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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 483 Documents
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English English: English Triasari Oktavriana; Bobby Febrianto; Ihsan Hanif; Azhar Arrosyid; Lian Kamilah; Fanny Fauziyyah Heryadi; Harijono Kariosentono
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 3, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss3.art16

Abstract

Maculopapular drug eruption (MDE) is the most typical type of hypersensitivity reaction. Patients with human immunodeficiency virus (HIV) infection may develop some complications, including wasting syndrome, contributing to immune system dysregulation. The late stage of HIV infection increases the risk of pulmonary tuberculosis (TB), in which the administration of anti-tuberculosis drugs (ATD) often induces drug eruptions. A 41-year-old man complained of itchy skin rash on his hands, body, and feet. The rash appeared after a streptomycin injection on the 9th day, accompanied by complaints of fever, weakness, dizziness, and chronic cough followed by fever at night. The patient was treated and diagnosed with a new case of pulmonary TB; and he also received first-line ATD. The streptomycin injection was given because systemic manifestation still appeared. The researchers diagnosed the patient with HIV infection with wasting syndrome. He was hospitalized and given methylprednisolone injection, paracetamol infusion, omeprazole injection, oral cetirizine, and moisturizer. After that, clinical improvement occurred, and he was discharged on the fourth day. Patients with HIV infection often develop MDE. Clinical manifestations of maculopapular drug eruption are generally mild without systemic complaints; however, in certain conditions, such as HIV infection with wasting syndrome, more severe systemic symptoms can appear due to excess secretion of several proinflammatory cytokines. Several studies have also reported an increased incidence of maculopapular drug eruption caused by first-line anti-HIV drugs, especially in patients with HIV infection.
In silico determination of fenthion, permethrin, and carbaryl as FFAR2 inhibitors: Type 2 diabetes mellitus pathomechanism study Elly Nurus Sakinah; Nabil Athoillah; Komang Yunita Wiryaning Putri; Yunita Armiyanti
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 3, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss3.art3

Abstract

Background: In the last few decades, many studies have shown that pesticides have a close relationship with increasing blood glucose levels and the incidence of diabetes. Some examples of pesticides include fenthion, permethrin, and carbaryl. Recently, free fatty acid receptor 2 (FFAR2) was identified as having a critical function in preventing insulin resistance. Activation of FFAR2 will reduce fat accumulation and induce glucagon-like peptide 1 (GLP-1) secretion, which plays an important role in regulating type 2 diabetes mellitus (T2DM) prevention.Objective: This study aims to determine a comparison of the binding ability between fenthion, permethrin, and carbaryl to FFAR2 protein for predicting the mechanism of pesticide toxicity to T2DM through an in silico study.Methods: This is an exploratory bioinformatic study. The protein structure was FFAR2 receptor (UniProt: O15552), while the ligand was fenthion (PubChem CID: 3346), permethrin (PubChem CID: 40326), and carbaryl (PubChem CID: 6129). This molecular docking was conducted in October 2022 using Asus X202XE with Intel® Core™ i3-3217U CPU equipped with BIOVIA Discovery Studio, AutoDockTools, and AutoDock Vina. Results: The binding affinity values generated after docking between fenthion, permethrin, and carbaryl with FFAR2 indicate that the binding affinity comparison is permethrin < carbaryl < fenthion. This explains that permethrin could form a stronger bond with FFAR2 protein than other pesticides. However, the visualisation results of the form of bond interactions show that permethrin does not bind to the active site of FFAR2, so it could not be called an inhibitor. This is different from fenthion and carbaryl, which could bind to several amino acid residues on the active site of FFAR2 and have the potential to become inhibitors.Conclusion: Carbaryl is a pesticide with the strongest FFAR2 inhibitor. Carbaryl could cause type 2 DM through its inhibitory pathway to FFAR2.
Comparison between Pilates exercise and combination with transcen-dental meditation towards short-term memory among adult females Almira Fadhila Az Zahra; Yuswo Supatmo; Muhammad Reza Wijoko Ekaputera
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 3, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss3.art8

