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Asian Journal of Health Research
Published by Ikatan Dokter Indonesia Wilayah Jawa Timur
ISSN : 28292979     EISSN : 28289269     DOI : https://doi.org/10.55561/ajhr
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Asian Journal of Health Research (AJHR) is an open access journal published by Ikatan Dokter Indonesia Wilayah Jawa Timur and launched in 2022. This journal is peer reviewed publishing to communicate high quality research, general articles, and all fundamental research/ clinical studies relevant to health science. The journal publishes articles Medical Sciences scope including (Obstetrics and Gynaecology, Pediatrics, Internal medicine, Ophthalmology, Surgery, Neurology, Otolaryngology, Cardiology and Vascular Medicine, Anaesthesiology and Reanimation, Dermatovenerology, Orthopaedics and Traumatology, Urology, neurosurgery, Cardiothoracic surgery, Orthopaedics and Traumatology, Plastic Reconstructive Surgery and Aesthetics, Pulmonology and Respiratory Medicine, Forensic Medicine, and Medicolegal, Psychiatry Medicine and Rehabilitation). AJHR journal is published three times per year in April, August, and December.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 148 Documents
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Efficacy of Non-Soy Isoflavone (Pueraria phaseoloides) on The Symptoms Severity Scoring by Kupperman Index in Menopausal Women Made Tangkas; Widjajanto Ngartjono; Achmad Hidayat; Leny Silviana Farida
Asian Journal of Health Research Vol. 1 No. 3 (2022): Volume 1 No 3 (December) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v1i3.1

Abstract

Introduction: Menopause is defined by a decline in estrogen levels, which causes various symptoms. Treatments based on foods or supplements enriched in phytoestrogens, notably isoflavones, plant-derived compounds with estrogenic effects, have recently become quite popular. This study aims to see how effective non-soy isoflavone supplementation is for menopausal symptoms in women. Methods: 26 menopausal women were given 67.5 mg of non-soy isoflavone, and 25 menopausal women were given a placebo daily for 12 weeks in an analytical double-blind, randomized clinical trial (RCT). Inclusion criteria were (1) RCT, (2) perimenopausal or postmenopausal women experiencing menopausal symptoms, (3) intervention with an oral non-soy isoflavone. Symptoms Severity Score (SSS) based on the Kupperman index (KI) questionnaire was administered to the patients before starting and at the end of the study. The Statistical Package for Social Sciences (SPSS) software was used to analyze the responses. Results: The difference in SSS scores between the treatment and control groups was significant (p = 0.000). Women receiving 67.5 mg of non-soy isoflavone daily, reduced myalgia, fatigue, and hot flushes by 92.3%, 77%, and 53.8%, respectively. For clinical significance rating, relative risk reduction (RRR) is used. A significant RRR value resulted from myalgia symptoms (76.6%), fatigue (55.7%), hot flushes (39.2%), and SSS (68.7%). Conclusion: Isoflavones did not bring a significant change in Kupperman Index compared to placebo but provided significantly improved Symptoms Severity Scoring in menopausal women.
Effect of Escherichia Coli on Decorin and Type I Collagen Levels in Fetal Membranes of Premature Balb/c Mice Nirwan Nugraha; Suheni Ninik Hariyati; Didik Agus Gunawan; Mokhammad Nooryanto; Pande Made Dwijayasa
Asian Journal of Health Research Vol. 1 No. 3 (2022): Volume 1 No 3 (December) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v1i3.26

Abstract

Introduction: Premature birth is a global problem in various countries worldwide. The pathogenesis leading to preterm labor may occur in early pregnancy and is associated with inflammatory pathways and changes in the angiogenic process. Decorin and biglycan are hypothesized to play a role in pregnancy maintenance, wherein preterm delivery, these levels are thought to be reduced. This study was examined effect of Escherichia coli on Decorin and Type I Collagen levels in fetal membranes of Premature Balb/c Mice Methods: There were 28 pregnant Balb/c mice divided into 4 groups, with a post-test-only control group design in true experimental design research. The first control group (N1) was a group of pregnant mice dissected on day-15, while the second control group (N2) were mice pregnant at term followed up to parturition. Group P1 were given Escherichia coli 1x109 CFU/ ml dose on the cervix on day-15, while the second treatment group (P2) were given Escherichia coli in the cervical canal on day-15 followed by delivery. We examined the Decorin and Type I Collagen levels between group. One-way ANOVA was used to analyze the collected data. Results: There was a significant difference in the mean decorin levels between the control group N1 vs P2 (12.35±2.24 ng/mL vs 6.62±1.50 ng/mL; p=0.000). In addition, a significant difference was also found in the mean level of type 1 collagen between the control group N1 vs P2 group (283.5±31.3 ng/mL vs 170.6±38.8 ng/mL; p=0.000). Conclusion: A decrease in decorin levels affects the reduction in collagen type 1 levels in fetal membranes of Balb/C mice in premature models.
Case Report: Generalize Pustular Psoriasis Pregnancy (GPPP) in Multiple Pregnancies Aida Musyarrofah; Probo Yudha Pratama Putra; Dwi Nurwulan Pravitasari; Yulia Nugrahanitya
Asian Journal of Health Research Vol. 1 No. 3 (2022): Volume 1 No 3 (December) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v1i3.34

