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Asian Journal of Health Research
Published by Ikatan Dokter Indonesia Wilayah Jawa Timur
ISSN : 28292979     EISSN : 28289269     DOI : https://doi.org/10.55561/ajhr
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Asian Journal of Health Research (AJHR) is an open access journal published by Ikatan Dokter Indonesia Wilayah Jawa Timur and launched in 2022. This journal is peer reviewed publishing to communicate high quality research, general articles, and all fundamental research/ clinical studies relevant to health science. The journal publishes articles Medical Sciences scope including (Obstetrics and Gynaecology, Pediatrics, Internal medicine, Ophthalmology, Surgery, Neurology, Otolaryngology, Cardiology and Vascular Medicine, Anaesthesiology and Reanimation, Dermatovenerology, Orthopaedics and Traumatology, Urology, neurosurgery, Cardiothoracic surgery, Orthopaedics and Traumatology, Plastic Reconstructive Surgery and Aesthetics, Pulmonology and Respiratory Medicine, Forensic Medicine, and Medicolegal, Psychiatry Medicine and Rehabilitation). AJHR journal is published three times per year in April, August, and December.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 160 Documents
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The Effect of Calcium on Biomarkers of Ovarian Fertility in Premature Ovarian Failure: A Systematic Review Sutrisno Sutrisno; Tri Aji Bangun Nuswantoro
Asian Journal of Health Research Vol. 2 No. 2 (2023): Volume 2 No 2 (August) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i2.29

Abstract

Introduction: Premature ovarian failure (POF) is a condition in which ovarian function decreases or follicles are depleted in women aged less than 40 years. Calcium, along with vitamin D, is a mineral with many benefits for the reproduction system. This review is written to observe the effect of calcium on ovarian fertility biomarkers in premature ovarian failure. Methods: The literatures search was conducted utilizing numerous search engines, namely PubMed, Cochrane, Springer, Science Direct, Nature, and Google Scholar. Article publication year was restricted from 2016 to 2022. Article search keywords included “calcium”, “vitamin D”, “premature ovarian failure”, “premature ovarian insufficiency”, “amenorrhoea”, “ovarian reserve biomarkers”, “estradiol”, “follicle stimulating hormone”, and “luteinizing hormone”. Article selection was performed using the preferred reporting items for systematic review and meta-analysis protocols guidelines (PRISMA-P). The first author’s name, publication year, samples number, age range of subjects, duration of data collection, geographical setting, study design, and conclusions of research results were extracted from the selected paper. Results: 8397 articles were obtained from the six search engines. 13 articles met the inclusion criteria. Research conducted by Iran reported a significant correlation between vitamin D levels and AMH levels (p<0.001). In comparison, the research in Bangladesh showed a significant positive correlation between vitamin D levels and AMH levels (r=0.433; p=0.001) and vitamin D levels and AFC values (r=0.419; r=0.001). However, 11 other researchers reported contradictory results. Conclusion: The calcium and vitamin D effect on reproductive health related to POF occurrence is still inconsistent. Therefore, observational and experimental research is needed to analyze this topic.
Implementation of Early Recovery After Caesarean Surgery Protocol in Floating Hospital (Case Series) Akhyar Nur Uhud; Berta Welantika; Senda Sulvain Rahmaningrat; Talitha Yuliaputri Aden
Asian Journal of Health Research Vol. 2 No. 2 (2023): Volume 2 No 2 (August) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i2.67

Abstract

Introduction: Enhanced Recovery After Caesarean Surgery (ERACS) is a new concept that combines various evidence-based perioperative care to reduce post-operative complications and accelerate patient recovery after Caesarean Surgery (C-Section). The advantages of the ERACS Protocol, including accelerating patients' recoveries, shortening hospital stays, and reducing post-operative complications, make it suitable to be applied in floating hospitals. The problem is whether this protocol can be applied if it is carried out in a floating hospital with all its limitations. We would like to present our case series with modified ERACS protocol in Floating Hospital Ksatria Airlangga. Case Presentation: We present 4 patients scheduled for elective C-Section. Neuraxial opioids with low-dose morphine, the most frequently used technique in ERACS, were not administered due to its unavailability in Ksatria Airlangga Floating Hospital. We provide pre-emptive analgesia and multimodal analgesia to obtain adequate perioperative analgesia. All patients were admitted to the nearest public health centre for post-operative observation and discharged after 1 to 2 days. Satisfaction was achieved in all patients without any significant postoperative complications. Conclusion: The ERACS protocols’ main goal can be achieved even under limited conditions, but several adjustments are required according to the available resources.
Suspicion of Duchenne Muscular Dystrophy in A 7-Year-Old Madurese Boy: A Rare Case Report Suci Rizalah Islamiyah; Garata Dwi Yulia Nurul Putri
Asian Journal of Health Research Vol. 2 No. 2 (2023): Volume 2 No 2 (August) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i2.88

