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Zahratul Aini
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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 15 Documents
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Search results for , issue "JKKI, Vol 14, No 2, (2023)" : 15 Documents clear
Detecting miRNAs expression as the early prognostic factor for patients with colorectal cancer in Dr. Sardjito Hospital Yogyakarta : A preliminary study Adeodatus Yuda Handaya; Didik Setyo Heriyanto; Hendra Susanto; Yudi Susanto; Kamal Agung Yudayana; Ida Ayu Setyawati Sri Krisna Dewi; Aditya Rifqi Fauzi; Joshua Andrew; Kevin Radinal; Azriel Farrel Kresna Aditya
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art9

Abstract

Background: Colorectal cancer (CRC) is the third highest-ranked cancer and causes high mortality in patients with a low survival rate. The lack of sensitivity and specificity of clinical and other diagnostic modalities results in a higher mortality rate. Therefore, the exploration of potential early biomarkers for CRCs is necessary.Objective: We aimed to evaluate the local expressions of potential tumor suppressor and oncogenic miRNAs in CRC patients in Indonesia. Methods: This retrospective cohort study involving thirty-one colorectal carcinoma patients at Dr. Sardjito Hospital Yogyakarta from January 2014-December 2017. Total RNA was isolated, and the expressions of miR-21, miR-92a, miR-96, miR-26b, miR144, and miR-195 were measured by real-time quantitative PCR. The correlation between miRNAs and other predictors was determined by Spearman correlation, and the association of miRNA expression and other clinical parameters used logistic regression.Results: The local expression of miR-195 decreased significantly in the tumor sites. In contrast, miR-21 activity tends to increase in the local tumor. Meanwhile, the expressions for miR-92a, miR-96, miR26b, and miR-144 in the same subjects were non-significant. MiR-195 was also significantly associated to cancer stage (r=-0.570, p=0.001) with significant odds ratio (OR=0.892, 95% CI=0.804–0.990, p=0.031).Conclusion: Our study was the first to report aberrant expressions of miRNA-21, miRNA-195, miRNA-92a, miRNA-26b, miRNA-96, and miRNA-144 in Indonesian CRC patients. The tumor suppressor miRNA-195 expression was superior among others to serve as an early biomarker in detecting and predicting CRC disease progression.
Studi Literatur: Bioaktif Tanaman Mengkudu (Morinda citrifolia L.) sebagai Antikanker Herbal Oktavia Beni Kujariningrum; Sri Winarni; Kharisma Olivia Anugrah Cahyani; Nadia Puji Anggitasari; Waviq Azizah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art10

Abstract

In Indonesia, the noni plant (Morinda citrifolia L.) has gained popularity as an alternative treatment for various diseases. Cancer is the second cause of death worldwide, with chemotherapy as the primary treatment. There is growing interest in exploring phytochemicals found in noni plants such as anthraquinones, chitosan, phenols, and flavonoids. These antioxidant compounds hold potential as alternative treatments for cancer. This study explores the active compounds in noni plants that exhibit anti-cancer properties. This study employed a scoping review approach. Previous original articles were retrieved from Scopus, Science Direct, ClinicalKey, Springer Link, and Google Scholar with keywords in Morinda citrifolia L., component, bioactive, antioxidant, anti-inflammatory, and anti-cancer. We included 34 articles that met the inclusion criteria. The findings of this study highlight the anti-cancer activity of several phytochemicals found in noni plants. Damnacanthal has been shown to reduce the number of MCF-7 cells. Nordamnacanthal inhibited the development of the H400 cell cycle by increasing the activity of Cytochrome C, Caspase-9, and Caspase 3/7 and induced the death of MDA-MB231 and MCF-7 cells. Chitosan nanoparticles can inhibit the growth of A549 cells. Scopoletin can inhibit cancer cell proliferation by inducing cells in the G0 / G1 and S phases. Epicatechin can inhibit the growth of PC-9 cells. Damnachanthal, nordamnacanthal, chitosan nanoparticles, scopoletin, and epicatechin are active compounds presented in noni plants that can act as anti-cancer.
Le Fort I and nasal fracture, primary reduction, and secondary revision saddle nose: A case report Al Hafiz; Wahyu Julianda
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art14