Abstract

Introduction: General Pustular psoriasis pregnancy (GPPP) is a dermatosis that occurs in pregnancy and requires serious management to reduce the risk of mortality and morbidity in both pregnancy mother and fetus. This disorder is also called impetigo herpetiform. Case Presentation: We report a woman with multiple pregnancies, G3P2A0 at 21 weeks gestation, with well-defined erythematous macules 5–10 cm in diameter, partly coalescent, with thick scales, and 0.1–0.2 cm diameter pustules and leukocytosis. Patients receive 1 mg of dexamethasone every morning, clobetasol cream 0.05% twice daily, gentamycin 0.1% three times daily, and 3% salicylic acid cream, while to avoid the emergence of preeclampsia aspirin is given at a low dose of 75 mg/day, and we use vipalbumin to treat hypoalbuminemia. The patient gave birth to premature twins by normal delivery. Conclusion: GPPP is a rare dermatosis with serious risks and consequences for both mother and child. Supportive management is needed to maintain pregnancy and prevent complications.
Effect of Phaleria macrocarpa Extract on NF-KB, MMP-2, and MMP-9 Expression in Endometriosis Mice Model Annissa Febriani; Sutrisno Sutrisno; Yahya Irwanto; Irfani Baihaqi; I Wayan Arsana Wiyasa; Bambang Rahardjo
Asian Journal of Health Research Vol. 1 No. 3 (2022): Volume 1 No 3 (December) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v1i3.35

Abstract

Introduction: Endometriosis is the most common disease that affects the reproductive health and function of women of reproductive age. Treatment for endometriosis includes surgery and medication. Phaleria macrocarpa is a plant native to Indonesia that contains bioactive fractions known to have antiproliferative and apoptotic effects. Therefore, this study aimed to evaluate the effect of Phaleria macrocarpa extract on matrix metalloproteinases (MMP-2 and MMP-9) and NF-KB expression in the endometriosis mice model (Mus musculus). Methods: This study used a Randomized Post-Test Only with Control Group Design. Involves six groups, namely a negative control group (healthy mice without flavonoids from Phaleria macrocarpa fruit extract), a positive control group (an endometriosis model without being given flavonoids from Phaleria macrocarpa fruit extract), and a treatment group, namely a group given four different doses of flavonoids from Phaleria macrocarpa fruit extract: 3.75 milligrams per day, 7.5 milligrams per day, 11.25 milligrams per day and 15 milligrams per day. expressions of NF-KB, MMP-2, and MMP-9 were seen using Immunohistochemistry staining and observed under a microscope with 40x magnification. The data collection used an immunoratio technique with ImageJ analysis software. Furthermore, data analysis using the one-way ANOVA method. Results: In this study, the treatment group with four different doses of Phaleria macrocarpa extract could reduce the expression of MMP-2, MMP-9, and NF-KB. Groups with higher doses of Phaleria macrocarpa extract showed lessen of MMP-2, MMP-9, and NF-KB expression. Conclusion: In the endometriosis mice model, Phaleria macrocarpa fruit can reduce NF-KB, MMP-2, and MMP-9 expression.
Maternal Blood Trace Element Levels in Preeclampsia: Comprehensive Systematic Review and Meta-Analysis Wening Hapsari; Achmad Januar Er Putra
Asian Journal of Health Research Vol. 1 No. 3 (2022): Volume 1 No 3 (December) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v1i3.42

