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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 468 Documents
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Integrating biomarkers, diagnostic innovation, and behavioral determinants into healthcare management systems Rahman, Ferry Fadzlul
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 2, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss2.art1

Abstract

Neutrophil lymphocyte ratio: An accessible biomarker for suicide risk stratification in affective disorder Wahdini, Ade Indah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 2, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss2.art2

Abstract

Brugada pattern associated with febrile gastroenteritis: A case report Edi, Larasati Cahyaning; Aminanto, Ahmad Ma'ruf Muttaqin; Paranita, Indah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 2, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss2.art14

Abstract

The Brugada pattern is an electrocardiographic manifestation that mimics true Brugada syndrome, potentially triggered by transient and reversible conditions. This case describes a 66-year-old Indonesian male with acute gastroenteritis, characterized by mild hypokalemia (3.2 mmol/L) and fever, who exhibited a Brugada type 1 ECG pattern. The patient experienced over 10 episodes of diarrhea, more than seven episodes of vomiting, and a fever of 39 °C, with no cardiac symptoms or family history of sudden cardiac death. The electrocardiogram (ECG) showed coved-type ST-segment elevation greater than 2 mm, accompanied by inverted T waves in leads V1-V3, which is indicative of a Brugada type 1 pattern. Laboratory results confirmed mild hypokalemia and leukocytosis, while echocardiography and chest X-ray showed no structural abnormalities. The patient received a comprehensive treatment plan including mineral sorbitol infusion, paracetamol, cefixime, potassium supplementation, and notably, cilostazol—a phosphodiesterase-3 inhibitor not previously documented for gastroenteritis-associated Brugada pattern. After three days of treatment, the Brugada pattern resolved. This case offers important insights for clinical practice in Indonesia by considering Brugada pattern in febrile gastroenteritis with ST-segment elevation, even with mild hypokalemia. It also raises the possibility that the combination of electrolyte correction and cilostazol may facilitate ECG normalisation. Further studies are needed to evaluate the therapeutic potential of cilostazol and to improve diagnostic accuracy in differentiating transient Brugada patterns from Brugada syndrome.
Board game-based education on helminthiasis knowledge of elementary school students: An effectiveness study Rusjdi, Selfi Renita; Hendra, Gabriel Septian; Fadhilah, Maisarah; Muhammad Nur Alif Johar; Utami, Mutia; Rahmaddiansyah, Refa; Wulandari, Wulandari; Yustian, Ahmad Raffi; Aisyah, Siti; Kaltsum, Nilam Fa'izah; Satiya, Selin Faysa
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 2, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss2.art10

Abstract

Background: School-aged children are particularly vulnerable to soil-transmitted helminths (STH) infections due to frequent exposure to contaminated soil during play and poor personal hygiene practices. Although games have been widely used as educational tools in health promotion, there is limited research on the effectiveness of board games specifically designed to prevent STH infections in children.Objective: This study aimed to evaluate the effectiveness of a board game-based educational intervention in enhancing knowledge of STH among elementary school students.Methods: Analytical experimental design using a pre-test and post-test intervention approach without a control group was employed. The subjects of this study were elementary school students in grades 3 to 6 who met specific criteria. A total of 94 students participated. Knowledge was assessed using questionnaires. The intervention involved small-group sessions (4–6 students per group) using a custom-designed educational board game about STH. The collected data were analyzed using a dependent t-test, while multivariate ordinal regression was employed for multivariate analysis. Results: The average test score improved from 0.60 (± 0.15) to 0.74 (± 0.14) post-intervention, representing a significant 14% increase in knowledge (p = 0.00). Age was not a significant predictor of post-test performance (β = 0.310; p = 0.429). Male students (β = 1.068; p = 0.013) and those in grade 4 (β = 2.031; p = 0.036; OR = 7.62, 95% CI: 1.15–50.56) were significantly more likely to achieve higher post-test scores.Conclusion: Board game-based education effectively improved knowledge about soil-transmitted helminth infection among elementary school students. This study offers novel evidence supporting the use of board games for helminthiasis prevention.
The use of policresulen concentrate in the management of hypergranulation in diabetic foot ulcers: A case report Ritonga, Sukhri Herianto; Rangkuti, Juni Andriani; Lubis, Arisa Harfa Said; Nasution, Nur Arfah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 2, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss2.art15

Abstract

Diabetic foot ulcers are a severe complication of diabetes, causing pain, infection risk, and reduced quality of life. Timely and effective wound management is crucial to prevent delayed healing, which may ultimately result in amputation. One of the complications often encountered in diabetic foot ulcers is hypergranulation tissue. Policresulen, known for its hemostatic and antimicrobial properties, presents a potential option for managing hypergranulation. This case report explores the effects of applying policresulen concentrate to a diabetic foot ulcer complicated by hypergranulation tissue. The case involved a 61-year-old male patient with a 15-year history of diabetes mellitus which developed a diabetic foot ulcer two years prior. Despite 10 months of various treatments, wound healing remained suboptimal due to persistence hypergranulation tissue. Policresulen concentrate was applied every three days for a total of 16 wound care sessions, and healing progress was evaluated using the Bates-Jensen Wound Assessment Tool. Over the course of treatment, the hypergranulation tissue gradually diminished, and the wound progressively closed until complete epithelialization was achieved. This case demonstrates that policresulen concentrate may be effective in managing hypergranulation and facilitating wound closure in diabetic foot ulcers. No adverse effects were observed during the treatment period.
Association between ApoA1, ApoB, and the ApoB/ApoA1 ratio with the risk of diabetic neuropathy: A systematic review and meta-analysis Gosal, Ervina; Djuartina, Tena; Sutrisno, Alfred; Budianto, Iskandar R.
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 2, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss2.art12

