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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 468 Documents
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Multidrug-resistant Klebsiella pneumoniae from clinical isolates at dr. Soeradji Tirtonegoro central hospital Klaten Handi Virawan; Titik Nuryastuti; Hera Nirwati
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 2, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss2.art3

Abstract

Background: Klebsiella pneumoniae is a Gram-negative bacterium that often causes nosocomial infections. Use of broad-spectrum antibiotics as an empiric therapy has contributed to increases of K. Pneumoniae strains that are resistant to antibiotics. Therefore, a test on antibiotic susceptibility of K. pneumoniae is needed as a guide in treating a definitive therapy. Objective: This study aimed to measure the percentages of multidrug-resistant (MDR) of K. pneumoniae and its susceptibility at dr. Soeradji Tirtonegoro Central Hospital, Klaten, Central Java in 2017. Methods: This study was a descriptive study using secondary data at the Clinical Microbiology Laboratorium of dr. Soeradji Tirtonegoro Central Hospital, Klaten. The K. pneumoniae was isolated from patients hospitalized in the hospital from January 1, 2017, to December 31 2017. Identifications of the K. pneumoniae were conducted by a colony morphology observation, a gram staining, and a biochemical test. The test of antibiotics susceptibility used Kirby-Bauer method based on Clinical and Laboratory Standards Institute (CLSI). The data were analyzed by univariate analysis.Results: In 2017, there were 213 K. pneumoniae isolates from various clinical samples. Among them, 122 isolates were MDR K. pneumoniae (57.28%). The majority of MDR K. pneumoniae were resistant to a wide range of antibiotics. The MDR K. pneumoniae had only a good sensitivity to meropenem (98.43%), amikacin (93.75%), nitrofurantoin (88.89%), and fosfomycin (88.89%). In contrast, all non-MDR K. pneumoniae had good sensitivity to all tested antibiotics, except to ampicillin.Conclusion: The percentage of MDR K. pneumoniae isolates at the dr. Soeradji Tirtonegoro Cental in 2017 was 57%. Meropenem and amikacin could be considered as empirical therapies to cure an MDR K. pneumoniae infection. 
Risks of preterm birth and low Apgar score among preeclamptic women Chiquita Febby Pragitara; Risa Etika; Lilik Herawati; Aditiawarman Aditiawarman
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 1, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss1.art3

Abstract

Background: Preeclampsia has been a major problem for obstetric care in Indonesia due to risks of preterm birth and lower Apgar score. Objective: This study is to examine relationships of preeclampsia, preterm births, and Apgar Score.Methods: This used an analytic study with retrospective case-control design in Dr. Soetomo Academic Hospital. A case group was taken by total sampling from medical records of all patients who had preterm delivery in 2017, and a control group of term deliveries was taken by random sampling. Then the data were analysed by using Chi-square test and Fisher’s Exact Test.Results: There were 80 samples for each group. 63.75% of patients by age of 20-35 years were who delivered preterm birth, 40.00% had normal BMI, 40.00% were nulliparous, 92.50% did not have history of preterm labour, 50.00% had preeclampsia with severe features, and 46.25% had spontaneous vaginal delivery. Around 47.14% neonates from preeclamptic women were born at 32-<37 weeks gestation, 50.00% were born with low birth weight, 52.86% had the first minute Apgar score <7, and 72.86% had the fifth minutes Apgar score =7. The statistical analysis showed a significant relationship between the preeclampsia and the preterm birth (p<0.007; OR=2.54, 95% CI 1.34-4.83). The preeclampsia was also related to lower Apgar score at 1st minute (p<0.042; OR=2.03, 95% CI 1.07-3.85) and 5th minute (p<0.046; OR=2.42, 95% CI 1.08-5.41). Preterm neonates born from preeclamptic mothers were related to lower Apgar score at 1st minute (p<0.002; OR=5.82, 95% CI 1.99-17.02) and 5th minute (p<0.001; OR 17.31, 95% CI 2.15-139.54).Conclusion: Preeclampsia could make pregnant women at risks of delivering preterm birth and neonates with low Apgar score.
Evaluation of vector mediated gene therapy as a novel approach to mitigate cardiovascular diseases; A short review Saleh Muhammad Raqib; Syaefudin Ali Akhmad
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 3, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss3.art11

Abstract

Positioning in the top list of mortality and morbidity, cardiovascular disease (CVD) is required new approaches to mitigate the risk and prevalence. Recombinant DNA (rDNA) technology and genome sequencing explore the new horizon to treat CVD through modified therapy. Gene transfer mechanism eventually angiogenic gene therapy provides efficacy in early-stage heart failure. Targeted gene delivery system depicts the novel therapeutic pattern for both genetic disorder and pathophysiological deficit and opens the pathway of early diagnose and treatment. Despite  some limitations of a specific vector (viral vector) mediated gene transfer, these new approaches make  hope on CVD treatment rather than the surgery and other ways.  Furthermore, some vectors are less hazardous than viral vectors to suggest successful non-viral gene modulations to Cardiovascular tissues and perform in the clinical trial. However, plasmid-mediated gene transfer method along with genome editing technology might be the best possible approach for future CVD prognostics and diagnostics.
Effects of a support group to self efficacy of breast cancer patients that receiving chemotherapy Hanik Rohmah Irawati; Yati Afiyanti; Mondastri Korib Sudaryo
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 3, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss3.art7