Abstract

Introduction: Deficit in trace elements was frequent in pregnant women and could lead to preeclampsia development. This meta-analysis aimed to determine calcium, magnesium, zinc, iron, and copper serum levels in preeclampsia women compared to healthy pregnant women. Methods: A systematic search is conducted in PubMed, ScienceDirect, and Google Scholar from inception into March 25th, 2022 using keywords of “("calcium" OR "magnesium" OR "zinc" OR "copper" OR "iron" OR "trace element" OR "trace elements") AND ("serum" OR "blood") AND ("preeclampsia")”. Articles obtained from PubMed, ScienceDirect, and Google Scholar were 62, 31, and 119 respectively.  The article screening process was based on the PRISMA 2020 guidelines. Study quality was assessed using NOS. Results: Fifty-four studies were included in this systematic review. Pooled analysis revealed that serum calcium (SMD = (-1.66; 95% CI = -2.05 to -1.28, magnesium (SMD = -1.28; 95% CI = -1.37 to -1.20, and zinc were significantly lower in preeclampsia (SMD = -2.4; 95% CI = -4.11 to -0.7. Serum iron was higher in preeclampsia (SMD = 1.71; 95% CI = 0.21 to 3.21). No significant different difference in serum copper level. Conclusion: The mean blood levels of calcium, magnesium, and zinc were considerably lower, while blood iron levels were higher in preeclamptic women compared to the healthy pregnant group. Copper levels were not significantly different between the two groups.
Case Report: Combination of Electrocautery and Echinacea Therapy in Condylomata Acuminata Raras Pratita; Lita Setyowatie
Asian Journal of Health Research Vol. 1 No. 3 (2022): Volume 1 No 3 (December) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v1i3.48

Abstract

Introduction: Condylomata acuminata or genital warts are classified as sexually transmitted infections caused by the Human Papilloma Virus. The main purpose of Condylomata acuminata treatment is to remove warts and prevent recurrence. Monotherapy is often unsatisfactory. Combination therapy can be done for a better response and minimizing recurrences, one of which is by using an immunomodulator, namely Echinacea. Case Presentation: A 47-years-old woman, widowed, heterosexual, with complaints of genital warts since 2 months ago. Dermatovenerological examination on the major and minor labia showed papules with skin and mucosa color, verucose, multiple, no tenderness and no bleeding. Inspeculo examination found no lesions on the vaginal wall. The acetowhite test showed a positive white color. Patient was diagnosed with condylomata acuminata. The patient received electrocauter therapy once and Echinacea 500 mg for 3 months. Follow-up for 6 months did not reveal any new or recurrent lesions. Conclusion: Therapy for condylomata acuminata is still challenging. Monotherapy is often unsatisfactory due to high degree of recurrence. The use of combination therapy is aimed at minimizing recurrences, one of which is the use of imunomudulator. In this case report, there were no relapses in the 6th month of follow up with combination treatment. These case report can increase knowledge about therapeutic options for CA to avoid recurrences.
Case Report: Secondary Syphilis And Human Immunodeficiency Virus Coinfection Lita Setyowatie; Adya Sitaresmi
Asian Journal of Health Research Vol. 1 No. 3 (2022): Volume 1 No 3 (December) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v1i3.50

Abstract

Introduction: Syphilis is a sexually transmitted infection that is chronically progressive, with a broad spectrum of active clinical and asymptomatic periods. A total of 80.6% of men with syphilis were Men Who Sex with Men (MSM), 47% of the population was coinfected with Human Immunodeficiency Virus (HIV). Case Presentation: Male, 23-yo, MSM, unmarried, HIV, complaining of red bumps and spots on the palms, soles, and upper arms since 4 days ago. One week earlier, he complained of sores in the genitals, which recurred 1 year ago and healed on their own. Dermatological examination revealed multiple erythematous patches and papules. The corpus penis, glans penis, and scrotum showed erosions and multiple ulcers with an erythematous-based, covered with yellowish crusts. VDRL and TPHA were reactive. The patient was diagnosed with secondary syphilis and treated with an intramuscular injection of benzathine penicillin 2.4 million IU once. A 1-month evaluation showed significant lesion improvement, VDRL titer 1:64. Evaluation of the 3rd and 6th months revealed a VDRL titer of 1:4. Conclusion: The clinical manifestations of syphilis patients with HIV coinfection are generally more atypical, aggressive, and overlap caused by changes in the immune system in HIV infection. Unsafe sexual behavior in MSM increases the transmission of syphilis infection. Diagnosis and therapy are generally the same. Men Who Sex with Men is a factor that allows the transmission of syphilis in HIV patients. Administration of benzathine penicillin injection once gave lesion improvement and significantly reduced VDRL.
Effect of Red Bean Extract (Phaseolus Vulgaris L. Sp) on Il-6 Levels and AMH Levels as The Prevention of Premature Ovarian Failure in Mice Model of The Systemic Lupus Erythematosus Adin Permana; Mukhamad Nooryanto; I Wayan Agung Indrawan; Cholid Rohman Riskianto
Asian Journal of Health Research Vol. 1 No. 3 (2022): Volume 1 No 3 (December) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v1i3.51

