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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 468 Documents
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Euphorbia milii and propolis combination tea reduced hepatic steatosis and hepatocyte apoptosis in high-fat diet rat model Linawati, Ni Made; Sundari, Luh Putu Ratna; Widarta, I Wayan Rai; Arijana, I Gusti Kamasan Nyoman; Wande, I Nyoman; Luvianto, Juven
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art10

Abstract

Background: Dyslipidemia can cause various organ disorders, such as fatty liver disease. Over time, fatty liver disease has become more commonplace worldwide and may cause mortality if the progression worsens. Natural components from Euphorbia milii (E. milii) and propolis (EMP) have been demonstrated as immunomodulators that reduce total cholesterol levels.Objective: To prove the effect of EMP tea on inhibiting fatty liver and hepatocyte apoptosis in high-fat diet (HFD)-induced rats.Methods: This study applied a post-test-only control group design using 18 Wistar rats, which were divided into three groups: K0 (received standard feed), KN (received HFD of 2 g/200 g Body weight (BW) in a day), and P (received HFD of 2 g/200 g BW in a day and EMP of tea 40 mg/100 g BW in a day). The interventions were conducted for 30 days, followed by termination on day 31 for liver tissue collection and analysis. We calculated the hepatic steatosis with the help of hematoxylin-eosin (HE) staining. Hepatocyte apoptosis was also determined with terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining.Results: The K0 group had a lower hepatic steatosis percentage (17.87 ± 1.81) than KN (63.75 ± 15.88). We also found no hepatocyte apoptosis in the K0 but a high hepatocyte apoptosis index in the KN (3.98 ± 0.29). The combination of EMP tea in HFD-induced rats significantly reduced hepatic steatosis and apoptosis percentage (25.33 ± 1.17 and 0.91 ± 0.61, respectively). Conclusion: We demonstrated that combining EMP tea reduced hepatic steatosis and hepatocyte apoptotic index in HFD-induced rats, suggesting its potential as a treatment for these conditions.                                       
Association between prenatal factors and incidence of stunting in toddlers aged 0 – 23 months: A case-control study Maula, Fanindy Ghanif; Ratnawati, Ratnawati; Zulaikhah, Siti Thomas
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art8

Abstract

Background: Stunting is impaired growth caused by chronic malnutrition in the first thousand days of life divided into prenatal and postnatal period. The prenatal period starts from conception until before time of birth. It is caused by multifactor including dietary consumption, infectious diseases, maternal nutrition, socioeconomic factors, and environmental factors. Objective: This study aims to identify the correlation between prenatal factors and incidence of stunting in toddlers aged 0 – 23 months in the area of Puskesmas Guntur II (Guntur II Primary Health Care), Demak Regency.Methods: This was an analytic observational study with a case control design. Independent variables in this study were haemoglobin levels, iron tablet consumption behaviour, chronic energy deficiency (CED) status, maternal height, and antenatal care (ANC) frequency. Its sampling technique was a purposive and consecutive sampling. Its data were analysed by chi-square for bivariate analysis and logistic regression test for multivariate analysis.Results: The results of correlation between haemoglobin levels (p = 0,012; OR = 4,375; CI = 1,320 – 14,504), iron tablet consumption behaviour (p= 0,297; OR = 1,727; CI = 0,616 – 4,845), chronic energy deficiency status (p = 0,045; OR = 3,333; CI = 0,998 – 11,139), maternal height (p = 0,045; OR = 3,333; CI = 0,998 – 11,139), and ANC frequency (p = 0,067; OR = 2,667; CI = 0,924 – 7,699) with incidence of stunting . Risk factors for stunting based on multivariate analysis are chronic energy deficiency status (β = 1,703; p = 0,014; OR = 5,489; CI = 1,417 – 21,263) and frequency of ANC (β = 1,460; p = 0,018; OR = 4,307; CI = 1,287 – 14,417).Conclusion: The haemoglobin levels, maternal height, and CED status have significant correlation with incidence of stunting in toddlers aged 0 – 23 months. The CED status is the dominant risk factor of incidence of stunting in toddlers aged 0 – 23 months.
Exploring the remarkable effect of ursodeoxycholic acid and Allium sativum combination on MMP-9 and TIMP-1 levels in cholestatic rat’s model Sekartaji, Anindhita Dyah; Prasetyo, Sigit Adi; Muniroh, Muflihatul
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art5