Abstract

Introduction: Duchenne Muscular Dystrophy (DMD) is an X-linked disorder presenting in early childhood and characterized by proximal muscle weakness and calf hypertrophy in affected boys associated with a functional deficiency of dystrophin. The incidence of these cases reached 1 in 3500-6000 male births. Research at RSUPN Dr Cipto Mangunkusumo (RSCM) showed that DMD is the second most frequent neuromuscular disorder in children regardless there is no prevalence data available yet in Indonesia. It is quite complicated to diagnose DMD due to the limited facilities of genetic testing and its high cost. Case Presentation: A 7-year-old boy came with the main complaint of weakness in both legs progressively two years before admission. He had to hold onto the floor and then both knees when started to stand. There was a history of motor and speech delay but family history was denied. Vital signs and nutritional status were within normal. Laboratory examination revealed significantly elevated levels of CK, ALT, and AST. The EMG result supported the presence of myopathy. Due to a lack of facilities, genetic testing or muscle biopsy could not be done. He received prednisone once a day with a 14 mg dose and was scheduled to attend regular physiotherapy. Conclusion: In a limited facilities area, the clinician should have a suspicion of DMD not only by anamnesis and clinical features, but also by considering the elevated levels of CK and myopathies on EMG.
Effect of Red Bean Extract (Phaseolus vulgaris L.) on IL-10 Levels in Systemic Lupus Erythematosus Model Mukhamad Nooryanto; Tatit Nurseta; Cholid Rohman Riskianto; Syah Sembung Wasiso; Yudistira Yunus
Asian Journal of Health Research Vol. 2 No. 2 (2023): Volume 2 No 2 (August) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i2.96

Abstract

Introduction: Systemic Lupus Erythematosus (SLE) is a is a chronic autoimmune inflammatory disease of unknown etiologic. Multiorgan dysfunction in women with SLE causes menstrual irregularities, ovarian failure, follicular atresia, and premature ovarian failure (POF) leading to the cessation of menstruation. Phaseolus vulgaris L. contains isoflavones that can trigger oocyte maturation, stimulate the formation of antral follicles, increase FSH receptor expression and proliferate cell nuclear antigen (PCNA) expression. This study aims to prove the effect of red bean extract (isoflavones) in SLE by and increasing the secretion of anti-inflammatory IL-10 levels. Material and Methods: This study used a true experimental design with a post-test-only controlled group design. The samples used in this study were at least 25 female Balb/c mice. Data on serum IL-10 levels in mice were obtained by measurement using ELISA. The data were statistically analysed using SPSS 16 for Windows software program. The data were tested for normality and homogeneity using parametric non-parametric analysis. Results: The results showed that there was a significant difference in ANA levels with a p-value of 0.000 in each sample. From this test, it was proven that there was a significant increase in IL-10 levels at doses of 75 mg/KgBW (P2) and 100 mg/KgBW (P3) (p-value=0.000) due to the administration of various doses of red bean extract (isoflavones). Conclusion: Red bean extract (isoflavones) had a significant effect in increasing IL-10 levels.
Bilateral Steroid Induced Glaucoma In A 10-year-old Boy Rosalia Adriani Malika; Lydia Nuradianti
Asian Journal of Health Research Vol. 2 No. 2 (2023): Volume 2 No 2 (August) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i2.97

