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Vita Widyasari
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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 498 Documents
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Delayed management of blowout fractures: A case report on challenges and clinical recommendations Hafiz, Al; Septiany, Dwi Tika
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 1, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss1.art13

Abstract

Maxillofacial trauma is frequently encountered in emergency departments. Approximately 40% of orbital fractures are associated with concomitant maxillofacial fractures. Blowout fractures often result in both aesthetic and functional impairments. Clinical manifestations may include enophthalmos, hypoglobus, diplopia, ocular motility disorders, and visual disturbances. Optimal reconstruction is recommended within 14 days after trauma to prevent long-term sequelae. We reported a 24-year-old male patient diagnosed with a closed nasal bone fracture, deviated nasal septum, and orbital blowout fracture, with a month delayed since injury. The patient underwent endoscopic septorhinoplasty and orbital floor reconstruction utilizing a titanium plate and screw fixation. Proper and timely management of blowout fractures leads to satisfactory functional and aesthetic outcomes while significantly reducing the risk of permanent deformities. Delayed management of blowout fractures presents several challenges, including identifying orbital soft-tissue involvement, determining the optimal timing for intervention, and selecting appropriate implant materials. Clinical recommendations emphasize the importance of CT imaging and an integrated multidisciplinary approach involving ENT, ophthalmology, and radiology specialists to achieve the best possible functional and aesthetic outcomes for the patient.
Exosome therapy from hypoxia-preconditioned mesenchymal stem cell exosomes: Anti-inflammatory and wound closure effects in third-degree burns : Soemitha, Christiani Natalia; Setiawan, Eko; Chodidjah, Chodidjah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 1, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss1.art6

Abstract

Background: Third-degree burns cause extensive tissue damage, prolonged inflammation, and delayed wound healing. Increased expression of pro-inflammatory cytokines, particularly interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), may worsen tissue injury and impair repair. Modulating these mediators may improve healing outcomes in third-degree burns.Objective: To evaluate the effect of hypoxia-conditioned mesenchymal stem cell exosomes (HC-MSC-Exo) on IL-1β and TNF-α mRNA expression in a model of third-degree burns.Methods: An experimental post-test-only for control s study was conducted using thirty male Wistar rats (6–8 weeks; 200–250 g). Animals were randomly divided into five grups study: healthy control, burn + NaCl, burn + silver sulfadiazine, burn + HC-MSC-Exo 100 μg/mL, and burn + HC-MSC-Exo 200 μg/mL. Third-degree burns were induced using a 2 × 2 cm2 heated copper plate. The HC-MSC-Exo was administered subcutaneously around the wound. Wound evaluation was performed on days 0, 3, and 7. On day 7, burn tissue was collected for analysis of IL-1β and TNF-α mRNA expression.Results: Untreated burn wounds showed higher IL-1β and TNF-α mRNA expression than healthy controls. HC-MSC-Exo administration reduces the expression of both inflammatory markers, with the 200 μg/mL group showing the lowest levels. Macroscopic wound healing also improves in the HC-MSC-Exo, particularly in the 200 μg/mL , as indicated by smaller wound area and less visible necrotic tissue.Conclusion: HC-MSC-Exo reduces IL-1β and TNF-α mRNA expression and improves macroscopic wound healing in a model of third-degree burns, suggesting that HC-MSC-Exo may be a promising therapeutic approach for burn injury.
Profile and outcome of atypical progressive acute kidney injury in children in a tertiary care hospital in Indonesia Fitria, Fitria; Sovira, Nora; Haris, Syafruddin; Yusuf, Sulaiman; Herdata, Heru Noviat; Ismy, Jufitriani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 1, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss1.art8

