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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 468 Documents
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The effect of curcuminoid turmeric rhizome extract on interleukin 1ß concentration in osteoarthritis patient Woro Rukmi Pratiwi; Nyoman Kertia
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 2, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss2.art8

Abstract

Background: Cytokine Interleukin (IL) 1ß is increased in synovial fluid and cartilage of patients with osteoarthritis (OA). Curcuminoid blocks lipopolysaccharides causing the suppression of IL 1ß production. The capability of curcuminoid to decrease IL 1ß secretion by the synovial fluid monocytes has not been previously studied. Objective: This study aimed to explore the activity of curcuminoid of turmeric rhizome extract (C. domestica Val.) in blocking the IL 1ß secretion by the knee synovial fluid monocytes of patients with osteoarthritis.Methods: This research was a prospective randomized open and blinded endpoint (PROBE) study. The subjects of the study were osteoarthritis patients who were divided into 2 groups. Subjects were administered 30 mg of turmeric rhizome curcuminoid extract (treatment group) and 25 mg diclofenac sodium capsules (control group) twice a day for 4 weeks. Knee synovial fluid was taken before and after treatment. The capability examination of IL 1ß secretion by synovial fluid monocytes was conducted by culturizing the monocyte cells. Level of IL 1ß was measured by ELISA Results: There were 80 subjects eligible to participate in the study according to the inclusion/exclusion criteria. The decrease of means of IL 1ß concentration of the curcuminoid group after the 4-week therapy was 70.24±81.46 pg/ml, while the decrease of means of diclofenac sodium was 61.90±60.42 pg/ml, with no significant difference between groups (p=0.691;95%CI:0.681-0.699).Conclusion: Curcuminoid of turmeric rhizome (C. domestica Val.) extract has the capability which is not weaker than that with diclofenac sodium in decreasing the IL 1ß secretion by synovial fluid monocytes of the OA patients’ joints. 
Correlation of serum calcium with blood pressure and Body Mass Index (BMI) among ischemic stroke patients in Bangladesh Nazia Sharmin; Abu Kholdun Al-Mahmood; Nasima Sultana
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 2, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/10.20885/JKKI.Vol10.Iss2.art6

Abstract

Background: Ischemic stroke more commonly occurs in hypocalcemic patients and presented with more severe clinical symptoms.Objective: We sought to observe the correlation of serum calcium with blood pressure and BMI among stroke patients in Bangladesh.Methods: We performed a case-control study using the Department of Biochemistry at Dhaka Medical College, Dhaka, Bangladesh from January 2014 to December 2014. The case were defined as patients diagnose with an acute ischemic stroke, and controls were defined as healthy subjects. In this identified population, 15 cases were matched on age and sex to 50 control subjects. The information regarding age, serum calcium level, height and weight of both cases and controls were taken to calculate BMI. Systolic and diastolic blood pressure (SBP and DBP) from the subject are taken to investigate the history of hypertension. Result: Serum calcium has statistically significant with a negative correlation with DBP (r =-0.335, p=0.017) and BMI (r =-0.426, p=0.002). A negative correlation between serum calcium and SBP also can be observed (r= - 0.194, p= 0.176). Conclusion: Findings of this study concludes that hypocalcemia is found to be negatively correlated with blood pressure and BMI among ischemic stroke patients in Dhaka, Bangladesh.
The importance of socialization in achieving universal health coverage: case study of Jaminan Kesehatan Nasional (JKN) implementation in two different region in Central Java province Ema Nur Fitriana; Ari Natalia Probandari; Eti Poncorini Pamungkasari; Tonang Dwi Ardyanto; Rizky Amalia Puspitaningrum
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 2, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss2.art3