Abstract

Background: Pilates is a kind of exercise that incorporates both physical and mental components in its practice. Transcendental meditation comprises a collection of approaches that center on attention and awareness cultivation. Upon reaching adulthood, a person must possess a significant level of cognitive ability to guarantee optimal production. Pilates and transcendental meditation have emerged as potential options for enhancing cognitive processes, especially short-term memory. Objective: This study aims to investigate the impact of Pilates exercise, both alone and in conjunction with transcendental meditation, on short-term memory.Methods: The present study used an experimental design including three parallel groups and performed a pre-test and post-test design. The participants in this study consisted of 45 adult females ranging in age from 25 to 55 years. They were selected using the purposive sampling method and were divided into three groups based on the interventions received. The first group received a combination of Pilates exercise and transcendental meditation (n=15), the second group received Pilates exercise alone (n=15), and the third group served as the control group (n=15). Both intervention groups participated in 16 sessions, which were performed three times per week over six weeks. The Scenery Picture Memory Test (SPMT) was used to assess short-term memory. The data analyses were done using the paired t-test and One-way ANOVA. Results: Significant improvements (p<0.05) in SPMT scores were found across all groups after their respective therapies. There were stark differences in the results of the SPMT between the group engaged in Pilates exercise and the group practicing transcendental meditation (p=0.001), as well as between the Pilates exercise group and the control group (p<0.001). Besides, a significant result was found between the Pilates exercise group and the control group (p=0.01).Conclusion: The Pilates exercise, whether performed alone or in conjunction with transcendental meditation, has been shown to enhance short-term memory. Notably, engaging in Pilates exercise with transcendental meditation has a more pronounced and efficacious outcome.
Analysis of influencing factors in chronic kidney disease incidence in Indonesia Meilinah Hidayat; Fabiola Motulo; Santoso Chandra; Stephanie Andamari; Janto Sulungbudi; Ronny Lesmana
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 3, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss3.art10

Abstract

Background: The incidence of chronic kidney disease (CKD) continues to increase from year to year. There was an increase in CKD rates in the 2013 and 2018 basic health research or Riset kesehatan dasar (Riskesdas). Several provinces in Indonesia show a high incidence of CKD and require hemodialysis. As the incidence of CKD increases, it is important to investigate the influencing factors.Objective: To identify the influencing factors of CKD incidence in Indonesia.Methods: Data from 11 provinces with the highest incidence of CKD and hemodialysis were obtained from the Indonesian Ministry of Health through the Riskesdas 2018 survey. For comparison, the incidence of hemodialysis patients in 2020 at Immanuel Hospital Bandung was included in the investigation. All data were analysed using a Python software program, and a decision tree was determined. The results of the decision tree were analysed using Chi-square. Subject profiles were descriptively analysed for some Riskesdas 2018 data and medical records at Immanuel Hospital. Results: The total data from Riskesdas was 130,787 subjects, among those, there were 610 people with CKD/hemodialysis, meanwhile data of 79 people with hemodialysis were obtained from Immanuel Hospital. The odds ratios of diabetes mellitus was 4.54 (p=0.000), hypertension was 3.00 (p=0.000), salty food was 2.26 (p=0.000), waist circumference (WC) was 1.35 (p=0.025), and body mass index (BMI) was 1.06 (p=0.605). Conclusion: Diabetes, hypertension, salty foods, WC and BMI are the five most important factors influencing the incidence of CKD in Indonesia. These variables need to be managed properly to reduce the incidence of CKD.
Effects of ethyl acetate extracts of Marsilea crenata Presl. leaves on risks of atherosclerosis in dyslipidemic rats Jatmiko Susilo; Dian Oktianti; Feronika Wiji Ashari; Ahmad Nurfahmi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 3, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss3.art5