Abstract

Maxillofacial trauma is a common clinical situation in emergency rooms. Lesions involving the maxillofacial complex pose a significant public health challenge, not only due to their costs but also because of the potential functional and aesthetic issues that patients may experience. While some fractures are more suitable for delayed treatment, others necessitate immediate attention, requiring intervention within 24 hours of the trauma occurrence. Different types of reduction and fixation exist depending on the patient’s age, location, type of fracture, and the surgeon’s preferences. We reported a case of a 20-year-old female patient diagnosed with Le Fort I bilateral fracture and closed nasal fracture followed by saddle nose. The patient was managed with open reduction internal fixation and closed reduction nasal bone. The saddle nose in the patient was managed four months later by augmentation rhinoplasty with rib cartilage and pearl fat graft. Proper management of Le Fort I fracture and nasal fracture accompanied with saddle nose by open reduction internal fixation and augmentation rhinoplasty with rib cartilage and pearl fat graft can restore occlusion and improve symmetrical, proportional facial aesthetics, which is the indicators of a successful holistic maxillofacial trauma management.
FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN IKUTAN PASCA IMUNISASI COVID-19 Hoirun Nisa; Putri Kurniawati; Rifka Qatrunnida; Dadang Mulyono
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art5

Abstract

Background: Evidence indicates that COVID-19 vaccines are effective at helping to prevent serious infection and risks of hospitalization due to COVID-19. Seven types of vaccines have been used in Indonesia. Adverse events following immunization (AEFI) may occur after the COVID-19 vaccination. Objective: This study aimed to determine factors associated with AEFI of the COVID-19 vaccination.Methods: This cross-sectional study included 160 respondents who had been vaccinated against COVID-19. Data were collected by using google form distributed through social media from October 12-20, 2021. Multivariate analysis was performed by using a logistic regression test.Result: The incidence of AEFI of the COVID-19 vaccination was 69.4%, and the AEFI symptoms were lower in the second dose of COVID-19 vaccine than the first dose. Poor dietary habits were associated with higher risks of the AEFI (OR=2.34 CI 95% 1.14-4.80). The second vaccine dose was related to decreased risks of the AEFI (OR=0.35 CI 95% 0.13-0.92).Conclusion: The incidence of AEFI of the COVID-19 vaccination was quite high, and the common AEFI was systemic symptoms. Dietary habits and vaccine doses were associated with the AEFI of the COVID-19 vaccination. These findings suggest that poor dietary habits may increase the risks of the AEFI, and decreased risks of the AEFI may be experienced in the second dose of COVID-19 vaccine. Further studies are warranted to explore the effects of both doses of COVID-19 vaccines on the AEFI.
Tuberkulosis Kutis Verukosa pada Pasien Tuberkulosis Paru Mimi Maulida; Nanda Earlia; Vella Vella; Karamina Maghfirah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art13

Abstract

Cutaneous tuberculosis is a skin disorder caused by Mycobacterium tuberculosis, commonly classified according to its spreading route into endogenous, exogenous, and hematogenous, with distinct skin morphology and histopathological findings. Tuberculosis verrucosa cutis is a classification form of cutaneous tuberculosis, a paucibacillary disease caused by exogenous reinfection (inoculation) after sensitization on an immunocompromised individual. Management of cutaneous TB is generally similar to the management of pulmonary TB. In this paper, we presented a case of 62 years old male with a purplish rough patch on the right dorsum of the foot that began 1,5 years. There is a history of trauma and pulmonary TB. On the right dorsum of the foot, we identified a verrucous lesion with a livid base, irregular with the size of 6x3 cm. The diagnosis is established based on clinical features and histopathology evaluation. The patient received treatment with antituberculosis medication, topical mupirocin ointment 2%, and vaseline petroleum jelly. Improvement of the lesions was observed after the patient completed the intensive phase in two months of treatment with antituberculosis drugs.
A male Covid-19 convalescent plasma donor with long existence of SARS-Cov-2 antibodies: a case report Teguh Triyono; Usi Sukorini; Andri Christianalusi; Sri Mulatsih; Hans Vrielink
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art12