Abstract

Background: Cholestasis is a disturbance in the production or flow of bile that causes excessive accumulation of bile fluid and damage in the liver. Chronic liver damage will lead to liver fibrosis. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitors of metalloprotease-1 (TIMP-1) play a critical role in liver fibrosis formation. Although ursodeoxycholic acid (UDCA) and Allium sativum extracts have long been renowned for improving liver function, their combination in alleviating liver fibrosis through the MMP-9 and TIMP-1 inhibitory pathways has yet to be studied.Objective: This study was conducted to assess the efficacy of UDCA and Allium sativum extract combination in altering MMP-9 and TIMP-1 levels, which are the main factors in the progression of liver fibrosis.Methods: We performed an experimental study with a post-test-only control group on 36 Sprague-Dawley rats, which were randomly grouped into healthy, negative, positive, and three treatment groups with UDCA (13.5 mg) and graded doses of Allium sativum extract (3.6 mg; 7.2 mg; and 14.4 mg). Cholestasis induction was done by a choledochal duct ligation, and treatment was given for 14 days. Levels of MMP-9 and TIMP-1 were analyzed after treatment.Results: Combining UDCA and Allium sativum improved the MMP-9 levels significantly in cholestatic rats, compared to administrating UDCA only (p <0.05). Combining UDCA and Allium sativum increased the TIMP-1 level (p < 0.05). Although the MMP-9 level results were under our existing hypothesis, TIMP-1 results showed surprising results. Matrix metalloproteinase-9 levels were strongly negatively correlated with TIMP-1 levels, with a r-value= 0.981.Conclusion: Combining Allium sativum and UDCA alleviates liver fibrosis progression through lowering levels of MMP-9 and increasing levels of TIMP-1.
Spatial analysis of tuberculosis cases among stunted toddlers in Rambipuji District, Jember Regency Utami, Wiwien Sugih; Amrina, Adinda Putri Yusri; Armiyanti, Yunita; Maududie, Achmad
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art8

Abstract

Background: The ongoing prevalence of tuberculosis (TB) and stunting presents significant health challenges, frequently localized within specific regions of Indonesia. Spatial analysis is essential in controlling infectious diseases like TB, as it identifies disease clusters and patterns of local TB spread within an area. Objective: This study aimed to analyze the distribution of TB cases among stunted children through spatial analysis. Methods: We used a cross-sectional analytical descriptive study. We interviewed parents of stunted children using a questionnaire. The diagnosis of TB was made based on the pediatric TB scoring table. Coordinate data of sample sites were obtained using a Geographic Information System (GIS), supported by risk factor analysis of TB. We then created a disease distribution map using the spatial analysis by Moran's Index and Nearest Neighbor Index (NNI) methods. Results: There were 15 childhood TB cases (8.2%) among stunted children in Rambipuji District. The spatial autocorrelation test using Moran's index showed that TB cases were clustered in Rambigundam village (Moran’s index 0.2364, p-value <0.05 and Z-score >1.96). The results of the NNI analysis showed dispersed results (p-value=0.000) in all villages. Conclusion: The distribution of childhood TB cases among stunted children in Rambipuji District is primarily random, except for Rambigundam Village, which shows a clustering of cases. According to the NNI methods, childhood TB cases among stunted children are spreading throughout all villages. These results underscore the need for initiatives to curb TB transmission, especially among stunted children, which should be targeted at all villages.
Cauda equina syndrome successfully treated with microdiscectomy and methylprednisolone therapy: A case report Henderson, Alhoi Hendry; Ibrahim, Sabri
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art16