Abstract

Introduction: Continuous SLE treatment causes Premature Ovarian Failure (POF) and occurred in 27.3% SLE patients treated with cyclophosphamide. IL-6 plays a critical role in the B cell hyperactivity and immunopathology of human SLE. Phaseolus Vulgaris L. Sp have a high total phenolic content and have been shown to have anti-inflammatory and antioxidant effects. This study’s objective is to prove the effect of red beans (Phaseoulus vulgaris L. sp.) in reducing inflammation (IL-6) and increasing AMH levels. Methods: This is a true experimental design with a post-test-only controlled group design. The sample used in this study was 25 female Babic mice divided in two control groups and three treatment groups. Subjects were given intraperitoneal injection of Pristan (0.5 ml), busulfan (30 mg/kg BW), cyclophosphamide (120 mg/kg BW) to induce POF. ANA test was carried out to prone SLE induction was success. Red bean extract was given at 50 mg/kg BW (in treatment group 1), 75 mg/kg BW (in treatment group 2), and 100 mg/kg BW (in treatment group 3). Data of IL-6 and AMH levels in mice serum were obtained by measurement using ELISA. Results: The study showed a significant difference in ANA levels with a p-value of 0.000 in every sample. The study has proven a significant decrease in IL-6 levels with a p-value of 0.000 and a significant increase in AMH levels at a dose of 100 mg/kg BW (P3) with a p-value of 0.000. Conclusion: Phaseolus vulgaris extract had a significant effect on follicle changes in Balb/c mice in dose of 50 mg/kg and 75 mg/kg but not significantly reduce inflammation (IL-6).
The Influence of Video-Based Health Education in Modifying Early Screening Efforts for Polycystic Ovary Syndrome (PCOS) Ni Komang Surya Ariani; Ni Luh Putu Dina Susanti; Ni Wayan Manik Parwati; Ni Putu Sri Haryati
Asian Journal of Health Research Vol. 1 No. 3 (2022): Volume 1 No 3 (December) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v1i3.54

Abstract

Introduction: Polycystic Ovary Syndrome (PCOS) is the most common causes of infertility in reproductive age women. The lack of knowledge about this disease causes PCOS is often late diagnosed. This study aims to determine the influence of health promotion in video-based learning form on young women’s knowledge, attitudes and behaviors in early screening efforts for PCOS. Methods: This is a pre-experimental study with one-group pretest-posttest design. The sample used was 261 female students in one of the senior high schools in Denpasar with a simple random sampling technique. The research instrument used is a questionnaire in which each variable, namely the knowledge, attitude, and the behavioral. The data was analyzed by using the Wilcoxon Rank Test. Results: There was a significant change between the provision of health promotion in the form of video-based learning form on young women’s knowledge, attitudes and behaviors related to the PCOS early screening in each variable, i.e. the knowledge variable p-value = 0.001, the attitude variable p-value <0.001, and the behavior variable p-value <0.001. Conclusion: There was an influence of health promotion in video-based learning form on young women’s knowledge, attitudes and behaviors related to the PCOS early screening.
The Effect of Exposure to Escherichia coli with Low Molecular Weight Hyaluronan, High Molecular Weight Hyaluronan, Hyaluronidase in the Cervix Premature Pregnant Model of Balb/C Mice Fikhy Rizky Hapsari; Suheni Ninik Hariyati; I Wayan Arsana Wiyasa; Teguh Wiyono; Dewi Santosaningsih
Asian Journal of Health Research Vol. 1 No. 3 (2022): Volume 1 No 3 (December) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v1i3.56

Abstract

Introduction: Infection is the biggest cause of preterm labor, about 25-40%, and ascending infection through the vagina is the most common route of infection. This study aims to evaluate the level of Low Molecular Weight Hyaluronan (LMWHA), level of High Molecular Weight Hyaluronan (HMWHA), and the level of the enzyme hyaluronidase in Balb/c premature labor due to infection with Escherichia coli model mice. Methods: This study used an actual experimental design carried out in the laboratory in vivo on balb/c mice exposure to Escherichia coli with a randomized post-test only with a control group design. In the premature model of exposure to Escherichia coli balb/c mice on the cervix of 109 CFU/ml, cervical samples were taken and the levels of LMWHA, HMWHA, and hyaluronidase were measured using spectrophotometry. This study was divided into 2 groups. Control group and treatment group. Results: Low Molecular Weight Hyaluronan (LMWHA) and of the hyaluronidase enzyme levels in premature Balb/C cervical mice exposed to E. coli were higher than in Balb/C cervical mice. High Molecular Weight Hyaluronan (HMWHA) levels in premature Balb/C cervical mice exposed to E. coli were lower Conclusion: In the cervix of the infected by E. coli mice model, LMWHA and hyaluronidase enzymes increased and HMWHA decreased.    

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