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Asian Journal of Health Research
Published by Ikatan Dokter Indonesia Wilayah Jawa Timur
ISSN : 28292979     EISSN : 28289269     DOI : https://doi.org/10.55561/ajhr
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Asian Journal of Health Research (AJHR) is an open access journal published by Ikatan Dokter Indonesia Wilayah Jawa Timur and launched in 2022. This journal is peer reviewed publishing to communicate high quality research, general articles, and all fundamental research/ clinical studies relevant to health science. The journal publishes articles Medical Sciences scope including (Obstetrics and Gynaecology, Pediatrics, Internal medicine, Ophthalmology, Surgery, Neurology, Otolaryngology, Cardiology and Vascular Medicine, Anaesthesiology and Reanimation, Dermatovenerology, Orthopaedics and Traumatology, Urology, neurosurgery, Cardiothoracic surgery, Orthopaedics and Traumatology, Plastic Reconstructive Surgery and Aesthetics, Pulmonology and Respiratory Medicine, Forensic Medicine, and Medicolegal, Psychiatry Medicine and Rehabilitation). AJHR journal is published three times per year in April, August, and December.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 148 Documents
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The Vertical Rectus Abdominis Myocutaneous Flap for Complex Abdominal Wall Reconstruction on a Relapse Case of Monophasic Synovial Sarcoma Alfadz Kholifah Akbar; Muhammad Pratama Mandala Putra; Denny Irwansyah
Asian Journal of Health Research Vol. 2 No. 1 (2023): Volume 2 No 1 (April) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i1.70

Abstract

Introduction: Vertical Rectus Abdominis Myocutaneous (VRAM) flap is a chosen method for a large wound closure instead of Anterolateral Thigh (ALT) flap. Both versatile and highly vascularized flaps share almost similar advantages for large wound closure. In our case, the site and size of the wound are the points of consideration. Case Presentation: A 16-year-old girl with a chief complaint of a large progressive lower abdominal mass enlarged since January 2021 that has grown back from the same site. Abdominal CT-Scan shows a tumor in the right lower abdomen infiltrated to the pelvic cavity and spanning from the lower abdominal area all the way to the groin area. Histopathology interpretation suggests a Monophasic Synovial Sarcoma. The patient underwent a second tumor resection with VRAM flap as the wound closure. The benefits of this versatile flap are excellent dead space obliteration and low Surgical Site Occurrence (SSO’s). Conclusion: As postulated in many studies VRAM flap is an excellent flap for a CAWR procedure. The expected SSO’s is non-existence during the postoperative follow-up
Region Variation of Hematological Malignancies and Solid Tumors in Children in East Java Andi Cahyadi; Esthy Poespitaningtyas; Diah Kusuma Arumsari; Maria Christina Shanty Larasati; Mia Ratwita Andarsini; I Dewa Gede Ugrasena
Asian Journal of Health Research Vol. 2 No. 1 (2023): Volume 2 No 1 (April) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i1.71

Abstract

Introduction: The prevalence of childhood cancer in East Java is unevenly associated with differences in exposure to carcinogens in urban-industrial areas, agricultural chemicals, industrial waste along the river, and socio-culture. However, there are no data on regional variations in childhood cancer in East Java. We describe the regional variation of hematological malignancies and solid tumors in East Java. Material and Methods: The study was conducted by cross-sectional on children with cancer aged <18 years in dr. Soetomo General Academic Hospital in 2014-2015. The data evaluated were gender, age, and cancer type (hematological malignancy and solid tumor). They came from Mataraman, Madura Island, industrial-urban areas (Surabaya-Sidoarjo-Gresik), and Tapal Kuda. We used the Chi-square test and Logistic Regression for data analysis (p<0.05 for two-tailed test). Results: During the study period, there were 353 children with cancer, consisting of 56.9% hematological malignancies and 43.1% solid tumors: 60.9% boys, and 82.4% aged <10 years. Hematological malignancies in industries-urban areas are more numerous than in Mataraman, Madura Island, and Tapal Kuda; 67.8%, 52.8%, 47.2%, and 50.9%, respectively (p=0.031). Hematologic malignancies were also more common in aged <10 years (60.5% vs 40.3%; p=0.004 OR=2.265; 95% CI=1.295-3.362) and Javanese race (p=0.025; OR=3.257; 95% CI=1.121-5.263). Children in industrial-urban areas had more hematological malignancies than Mataraman (p=0.027; OR=2.353; 95% CI=1.101-5.030) also Tapal Kuda (p=0.015; OR=1.881; 95% CI=1.132-3.124) and Madura Island (p=0.032; OR=2.033; 95% CI=1.064-3.882). Conclusion: Hematological malignancies in industry and urban areas are more numerous than Mataraman, Madura Island, and Tapal Kuda area. Solid tumors were mostly found on Madura Island.
Effect of Red Bean Extract (Phaseolus vulgaris L. Sp) on Interleukin-1, Inhibin Β and PCNA Expression in Systemic Lupus Erythematosus Mice Model Albert Novriadi; Muhammad Nooryanto; I Wayan Agung Indrawan; Puspita Handayani
Asian Journal of Health Research Vol. 2 No. 1 (2023): Volume 2 No 1 (April) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i1.81