Abstract

Background: The self-efficacy to cope with breast cancer patients can improve their adaptive coping skills, well-being and quality of life. Objective: This study aims to identify the effects of a support group to improve self-efficacy of breast cancer patients that receiving chemotherapy.Methods: This study used a quasy-experimental design with non-equivalent control pre-test post-test design. As much as 76 patients with breast cancer were assigned into either an experimental group or a control group (38 person each). All of them were selected through a consecutive sampling method. In addition, it used an instrument of cancer behavior inventory version 2. Results: Respondents who were supported by the support group had 1.4 times higher level of self-efficacy to cope with cancer than those who were not supported by a support group. No significant difference in the level of self-efficacy to cope with the cancer between the experimental group and the control group (RR 1.4 with 95% CI 1.0-1.8, a > 0.05).Conclusion: Supports provided by the support group had no effect on the level of self-efficacy to cope with the cancer.
Moxibustion for nausea and vomiting in pregnancy Siti Raihanah; Masrifan Djamil; Sutopo Patria Jati
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 1, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss1.art10

Abstract

Background: Nausea and vomiting are common symptoms that occur for 70-80% of pregnant women. Alternative treatments such as herbal medicine, acupressure and moxibustion have been suggested to control pregnancy-induced nausea-vomiting.Objective: This study is to observe effects of moxibustion at P6 and ST36 point on nausea and vomiting in pregnancy. Methods: This study applied a queasy experimental study by pretest-posttest design on two groups of study. Moxibustion in this study was a heat stimulation technique at P6 and ST36 points for 5 days (7 minutes per day). The P6 point was located on the inner wrist, 2-3 fingers above the wrist between the tendons and the ST36 point was located on 4 fingers below the lower limit of the patella. A random sampling was conducted for 30 pregnant women with gestational age<16 weeks of pregnancy that randomly was divided into 2 groups, or 15 women for each group. Instruments used to measure the nausea and vomiting applied Pregnancy Unique-Quantification of Emesis (PUQE) and B-endorphin.Results: Moxibustion at the P6 point could reduce symptoms of nausea and vomiting (p<0.05). However, Moxibustion at the ST36 point was not effective in reducing symptoms of nausea and vomiting in pregnancy (p>0.05). Conclusion: Moxibustion can more effective at P6 point than at ST36 point in reducing symptoms of nausea and vomiting in pregnancy.
Bullying of adolescent in Yogyakarta: Responses and impacts Ema Waliyanti; Farhah Kamilah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 3, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss3.art9

Abstract

Background: Phenomena of bullying for adolescents in Indonesia require a serious concern from the government, schools and parents. A high number of bullying incidents on adolescents can have negative impact physically and psychologically for actors and victims. Adolescent responses on bullying can be indicated as self-defence of a victim when being bullied.Objective: This research aimed to identify adolescent responses on bullying and its impacts for the adolescents in Yogyakarta.Methods: This study used a qualitative method of phenomenology. Data in this study were collected through observation and in-depth interviews. Participants included in this study were 14 people who consists of parents, adolescents, and teachers, and they were determined by purposive sampling. Validating of the data was conducted by using methodological triangulation, data triangulation and peer debriefing. Thematic data analysis was conducted by using the open code software 4.02.Results: This study found that the responses of adolescents to the bullying included resistance, avoidance, silence, and fear. Then impacts of the bullying could make the victims have avoidant personality disorder or shift them as actors. For actors, they would feared by his friend at school and get punishment from the school.Conclusion: Prevention of bullying of adolescents is urgently needed to overcome the impacts for the adolescents. The results of this study could be used as basic data to deal with bullying of the adolescents.
Hubungan antara Disfungsi Tiroid dengan Profil Lipid pada Pasien Struma di Klinik Litbang GAKI Magelang Yusi Dwi Nurcahyani; Prihatin Broto Sukandar; Raden Edi Fitriyanto; Syaefudin Ali Akhmad
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 2, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss2.art5

