 patients died) despite rational empirical antibiotic therapies were high.This study concluded that empirical antibiotic therapies in sepsis patients according to guidelines adopted in Soetomo General Hospital, albeit deemed rational, was no longer appropriate according to local antibiogram issued by microbiological department of Soetomo General Hospital.
PERKEMBANGAN TERKINI TERAPI RHEUMATOID ARTHRITIS (bagian 2) Hendrata Erry Andisari
Denta Journal Kedokteran Gigi Vol 1 No 2 (2018): Oceana Biomedicina Journal Volume 1 Issue (No) 2 July - December 2018
Publisher : Universitas Hang Tuah

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Abstract

Therapy in RA has undergone many advances today and in line with knowledge of the pathogenesis of RA, the current therapeutic goal is to alter the journey and control the activity of RA disease. Several groups of drugs have been used in RA therapy including non-steroidal anti-inflammatory drugs (NSAIDs), conventional disease-modifying antirheumatic drugs (DMARDs) as well as biological agents (bDMARD), glucocorticoids and anti-pain medicines. In recent years, the development of biological agents that have specific targets for inflammatory mediators such as interleukin (IL) -1, IL-6 and Tumor Necrosis Factor (TNF) suggests a potent therapeutic effect on RA. In this article will be presented the latest biological agents as the latest therapy on RA.
CERVIX CARCINOMA: PATHOLOGICAL ASPECT Eva Pravitasari Nefertiti
Denta Journal Kedokteran Gigi Vol 1 No 2 (2018): Oceana Biomedicina Journal Volume 1 Issue (No) 2 July - December 2018
Publisher : Universitas Hang Tuah

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Abstract

Cervix carcinoma is a malignancy at squamocollumnar junction, in the border between ecto and endo cervix. Lesion at this site is frequently correlated with chronic inflammatory of the cervix, displacia, and in situ carcinoma. In Indonesia, cervix carcinoma is the most common malignancy in women. At Obstetry and Gynecology Department of RSCM during 1986-1990 period, 2360 gynocology carcinoma were found, and 1821 (77,2%) cases of them were cervix carcinoma.The diagnosis was made based on cytology, colposcopy, biopsy, endocervix curettage and conitation. Papanicolaou test is a useful in detecting early stage of cervix carcinoma up to 90% accuration. The speciment for paps smear is secrets of the vagina, cervix, endocervix, endometrium, and posterior fornix.
Molecular Mechanism of Cholerae Toxin (ctx) in Causing Diarrhea Rian Ka Praja; Reny Rosalina
Denta Journal Kedokteran Gigi Vol 1 No 2 (2018): Oceana Biomedicina Journal Volume 1 Issue (No) 2 July - December 2018
Publisher : Universitas Hang Tuah

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Abstract

Vibrio cholerae is one of the pathogenic bacteria transmitted through contaminated food, especially contaminated seafood and beverages. V. cholerae produces cholerae toxin (ctx) which is encoded by the ctx gene located within its chromosome. This toxin has been recognized as one of the toxins responsible for cholera outbreaks. The mechanism of ctx gene expression is induced by environmental signals such as pH, osmolarity, temperature, bile, amino acids, and CO2. These signals will be a positive transcriptional factor to the ToxR gene that regulates the biogenesis of cholerae toxin. After cholerae toxin has been successfully expressed, V. cholerae uses a type II secretion (T2S) pathway to deliver cholerae toxin to the extracellular environment. Cholerae toxin consists of A and B subunits. The B subunit plays a role in attaching to the receptor Manosialosyl Ganglioside (GM1 ganglioside) and the Asubunit plays a role in catalyzing ADP-ribosylation of Gs (stimulatory) protein and turning them into active condition. The Gs protein will convert the inactive adenilate cyclase (AC) into active AC. The increase of AC activity will increase the cyclic adenosine 3'5'-monophosphate (cAMP) concentration along the cell membrane. The cAMP then causes theactive secretion of sodium (Na+), chloride (Cl-), potassium (K+), bicarbonate (HCO3-), and water (H2O) out of the cell into the intestinal lumen, resulting in large fluid losses and electrolyte imbalances.
Prospek Pemanfaatan Biji Pepaya sebagai Biomaterial Pengendali Populasi Tikus Liar melalui Mekanisme Antifertilitas Erfan Andrianto Aritonang
Denta Journal Kedokteran Gigi Vol 2 No 1 (2019): Oceana Biomedicina Journal Volume 2 Issue (No) 1 January - June 2019
Publisher : Universitas Hang Tuah