Abstract

Diabetic neuropathy is a common complication of diabetes mellitus and a major contributing factor to the development of diabetic foot ulcers (DFU). Apolipoproteins A1 (ApoA1) and B (ApoB), as well as the ApoB/ApoA1 ratio, play a crucial role in lipid metabolism and are believed to be involved in the development of neuropathic damage in individuals with diabetes. This study highlights the association between ApoA1, ApoB, and the ApoB/ApoA1 ratio with the risk of developing diabetic neuropathy. A systematic review was conducted following the PRISMA guidelines. An extensive literature search was conducted on December 7, 2024, using multiple databases, including PubMed, ProQuest, EBSCOhost, and Medline. There were no language or publication date restrictions. This synthesis relied solely on odds ratios (ORs) with 95% confidence intervals (CIs) as effect sizes. Included studies were observational in design, examining the association between ApoA1, ApoB, or the ApoB/ApoA1 ratio with diabetic neuropathy in an adult population. Of the 320 studies identified, 5 met the criteria for inclusion in the qualitative synthesis and meta-analysis, involving 2,756 diabetic patients. Findings showed higher ApoB levels and lower ApoA1 levels in patients with diabetic neuropathy compared with controls. However, no significant association was found between ApoB, ApoA1, or the ApoB/ApoA1 ratio with diabetic neuropathy or DFU risk. This review found no significant association between ApoB, ApoA1, or the ApoB/ApoA1 ratio with diabetic neuropathy or DFU. Further research is needed to explore their potential role in DM complications.
Opioid-sparing versus opioid-free anesthesia following cancer surgery : Effect on pain severity and patient-reported outcomes Dananjaya, Vigyan; Adi Santika, Suparno
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 2, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss2.art13

Abstract

Opioid use in anesthesia during cancer surgery causes concerns about adverse effects, including postoperative nausea, vomiting, respiratory depression, and potential impacts regarding cancer recurrence. In response, opioid-sparing and opioid-free anesthesia procedures have emerged as promising strategies to reduce opioid consumption while maintaining effective pain management. This study aimed to analyze the outcome of opioid-sparing anesthesia compared to opioid-free anesthesia on pain severity and patient-reported outcomes following cancer surgery. Randomized controlled trials and observational research that met predefined inclusion criteria were systematically selected, with data extracted and analyzed. The analysis revealed that both opioid-sparing and opioid-free anesthesia techniques reduced postoperative pain severity significantly in comparison to traditional opioid-based anesthesia. Additionally, patients who received opioid-free anesthesia reported better overall outcomes, including reduced nausea, faster recovery times, and improved satisfaction scores. Although pain control differences between opioid-sparing and opioid-free anesthesia techniques were statistically insignificant, both techniques showed substantial as safer, effective alternatives in perioperative cancer care, supporting their broader adoption in clinical practice.
A 57-year-old woman with chronic hepatitis B and left hepatic nodularity unmasking intrahepatic hilar adenocarcinoma: A diagnostic case report Pramana, Triyanta Yuli; Gunawan, Timotheus A.; Prasetyo, Didik; Darmayani, Aritantri; Jati, Agus; Wasita, Brian
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 2, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss2.art16

Abstract

Metastatic breast cancer involving the biliary tract is a rare case with an incidence rate of 1.49 per 100.000 persons. Chronic hepatitis B virus (HBV) infection is associated with tumor development and migration and promotes metastasis. While hepatocellular carcinoma is the most common primary liver cancer, cholangiocarcinoma is a rarer malignancy originating from epithelial cells in various parts of the bile ducts. Intraluminal adenocarcinoma of the common hepatic duct (CHD) is an exceptionally uncommon hepatic tumor. We reported that a 57-year-old female has been complaining of abdominal pain on the upper right side for 1 year, accompanied by nausea and icterus. The patient had a history of breast cancer in 1995 and chronic hepatitis B for 20 years on Tenovofir 1x300 mg. No abnormalities were found on physical examination. However, Magnetic Resonance Cholangiopancreatography (MRCP) revealed bilateral dilatation of the intrahepatic bile duct (IHBD), common hepatic duct (CHD), ductus cysticus, and common bile duct (CBD) distal to proximal, suggesting an intraluminal mass likely due to a tumor. A plastic stent was then placed, which reduced the lesion size. Immunohistochemistry (IHC) test confirmed adenocarcinoma, in which CK-7 and mammaglobin were positive, indicating metastatic breast cancer.. A thoracic MSCT revealed multiple lytic lesions in the T1, T7, T9–T12, and L2–L3 vertebral bodies. The patient was diagnosed with intraluminal adenocarcinoma of the CHD, representing metastatic Stage I triple-negative breast cancer with biliary, pulmonary, and osseous involvement, along with chronic hepatitis B. The chemotherapy regimen included carboplatin 370 mg and paclitaxel 260 mg, continued with Taceral 500 mg 2x3 in two weeks and Zometa every 6 weeks. Post-chemotherapy MRCP evaluation showed a solid intraluminal liver lobe lesion with partial obstruction. Metastatic adenocarcinoma of the CHD caused by breast cancer is a highly unusual clinical problem. In such cases, IHC plays a vital role in identifying the primary tumor site.

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