Abstract

Introduction: Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease characterized by multiple organ involvement. Chronic inflammation due to oxidative stress and autoimmune causes damage to related organs, one of which is the ovary which leads to Premature Ovarian Failure (POF) . Red bean (Phaseolus vulgaris L. Sp.) is an anti-inflammatory and antioxidant agent. This study aims to examine the effect of red beans on IL-1, Inhibin B, and PCNA. Methods: This is a true experimental study with a post-test-only controlled group design in vivo. The sample in this study were female Balb/c mice treated with red bean extract (Phaseolus vulgaris L. sp.) at doses of 50 mg/KgBW (P1), 75 mg/KgBW (P2), and 100 mg/KgBW (P3). IL-1, Inhibin B, and PCNA levels in each group were statistically analyzed using the SPSS 16 for Windows software program. Results: Red bean extract (Phaseolus vulgaris L. Sp.) administration at various doses was statistically proven to significantly reduce IL-1 levels (p<0,05) and increase Inhibin levels in all groups (p<0,05). The highest average Inhibin B levels were found in the 100 mg/KgBW dose group (P3), significant increase in PCNA expression in all groups given various doses of red bean extract (p<0,05). Conclusion: Administration of red bean extract (Phaseoulus vulgaris L. Sp.) can reduce levels of Interleukin-1, increase levels of Inhibin B and PCNA expression in SLE mice.
Comparative Study of BAX/BcL2 Expression Ratio in Menstrual Blood between Endometriosis Women and Women without Endometriosis Arghya Wicaksana; Pande Made Dwijayasa; Rahajeng Rahajeng; Cholid Rohman Riskianto
Asian Journal of Health Research Vol. 2 No. 1 (2023): Volume 2 No 1 (April) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i1.83

Abstract

Introduction: Endometriosis is characterized by the presence of endometrial tissue outside the uterus and is commonly associated with chronic pelvic pain and infertility. One of the endometrial changes that appear in the eutopic and ectopic endometrium of women with endometriosis is the regulation of apoptosis. The proportion value of the BAX/BcL-2 ratio is a crucial factor in determining the ability of cells to stimulate apoptosis. Higher apoptotic activity is linked to an increased BAX/BcL-2 ratio. The aim of this study was to compare the BAX/BcL-2 ratios in menstrual blood of endometriosis and non-endometriosis patients. Material and Methods: This research is a quantitative observational study with a cross-sectional method at dr. Saiful Anwar Malang. The case group was postoperative women with ovarian cysts with anatomical pathology examination results indicating endometriosis. While the control group was patients without endometriosis. Data analysis was carried out by using the Independent T Test with SPSS for Windows 19.0 software. Results: Each group consisted of 17 patients. The normality test for each variable shows p> 0.05. BAX average in patients with endometriosis 4556.29 ± 2338.33 and 6488.06 ± 2649.08 in patients without endometriosis (p = 0.031). The average BcL-2 in endometriosis patients was 6483.82±2489.36 and 4877.18±2023.82 in patients without endometriosis (p=0.047). The average BAX/BcL-2 ratio in patients with endometriosis was 0.698±0.19 and 1.367±0.26 in patients without endometriosis (p=0.000). Conclusion: The BAX/BcL-2 ratio in women with endometriosis cysts has a lower average rate than women without endometriosis cysts.
High Vigilance Concept: Preventive Transition Strategy Toward the Covid-19 Endemic Soroy Lardo, BG (Ret), MD, PhD
Asian Journal of Health Research Vol. 2 No. 1 (2023): Volume 2 No 1 (April) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i1.94