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Tikus liar merupakan satwa liar yang paling sering bersosialisasi dengan masyarakat dan merupakan salah satu vektor serta penyebar penyakit yang beberapa diantaranya bersifat zoonosis. Pengendalian tikus liar sangat penting dilakukan guna mengurangi terjadinya penyakit zoonosis yang diakibatkan oleh hewan tersebut. Metode yang efektif digunakan sebagai pengendali populasi tikus liar adalah melalui mekanisme antifertilitas. Salah satu bahan yang memiliki mekanisme antifertilitas adalah biji pepaya. Kandungan saponin, flavonoid, alkaloid, dan papain pada biji pepaya terbukti memberikan efek infertil pada mencit dan tikus putih, dimana mencit dan tikus putih merupakan hewan yang semarga dengan tikus liar. Hewan yang semarga memiliki susunan anatomi dan fisiologis yang serupa, sehingga pengaruh antifertilitas tersebut menjadi sebuah prospek untuk mengembangkan biji pepaya sebagai biomaterial pengendali populasi tikus liar. Populasi tikus liar yang dihambat akan berdampak pada penurunan angka kejadian zoonosis dalam masyarakat
Characteristics of The Patients with Low Back Pain in The Medical Rehabilitation Clinic, dr. Ramelan Naval Hospital Surabaya Lena Wijayaningrum; Herin Setianingsih; Agustin Silfi Rahayu
Denta Journal Kedokteran Gigi Vol 2 No 2 (2019): Oceana Biomedicina Journal Volume 2 Issue (No) 2 July - December 2019
Publisher : Universitas Hang Tuah

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Background : The total number of visit of patients with low back pain in the Medical Rehabilitation Subdepartment of Dr. Ramelan Naval Hospital Surabaya from January to November 2018 is approximately 38.7% of all visits. Low back pain is defined as pain between the edge of the ribs and the gluteus fold which can be.Material and Methods : This was a cross sectional study, based on the analysis of the medical records from the LBP patients in July to September 2018, in the Dr. Ramelan Hospital RSAL Medical Rehabilitation Clinic. The inclusion criteria of LBP is: patient with main symptom of pain or other unpleasant feelings in the lower spine and surrounding areas, between the edge of the ribs and the gluteus fold. Results : There were 151 data analyzed from July to September 2018, patients with pain complaints were (86.84%). The data obtained showed majority of patients was 51-60 years old. Most of the patients were women.Conclusion : Most of the patients diagnosed with Low Back Pain (LBP) at the Medical Rehabilitation Clinic of RSAL Dr. Ramelan Surabaya, was 51-60 years old, women were the majority, 80%s had complain of pain and there were any of comorbidities.
Dental Calculus as The Unique Calcified Oral Ecosystem A Review Article Natallia Pranata
Denta Journal Kedokteran Gigi Vol 2 No 2 (2019): Oceana Biomedicina Journal Volume 2 Issue (No) 2 July - December 2019
Publisher : Universitas Hang Tuah

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The prevalence of periodontal disease in Indonesians is very high, which is around 95%, and 70% of these values occur above 30 years or the adult age group. There is controversy about whether dental calculus is an etiological factor in periodontal disease, or is it just a predisposing factor. Dental Calculus is a calcified oral ecosystem or dental plaque, can accumulate on supragingival or subgingival. Plaque is a bacterial biofilm complex on the tooth surface, including pathogenic microorganisms that invade periodontal tissue. Periodontal disease is the result of interactions between pathogens and the host immune system. Damage to periodontal tissue can occur if the pathogenicity of the microflora is more dominant in the immune response. In calcified conditions, these microorganisms lose their pathogenicity. The dental calculus is one form of the body's defense mechanism against pathogens. But the accumulation of dental calculus, with its rough surface, is a predisposing factor for plaque accumulation. The oral ecosystem trapping on the unique calcified material which are called dental calculus.

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