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Erina Yatmasari
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Oceana Biomedicina Journal
Published by Universitas Hang Tuah
ISSN : -     EISSN : 26140519     DOI : https://doi.org/10.30649/obj
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
Oceana Biomedicina Journal is an open access journal of health and medicine. Specifically, the journal focuses on marine medicine, hyperbaric medicine and health, medicine on ships, harbor health, maritime and coastal health, medicolegal studies related to ships, ports and districts, maritime/coastal communities and fishermen, epidemiological aspects of diseases, disabilities and disorders that occur on ships and affect boat workers, ports and maritime zones, coastal areas, fishermen communities and their families, including pharmacological and non-pharmacological prevention and treatment management policies; and miscellanous.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 51 Documents
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Seorang Penderita SLE dengan Emboli Paru Akut dan Hipertensi Pulmonal (Studi Kasus) Hendrata Erry Andisari; Gede Kambayana; Ketut Suega
Denta Journal Kedokteran Gigi Vol 3 No 1 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 1 January - June 2020
Publisher : Universitas Hang Tuah

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Abstract

Kondisi Pulmonary embolism (PE) merupakan bagian dari spektrum penyakit yang disebut Venous thromboembolism (VTE). Seorang pasien dengan keluhan utama batuk yang mengeluarkan dahak berwarna keputihan datang ke RSUP Sanglah, Bali untuk mendapatkan terapi. Riwayat sebelumnya, pasien pernah dirawat inap di RSUP Sanglah tersebut.Saat ini diagnosis akhir pasien ini: SLE on treatment dengan moderate pulmonary hipertension dan suspek emboli paru, suspek pneumonia (HCAP) dengan severe sepsis dan syok sepsis, asidosis metabolik, observasi transaminitis ec reaktif dan hiponatremia kronik asimptomatik hipoosmoler euvolemic cb SIADH. Selanjutnya dilakukan tindakan terapi dan evaluasi terhadap terapi yang diberikan.
Identifikasi dan Penetapan Kadar Senyawa Saponin Ekstrak Etanol Bunga Senggani (Melastoma malabathricum L) Metode Gravimetri Yuska Noviyanty; Hepiyansori Hepiyansori; Berliana Rosita Dewi
Denta Journal Kedokteran Gigi Vol 3 No 1 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 1 January - June 2020
Publisher : Universitas Hang Tuah

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Abstract

Traditional medicine is an ancestral cultural heritage derived from natural materials and to this day continue to be used by the general public. One of the plants that can be used as a traditional medicine is a plant Senggani (Melastoma malabathricum L). The purpose of this study was to determine the saponins contained from flower extracts Senggani (Melastoma malabathricum L) and percent saponin levels of Senggani flower extract (Melastoma malabathricum L). Extraction is done by maceration using ethanol 96% for 5 days. Extraction obtained is then concentrated by means of a rotary evaporator. The results were qualitative identification of the foam test and color test and quantitative assay with gravimetric method.Based on research conducted Senggani ethanol extracts of flowers (Melastoma malabathricum L) contains saponins types of triterpenoids seen from the ring in maroon and obtained the average level of interest saponin Senggani (Melastoma malabathricum L) is 11.46%.
Perawatan Komprehensif Geligi Campuran pada Anak Usia 8 Tahun dengan Riwayat Ibu memiliki Celah Bibir – Laporan Kasus Anisa Nursantika; Jeffrey Jeffrey
Denta Journal Kedokteran Gigi Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

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Abstract

Cleft lip and palate are abnormal clefts in the orofacial region that affect lip, alveolar bone, hard palate, and or soft palate. An eight-year-old girl came to Dental Hospital of Unjani with her mother, with chief complaint tooth cavity on the left and right of the lower arch and want to be treated. Intraoral findings found that the patient’s teeth are crowded with a narrow jaw arch. From the anamnesis, the mother of the patient had a cleft lip and extend to the alveolar bone, but the patient itself has no cleft lip and palate. The comprehensive treatments that done to the patient are amalgam restoration of tooth 75 and pulp capping of tooth 85 with stainless steel crown as follow up restoration.
Analisa in Silico Kunyit (Curcuma longa) sebagai Inhibitor Murine Double Minute 2 Protein untuk Terapi Glioblastoma Multiforme Benny Iswanto Pantoro; Nancy Margarita Rehatta; Siti Khaerunnisa; Anna Surgean Veterini; Yuani Setiawati
Denta Journal Kedokteran Gigi Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