Abstract

Cauda equina syndrome (CES) caused by lumbar disc herniation is a rare neurosurgical emergency in young adults that requires immediate decompression. A surgical delay over 48 hours may result in irreversible ramifications, underscoring a crucial timeframe for managing this condition. We presented a 26-year-old man with lower limb weakness persisting for one week, accompanied with exacerbating bowel and bladder issues after massage. The patient had a history of low back pain and tingling sensations radiating to the left leg over the past year. His physical examination showed right motor strength of 5/4 and left motor strength of 5/3, with weakened bowel peristalsis, loose anal sphincter and saddle anaesthesia. A spinal MRI revealed protruded discs extending to the intervertebral levels of L4-L5 and L5-S1, implicating herniated discs as the likely cause of CES. He underwent a microdiscectomy with a posterior approach, and intravenous methylprednisolone was administered before the procedure. The next surgery demonstrated enhancements in motor strength, bowel and bladder function, and it also reduced pain. He was discharged with persistent tingling sensations in his both legs. We concluded that CES represents a critical neurosurgical emergency, which is diagnosed through clinical symptoms and neuroimaging. Rapid decompression and intravenous administration of methylprednisolone are associated with better prognosis.
Radiographic findings and body mass index in elderly patients with knee osteoarthritis: A cross-sectional study Lie, Yose Steven; Kusumaningrum, Sulistyani; Budiningsih , Fatichati; Wijaya, Bayu Basuki
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art3

Abstract

Background: Osteoarthritis (OA) is a chronic condition characterized by the gradual wearing down of joint cartilage. Its prevalence is increasing due to aging populations and obesity rates. The Kellgren and Lawrence classification system is commonly used to assess OA severity based on radiologic findings.Objective: This study aims to determine the relationship between body mass index (BMI) and the radiological severity of knee OA as classified by the Kellgren and Lawrence system, in elderly patients.Methods: We conducted a cross-sectional analysis of outpatients diagnosed with knee OA at a Dr. Moewardi Regional Public Hospital from January 2020 to August 2023. Patient records and knee X-rays graded by the Kellgren and Lawrence system were reviewed. Two radiologists independently assessedthe X-rays to ensure accuracy. BMI was calculated using the formula weight (kg) divided by height (m2), with weight and height measured suing calibrated instruments. Spearman's rho bivariate correlation analysis was performed to analyze the data.Results: A total of 96 patients were analyzed, with the majority being female (62.50%) and aged 60-69 years (59.30%). The most prevalent OA severity was grade 3 (46.89%), and the most common OA location was bilateral (73.96%). There was a significant moderate correlation between Kellgren & Lawrence and BMI (p=0.000; rho=0.401).Conclusion: A moderate correlation exists between the severity of knee OA and BMI in elderly patients. Those with a higher BMI tend to present with more severe OA.
Anemia in young pregnant women: A cross-sectional study in Indonesia Kuntari, Titik; Supadmi, Sri
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art3

Abstract

Background: The prevalence of anemia among pregnant women in Indonesian remains high at 48.9%, with the highest rates observed among young mothers aged 15-24 years. Anemia is associated with adverse outcomes for both mothers and their children. Understanding the determinants of anemia in young mothers is crucial for taking preventive measures. However, there are currently no national studies in Indonesia on the prevalence and risk factors of anemia in pregnant women aged 15 to 24 years.Objective: To measure the prevalence and factors associated with anemia in young pregnant women in Indonesia.Methods: This cross-sectional study utilized on secondary data from the 2018 Basic Health Research (Riset Kesehatan Dasar= Riskesdas). The subject of this research were pregnant women aged 15 to 24 years who participated in Riskesdas 2018 and had independent variables data including hemoglobin measurement data, age, education, residence, occupation, travel time to health facilities, age at first pregnancy, ownership of the maternal and child health (MCH) handbook, history of previous abortion, gestational age, number of iron supplement tablets, supplementary feeding, and chronic energy deficiency. Univariate analysis was conducted to analyse the subject characteristics and hemoglobin data, while chi-square and logistic regression were used to determine factors associated with anemia in young pregnant women Results: The study found that 36.2% of young pregnant women had anemia. The incidence of anemia was associated with gestational age but not with other factors. Pregnancy in the first trimester poses the highest risk compared to other trimesters (cOR=3.89; 95%CI:1.47-10.30; p=0.006), as confirmed by multivariate analysis (aOR=4.44; 95%CI: 1.41-13.95; p=0.01).Conclusion: Anemia affects 36.2% of pregnant women aged 15 to 24 years in Indonesia. The risk of anemia in young pregnant women is significantly associated with gestational age with the first trimester being the most critical period.  
Comparison of lipid-lactate levels between brain abscesses and brain tumors through magnetic resonance spectroscopy examination Syafa, Nahdah Ardelia; Fatmawati, Heni; Putri, Komang Yunita Wiryaning; Hairrudin; Adji, Novan Krisno
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art7