Abstract

Background: Atypical progressive acute kidney injury (APAKI) in children is a severe form of acute kidney injury (AKI) marked by rapid progression to end-stage and high mortality. Since August 2022, Indonesia has reported a surge of pediatric AKI, predominantly in previously healthy children, linked to contamination of syrup medications with diethylene glycol (DEG) and ethylene glycol (EG).Objective: The objective of this research is to identify the characteristics and clinical outcomes of children with APAKI at Dr. Zainoel Abidin Hospital in Banda Aceh, a tertiary care hospital in Indonesia.Methods: This analytical observational study used secondary data from pediatric medical records of APAKI cases between June and December 2022. A total sampling technique identified 31 eligible patients aged 1–18 years old. Clinical characteristics, laboratory parameters, and outcomes were analyzed using descriptive statistics and Fisher’s Exact tests.Results: Thirty-one pediatric patients with APAKI are included; most are male (64.5%), aged 1–5 years (93.5%), domiciled outside Banda Aceh (58.1%), and had good nutritional status (80.6%). The mortality is high (74.2%). Genitourinary symptoms such as oliguria/anuria are the most frequent (87.1%), and dialysis is the main therapy (64.5%). Poor outcomes are significantly associated with respiratory symptoms (OR=16; 95%CI: 1.643-155.77), PELOD-2 score ≥10 (OR=10.89; 95%CI: 1.140-103.98), and mechanical ventilation (OR=16; 95%CI: 1.643-155.77). Laboratory predictors of mortality included leukocytosis (OR=11.11; 95%CI: 1.701-72.564), thrombocytopenia (OR=1.90; 95%CI: 1.207-2.957), elevated urea (OR=13.2; 95%CI: 1.124-154.920), elevated creatinine (OR=36.67; 95%CI: 3.124-430.333), reduced eGFR (OR=22; 95%CI: 1.924-251.539), and elevated SGOT (OR=22; 95%CI: 1.924-251.539) and SGPT (OR=36.67; 95%CI: 3.124-430.333). Toxicology testing is correlated with better survival (OR=0.07; 95% CI: 0.006-0.889).Conclusion: APAKI in children is associated with high mortality. Poor outcomes are strongly linked to respiratory involvement, high PELOD-2 scores, mechanical ventilation, and multiple laboratory abnormalities, highlighting the importance of early risk identification and timely management.
Efficacy and safety of 100% TCA CROSS for atrophic acne scar: A systematic review Satmoko, Valentino Yosarian; Elfiah, Ulfa; Aziz, Ayu Munawaroh
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 1, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss1.art9

Abstract

Acne scars result from impaired healing following skin inflammation, with atrophic acne scars accounting for 98% of cases. Although various treatments are commonly used, no gold-standard therapy exists. Chemical reconstruction of skin scars using 100% trichloroacetic acid (100% TCA CROSS) has emerged as a novel intervention for atrophic acne scars. However, evidence supporting its efficacy and safety remains limited, necessitating further evaluation. This systematic review was conducted in accordance with PRISMA and SWiM guidelines. Literature searches were performed in PubMed, Cochrane Library, Google Scholar, and ScienceDirect. Studies were included if they involved patients with atrophic acne scars and utilized 100% TCA CROSS as the intervention, with comparators comprising other acne scar treatments. The primary outcome was efficacy, and the secondary outcome was safety. Only randomized controlled trials (RCTs) were included. Two independent reviewers assessed risk of bias, extracted data, and conducted qualitative analysis. Six studies met the eligibility criteria, with comparators including CO2 laser pinpoint irradiation, microneedling, percutaneous collagen induction dermaroller, platelet-rich plasma (PRP) injection, and PRP injection with needling. One study favored the comparator, while five studies demonstrated no clear difference. Within-group analyses indicated improvements following 100% TCA CROSS. No severe complications were reported. Meta-analysis was not performed due to heterogeneity in outcome measures. In summary, 100% TCA CROSS appears effective and safe for atrophic acne scars.
Association between MC4R rs17782313 genotype and body fat percentage as an indicator of obesity among Indonesian adults Faradilla, Meutia Atika; Yohana, Yohana; Yastani, Deasyka; Handayani, Astri; Suweino, Suweino
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 1, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss1.art5

Abstract

Background: Obesity is influenced by both environmental and genetic factors, including variation in the melanocortin-4 receptor (MC4R) gene, which plays a role in appetite regulation and energy balance. Identifying genetic risks, particularly whether obesity linked to inherited dysregulation of appetite, is crucial for early intervention and personalized prevention strategies.Objectives: This study aimed to examine the association between MC4R genotype and body fat percentage as an indicator of obesity among Indonesian adults. Methods: A cross-sectional study was conducted among 79 Indonesian adults aged 21–56 years in Jakarta. Participants were consecutively recruited and screened based on predefined inclusion and exclusion criteria. Anthropometric data, including height and weight, were obtained using a standardized stadiometer and digital scale to calculate body mass index (BMI). Body fat percentage (BFP) was assessed using bioelectrical impedance analysis (BIA) with an Omron Karada Scan device. Genomic DNA was extracted from venous blood samples, and the MC4R rs17782313 polymorphism was genotyped using the polymerase chain reaction– fragment length polymorphism (PCR-RFLP) method. Statistical analyses were performed to assess the association between genotypes and body fat percentages. Results: Most participants were classified as overweight (36.1%) or obese (41.7%) based on BMI. The genotypic distribution of rs17782313 was TT (48.1%), CT (39.2%), and CC (12.7%). Higher body fat percentages were significantly more common among individuals carrying the C allele. The CC genotype demonstrated the strongest association with obesity, with an odds ratio (OR) of 4.00 (95% CI: 1.02–15.64, p=0.04) compared to the wild-type TT genotype. Conclusion: Variations in the MC4R rs17782313 gene are associated with increased body fat percentage and a higher risk of obesity among Indonesian adults. Individuals carrying the risk allele may have greater susceptibility to excess fat accumulation, underscoring the importance of incorporating genetic factors into obesity prevention and management strategies.
Blast injury of the hand in a pediatric patient with open fracture: A case report Nugroho, Arie; Zahra, Afifah Az; Yahya, Taufik Nur
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 1, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss1.art15