Abstract

The transboundary disease, Covid-19, which has been ongoing since 2020, crosses borders and affects many parts of society. The ensuing health issues have weakened the nation’s economy, workforce, quality of life, and overall resiliency. Based on information from the Covid-19 Task Force and Emerging Infections of the Ministry of Health, the Cumulative Situation of Covid-19 in Indonesia as of July 18, 2022, shows 6,138,953 confirmed cases, 27,550 active cases, 156,849 deaths, and 5,950,554 recoveries from a total of 102,088,388 specimens tested. This cumulative mortality rate is 2.6% greater than the global average of 1.14%. Current evidence from epidemiology and transmission demonstrates that Covid-19 has mutational traits that make it a community spreader, demonstrated by an uptick in asymptomatic positive cases, mobilization, and international migration. However, keeping an eye out for comorbid groups with varying clinical signs and organ problems is still important. The government has to re-encapsulate the upstream and downstream techniques into a single integration if it is to cope with the present situation. Hospital emergency plans and the notion of “High Vigilance” (also known as “High Alert”) are both included in this plan as a means of making the shift from a pandemic to an endemic. High Vigilance’s strategy is to build organizational awareness and community participation by empowering Leadership, Best Practices, and Environmental Without Error as an integrated policy with measuring tools for the dynamic implementation of the rapid – detect- respond and prevention program.
Efficacy of Dienogest on Pelvic Pain and Dyspareunia: Comprehensive Meta-Analysis and Systematic Review Sutrisno Sutrisno; Wildan Aulia Firdaus
Asian Journal of Health Research Vol. 2 No. 1 (2023): Volume 2 No 1 (April) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i1.73

Abstract

Introduction: Endometriosis is a severe disorder marked by endometrial tissue outside the uterus and linked to infertility, although typically manifesting as discomfort in the form of dysmenorrhea, dyspareunia, and pelvic pain. Dienogest is indicated as a first-line hormone treatment for endometriosis-related discomfort. The aim of this study is to analyze the efficacy of Dienogest on treating pelvic pain and dyspareunia compared to placebo or combined oral contraceptives (COC) in women with endometriosis. Methods: A systematic search is conducted in PubMed, ScienceDirect, and Google Scholar. The PRISMA 2020 rules were used to screen the articles that were obtained. For the review, studies that examined how using dienogest in improving endometriosis were exposed to were taken into consideration. In a meta-analysis utilizing a random-effects model, odds ratios with their 95% confidence intervals (CI) were provided. Results: Five studies that met the criteria for inclusion were determined to be pertinent to the association between using dienogest in improving endometriosis (n=711). The Dienogest group had substantially improve pelvic pain with a mean difference of 1.01 (95% CI 1.2, 0.82; p<0.00001) and dyspareunia with a mean difference of 0.58 (95% CI 1.09, 0.08; p=0.02) compared to placebo. Compared to combined oral contraceptives, COC had substantially improves dyspareunia with a mean difference of 0.99 (95% CI 0.62, 1.37; p<0.00001) and pelvic pain with a mean difference of 1.15 (95% CI 0.23, 0.83; p=0.01). Conclusion: Dienogest should be considered as an alternate treatment for endometriosis-related symptoms. In double-blind research, DNG efficacy was compared to placebo.
Abdominal Epilepsy, A Diagnosis to Consider in Children with Recurrent Vomiting: A Case Report Fatia Murni Chamida; Nirmala Muflihatul Khalida
Asian Journal of Health Research Vol. 2 No. 1 (2023): Volume 2 No 1 (April) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i1.76

Abstract

gastrointestinal complaints and central nervous system involvement, mainly confusion, fatigue, headache, dizziness, syncope, and lethargy resulting during the abdominal seizure activity. Chronic vomitting or other gastrointestinal symptoms often lead to fluid and nutritional deficiencies which resulted in malnutrition. To date, there was no study has been reported on abdominal epilepsy in Indonesia. Case Presentation: We presented a case of two-year-old girl with chief complaint of recurrent profuse vomiting every month for the past year. Patient complained of headaches and abdominal pain and tended to sleep all day during relapse. Physical examination showed sunken eyes and decreased skin turgor. EEG showed abnormal results, diffuse irritative, epileptiform with normal basic rhythm. Esophageal polyps were also found on endoscopy. Patient was given anti-epileptic drugs and histamine H2 receptor antagonists and responded well to those therapies. Conclusion: Abdominal epilepsy is a rare case which may resulted in vomiting and abdominal pain in children. EEG examination is an important test for diagnosing abdominal epilepsy. Treatment with anti-epileptic drugs is known to respond well in this case.
Maternal Comorbidities with Full-Term Pregnancy Who Gave Birth to Low Birth Weight Babies at Dr. Saiful Anwar Malang General Hospital I Wayan Agung Indrawan; Obi Candra Kapisa
Asian Journal of Health Research Vol. 2 No. 1 (2023): Volume 2 No 1 (April) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i1.85