Abstract

Covid-19 Convalescent Plasma (CCP) was one of alternative therapy for Covid-19 patients. The use of convalescent plasma as an adjunct therapy must consider its efficacy, benefits, and risk, both for the patient and the donor. Convalescent Plasma was produced from purified human plasma. Convalescent Plasma was a passive immunity which provide active antibodies. CCP give immunity to the patient through the transfusion of a survivor’s antibodies. We were reporting a case of male CCP donor with long existence of SARS-Cov-2. This donor performed up to 16 donations, which was an unusual case in CCP donor. The SARS-CoV-2 antibody titer was analyzed using Elecsys® Anti-SARS-CoV-2 (Roche Diagnostics). The SARS-CoV-2 antibody showed high level of total SARS-CoV-2 antibodies, with the Cut off Indexes (COI) anti SARS-Cov-2 antibody were still quite high (132 U/mL). The highest donor antibody COI (204.6 U/mL) was seen in 11th donation at 6 months after recovery, while the lowest antibody COI (130.8 U/mL) was in 15th donation at 7 months after recovering. Evaluation of donor health status were performed after the 16th donation and analyzed as well. In conclusion, 16 CCP donations of 600 mL resulting in 48 units of 200 mL plasma in 8 months was safe for the donor, with the SARS-Cov-2 antibody titer remained high in the whole period.
EFEK SAMPING OBAT YANG TIDAK BERHUBUNGAN DENGAN KEPATUHAN PENGOBATAN PASIEN KUSTA DI SUBANG Tinalda Nur Amelia Wijaya; Meiyanti Meiyanti
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art4

Abstract

Background: Indonesia is currently contributing to the third highest incidence of leprosy in the world. Leprosy sufferers who do not undergo regular treatment have risk in transmitting the disease to others. Moreover, it may also cause disability problems and social impacts. Objective: This study aims to analyse relationships between drug side effects, subject characteristics and adherence to treatment of leprosy patients.Method: This was an observational analytic study with a cross-sectional research design with a sample of 115 leprosy patients. This study was conducted at four Puskesmas (Community Health Centre) of Sukasari sub-district, Subang from October to December 2021. Its data was collected by using a questionnaire consisting of patient characteristics; the MMAS-8 questionnaire was used to assess levels of the adherence and the side effects. Then the data were analysed by Chi-Square and Fisher's Exact test, with a significance level of 0.05.Results: The results of this study revealed that 60 (52.2%) of the subjects were categorized in the medication adherence with a score of 0 and 22 (19.1%) of them were relatively high adherence with a score of 1-2. Most of the 93.9% of subjects experienced drug side effects while undergoing the leprosy treatment. There was no significant relationship between drug side effects (p=0.442), genders (p=0.848), ages (p=0.275), education levels (p=0.134), types of occupations (p=0.847) and adherence to treatment of leprosy patients. Conclusion: Several factors such as drug side effects, ages, genders, education levels and occupations were not significantly related to medication adherence in the leprosy patients.
PERBANDINGAN RIWAYAT PEMBERIAN ASI EKSKLUSIF DAN MPASI TEPAT WAKTU PADA BALITA MALNUTRISI DAN NUTRISI NORMAL Elman Boy; Rudi Iskandar Hasibuan; Ashil Muhammad Abdul Rasyid; Nugraha Ilhamsyah; Cut Shanaz Dhiya Shafira; Annisa Fitri Hendewi; Raudatul Husna Pranata; Putri Maulia Amami Harun
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art8