Abstract

Blast injuries can cause severe, multi-tissue damage, including open fractures and extensive lacerations. Management of pediatric hand blast injuries is particularly challenging due to a high risk of contamination and infection. We report the case of a 10-year-old boy who sustained a left-hand blast injury caused by a firecracker. The patient presented with a contaminated lacerated wound, active bleeding, tissue avulsion, and retained foreign bodies, accompanied by crepitus and cyanosis of the index finger. Initial management included debridement and irrigation. Surgical intervention consisted thorough debridement, exploration of tendon and neurovascular structure, and K-wires fixation of the index finger. Despite appropriate initial management, the patient developed chronic necrotic tissue infection, necessitating ray amputation of the index finger to control the infection. Further evaluation suggested that primary vascular disruption, exacerbated by contamination and infection, contributed to progressive necrosis, particularly at the metacarpophalangeal level. To prevent further infection spread and salvage overall hand function, repeated debridement followed by amputation at the metacarpophalangeal joint and removal of fixation wires was performed. Structured rehabilitation was subsequently initiated. Pediatric hand blast injuries represent complex traumatic conditions with a high risk of tissue necrosis. Early diagnosis and aggressive surgical management are essential; however, compromised tissue viability and severe infections may necessitate amputation as a limb-salvage strategy. This case underscores the importance of comprehensive management and highlights the need for improved community-based prevention efforts.
Post-hajj acute respiratory infections: Proportion and associated factors pilgrims from an Indonesian hajj guidance group Devita, Ninda; Rachmawaty, Farida Juliantina; Andriyanto, Eko; Muhammad, Afivudien
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 1, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss1.art7

Abstract

Background: The Hajj pilgrimage is the largest mass gathering, posing a high risk of acute respiratory infection (ARI) transmission. Post-Hajj ARI represents a major public health concern, as returning pilgrims may serve as carriers and potentially transmit pathogens to their home communities. Identifying the proportion and risk factors of post-Hajj ARI is essential for developing effective preventive strategies.Objectives: This study aimed to determine the proportion of post-Hajj ARI and associated risk factors among pilgrims from KBIHU (Indonesian hajj and umrah guidance group) Multazam Ad-Dakwah Yogyakarta 2025.Methods: This cross-sectional study used an online questionnaire. Respondents were pilgrims from KBIHU Multazam Ad-Dakwah Yogyakarta who experienced ARI symptoms after the 2025 Hajj. Sociodemographic characteristics, vaccination history, preventive behaviors, and metabolic risk factors were collected. Data were analyzed using multivariate logistic regression. Odd ratios with 95% CIs were calculated. P-values <0.05 were considered statistically significant.Result: In total, 112 pilgrims were included. Of these, 20.5% were aged 60 years or older. More than half (57.1%) reported comorbidities, mainly hypertension and dyslipidemia. Most participants were non-smokers (82.1%). They reported moderate adherence to preventive behaviors, including mask use (54.5%) and hand hygiene (56.3%). Meningococcal vaccination coverage was universal. Coverage for influenza (75.0%), COVID-19 (46.4%), and pneumococcal vaccination (6.3%) was lower. Overall, 100 pilgrims (89.3%) experienced ARI symptoms. Bivariate analysis showed that age over 60 years was significantly associated with ARI (cOR 4.697; 95%CI: 1.206–18.295; p=0.026). Multivariate logistic regression confirmed that older age was the only significant determinant of ARI (aOR 4.88; 95% CI: 1.22–19.53; p=0.02).Conclusion: Age 60 or over is a significant risk factor for post-Hajj ARI. Focused preventive strategies targeting elderly pilgrims are essential to reduce ARI-related morbidity and mortality after the Hajj.
Transparency gap in AI-assisted medical writing and its implications for research integrity Widyasari, Vita
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 1, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss1.art1

Abstract

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