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Abstract

Brain tumor consists of tumor which grows primarily from cells in the brain (primary brain tumor) or systemic tumor which metastasized into the brain (secondary brain tumor). From all types of primary brain tumor, Glioblastoma Multiforme is the most common and the most malignant tumor. In 85% of Glioblastoma Multiforme cases are found a molecular alteration of the tumor suppresor gene p53 pathway, which promotes current studies to focus on this pathway. One of the pathway that can be used as therapeutic model is through inhibiting the murine double minute 2 protein (MDM2), which in itself is a p53 inhibitor. Turmeric (curcuma longa) is one of the traditional plants which is commonly used as herbs and its extracts has been studied to have an anti-cancer properties. This study is an in silico study which evaluate the potential efficacy of turmeric extract as a murine double minute 2 protein inhibitor using AutoDock 4.2 based on the Lamarckian genetic algorithm principle. Docking result shows binding energy ranging from -4.81 kcal/mol to -2.34 kcal/mol, with curcumenol having the lowest binding energy and curcumin having the highest binding energy. This study may be used as a base in further study (consists of in vivo and in vitro) of turmeric extract and its effect as the therapeutic regiments for Glioblastoma Multiforme.
Pengaruh Pemberian Ekstrak Rumput Laut Cokelat (Sargassum duplicatum) terhadap Peningkatan Kadar Hematokrit pada Darah Tikus Putih Jantan Galur Wistar (Rattus norvegicus) Anemia yang Diinduksi NaNO2 Ayu Mayang; Liliawanti Liliawanti; Wachjudi Kurnia
Denta Journal Kedokteran Gigi Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

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Abstract

Anemia is still a high prevalence disease in Indonesia, caused by a lack of iron in the body. The components from brown seaweed such as cobalamin (vitamin B12), pyridoxine (vitamin B6), chlorophyll and iron (Fe) can increase red blood cells in the body. The purpose of this research was to determine the effect of brown seaweed (Sargassum duplicatum) which can increase hematocrit levels in the blood of white male wistar strain rat (Rattus norvegicus) suffered from anemia in induction NaNO2. This research uses an experimental laboratory method with a post test only control group design. The samples were 30 male rats divided into 3 treatment groups, the negative control group (K0) without treatment, the positive control (K1) be treated anemia given NaNO2 for 18 days without Sargassum duplicatum extract and treatment group (K2) treated with anemia given NaNO2 for 18 days without Sargassum duplicatum extract at a dose of 2,45gr / kgBB. On the 40th day, a blood sample was taken, then measured the hematocrit level.The results showed that the mean number of blood hematocrit levels in K2 was higher than K1, it showed a significant difference descriptively. Based on the KruskalWallis test, a value of 0.260 was obtained that p > 0,05 showed that there were no statistically significant differences between groups of experimental animals.From the results of this research, the conclusion is the administration of brown seaweed extract (Sargassum duplicatum) descriptively increased, but not statistically significant.
Comparison of Cerebral Malaria Mice Models Infected by P. berghei ANKA Prawesty Diah Utami; R. Varidianto Yudo Tjahjono; Indi Jazilah; Ismy Azizah Sisnawati
Denta Journal Kedokteran Gigi Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

