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Zahratul Aini
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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 468 Documents
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Supplementation and fortification program in eradicating micronutrient deficiencies in Indonesia Lestari Octavia; Johan Harlan
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art11

Abstract

Micronutrients play a significant role in metabolism reaction although this only needs a few micronutrients such as iron (Fe) and folic acid as folate substitutes. Fortification and supplementation program aims to meet the requirement of micronutrients by providing synthetic formula. The Indonesian government has applied iron-folic acid fortification (IFA) in flour. Moreover, the IFA supplementation program was given to vulnerable groups, pregnant mothers and women at reproductive age, including adolescent girls. The program has been applied for almost five decades, but the micronutrients deficiencies remain high. This study aims to review effects of the supplementation and fortification to vulnerable groups in Indonesia. This is necessary to  to determine their effectiveness within a specified period since the program has been applied for decades and to assess whether an additional program is needed or not. The data of this study were collected from verified international journal articles in the National Centre for Biotechnology Information (NCBI)/PubMed and Cochrane Library website. 11 articles related to the program were obtained. The program has been conducted for an extended period, yet its effectiveness should be reinforced to diminish the micronutrient deficiencies. It is mandatory to reformulate an additional program to strengthen the program. Nutrition education program, campaign for a healthy and balanced diet, protein consumption based local resources can be designated to assist the eradication of micronutrient deficiencies.
Correlation between transduction signal route with serum dehy-drogenase lactate level in non-Hodgkin’s lymphoma Hary Gustian
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art5

Abstract

Background: PPI3K/pAKT/pMTOR expression is important in NHL patients. The cascade of biomarker signals regulates translational events, cell survival, cytoskeleton organisation, and ion transport. pPI3K/pAKT/pMTOR enhance gene transcription increasing lactate dehydrogenase (LDH). LDH is one of the important markers in plasma people with non-Hodgkin’s lymphoma (NHL).Objective: This study aims to determine the correlation between the expression of kPI3K, pAKT, and pMTOR and serum LDH levels in NHL patients.Methods: This study was used an observational approach with a cross-sectional design. The expression score of pPI3K, pAKT, and pMTOR was obtained from medical records and expressed in histoscore obtained from multiplication between intensity (1=weak, 2=medium, 3=strong) with an express area (1=<20%, 2=20-50%, 3=50-80%, 4=>80%). The correlation between the histoscore of pPI3K, pAKT, and pMTOR expressions with LDH levels was statistically analysed using Pearson correlation tests. Results: The mean of pPI3K, pAKT, and pMTOR expression respectively were 5.29 + 2.95; 4.71 + 2.26 and 7.62 + 1.86. There was a weak correlation between pPI3K expression and serum LDH levels in NHL patients (r=0.293). A very weak correlation occurred between pAKT (r=-0.064) and pMTOR (r=-0.172) with serum LDH in NHL patients.Conclusion: There is a weak correlation between pPI3K expression and serum LDH levels in NHL patients. There is a very weak correlation between pAKT and pMTOR with serum LDH in NHL patients.
Reactive oxygen species and Covid-19 Dwi Nur Ahsani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 2, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss2.art2

Abstract

No Abstract
Digital image analysis of immunohistochemistry KI-67 using QuPath software in breast cancer Hermin Aminah Usman; Fauzan Ali Zainal Abidin
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 1, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss1.art7

Abstract

Background: Today, pathology services are more developed for quantitative diagnostic evaluation. The quantitative diagnostic evaluation requires detailed accuracy and can be done using digital image analysis (DIA). Assessment of the Ki67 labelling index (LI) in breast carcinoma needs to be done quantitatively. A visual evaluation of Ki67 LI using light microscopy has high inter-observer variability. The evaluation of Ki67 LI could be done digitally with the DIA technique to overcome the inter-observer variability. The DIA technique is carried out by counting the Ki67 LI manually or automatically with bioimage analysis software. QuPath is one of the bioimage analysis software, has characteristics of cross-platform, intended for bioimage analysis and digital pathology.Objective: This study aims to compare the manual and automatic calculation of Ki67 LI digitally. Methods: This study was a cross-sectional study; a total of 240 digital Ki67 images from 30 slides were analyzed by counting manually and automatically using QuPath. Results: Statistical analysis using the T-test showed no significant difference between the manual and automatic counting of Ki67 LI (p = 0,801, a = 0,05). Conclusion: Digital image analysis using QuPath can be used to calculate the Ki67 LI automatically.
Effects of progressive muscle relaxation technique on affective and somatic signs in nursing students taking objective structured clinical examination Nurvita Risdiana; Jefry Leo Sandy; Johan Johan
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 1, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss1.art10