Abstract

Introduction: Stunting is a challenge for children's growth and development in the future, which has long-term impacts in the form of reduced cognitive abilities, decreased productivity, and increased risk of infection and non-communicable diseases. Low birth weight (LBW) is a major determinant of stunting in Indonesia. Various multidimensional factors contribute to low birth weight, including maternal factors. Material and Methods: Quantitative descriptive research was conducted at Dr. Saiful Anwar general hospital from July 2021 to September 2022. The variables studied were age, education, occupation, parity status, medical history, number of antenatal care controls, height, mother's body mass index, and baby's birth weight. Results: Of the 54 full-term pregnant women, the majority who delivered LBW babies were nulliparous (42.6%), aged 20-35 years during pregnancy (79.6%), had a history of hypertension during pregnancy (25.9%), antenatal care visits 1-5 times (48.1%), high school degree (48.1%), housewives (75.9%), height ranging between 151-160 cm (64.8%), and BMI 18.5 to 25 kg/m 2 (51.9%). Conclusion: Maternal factors that contribute to the birth of LBW babies include low parities, age 20 to 35 years during pregnancy, hypertension in pregnancy, infrequent antenatal care visits, high school degree, work as a housewife, height ranging between 151 -160 cm, and had a normal BMI. The representation of the mother's BMI and educational level in this study differs from that in previous studies.
Genistein Effect on Estrogen Receptor especially Interleukin-6 and Tumor Necrosis Factor-α in Mice Model of Endometriosis: a Systematic Review and Meta-analysis Sutrisno Sutrisno; Lovin Destikatari
Asian Journal of Health Research Vol. 2 No. 1 (2023): Volume 2 No 1 (April) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i1.90

Abstract

Introduction: Endometriosis is the endometrial tissue proliferation outside the uterine space. Anti-angiogenic agents from different groups of substances are currently being discussed as promising therapies for the treatment of endometriosis in the future, one of which is therapy using the phytoestrogen genistein. At the molecular level, genistein's effects on cells include inhibition of proliferation, induction of differentiation, apoptosis, and cell arrest in the cell cycle, which are related to the transforming growth factor. Genistein inhibits cell growth by modulating the signal-transforming growth factor pathway. Methods: We searched PubMed, Scopus, Cochrane Library and Proquest from its inception to December 2022 to collect observational and interventional studies of Genistein consumption in endometriosis mice. Two authors independently screened the literature according to the inclusion and exclusion criteria, extracted data, and assessed the risk of bias. Safety analysis was assessed through TNF-α and IL-6 values of estrogen expression. Results: No significant difference in the values of IL-6 and TNF-α in rats with endometriosis that were given genistein at these three doses. However, if analyzed further, the IL-6 outcome compared to the 0.78mg/day dose most affected the IL-6 value between the two groups, and the TNF-α output compared to the 0.78 mg/day dose most affected the TNF-α value between the two groups. So, a genistein dose of 0.78 mg/day can affect IL-6 and TNF-α in mice with endometriosis. Conclusion: Genistein modulated estrogen expression of TNF-α and IL-6 at all doses, but the best dose for its effect was 0.78 mg/day.
Analysis of Screen Based Activity on Digital Eye Strain in School-Age Children in Peniwen Village, Malang, East Java Minarni Wartiningsih
Asian Journal of Health Research Vol. 2 No. 1 (2023): Volume 2 No 1 (April) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i1.98

Abstract

Introduction: The use of digital devices has increased across all age groups and professional fields, making them inseparable from everyday life. This increase in the duration of screen-based activities causes various symptoms of eye health problems. This study aimed to determine the prediction of the relationship and influence between Screen-Based Activity (SBA) and the incidence of Digital Eye Syndrome (DES) in children aged 9-12 years in Peniwen Village, Malang. Material and Methods: This study used a cross-sectional analytical observational design. There were 62 respondents in the research samples, or the same number as the total population. The analysis technique used in this study is the Partial Leas Square (PLS) modeling technique with testing using software such as SmartPLS (v3.2.9). Results: Based on the results of the analysis, obtained t-count (23.821) is greater than the t-table (1.96), meaning that there is a relationship and influence between SBA variables on DES. The correlation coefficient of SBA to DES is positive 0.818 which means the higher the Screen Based Activity, the higher the risk of Digital Eye Strain. The use of handphone (X2) is an indicator of SBA with the highest correlation strength of 88.1%. Conclusion: There is an association between the duration of Screen Based Activity and the incidence of Digital Eye Strain in children. The higher the Screen Based Activity, the higher the risk of Digital Eye Strain. In addition, the use of handphones has the highest correlation in influencing the occurrence of Digital Eye Strain in school-age children in Peniwen Village.

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