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Abstract

The high morbidity and mortality due to malaria infection makes it a global health problem. The pathogenesis and pathophysiology of cerebral malaria has not been fully understood. The use of cerebral malaria model mice is one alternative to understand its pathogenesis and pathophysiology. The purpose of this study was to compare Swiss mice and C57BL / 6 mice inoculated by P.berghei ANKA as a model of cerebral malaria mice. Methods: The study design was a randomized Post Test Control Only Group Design using 12 Swiss mice and 12 C57BL / 6 mice divided into 2 groups each: the treatment group inoculated by P. berghei ANKA and the control group without inoculation. Observation of clinical manifestations and parasitemia level was carried out from day 1 to day -10. The study results showed that K2 group showed a significant increase in the degree of parasitemia compared to K4. K4 group showed clinical manifestations of cerebral malaria while K2 did not show clinical manifestations of cerebral malaria. Conclusion: C57BL / 6 mice inoculated by PbA can be used as cerebral malaria animal models.
Perawatan Space Regainer pada Premature Loss Gigi Molar Sulung Rahang Atas dan Bawah – Laporan Kasus Anatasya Rachmadani; Jeffrey Jeffrey
Denta Journal Kedokteran Gigi Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

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Abstract

Caries is one of the most common illnesses in children and young adults. Dental caries and dental trauma that occur in children can cause missing teeth prematurely, commonly called premature loss, which can cause occlusion abnormalities caused by narrowing of the arch. A space regainer is an active device used to recover space that has narrowed to the dental arch a result of premature loss. A 9-year-old boy accompanied by his mother came to RSGMP Unjani in 2018 with complaints of upper right and back right and lower left teeth missing because extraction. The patient's mother is worried that her replacement teeth will overlap. Intra oral examination showed tooth loss 54,75,84,85. Analysis of the model shows a narrowing of the -0.9 space in the maksila and -0.7 in the mandible. Patients were treated for maksila and mandibular removable space regainer accompanied by expansion screws. Activation of expansion screws is done once a week with ¼ turns. Space regainer treatment in this patient was done 4 times and the results were very satisfying.
Pengaruh Ekstrak Daun Jeruju (Acanthus ilicifolius) terhadap Penurunan Kadar LDL Darah pada Tikus Putih (Rattus norvegicus) Jantan Galur Wistar Diabetes yang Diinduksi Aloksan Anggita Saraswati; Irmawati M. Dikman; Retno Budiarti
Denta Journal Kedokteran Gigi Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

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Abstract

Background : DM is a chronic disease that has long-term complications. Alloxan is a fast way to produce experimental diabetic (hyperglycemic) in animal experiments related to elevated LDL. Jeruju (Acanthus ilicifolius) is a low-growth herbaceous plant that easily grows containing secondary metabolites such as Alkaloids, Saponins, Flavonoids, Terpenoids, and Phenols. Objective : To determine the effect of jeruju leaf extract on the decrease in blood levels of LDL of male Wistar rat (Rattus norvegicus) induced Alloxan.Methods : This research is an experimental laboratory type with Post Test Only Control Group Design. The sample using 24 rats, which were divided into 3 groups: negative control group (K-) were given standard feed; positive control group (K +) induced alloxan 120 mg/kgBW on 1st day; the treatment group (P) induced alloxan 120 mg/kgBW on 1st day and was given jeruju leaf extract 67.2 mg/kgBW on 5th-14thday. The 15th day a blood sample was taken to determine LDL levels.Result : The results of One-Way ANOVA test showed an insignificant mean difference (p = 0.270) in LDL level of K- ( = 9.75 mg/dl) and the K+ ( = 11.38 mg/dl ). Insignificant mean difference (p = 0.270) in P ( = 9 mg/dl) with blood LDL levels in theK+ ( = 11.38 mg/dl) and the K- ( = 9, 75 mg/dl).Conclusion : Giving alloxan can increase blood levels of LDL and administration of jeruju leaf extract can reduce blood levels of LDL in experimental animals but not statistically significant.
PERBANDINGAN EFEKTIVITAS OBAT KUMUR POVIDONE IODINE DENGAN KLORHEKSIDIN TERHADAP INDEKS PLAK Novia Septiani Fauzia; Hanri Hartman; Jeffrey Jeffrey
Denta Journal Kedokteran Gigi Vol 4 No 1 (2021): Oceana Biomedicina Journal Volume 4 Issue (No) 1 January - June 2021
Publisher : Universitas Hang Tuah