Abstract

Background: Breast milk and complementary feeding are important sources of nutrition in the first 1000 days of life, so nutritional deficiencies in this period of life cause problems in both short and long terms. Hence, investigating the association between breastfeeding, complementary feeding history, and toddlers’ nutritional status is important.Objective: This study aims to assess the influence of exclusive breastfeeding and timely complementary feeding on the nutritional status of children under five.Methods: This cross-sectional study was conducted in a Public Health Centre (Puskesmas) in Medan, North Sumatera. Data regarding the toddlers’ height and weight were obtained through direct measurements, whereas information about breastfeeding and complementary feeding history was gathered through interviews with the toddlers’ mothers. Chi-square analysis was performed for statistical analysis.Results: The study involved 50 toddlers, 30 boys and 20 girls. Among them, 58% received both exclusive breastfeeding and timely complementary feeding, while 42% did not. Among toddlers who received exclusive breastfeeding and timely complementary feeding, 82.7% demonstrated normal nutritional status, whereas 10% experienced malnutrition. Conversely, in toddlers not given exclusive breastfeeding and timely complementary foods, only 38% had normal nutrition, with the remaining 62% facing malnutrition. There was an association between exclusive breastfeeding, timely complementary feeding, and toddlers’ nutritional status (P < 0.05). Toddlers receiving exclusive breastfeeding had 7.8 times higher odds of experiencing normal nutritional status compared to those without it. Similarly, toddlers exposed to timely complementary feeding had 4.3 times higher odds of experiencing normal nutrition.Conclusion: Exclusive breastfeeding and timely complementary feeding played an important role in the nutritional status of toddlers.
EFEK PAPARAN ASAP BIOMASSA GAMBUT TERHADAP STRESS OKSIDATIF PADA TIKUS WISTAR Uly Astuti Siregar Uly Astuti Siregar; May Valzon; Fitrianti; Arif Budianto
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art2

Abstract

Background: Indonesia ranks third in the world regarding air pollution due to forest and land fires; most of the land burned is a peatland. Particulate matter (PM) 2.5 is the largest component of the total smoke particles. Short-term and long-term exposure to PM2.5 remains a hazard to human health.Objective: This study aims to examine the effect of exposure to peat biomass smoke on serum malondialdehyde (MDA) levels and body weight of Wistar rats.Methods: Experimental animals were randomly divided into three groups: Control group (C) is not given treatment, and treatment groups (X1 and X2) are exposed to smoke from peat biomass of 100 g and 150 g of biomass for 60 seconds per day for 14 days. The body weight was examined before and after treatment, while Serum MDA levels were examined after treatment.Results: The results showed significant differences (p < 0.05) in serum MDA levels between groups. The highest serum MDA levels were found in group X2 (3.03 ± 0.185 nmol/ml), followed by group X1 (2.67 ± 0.212 nmol/ml) compared to the control group (2.24 ± 0.476 nmol/ml). In contrast, increasing body weight between groups did not show a significant difference.Conclusion: Exposure to PM 2.5 from peat biomass smoke increases oxidative stress in experimental animals.
Transcystic versus transcholedochal laparoscopic common bile duct exploration: Choosing the right approach – A Case Series Singgih Annas Fuadhi; Adeodatus Yuda Handaya; Agus Barmawi; Imam Sofii; Nurcahya Setyawan
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 2, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss2.art15

Abstract

Laparoscopic common bile duct exploration (LCBDE) is a relevant therapeutic option in managing cholecysto-choledocholithiasis. The success of this procedure is highly dependent on selecting an appropriate method, either transcystic or transcoledocal. Intraoperative choledochoscopy proves its importance in evaluating the condition of the choledochal duct and sphincter of Oddi. In this case series, we report 2 cases of patients with complaints of right upper abdominal pain and jaundice. Both patients were diagnosed with multiple cholecysto-choledocholithiasis at Dr. Sardjito Hospital, Yogyakarta. The interventional measures applied to both patients were transcystic and transcoledocal exploration. In the first patient, the transcystic method was chosen because the cystic duct was widening up to 9 mm in diameter. While in the second patient, the transcoledocal method was taken because the diameter of the cystic duct was still within normal limits. The duration of surgery in transcystic surgery was shorter than in transcoledocal surgery, with a time ratio of 129 minutes versus 162 minutes. Postoperatively, both patients were discharged on the second day after the procedure, and both experienced recovery without any significant complications. Overall, LCBDE has been shown to be safe to perform. The one-stage surgical approach has been shown to reduce the risk of complications, cost, and duration of treatment required. The choice between the transcystic or transcoledocal method should be based on each patient’s clinical condition.

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