Abstract

Introduction: Topical steroids are used in the treatment of various ocular disorders. However, it can cause numerous side effects. Steroid-induced glaucoma is the most severe complication of the unmonitored use of steroids. It is diagnosed by visual field defects, increased intraocular pressure (IOP), and glaucomatous optic neuropathy (GON) due to prolonged usage of steroids. Case Presentation: a 10-year-old boy presented to the outpatient clinic in Undaan Eye Hospital complaining of headache, re dness and itchiness in both eyes. He started using dexamethasone 0.1% eye drops without a physician's supervision for the last 2 years. Steroid-induced glaucoma was diagnosed in both eyes. Topical and oral glaucoma medications were given. Both eyes IOP were still elevated in the following months. Trabeculectomy in both eyes was performed due to medically uncontrolled glaucoma. Furthermore, both eyes IOP were getting normal without any topical and oral glaucoma medications. Conclusion: Unmonitored steroid usage must be avoided. This case suggests general practitioners and health care providers in the front line be aware of the usage of topical steroids. By increasing awareness concerning steroid-induced glaucoma, a patient's visual acuity can be saved, and irreversible blindness can be prevented, especially in children.
Cutaneous Manifestations of Scleroderma: A Case Report Tessa Thendria; Amira Suryani Rahmatika; Evy Ervianti; Dwi Murtiastutik; Trisiswati Indranarum; Hasnikmah Mappamasing; Septiana Widyantari
Asian Journal of Health Research Vol. 2 No. 2 (2023): Volume 2 No 2 (August) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i2.103

Abstract

Background: Scleroderma or systemic sclerosis is a rare multisystemic autoimmune disease characterized by vasculopathy, inflammation, and progressive fibrosis of the skin and multiple organs. Cutaneous manifestations and Raynaud’s phenomenon, usually becomes the initial presentation of scleroderma which noticed by the patient. Case: A 47-year-old-women presented with hardened and thickened skin on her arms and legs for 3 years which spreaded to her face and trunk. The lesions initially appeared as multiple red patches which progressed into white, thick and hard patches. The patient had history of recurrent Raynaud's phenomenon, dry cough, and shortness of breath. In the physical examination, the patient had skin hardening with salt and pepper appearance on her upper back and chest. The thoracic CT scan revealed interstitial lung disease. The patient diagnosed as definitive scleroderma based on The European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) criteria with score of 18. She has treated with methotrexate, methylprednisolone, topical corticosteroid and moisturizer. The skin lesion improved with the reduction of Rodnan skin score from 31 to 19 after 4 months of treatment. Conclusion: Cutaneous manifestation could be the early alarm and initial manifestation of scleroderma. As the pathology is deep beyond the skin, throughout examination should be performed to find any organ involvement. Dermatologist play a significant role in early identification of skin disorder and made multidiciplinary refferal. Early diagnosis and prompt treatment could reduce morbidity and mortality in scleroderma
The Relationship and Factors The Parenting Style of Parents Who Married Early with The Development of Children Aged 1-5 Years Faza Nabila; Ariani Ariani; Safrina Dewi Ratnaningrum
Asian Journal of Health Research Vol. 2 No. 2 (2023): Volume 2 No 2 (August) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i2.106

Abstract

Introduction: Early marriage is a major problem in the process of child rearing. Improper parenting patterns can hinder the growth and development of children. This study aims to analyze the relationship and factors that influence the parenting style of parents who marry early on the development of children aged 1 to 5 years in the Tulungagung district. Material and Methods: Research using cross-sectional analitic observation, a sample of 203 respondents who were married under 19 years of age in 2017-2021 and had children aged 1-5 years using a questionnaire and Denver II. Statistical analysis calculation using chi-square and path analysis. Results: The chi-square test results showed a significant relationship between the parenting style of parents who early marriage and the development of children aged 1-5 years (p<0.05). Path analysis showed that there is an influence of the parenting style of parents who early marriage on the development of children through education and number of children (p<0.05). while in terms of occupation, income, and family support, there is no influence of the parenting style of parents who early marriage on the development of children (p>0.05). Conclusion: Parents who marry early tend to adopt an authoritarian parenting style, which can lead to poor child development. Authoritarian parenting styles have low levels of democracy and parental affection. High achievement demands on children are not matched by parental love so that it makes children feel depressed.
A Challenging Case: Colorectal Cancer During Pregnancy Caesar Ahmad Tidel; Syifa Mustika
Asian Journal of Health Research Vol. 2 No. 2 (2023): Volume 2 No 2 (August) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i2.108