Abstract

Background: Jaminan Kesehatan Nasional (JKN) is Indonesia's health policy to achieve universal health coverage (UHC). Towards 2019, not all regions have succeeded in achieving UHC. One of the reasons is the uneven distribution of information regarding JKN policies. Socialization is needed so that the JKN policy is understood by the people of Indonesia. Objective: This research was design to describe the importance of JKN policy socialization to reach UHC. Methods: Qualitative research was conducted in September 2018- February 2019 in two districts in Central Java, that were the district that had reached UHC and districts that had not yet reached UHC. The informants consisted of leaders of regional organizations and also the community. The researcher conducted an interactive model analysis on the interview transcript. Results: In districts that had reached UHC, socialization was conducted directly and indirectly through the government, community cadres and BPJS cadres. The district government provided support by issuing circulars letters. The district socialization effectively increases JKN participants. Meanwhile, in districts that had not yet reached UHC, there was found differences between community and the government. The government said that they had conducted effective socialization. But the community said that the information provided has not been effective and there is no detailed information about JKN.Conclusion: An effective socialization of JKN policies is needed to increase the understanding and awareness of the community to achieve UHC.
KORELASI KARAKTERISTIIK PASIEN DENGAN DRUG RELATED PROBLEMS PASIEN STROKE ISKEMIK GERIATRI DI RS X KABUPATEN TULUNGAGUNG Dhanang Prawira Nugraha; Antonius Adji Prayitno Setiadi; Yosi Irawati Wibowo
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 1, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss1.art8

Abstract

Background: Drug related problems (DRP) can cause problems in treatments of patients with ischemic stroke.Objective: This study was to determine the correlation between the characteristics of patients with ischemic stroke and the DRP.Methods: A population in this study was 53 patients at dr Iskak Public Hospital in Tulungagung. Inclusion criteria were patients who were = 60 years old and were diagnosed as acute ischemic stroke patients. The DRP was classified based on Pharmaceutical Care Network Europe version 6.2, especially problem and cause domain. Correlation between age, duration of treatment, number of comorbidities and number of drugs and the DRP was analysed by Spearman Rho or by Pearson analysis. The relationship between gender, guaranteed care and the DRP was analysed by using Eta analysis.Results: This study revealed that patients with 60-69 years were 24 patients (45.28%), men were 30 patients (57%), 1 comorbidity was 26 patients (49.06%), duration of 5 days was 14 patients (26.42%), BPJS patients were 23 patients (35.94%), using 6 types of drug was 11 patients (20.75%). Age, sex and care guarantee did not correlate with the DRP (p-values > 0.05). Duration of treatment, number of comorbidities and number of drugs correlated with the DRP (p-value <0.05) with consecutive correlation strength: weak (R = 0.32), moderate (R = 0.45), strong (R = 0.56).Conclusion: Duration of treatment, number of comorbidities and number of drugs correlated with increasing incidences of the DRP in geriatric ischemic stroke patients.
Split Thickness Skin Grafts (STSG): Approach in necrotising fasciitis, a rare case report Agung Widianto; Wahyu Kartiko Tomo
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 1, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss1.art13

Abstract

Treatment of necrotising fasciitis including systemic antibiotic and radical surgical debridement is often resulting in large wounds that need to be closed using methods such as split-thickness skin grafts, local flaps, or guided tissue regeneration procedures. In this case report, 53 year-old male was diagnosed with necrotising fasciitis and treated surgically. The wound was treated initially with extensive debridement, wound treatment with platelet-rich plasma and finally closing the wound with split-thickness skin grafts. Split-thickness skin grafts can provide fast recovery and functional skin.
Recurrent Mycobacterium tuberculosis infection in systemic lupus erythematosus patient: case report and review Anthony Paulo Sunjaya; Devi Astri Rivera Amelia
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 1, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss1.art14

Abstract

Systemic Lupus Erythematosus (SLE) is an autoimmune disorder characterised by an underlying immunodeficiency state, worsened by the use of immunosuppressive drugs in its treatment. Hence patients with SLE are at increased risk of opportunistic infections, one of which is tuberculosis. Tuberculosis (TB) is one of the most common infectious diseases globally, with Indonesia having the second highest prevalence in the world. Further research towards better management of these two disease entities is thus required. We report a patient with SLE flare and recurrent tuberculosis infection.
Achievement of universal health coverage in Surakarta city: policy analysis Rizky Amalia Puspitaningrum; Ari Probandari; Eti Poncorini Pamungkasari; Tonang Dwi Ardyanto; Ema Nur Fitriana
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 2, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/10.20885/JKKI.Vol10.Iss2.art7