Abstract

Background: Objective Structured Clinical Examination (OSCE) is an instrument for an evaluation test to asses observable skills. However, this situation of the test can lead to anxiety for students expressed in affective and somatic signs. Progressive muscle relaxation technique is one of non-pharmacology therapies and can be used to decrease the affective and somatic signs in the students. Objective: This study aims to determine effects of the progressive muscle relaxation technique on affective and somatic signs in nursing students when taking the OSCE. Methods: This study was a quasi-experimental with a pre-test and post- group design. Fifty eight participants were selected by inclusion criteria and divided into two groups (a treatment group and a control group). The progressive muscle relaxation before the OSCE was conducted for 30 minutes. Zung’s self-rating anxiety (ZSAS) was applied to measure the affective signs. A sphygmomanometer, manual heart rate palpation, and thorax inspection were used to measure the somatic signs. The data were analysed by using a Wilcoxon test.Results: The Wilcoxon test showed that the effects of progressive muscle relaxation technique on the affective signs indicated p-value of 0.0001 (p<0.005). Then it also affected the somatic signs as occurred in systolic blood pressure with p-value of 0.00, diastolic blood pressure with p-value of 0.004, heart rate with p-value of 0.00, and respiration rate with p-value of 0.00. The affective and somatic signs in the treatment group decreased after the treatment was given. However, they were not found in the control group.Conclusion: There are effects of progressive muscle relaxation technique on affective and somatic signs in nursing students when taking the OSCE. The affective and somatic signs in the treatment group were lower than in the control group.
N Terminal-Pro B Type Natriuretic Peptide (NT- PRO BNP) levels and severity of disease in elderly with heart failure Erlina Marfianti; Ana Fauziyati; Barmawi Hisyam
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 3, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss3.art9

Abstract

Background: Heart failure is a major health problem in the world. It is associated with high morbidity and high mortality especially in elderly patients. Most studies reported using N terminal pro-B type natriuretic peptide (NT-proBNP) in diagnosis of heart failure, but about of these tests in determining classification of severity of heart failure in the elderly remain unclear.Objective: To determine the differences NT-pro BNP levels based on the severity of diease of heart failure in elderly patients.Methods: This is an observational study with cross sectional design. Subjects were patients with diagnosed heart failure and aged = 60 years. Patients were divided into two groups, mild and severe heart failure groups according to severity of heart failure in New York Heart Association (NYHA) class. The NT Pro-BNP levels were measured for all subjects in both groups. Data was analyzed with using unpaired t test and was considered significant if p <0.05.Results: This study involved 24 subjects, consisting of 2 gorups, there were mild heart failure groups (NYHA class I-II) and groups of patients with severe heart failure (NYHA III-IV). The mean age of the subjects was 64.50 ± 4.65 years with a minimum age of 60 years and a maximum of 78 years. The NT pro-BNP levels in the severe heart failure group (1.2587.58 ± 574.85 pg / ml) was higher than the mild heart failure group (867.83 ± 333.27 pg / ml), it was statistically significant with p = 0.040.Conclusion: The levels of NT-pro BNP serum in elderly patients with severe heart failure (NYHA III-IV) were significantly higher than in patients with mild heart failure (NYHA I-II).
Tryptophan in banana peel (Musa paradisiaca) as an anti-dementia alternative treatment: A narrative review Daffara Kinanthi Lustikaiswi; Sapto Yuliani; Rahmah Annura; Elmi Rahmadani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 2, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss2.art11

Abstract

As the prevalence of dementia increases from year to year, the discovery and invention of preventive measures are growing increasingly urgent. Banana peels contain tryptophan, an amino acid that plays a substantial role in the mechanism of dementia prevention, yet under-utilized for this purpose. Tryptophan acts as a precursor to serotonin and kynurenine. The serotonin metabolite, 5-hydroxyindoleacetate or 5-hydroxyindoleacetic acid (5-HIAA), can degrade amyloid-ß (Aß) oligomers, a peptide group of 36–43 amino acids derived from amyloid precursor protein found in people with Alzheimer's disease. The degradation of brain cells through the increase of neprilysin (NEP) and melatonin inhibits glycogen synthase kinase-3ß (GSK3ß) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?ß) by reducing the decrease in peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1). Meanwhile, in the kynurenine pathway, kynurenic acid (KYNA) also induces the NEP gene, thus preventing Aß.
Prevalence and characteristics of sleep problems of Indonesian children in 0 – 36 months old Giwang Yayi Retnosari; Irwanto Irwanto; Lilik Herawati
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 1, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss1.art6

