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Asian Journal of Health Research
Published by Ikatan Dokter Indonesia Wilayah Jawa Timur
ISSN : 28292979     EISSN : 28289269     DOI : https://doi.org/10.55561/ajhr
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Asian Journal of Health Research (AJHR) is an open access journal published by Ikatan Dokter Indonesia Wilayah Jawa Timur and launched in 2022. This journal is peer reviewed publishing to communicate high quality research, general articles, and all fundamental research/ clinical studies relevant to health science. The journal publishes articles Medical Sciences scope including (Obstetrics and Gynaecology, Pediatrics, Internal medicine, Ophthalmology, Surgery, Neurology, Otolaryngology, Cardiology and Vascular Medicine, Anaesthesiology and Reanimation, Dermatovenerology, Orthopaedics and Traumatology, Urology, neurosurgery, Cardiothoracic surgery, Orthopaedics and Traumatology, Plastic Reconstructive Surgery and Aesthetics, Pulmonology and Respiratory Medicine, Forensic Medicine, and Medicolegal, Psychiatry Medicine and Rehabilitation). AJHR journal is published three times per year in April, August, and December.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 148 Documents
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Comparison of the Effects of Dienogest and Leuprolide Acetat on Serum Interferon (IFN-Æ”) Levels in a Mouse Model of Endometriosis (Mus musculus) Maria Antonia Barbara Batu Mali; Siskanita Nur Fitriana; Sutrisno Sutrisno; Husnul Khotimah; I Wayan Arsana Wiyasa; I Wayan Agung Indrawan; Maharani Maharani
Asian Journal of Health Research Vol. 2 No. 2 (2023): Volume 2 No 2 (August) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i2.111

Abstract

Introduction: Endometriosis is a medical condition in which there is abnormal growth of tissue resembling the endometrium outside the uterus. It can cause symptoms of pain and/or infertility. The current medical therapy focuses on reducing estradiol levels or stimulating progesterone response. One of the most effective options for medical treatment is the use of GnRH analogs. Dienogest have a direct anti-inflammatory effect on endometriotic stromal cells. However, a comparison of the anti-inflammatory effects of these drugs on IFN-Æ” has not been previously investigated. Therefore, this study aims to compare the effects of reducing IFN-Æ” by both Dienogest and Leuprolide Acetat in a mouse model. Material and Methods: This study employed a post-test only control group design and involved 4 groups, namely the negative control group, positive control group, and two treatment groups: one group administered Dienogest at a dosage of 0.0052 milligrams per day for 14 days, and the other administered Leuprolide Acetat at a dosage of 0.00975 milligrams once every 5 days for a period of 14 days. Serum IFN-Æ” levels were measured using Enzyme-Linked Immunosorbent Assay (ELISA). The data were subsequently analyzed using IBM SPSS 25 with One-Way ANOVA test. Results: This study demonstrated that Leuprolide Acetat significantly decreased serum levels of IFN-Æ”, whereas Dienogest actually increased the levels . Conclusion: In a mouse model of endometriosis (Mus musculus), Leuprolide Acetat effectively reduced the levels of IFN-Æ” (pro-inflammatory). Conversely, Dienogest increased the levels of IFN-Æ” (anti-inflammatory) in the mouse model of endometriosis.
Exploring The Relationship Between Lactate Dehydrogenase Levels, Leukocyte Counts, Low Birth Weight, and The Severity of Preeclampsia in Pregnant Women: A Cross-Sectional Study at Saiful Anwar Hospital Malang (July 2021 to June 2022) Bambang Rahardjo; Talita Nandia Primarintan
Asian Journal of Health Research Vol. 2 No. 2 (2023): Volume 2 No 2 (August) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i2.112

Abstract

Introduction: This study investigates the connection between lactate dehydrogenase (LDH) levels, leukocyte counts, low birth weight, and the severity of preeclampsia among pregnant women. Conducted at Saiful Anwar Hospital in Malang from July 2021 to June 2022. Material and Methods: This research utilizes a descriptive and analytical observational approach with a cross-sectional design. Pregnant women meeting specific criteria were evaluated for LDH levels, leukocyte counts, preeclampsia severity, and newborn birth weights. Statistical analyses, including the Kruskal-Wallis test and Spearman correlation, were employed to explore relationships and significance among variables. Results: There is significant differences in LDH levels and low birth weight across patients with mild preeclampsia, severe preeclampsia, and eclampsia. LDH levels were linked to preeclampsia severity, while low birth weight correlated with eclampsia. Leukocyte levels, however, did not exhibit notable differences among these group. Conclusion: This study underscores the necessity of early assessment and monitoring of these factors in pregnant women, aiming to enhance maternal and fetal outcomes. Further research is recommended to validate these findings in diverse populations and explore additional risk factors associated with preeclampsia-related conditions. In conclusion, this research illuminates the interplay between LDH levels, leukocyte counts, low birth weight, and preeclampsia severity. The outcomes emphasize their importance as potential markers for evaluating and managing preeclampsia-related complications.
Headache Characteristic in Covid-19 Infected Patient: A Systematic Review Vina Lidya Setjaputra; Steven Christian Susianto; Abdulloh Machin
Asian Journal of Health Research Vol. 2 No. 2 (2023): Volume 2 No 2 (August) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i2.113