Abstract

Background: Dyslipidemia is widely known as a significant contributor to the incidence of cardiovascular diseases (CVD). Over the years, traditional therapeutic strategies, including the use of herbs, have been recognized. Marsilea crenata Presl. (MC), or a plant known for its phytoestrogen content, has shown biological activities similar to oestrogen. These activities comprise the reduction of serum cholesterol levels, thereby having potential roles in managing dyslipidaemia and its associated cardiovascular risks.Objective: This study aims to examine the effects of ethyl acetate extracts of MC leaves on the serum lipid profile of experimental rats with dyslipidaemia induced by high-fat diet (HFD). Methods: This study applied a pretest-post-test study design with control group, involving 30 rats which are divided into 5 treatment groups, namely N (normal), HFD, STA (Simvastatin), MC1, MC2, and MC3. Group N was only treated with standard feed, and the others received HFD on days 1-14. On the 15th – 28th day, the HFD group was treated with standard feed, and the STA group received simvastatin 0.36 mg/200 g BW/day. The groups of MC1, MC2, and MC3 were treated with oral MC extracts at 100, 200, and 400 mg/kgBW, respectively. Their body weight was measured at the beginning of the study, as well as after 2 and 4 weeks. Subsequently, the experimental rats were fasted overnight on the 14th and 28th day. Their blood was collected on the 15th day (pre-test) and 29th day (post-test) to measure serum concentration of total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-c). Low-density lipoprotein cholesterol (LDL-c) concentration was also calculated by using the Friedewald formula. Results: MC3 extracts significantly reduced the TC (-40.95 ± 1.77), TG (-46.12 ± 3.79), and LDL-c levels (-0.017 ± 0.010), and it also increased levels of HDL-c (11.28 ± 2.34) mg/dL in the HFD-induced rats.Conclusion: Ethyl acetate extracts of MC leaves could reduce risk factors for atherosclerosis by returning lipid profile of the dyslipidemic rats to normal conditions with an increased dose.
Placenta accreta spectrum disorder: An updated literature review Putri Mirani; Peby Maulina Lestari; Krisna Murti; Iche Andriyani Liberty; Hana Andrina; Cindy Kesty; Bella Stevanny
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 3, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss3.art15

Abstract

Placenta accreta spectrum disorder (PASD) refers to a range of pathological placental adhesions to the uterine wall, previously classified into three subtypes: placenta accreta, placenta increta, and placenta percreta, based on the invasiveness of the villous tissue. This article provides an updated review of the literature on PASD with new insights into the etiopathology of PASD. Recent evidence suggests that extravillous trophoblasts are not overly invasive and that accreta placentation is more likely due to decidualisation failure resulting from blastocyst implantation within a caesarean scar defect (CSD). Previous caesarean delivery has been the most well-known risk factor of PASD, with the increased occurrence of PASD along with the increased number of previous caesarean deliveries. Antenatal identification of PASD is strongly recommended to improve outcomes before the onset of labour or bleeding, so that placental abruption can be avoided. Ultrasonography can identify PASD in the first trimester with good sensitivity and specificity. A standardised approach with a comprehensive multidisciplinary care team is required to manage PASD effectively. The Royal College of Obstetricians and Gynaecologists (RCOG), along with The American College of Obstetricians and Gynaecologists (ACOG), have published guidelines for the best clinical management of PASD. Future research should concentrate on gathering prospective data on the diagnosis and management of PASD in order to assess the association between prenatal imaging, clinical grading, and histology findings. This will lead to more accurate PASD screening, reliable diagnostic criteria, and alternatives to prenatal treatment.
Age group-based interventions to improve psychological outcomes in people living with HIV: A systematic review Novianti Lailiah; Nursalam; Retno Indarwati
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 3, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss3.art14

Abstract

People living with HIV (PLWH) experience higher psychological distress than the general population. Interventions to improve PLWH’s psychological condition need to be adjusted to the their age as each age group’s cognitive abilities are different. This systematic review aims to demonstrate age group-based interventions to improve psychological outcomes in PLWH. A search on articles (2014-2022) focused on experimental studies was conducted on Scopus, SAGE Journal, Science Direct, and PubMed. The searched articles tested interventions to improve psychological outcomes in PLWH and were published in English. The Joanna Briggs Institute (JBI) guidelines were used to assess their eligibility, and PRISMA diagram was used to compile the results of the search. Fifteen studies that matched the inclusion criteria were obtained, and they had experimental study designs. Several types of interventions were identified from the obtained literature. These interventions were designed according to their research subjects, and had been proven to have a significant effect on improving psychosocial conditions and quality of life in PLWH. Further research about age group-based interventions to improve psychological outcomes in PLWH is necessarily suggested. Future research is expected to be able to design interventions that focus on building resilience in individuals. The resilience is to make individuals manage their stress optimally. This may improve not only their psychosocial status but also their adherence to treatment and quality of life.
Clove flower extracts (Syzgium aromaticum) increased incision wound epithelization, platelet count, and TGF-β levels in methicillin-resistant Staphylococcus aureus-infected rats Suryo Wibowo; Endang Sri Lestari; Muhammad Thohar Arifin; Yan Wisnu Prajoko; Neni Susilaningsih
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 3, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss3.art4