Abstract

Background: Relationship between thyroid hormones and lipid profiles in patients with struma is a common condition found in IDD endemic areas. Objective: This study observes relationships between thyroid functions and lipid profiles in woman patients of childbearing age with struma. Methods: This paper is a cross-sectional study of 83 subjects/patients who met inclusion and exclusion criteria in this study. Total cholesterol, LDL, HDL, TSH, and free T4 concentration were measured in all the patients. Lipid concentrations in patients with thyroid dysfunction and patients with euthyroid were compared by using a linear regression model. Results: Total cholesterol, LDL, and HDL was significantly lower in patients with primary hyperthyroidism (N=19) than in patients with euthyroid (N=48) (mean±SD 122.8±20.09 mg/dl vs 187.3±33.66 mg/dl, p=0.000 unadjusted, p= 0.000 adjusted for age and BMI); (63.5±16.33 mg/dl vs 121.7±29.71 mg/dl, p=0.000 unadjusted, p= 0.000 adjusted for age and BMI); (48.8±9.66 mg/dl vs 53.6±8.49 mg/dl, P=0.049 unadjusted, p=0.026 adjusted for age and BMI. Serum total cholesterol and LDL was lower in patients with subclinical hyperthyroidism (N= 14) than in patients with euthyroid (N=48), but it was not statistically significant (181.6±32.07 mg/dl vs 187.3±33.66 mg/dl, p=0.577 unadjusted, P=0.719 adjusted for age and BMI); (110.5±14.83 mg/dl vs 121.7±29.71 mg/dl, p=0.181 unadjusted, p=0.250 adjusted for age and BMI). Serum HDL was similarly elevated in patiemts with subclinical hypothyroidism (N=14) than in patients with euthyroid (N=48), but it was not statistically significant (57.4±11.04 mg/dl vs 53.6±8.49 mg/dl, p=0.185 unadjusted, p=0.229 adjusted for age and BMI).Conclusion: Serum total cholesterol, LDL and HDL was significantly lower in patients with primary hyperthyroidism, but it was not significant for subclinical hyperthyroidism.
Efektivitas Ekstrak Kulit Batang Mimba (Azadirachta indica A.Juss) Sebagai Gastroprotektor Elisa Nuraida; Dwi Sutiningsih; Mohammad Hadi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 2, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss2.art7

Abstract

Background: Gastric ulcer is a digestive problem that has a high prevalence rate, peptic ulcer can cause complications such as bleeding in the gastrointestinal tract, perforation, recurrence, cancer and even death. The neem stem bark extract has a compound that can be a gastroprotective activity so that it can reduce the number of gastric ulcer and gastric acid levels. Gastroprotective effects of neem bark extract in combination have been widely studied can reduce gastric ulcer, but no one has examined the extract of neem bark as a single gastroprotector.Objective: This study aims to determine the dose of extract that can prove the extract of neem stem bark can inhibit the ulcer index by macroscopic observation and microscopic images of in ratsMethods: This research is a purely experimental study carried out in July – September 2019. The neem stem bark extract was given to Wistar male white rats with various dosages for seven days orally, after 24 hours of fasting, induced gastric ulcer with ibuprofen 400 mg/kg. Mice were dissected to activate the ulcer index after 8 hours of induction of gastric ulcer. Result: The ulcus index of negative group (ibuprofen), positive group (ranidin), and extracts of mimba rods 250, 500, 1000, and 2000 CMG/kgBB in a row were 7.13, 16.76, 7.41, 2.32, and 2.00 (p= 0.034). Microscopic observations suggest a much better picture of histology after this extract.Conclusion: The extract of a mimba bark has gastroprotective activity at 2,000 mg/kgBB.
Thoracic ectopia cordis: A case report Danang Himawan Limanto; Heroe Soebroto
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 1, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss1.art15

Abstract

Ectopia Cordis is a congenital anomaly in which the heart is located abnormally outside the thoracic cavity. Aetiology of this defect is still unclear with the incidence rate of 8:1,000,000 live births. Clinical manifestations usually present as severe sepsis respiratory distress due to heart failure as a result of an intrinsic abnormality of the heart which makes the management more challenging. Five days-old female newborn was referred to our hospital by a local doctor with “beating lump” outside her chest. The diagnosis of complete thoracic ectopia cordis was made by clinical examination, chest x-ray, and echocardiography. The Echo showed complete AV canal, ASD, mild pulmonary stenosis, and atrioventricular valve regurgitation. Palliative surgery was then undertaken with the initial goal to limit exposure and prevent further infection. The heart is covered with bovine pericardium sutured along the edge of the chest wall defect. Ectopia cordis is rare and has a poor prognosis especially thoracic and cervical types. Definitive surgery, to replace the heart to the thoracic cavity, is difficult to perform because of the hypoplastic thoracic cavity. Attempt to do palliative surgery, such as covering the heart with either skin flap or other material, becomes the choice of treatment in this case although there is no evidence reported of adulthood survivors.
PHYLOGENY MAGNITUDE OF Mycobacterium tuberculosis BASED ON GENOMIC ANALYSIS Budi Yanti; Mulyadi Mulyadi; Soetjipto Soetjipto; Ni Made Mertaniasih; Muhammad Amin
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 2, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss2.art12

Abstract

Mycobacterium tuberculosis (MTB) is mostly found in humans, and it can cause more than two million deaths each year with increasing morbidity. Although lineages of MTB show identical nucleotide relationships, they have different characteristics such as evolution, transmission, drug resistance, host interaction, latency, and vaccine effectiveness. It is necessary to have better understanding of MTB relationships based on similarities in genome sizes and phylogenetic analysis. This paper observes the relationships of MTB based on nucleotide through phylogenetic frameworks. The MTB species consist of six lineages, and each lineage has various size of genomes . This difference contributes to virulence of MTB affecting levels of severity, morbidity, and mortality of diseases. Genetic diversity of MTB can contribute to global threats in the world such as outbreak of tuberculosis, Multi Drug Resistant (MDR) and Extensively Drug Resistant (XDR) tuberculosis.

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