Abstract

Introduction: The neurotropism of COVID-19 virus has been addressed in several studies, and headache is one of the most frequent neurologic manifestations of COVID-19, with various results of characteristics and phenotype. In this systematic review, we aimed to characterize the most common phenotype of headache in COVID-19 infected patients. Methods: A systematic literature was conducted through Pubmed, SciElo and Cochrane databases with keywords (headache[Title]) AND (covid-19[Title]), ((neurological) AND (headache) AND (characteristic)) AND (covid-19), ((phenotype) AND (headache)) AND (covid-19). We extracted the study design, demographics of subjects, and characteristics of headache (onset, site, lateralization, quality, intensity, and additional symptoms related to headache). Results: We included 1381 subjects with COVID-19 infection who experienced headache symptoms from eligible 9 studies. The majority of our patients had headaches that occurred with COVID-19 symptoms onset (94.2%), ranging from 1 to 10 days after the first COVID-19 symptoms. The most common headache site was frontal (42.3%), followed by diffuse/ holocranial (40.1%), periorbital/retroorbital (24.2%), and temporal (23.8%), with no lateralization/occurring bilaterally (85.9%), and pain characteristic predominantly pressing and tightening (55.9%), throbbing (25.3%), and stabbing (9.8%). Headache intensity measured by VAS score ranged mild to moderate in most cases with duration mostly 1-24 h. 57% of headache patients were also accompanied by fever symptoms. Additional headache symptoms were also recorded, predominantly anosmia/ageusia, followed by photophobia/phonophobia, and nausea/vomiting. Conclusion: Bilateral, long-lasting, with pressing-tightening characteristic headaches accompanied by fever, were more frequent in COVID-19 infected patients, in conjunction with anosmia/ageusia. These features may help physician to determine the headache related to COVID-19.
The Effect of Establishing Escherichia coli on Balb/C Rats as A Model of Preterm Labor Suheni Ninik Hariyati; Dewi Santosaningsih; Arief Satria Hardika; Fikhy Rizky Hapsari; Nirwan Nugraha L.; Wildan Aulia Firdaus
Asian Journal of Health Research Vol. 2 No. 2 (2023): Volume 2 No 2 (August) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i2.115

Abstract

Introduction: The prevalence of preterm labor in Indonesia is estimated at 7-14%, which is around 459,200-900,000 babies per year. The mechanism of infection is the biggest cause of preterm labor. The bacteria that often causes infection is Escherichia coli. This study aims to see the effect of giving Escherichia coli to produce premature models of mice. Material and Methods: This study used a true experimental method with a post-test only control group design approach. The independent variables were preterm labor & cervical tissue culture, amniotic membranes, and placenta. The dependent variable of the study was the administration of Escherichia coli 109 CFU to the cervix. This research will be tested with a comparative test. Results: The treatment group were given Escherichia coli experienced parturition with the fastest time of 38 hours 22 minutes and the longest time of 42 hours 12 minutes. Escherichia coli colonies on Eosin Methylene Blue (EMB) culture media with a glowing green image was obtained. Cervical culture, amniotic membranes and placenta from the treatment group of Balb/C mice showed the growth of Escherichia coli colonies. Neutrophil infiltration and edema in the cervical stroma was found to be more severe in Balb/C mice that received treatment with Escherichia coli 109 CFU/ml. Conclusion: Escherichia coli shortens the time of delivery and increases the bacterial load in pregnant Balb/C mice.
Correlation between Secreted Aspartyl Protease-5 (SAP5) on Increasing Vaginal Acidity in Vulvovaginal Candidiasis Nur Sophia Matin; Regina Ayu Fristiyanti; Safrina Dewi Ratnaningrum; Nurdiana Nurdiana; Sanarto Santoso; Bambang Rahardjo
Asian Journal of Health Research Vol. 2 No. 2 (2023): Volume 2 No 2 (August) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i2.116