Abstract

Background: The wound healing process consists of three phases, namely inflammation, proliferation, and remodeling. Many cells and mediators are involved in this process, including platelets and transforming growth factor-β (TGF-β). Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterial strain resistant to beta-lactam antibiotics. Clove flower (Syzygium aromaticum) is an herb with properties to promote wound healingObjective: To determine the effect of clove flower extract on increasing epithelialization of incision wounds, platelet counts, and TGF-β levels in mice infected with MRSAMethods: A randomized experimental study on 30 male wistar rats (Rattus norvegicus) infected with MRSA. All rats were randomly divided into six groups; healthy control, positive control induced by MRSA and Vancomycin 9 mg/200 gram body weight (gbw), negative control MRSA with normal saline, and administration of clove flower extract (CFE) 25 mg/200 gbw, CFE 50 mg/200 gbw, and CFE 100 mg/200 gbw. Examination of the sectioned wound epithelium was performed histologically using Hematoxylin-Eosin (HE), while platelet count and TGF-β levels were measured using an ELISA RAB0479 kit simultaneously on the 21st day. Results: Histological examination of rats treated with CFE 100 mg/200 gbw and uninfected rats showed complete epithelization. Platelet counts and TGF-β levels were significantly higher in rats administered CFE 100 mg/200 gbw (p<0.001) compared to the other five groups. Conclusion: Administrating CFE increased incision wound epithelialization, platelet count, and TGF-β levels in MRSA-infected rats.
Immunoexpression of human telomerase reverse transcriptase in fibroepithelial tumors of the breast Fairuz Fairuz; Humaryanto Humaryanto
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 3, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss3.art11

Abstract

Background: Phyllodes tumors and fibroadenomas are groups of fibroepithelial tumors in the breast that have different therapeutic approaches due to their rate of progression. The observed phenomenon can be attributed to the proclivity for recurrence and shared histologic characteristics, particularly within the fibroadenoma (FAs), benign phyllodes and borderline phyllodes. It's pathomechanism is undetermined yet. Human telomerase reverse transcriptase (hTERT) is one of the genes thought to play a role in the pathomechanism of this tumor.Objective: This study aimed to determine the comparison of hTERT immunoexpression in the most common fibroepithelial tumor types.Methods: This research was an analytic observational study with cross sectional method. The samples used were FAs and phyllodes tumors (PTs) which were divided according to the 2019 World Health Organization (WHO) classification. Histopathological examination was conducted on paraffin-embedded tissue blocks with FAs and PTs. Staining was performed using immunohistochemistry techniques with hTERT antibodies. Results: A total of 69 samples were obtained consisting of 26 FAs, 17 benign PTs, 16 borderline PTs, and 10 malignant PTs. A significant difference was found in the loss of hTERT expression in fibroadenoma and phyllodes tumors in various grades. There was a positive correlation between hTERT immunoexpression and tumor type in this study (p= 0.0001). Conclusion: There were significant changes in hTERT immunoexpression in fibroepithelial tumors, suggesting a role for hTERT in the pathomechanism of breast fibroepithelial tumors can be considered.
The association between nutrient intake and physical activity with nutritional status of undergraduate medical students Ika Alifa Suryabrata; Witri Ardini; Sity Kunarisasi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 3, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss3.art12

Abstract

Background: Malnutrition, especially overnutrition, is a primary adult nutrition problem. Food intake and physical activity have been the primary factors that affect nutritional status. In college students, food consumption and physical activity tend not to be compatible with the recommendation. Objective: To know the association between nutrient intake and physical activity with the nutritional status of undergraduate students in the Faculty of Medicine of the Universitas Islam Negeri (UIN) Syarif Hidayatullah Jakarta.Methods: This study was an analytical cross-sectional at the Faculty of Medicine, UIN Syarif Hidayatullah Jakarta, from August to September 2019. The sample of this study was undergraduate medical students at the Faculty of Medicine UIN Syarif Hidayatullah Jakarta, with as many as 113 students meeting qualified criteria. The sample was chosen with a stratified sampling method. Data was taken using IPAQ (International Physical Activity Questionnaire) for physical activity, food records, and height and body weight measurements. Data was analysed using comparative analysis Results: Our analysis demonstrated an association between nutritional status and adequacy of calorie intake (p = 0.001), as well as macronutrient intake (p = 0.001). There was no association between nutritional status and physical activity (p = 0.737). Conclusion: There was an association between nutrient intake and the nutritional status of undergraduate medical students in the Faculty of Medicine UIN Syarif Hidayatullah Jakarta. On the contrary, there was no association between physical activity and the nutritional status of undergraduate medical students in the Faculty of Medicine UIN Syarif Hidayatullah Jakarta.

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