Abstract

Background: Intracranial masses are masses found in the intracranial space, such as brain abscesses and brain tumors. Magnetic Resonance Spectroscopy (MRS) examination is a noninvasive examination procedure with magnetic resonance regarding chemical composition or metabolites. One of the metabolites examined in MRS is lipid-lactate which will appear or increase if there are certain abnormalities such as in abscesses and brain tumors.Objective: This study analyzed the difference in lipid-lactate levels between brain abscess and brain tumor through MRS examination.Methods: This research adopted an observational analytic approach with a cross-sectional design. Samples in this study were brain abscess and brain tumor patients examined using MRI and MRS at Siloam Jember Hospital from June 2018 to October 2023. The sampling method employed encompassed a total sampling of 45 patients with 15 brain abscesses and 30 brain tumors. Results: The results of this study showed that the lipid-lactate levels of all brain abscess patients increased by 15 patients (100%), while in brain tumors, lipid-lactate levels increased by 19 patients (63.3%) and decreased by 11 patients (36.7%). The mean rank of lipid-lactate levels in brain abscesses was 14101,93 while in brain tumors was 6220,69. The statistical analysis results using the Mann-Whitney comparison test obtained a p-value of 0.008 (<0.05), meaning there is a significant difference.Conclusion: There is a significant difference in lipid-lactate levels in brain abscesses and brain tumors.
Eye yoga exercises to reduce eye fatigue syndrome during online learning Wilandika, Angga; Fatmawati, Ariani; Padhli, Fikri Nurul; Lusiani, Eli; Amalia, Maya
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art4

Abstract

Background: Eye fatigue syndrome increases as students use computers and smartphones during online learning. Interventions to reduce the eye fatigue syndrome and avoid the severity of its symptoms need to be performed with appropriate and easy-to-practice techniques.Objective: This study aims to determine effects of eye yoga exercises on eye fatigue syndrome in students during online learning. Methods: This study applied one group pretest-post-test design involving 30 students from Universitas ‘Aisyiyah Bandung, West Java Province, Indonesia. Its samples were collected by using a proportional stratified random sampling. The eye yoga exercises were practiced four times for one week and had to begin 30 minutes after the end of online learning. The eye fatigue syndrome was measured using the Computer Vision Syndrome Questionnaire (CVS-Q). The difference in the intervention effect was calculated by using the Wilcoxon Signed-Rank Test. Results: This study revealed that the yoga eye exercises significantly affected the eye fatigue syndrome (Z= -4.636; p-value < 0.05). The average eye fatigue score decreased; the eye fatigue score before the intervention was 14.40 ± 9.17, and it decreased to 9.17 ± 4.88 after the eye yoga exercise intervention was given.Conclusion: Eye yoga exercises can reduce the level of eye fatigue syndrome in students who are learning by using electronic devices. The exercises can be performed independently to reduce this syndrome when working with a computer or smartphone. This intervention can be a standard for preventing the syndrome in educational institutions by incorporating eye yoga exercises after learning activities, particularly in online learning.
The role of platelet indices in clinical research Nugraheti, Prita Murani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 1, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss1.art2

Abstract

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