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Abstract

Plaque is the main cause of the tooth and supporting tissues damage, so plaque control must be done. Chemical plaque control can be done by using mouthwash such as povidone iodine and chlorhexidine which is an effective antiseptics in reducing plaque formation. Both are proven to have antibacterial activity against Streptococcus mutans which is one of the plaque-causing bacteria. This research aims is to determine the difference of both mouthwash effectiveness to the plaque index. This research is pre-post test control group design by examining the plaque index before and after gargling. The subjects in this study are 32 students from SMPN 2 Cimahi who were 13 - 15 years old and were divided into two groups. This research was conducted by examining the plaque index before and after gargling using Silness and Loe plaque index. Data were tested for normality using Chi-square and analyzed by T-test. The results showed a difference average in plaque index before and after gargling with povidone iodine by 0.68 and chlorhexidine by 0.51 with a p-value of 0.11. Both mouthwash have almost the same effect on the plaque index.
PEMBERIAN EKSTRAK RUMPUT KEBAR (Biophytum petersianum Klotszch) TERHADAP VIABILITAS SPERMATOZOA MENCIT (Mus musculus) DIABETES MELITUS Prima Arundani; Rany I'tishom; Bambang Purwanto
Denta Journal Kedokteran Gigi Vol 4 No 1 (2021): Oceana Biomedicina Journal Volume 4 Issue (No) 1 January - June 2021
Publisher : Universitas Hang Tuah

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Abstract

Diabetes mellitus yang tidak ditangani dengan baik akan mengakibatkan infertilitas yang disebabkan oleh adanya kerusakan salah satu organ reproduksi yaitu testis. Hiperglikemia atau tingginya kadar gula dalam darah berperan dalam kerusakan sel dengan cara peningkatan reactive oxygen spescies (ROS) sehingga terjadi stres oksidatif jaringan yang mengakibatkan radikal hidroksil. Peningkatan Reactive Oxygen Species (ROS) menyebabkan cedera sel melalui mekanisme peroksidasi lipid dan kerusakan oksidatif protein serta DNA. Proses lipid periksidase pada akhirnya merusak membran spermatozoa dan mitokondria DNA sehingga menyebabkan penurunan kualitas spermatozoa.Penelitian ini bertujuan mengetahui efek ekstrak rumput kebar terhadap viabilitas spermatozoa mencit jantan (Musmusculus) model diabetes melitus.Penelitian ini merupakan penelitian eksperimental dengan rancangan post test only control group design. Ekstrak rumput kebar menggunakan metode maserasi dengan pelarut etanol 96%. Sebanyak 30 ekor mencit yang dibagi ke dalam 5 kelompok, yaitu kelompok kontrol negatif yaitu mencit diabates mellitus yang di sonde cmc na, kelompok kontrol positif yaitu mencit diabetes mellitus yang di sonde metformin, kelompok I, II, dan III yang di sonde ekstrak rumput kebar dengan dosis 67,5; 130; dan 270 mg/kg BB. Viabilitas spermatozoa dianalisis dengan mengambil sampel spermatozoa dari kauda epididimis. Hasil uji Kruskal Wallis menunjukkan hasil yang signifikan p = 0,005 (p ˂ 0,05) pada viabilitas spermatozoa mencit diabetes mellitus dan perbedaan yang bermakna pada kelompok kontrol negatif mencit dengan diabetes mellitus dengan kelompok perlakuan 3 yang diberi metformin dan ekstrak rumput kebar dosis 270 mg/kg BB. viabilitas spermatozoa pada kelompok kontrol negatif memiliki persentase terendah sedangkan pada kelompok perlakuan 3 memiliki persentase tertinggi. Simpulan penelitian ini adalah ekstrak rumput kebar (Biophytum petersianum Klotzsch) meningkatkan viabilitas spermatozoa mencit (Mus musculus) model diabetes melitus.

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