Abstract

Introduction: Colorectal cancer (CRC) occurring in younger women can lead to an increased incidence of colorectal cancer during pregnancy. The estimated frequency of malignancy during pregnancy with colorectal cancer specifically estimated at 1 in 13,000 pregnancies. However, the exact causes of colorectal cancer during pregnancy are not yet fully understood. Diagnosing and managing colorectal cancer during pregnancy pose significant challenges because the symptoms can be masked by the normal signs and symptoms of pregnancy. Case Pesentation: A 42-year-old pregnant patient, Mrs. L, presented with abdominal pain, a history of dark-colored bowel movements, and a lump on the left side of her neck that had been present for a year. She had also experienced a weight loss of 5 kg both before and during pregnancy, and there was no previous history of malignancy. The patient underwent various diagnostic procedures, including pregnancy ultrasound, abdominal ultrasound, and colonoscopy biopsy. Based on the comprehensive evaluation of the patient's medical history, physical examination, and supporting tests, she was diagnosed with stage IV rectal adenocarcinoma with metastases to the liver, kidney, and lymph nodes. The patient was in her second pregnancy (G2P1Ab0) at 27-29 weeks of gestation. Conclusion: Colorectal cancer during pregnancy poses diagnostic and therapeutic challenges, as the signs and symptoms are often attributed to the normal progression of pregnancy, resulting in delayed diagnosis at an advanced stage. Early detection, evaluation, and monitoring of nonspecific symptoms are crucial, and a multidisciplinary approach is necessary for the management of colorectal cancer during pregnancy.
Hepatotoxicity Oral Administration of Flavonoids Rich Extract from Phaleria Macrocarpha in Mice Siskanita Fitriana; Sri Andarini; Sutrisno Sutrisno; Gita Nawangtantrini; Maharani Maharani
Asian Journal of Health Research Vol. 2 No. 2 (2023): Volume 2 No 2 (August) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i2.109

Abstract

Introduction : Herbal medications are increasingly being used to treat a wide range of illnesses. Phaleria macrocarpa, often known as the crown of the gods, is a plant rich in flavonoids that is frequently used in herbal therapy. The goal of this study was to see what effect a flavonoid-rich extract from phaleria macrocarpa has on the livers of mice. Material and Methode : This study used adult female mice aged 6-8 weeks and weighing 20-30 gr as experimental animals, which were divided into four groups: the control group was given distilled water, group 2 was given a flavonoid dose of 500 mg/kg/day, group 3 was given a flavonoid dose of 1000 mg/kg/day, and group 4 was given a flavonoid dose of 2000 mg/kg/day. The flavonoid-rich extract of Phaleria macrocarpa was administered for 28 days. On the 29th day, the mice were necropsied, followed by surgery and examination of the mice's livers. Result : The flavonoid-rich extract of phaleria macrocarpa at a dose of 500 mg/kg body weight/day resulted in no changes in the weight or histological structure of the liver (p>0.05). Hydropic degeneration and necrosis were observed in the group administered the flavonoid-rich extract of phaleria macrocarpa at doses of 1000 and 2000 mg/kg body weight/day. Conclusion : The administration of a flavonoid-rich extract from Phaleria macrocarpa at a level of 500 mg/kg body weight/day caused no harm in the liver of mice. The use of more than 500 mg/kg body weight/day over an extended period of time has hazardous effects and is not recommended.
Characteristics of Pediatric Tuberculosis Patients at Simpang Lima Gumul Hospital, Kediri, East Java Rika Oktania Sari; Bayu Prabowo
Asian Journal of Health Research Vol. 2 No. 2 (2023): Volume 2 No 2 (August) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i2.110

Abstract

Introduction: Pediatric tuberculosis can cause a variety of problems, including growth failure, disability, and death. In 2021, WHO recorded 10.6 million individuals had tuberculosis globally, with pediatric tuberculosis accounting for 11% of these cases. Indonesia is the second highest high-burden country for tuberculosis, according to the WHO. Children with tuberculosis often present non-specific and uncommon symptoms, making diagnosis challenging and frequently delayed. This study aims to present an overview of the characteristics of pediatric tuberculosis patients at Simpang Lima Gumul Hospital in Kediri, East Java. Material and Methods: This was a descriptive retrospective study with a cross-sectional method. Pediatric tuberculosis patients who received treatment at the Simpang Lima Gumul Hospital in Kediri, East Java, were the subject of research. We compiled pediatric tuberculosis patients' demographic data and clinical characteristics using medical records. Results: Sixty-one children included in the study. Most of them were male (56%) between 1 to 5 years old (52%). Seventy-two percent had a positive tuberculin skin test; chronic cough was noted in 69% of cases. An adult contact history of tuberculosis was reported in 64% of cases, while 61% had radiographic findings from TB. 52% also had fever, 51% had lymphadenopathy, and 72% had good nutritional status. Conclusion: Tuberculosis occurs most commonly in male children 1 to 5 years of age. The most common symptoms of pediatric tuberculosis include a positive tuberculin skin test, chronic cough, contact with adults with tuberculosis, positive radiographic findings, fever, and lymphadenopathy.

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