Abstract

Introduction: Vulvovaginal candidiasis (VVC) is an infection of the vaginal mucosa that extends to the vulva due to excessive growth of Candida albicans, causing a progressive decrease of Lactobacillus spp., as the main of normal flora. Decrease in the number of Lactobacillus spp. causes a reduction of lactic acid production that it was causing increasing vaginal pH. The increase in pH is due to the progressive growth of C. albicans colonies in the vaginal mucosa. In addition, the mechanism of candidiasis is also influenced by the secretion of virulence factors by C. albicans. Secreted Aspartyl Protease-5 (SAP5) is the dominant virulence factor that plays a role in changing the morphology of yeast cells into hyphae. This study aims to identify the correlation between SAP5 levels and vaginal pH. Material and Methods: This research was conducted in vivo using a sample of Rattus norvegicus with a posttest randomized experimental group design approach. This study has two groups, i.e., Negative Control (NC) and Positive Control group (PC). SAP5 and pH samples were taken from vaginal fluids and then measured using ELISA and a digital pH meter. The statistical analysis used was Pearson Correlation to analyze the correlation between SAP5 and pH levels. Results: There was a strong correlation (R=0.846) that means the increase of SAP5 is related to the increase of vaginal acidity in the PC group. Conclusion: The increase in SAP5 levels is directly followed by an increase in the pH value of vaginal fluids,
Rhabdomyosarcoma of The Uterine Cervix: Case Report and Literature Review Tatit Nurseta; Ayu Rizky Widowati
Asian Journal of Health Research Vol. 2 No. 2 (2023): Volume 2 No 2 (August) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i2.118

Abstract

Introduction: Embryonal rhabdomyosarcoma (RMS) of the uterine cervix is a  rare mesenchymal tumor that occurs in less than 1% of all cervical cancers. These malignant tumors occur in adolescents and young adults. It starts from embryonic muscle tissue or pluripotent mesenchymal cells. This case reports an unusual case of embryonal rhabdomyosarcoma in a 33-year-old woman. Case Presentation: A 33-year-old woman came to the Obstetrics and Gynecology Department. She complained with exophytic cervical masses and vaginal bleeding. There were no remarkable findings about medical, family, and social history Histopathology confirms embryonal rhabdomyosarcoma (sarcoma botryoides) of the uterine cervix. A combination of radical hysterectomy and adjuvant chemotherapy was chosen as the therapeutic option in this case. Conclusion: Although the prevalence of cervical rhabdomyosarcoma in adults is very low, a multimodality approach is necessary for favorable prognostic.
Shortages of Medical Doctors in Indonesia, Is It True? Sutrisno, MD, PhD, OG (REI)
Asian Journal of Health Research Vol. 2 No. 2 (2023): Volume 2 No 2 (August) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i2.121

Abstract

All parts of Indonesia need medical doctors, but it is not a simple thing to be solved. The world of medicine in Indonesia faces many internal problems, specifically regarding medical doctor distribution. Where are the medical doctors in Indonesia being resided? Recently many areas in Indonesia experienced a ratio between doctors and population of more than 1 : 1000. Data from the Indonesia Medical Council (KKI) and Indonesia Medical Doctor Association (IDI) in the year 2023 total number of medical doctors are 214,878 doctors, dominated by general physician 165,453 doctors, and followed by doctors specialist  49,425. Total dentists are 41,940, and dentist specialists are 5,201. The fundamental problems, according to population ratios, is related to geographical and demographic handicap because Indonesia is an archipelago country with more than 17,000 islands with more than 280 million populations, with many specific problems in access,  communication, transportation system, socio-economic, cultural, and leadership.
Risk Factor of Vitamin-D Deficiency in Pregnant Women with COVID-19 Infection: Comprehensive Meta-Analysis and Systematic Review Leny Silviana Farida
Asian Journal of Health Research Vol. 3 No. 1 (2024): Volume 3 No 1 (April) 2024
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v3i1.49