Abstract

Background: A quarter of child population experiences sleep problems in their first three years of life. Inadequacy and problems of sleep for children may be caused by various causes that impact their mental health, emotional states, physical states, and immune systems. This also may culminate to behavioural problems. Objective: The aim of this study is to identify the prevalence of sleep problems in 0–36 months old Indonesian children. Methods: A cross-sectional study was conducted in Tulungagung, East Java, Indonesia. Children aged 0–36 months old were enrolled by using a quota sampling. Brief Infant Sleep Questionnaire (BISQ) was used in this study to assess the sleep problems. All obtained data were presented as a distribution and percentage of each variable referring to the BISQ indicators. Results: A total of 493 children were enrolled in this study. This study found that there were 153 children (31%) who had experienced sleep problems, 79 children (16%) who had nocturnal sleep duration less than 9 hours, 62 children (12,8%) who had nocturnal waking more than 3 times, and 20 children (4%) who had duration of wakefulness during the night more than 1 hour respectively.Conclusion: Although majority of parents thought that there were no sleeping problems with their children, the prevalence of sleep problems in 0–36 months old Indonesian children was quite high (31%), suggesting low parental awareness towards sleep problems of their children.
Aedes aegypti as potential vector of filariasis in Pekalongan, Central Java Province, Indonesia Siti Istianah; Budi Mulyaningsih; Sitti Rahmah Umniyati; Eggi Arguni
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 1, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss1.art8

Abstract

Background: The filariasis elimination program in Indonesia has been conducted, but new cases and some chronic cases are still often found.Objective: This study aims to determine levels of endemicity and to identify filarial worm species in filariasis cases and s and their surrounding communities by using microscopic examination, polymerase chain reaction (PCR), and to examine levels of infection in vectors mosquito by surgery and PCR. Also to to determine that Ae. aegypti can act as vector of filariasis. Methods: This study was conducted at 10 locations in Pekalongan Regency, Central Java Province, with a cross sectional design. Intravenous blood sampling was conducted on 102 respondents consisting of 10 elephantiasis patients and 92 non-elephantiasis patients at night, starting at 8 pm, then examined microscopically and PCR. Mosquitoes in this study were collected by using a human landing collection method for 12 hours from 6 pm to 6 am by volunteers. Artificial infection of microfilaria W. bancrofti was held against Cx. quinquefasciatus and Ae.aegypti from laboratory collection.Results: Results of this study found that there were 5.729 of mosquitos, consisting of 8 species, namely Culex quinquefasciatus, Culex vishnui, Culex tritaeniorhynchus, Aedes aegypti, Aedes albopictus, Anopheles subpictus, Anopheles vagus, and Armigeres kesseli. Microfilarial (mf) rate was 0.89%, and and the blood PCR showed infection rate of 3.92% and the blood PCR showed infection rate of 3.92%. No larva was found in female mosquito dissection. The PCR results showed that the infection rate was 9.10% in Ae. aegypty pool respectively. Artificial infection results was negative both dissecting microscopis and PCR.Conclusion: This study revealed that the locations were low of filariasis endemicity. The mf rate was less than 1%, and there was a moderate density to high density of microfilaria in the patients. The low level of infection rates in mosquito is suggested as an alert to its potential transmission.
Sexual experiences of girls engaged in child marriage: A review of qualitative Farhah Kamilah; Elyse Maria Rosa
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 1, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss1.art12

Abstract

Child marriage cases appear to occur in children between 15 and 18 years of age. Girls who are forced into marriage show fear of having sex with their husbands because they are foreign to this situation. Previous research has shown that child marriage causes trauma to girls due to forced sexual intercourse. This study aims to explore sexual aspects from the perspective of married girls. This study uses 3 databases PubMed, EbscoHost, and Proquest. The main keywords are "child marriage", "early marriage", "Sexual", "Experience", and "Qualitative". The search for articles was carried out in accordance with the guidelines of PRISMA. The findings were 5 main themes from 15 articles. The findings are the desire to have children soon after marriage, delay of having children, husband and wife relationship in child marriage, lack of knowledge related to reproductive health, and powerlessness makes reproductive health decisions. The problem of the sexual aspect of child marriage makes it difficult for girls to live their married lives. Girls must quickly adapt to their role as wives and be able to meet everyone's marriage expectations in general. However, another case also explains that families and partners understand the condition of girls who are not ready to face this phase. The views of society and families build perceptions of child marriage, including the fulfillment of sexual needs therein.

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