Abstract

Background: Jaminan Kesehatan Nasional (JKN) is the health policy of the Indonesian government to achieve Universal Health Coverage (UHC), where each City or District has a varied regional policy in implementing it. Surakarta City is one of the regions that has been able to reach UHC. Policy analysis triangle is used to understand the various factors involved in each policy process. Objective: This study aims to explore deeply the implementation of JKN policy in Surakarta City to be able to achieve UHC based on a policy analysis triangle.Methods: This type of research is a qualitative study with a case study approach. The study was conducted in Surakarta City, Central Java, from September 2018 to March 2019. Data collection was carried out through in-depth interviews and document analysis. Sampling technique with criterion sampling. The research informants were five people who were the leaders of the Surakarta City Government, and 10 people from the Surakarta City community. Data validity was done by triangulation, member check, and peer debriefing. Results: The implementation of JKN policy in the city of Surakarta to reach UHC was influenced by: actors who were highly committed and competent in the success of the JKN program, a dynamic process in adjusting central policy to the regions by implementing various strategies and innovations to increase JKN membership coverage; political factors with policy making that support the achievement of UHC, environmental factors where population density in Surakarta City is the most densely populated in Central Java, there is a high awareness and willingness of the people of Surakarta City to have JKN, and technological support that facilitates JKN coordination and implementation. Conclusion: Achieving UHC in Surakarta City is the result of optimizing the four factors in the triangle analysis policy.
GLYCATED ALBUMIN SEBAGAI KONTROL GLIKEMIK ALTERNATIF PADA DIABETES MELITUS TIPE 2 DENGAN HEMODIALISA Clara Elitha; Pusparini Pusparini
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 1, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss1.art7

Abstract

Background: Uses of HbA1c compared with glycated albumin as an indicator of glycemic control for hemodialysis patients(HD) needs to be evaluated. HbA1c has some limitations when used for HD because its results can falsely low or falsely high. It can be missunderstood if clinicians use HbA1c as glycemic control. Objective: This study aimed to evaluate correlation between HbA1c and GA in HD patients with Diabetes Mellitus (DM).Methods: This study was a cross sectional study conducted on November 2016 until January 2017. Its samples were obtained from 43 patients in HD with DM, fullfilling inclusion and exclusion criteria, located in a private hospital at east Jakarta. The HbA1c was measured by using a turbidimetric inhibition immunoassay method, and the GA was measured by using an enzimatic colorimetric method. In addition, a test of Pearson correlation was used to determine the correlation between HbA1c and GA with a significance of p<0.05.Results: Averages of patients age in this study was 57.16 ± 9.0 years old, including 24 men (55.8%) and 19 women (44.2%). The mean values of HbA1C were 8 ± 2.30%, and the mean values of GA were 30.02 ± 13.3%. The mean duration of the HD was 4.5 ± 1.3 years. The glycemic control based on GA was significantly better than the HbA1c with p = 0.028 (Chi-Square test). Pearson correlation showed that there were a significant correlation between HbA1c and GA with r = 0.759 and p = 0.000.Conclusion: There were a significant correlation between HbA1c with GA in HD patients with DM. Glycemic control based on GA was better than HbA1c.
Hubungan Perilaku Hidup Bersih dan Sehat dengan Kejadian Diare di Wilayah Kerja Puskesmas Delanggu Utari, Titik; Ghazali, Pariawan Lutfi; Mulyaningrum, Utami
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol1, No 1, (2009)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Program Perilaku Hidup Bersih dan Sehat merupakan program yang bertujuan memberikan pengalaman belajar atau menciptakan suatu kondisi bagi perorangan, keluarga, kelompok dan masyarakat dengan membuka jalur komunikasi, memberikan informasi dan melakukan edukasi untuk meningkatkan pengetahuan, sikap dan perilaku sehinggamasyarakat sadar, mau, dan mampu mempraktekkan Perilaku Hidup Bersih dan Sehat melalui pendekatan advokasi, bina suasana dan pemberdayaan masyarakat. Perilaku hidup bersih dan sehat seseorang dapat berhubungan dan meningkatkan kesehatan individu, keluarga, masyarakat dan lingkungannya. Perilaku hidup bersih dan sehatseseorang diduga mempunyai hubungan terhadap kejadian diare di wilayah kerja Puskesmas Delanggu. Mengetahui hubungan perilalku hidup bersih dan sehat dengan kejadian diare di wilayah kerja Puskesmas Delanggu. Jenis penelitian merupakan studi observasional (non eksperimental) dengan rancangan pene 'i tian cross sectional. Populasi dalam penelitian ini adalah seluruh warga yang berdomisili di wi!ayah kerja Puskesmas Delanggu. Sampel penelitian ini adalah sebagian dari populasi yang berdomisili di wilayah kerja Puskesmas Delanggu. Cara pengambilan sampel dari populasi digunakan sampling acak. Analisis data yang digunakan umuk pengolahan data penelitian ini adalah dengan uji Chi-Square dan t test, dengan tarat kemaknaan p=0,05 atau tingkat kepercayaan 95%. Data diperoleh dari 100 responden, 11 orang termasuk dalam kategori PHBS Sehat Pratama, 15 orang Sehat Madya, 36 orang Sehat Utama dan 38 orang Sehat Paripurna . Data dianalisis dengan program komputer dan didapatkan nilai kemaknaannya adalah 0,000. Oleh karena p < 0,05, maka dapat diambil kesimpulan bahwa terdapat hubungan antara perilaku hidup bersih dan sehat dengan kejadian diare di wilayah kerja Puskesmas Delanggu. Besar kekuatan korelasi antara perilaku hidup bersih dan sehat adalah sebesar 0,540 yang menunjukkan korelasi sedang. Rata-rata skor PHBS yang terkena diare adalah 8,74 dengan standar deviasi 2, 700. Sedangkan yang tidak menderita diare, rata-rata skor PHBS-nya adalah 11,53 dengan standar deviasi 2,894. Hasil uji statistik T-test for mean didapatkan nilai p=O,OOO, berarti pada alpha 5 % terlihat perbedaan yang signifikan rata-rata skor PHBS antara yang terkena diare dengan yang tidak terkena diare. Rata-rata skor PHBS penderita diare lebih rendah daripada skor PHBS yang tidak menderita diare. Ada hubungan yang bermakna antara Perilaku Hidup Bersih dan Sehat dengan kejadian diare di wilayah kerja Puskesmas Delanggu, dengan tarat hubungan sedang. Rata-rata skor PHBS (Perilaku Hidup Bersih dan Sehat) yang terkena diare lebih rendah secara signifikan daripada yang tidak terkena diare.
Status resistensi vektor Aedes aegypti terhadap malation dan enzim esterase non spesifik di kecamatan Tembalang Irneta Bela Novita; Martini Martini; Retno Hestiningsih; Sri Yuliawati; Nissa Kusariana; Mochammad Hadi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 3, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss3.art3