Abstract

Introduction: It has been suggested that coronavirus infection (COVID-19) in pregnant women may be influenced by vitamin D deficiency (VDD). The physiological changes brought on by pregnancy, and the body's partial immune suppression make pregnant women more susceptible to vitamin D deficiency and viral infections. Therefore, this review aims to synthesize the current information on the link between vitamin D levels and the risk of COVID-19 in pregnant women. Material and Methods: A systematic search is conducted in PubMed, ScienceDirect, and Google Scholar. Articles retrieved were screened based on the PRISMA 2020 guidelines. Studies that assessed the effect of vitamin D levels on pregnant women with COVID-19 infection were considered for the review. Odds ratios with their 95 percent confidence intervals (CI) from a meta-analysis using a random-effects model were reported. Results: Three eligible studies were relevant to the relationship between vitamin D deficiency and COVID-19 infection in pregnant women (n=1005). The metanalysis showed that vitamin D deficiency in pregnant women was 1.8 times (95% confidence interval, OR 1.72 to 1.88; p=0.0005) more likely to be infected with COVID-19. Conclusion: According to our results, vitamin D deficiency in pregnant women may increase the risk of COVID-19 infection. Therefore, we recommend adequate vitamin D levels to prevent COVID-19 and its severity.
The Effect of Flavonoid Extract from Phaleria macrocarpa to Proliferating Factors (MMP-1, MMP-3, MMP-7) in Endometriosis Mice Model Irwanto, Yahya; Wiyono , Teguh; Wardani, Kusuma
Asian Journal of Health Research Vol. 2 No. 3 (2023): Volume 2 No 3 (December) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i3.102

Abstract

Introduction: Endometriosis is an inflammatory disease influenced by estrogen characterized by ectopic growth of the endometrial stroma and glands. Matrix metalloproteinase (MMP) is a proteolytic enzyme that has an important role in the remodeling of the extracellular matrix in normal tissues but also contributes to pathologies such as tumor invasion. The therapy has many drawbacks, including being expensive and in need of herbal therapy as an alternative. Phaleria macrocarpa is a native plant of Indonesia that contains flavonoids. This study aimed to evaluate the effect of Phaleria macrocarpa flavonoid isolate on the development of apoptosis, proliferation, and angiogenesis in mice model endometriosis. Material and Methods: This research is a true experimental study with a Randomized Post-Test Only with a Control Group in the laboratory. Samples are divided into six groups, a control group and an intervention group, administered with flavonoid extract from Phaleria macrocarpa. Data analysis was carried out by using the Independent T-Test with SPSS for Windows 19.0 software. Results: Each control and intervention group consisted of 6 mice. The normality test for each variable shows p> 0.05. Administration of flavonoid in each group shows a significant decrease in MMP-1 (20.4 ± 7.74 vs 65.68 ± 10.97, p=0.000), MMP-3 (53.34 ± 9.66 vs67.47 ± 10.05, p=0.000), and MMP-7 expression (40.52 ± 5.43 vs 54.13 ± 4.08, p=0.000). Conclusion: Flavonoids from the Phaleria macrocarpa fruit extract were able to reduce the expression of MMP-1, MMP-3, and MMP-7 in mice model endometriosis.
Effect of Genistein on Proliferating Cell Nuclear Antigen (PCNA) Expression and Vascular Density in The Peritoneum of Endometriosis Mice Model Anggia Prameswari Wardhana; Yahya Irwanto
Asian Journal of Health Research Vol. 2 No. 3 (2023): Volume 2 No 3 (December) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i3.104

Abstract

Introduction: Survival of endometriosis lesions depends on the formation of blood vessels, cell proliferation, and oxygen supply. Their vascular densities can evaluate the vascularity of ectopic endometriosis tissues. Proliferating Cell Nuclear Antigen (PCNA) is one of the markers of cell proliferation that affects the growth of endometriotic lesions. Genistein is an isoflavone component that highly potential effect as an anti-angiogenic and inhibiting proliferation through the binding capacity to estrogen receptors. Material and Methods: This experimental study uses the Stored Biological Materials of mice peritoneum tissue. The paraffin block was divided into six groups, which are the negative control group, positive control group, and four treatment groups with genistein doses of 1.3 mg/day, 1.95 mg/day, 2.6 mg/day, and 3.25 mg/day. Immunohistochemical techniques and hematoxylin-eosin for vascular densities examined PCNA expressions. Preparation analysis uses OLIVIA software. Preparation calculations are done manually with cell count software. Observations were analyzed with the ANOVA test and Dunnett T3 5% test. Results: Based on analysis with ANOVA, there was a significant difference in PCNA expression and vascular densities because of the effect of genistein in various doses with a p-value of 0.001 (p<0.05). Based on Dunnett T3 5% test increase of PCNA expression by giving genistein doses 1,3 mg/day, 1,95 mg/day, and 2,6 mg/day, a reduction in dose of 3,25 mg/day. Vascular densities reduced significantly in all treatment groups. Conclusion: Administration of genistein in various doses significantly increases PCNA expression but reduces PCNA expression in a dose of 3.25 mg/day and significantly reduces vascular densities.

Page 7 of 15 | Total Record : 148

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