Abstract

Background: Controlling of dengue vectors around dengue haemorrhagic fever cases is often conducted by using insecticides, including a malathion insecticide in the city of Semarang. A research on susceptibility status of Ae. aegypti to insecticides, used for fogging and based on a high number of hemorrhagic fever cases in Tembalang district, Semarang city, needs to be observed.Objective: This study aimed to determine resistance status of Ae. aegypti mosquitoes based on bioassay and biochemical tests of esterase non-specific enzyme activity in the Tembalang District. Methods: This study used a cross sectional design, it was conducted in June-September 2018 in a population of Aedes sp. from Tembalang District, Semarang City. Samples of F2 generations of female Ae. aegypti were obtained by ovitraps in the Tembalang District consisting of 12 urban villages, and their resistance status were tested by impregnated paper bioassay with malathion at a diagnostic dose of 0.8%. Esterase enzyme activity in the Ae. aegypti mosquito body of this population was tested biochemically to prove an increase in a non-specific esterase enzyme on the a-naphthyl acetate substrate.Results: The bioassay results showed that mortality rates of Ae. aegypti at the 12 villages in Tembalang district after 24 hourtest by impregnated paper indicated a range of 0-62%. Mechanism of resistance indicating an increase of non-specific enzyme esterase activity on a-naphthyl acetate at Rowosari, Kedungmundu, Sambiroto, and Meteseh could not be seen, It began to be seen in a low percentage (15%) at Sendang Mulyo, Tandang, Sendangguwo and Bubusan, and in a moderate percentage (45-75%) in Tembalang, Jangli and Mangunharjo. The mechanism of high esterase enzyme activity could be seen in the Ae. aegypti population at Kramas with AV=0,700-0,900 by a percentage of 20%, and AV=0,900 by a percentage of 80%.Conclusion: This study provided information about some Ae. aegypti mosquitoes from Tembalang District that showed resistance to the malathion insecticide with an elevation of non-specific esterase enzyme activity ona-naphthyl acetate substrate in several villages except Kelurahan Rowosari, Kedungmundu, Sambiroto, and Meteseh.

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