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Zahratul Aini
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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 468 Documents
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Effectiveness of betel and kaffir lime combination form of leaf infusion as an in-vitro antiseptic candidate Budiarti, Lia Yulia; Isnaini; Nurzahida, Gusti Nadya; Derlin, Ellanda Permata; Fahmi, Yafi; Fahdyanoor
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art9

Abstract

Background: Natural antiseptics can be alternatives to reduce the adverse effects of alcohol. An antiseptic is classified as effective if it has an inhibitory ability and a phenol coefficient value ≥ 1. Betel plants (Piper betle L.) and kaffir lime (Citrus hystrix DC.) contain a variety of antibacterial compounds and have the potential to act as an antiseptic.Objective: To analyze the in vitro effectiveness of a combined leaf infusion preparation of betel (PB) and kaffir lime (CH) as potential antiseptic candidates.Methods: This quasi-experimental research employed a post-test-only control group design. We utilized diffusion (measuring inhibition zone) and dilution (determining phenol coefficients) methods. The treatments, performed in triplicate, included PB+CH infusion at concentrations 6.25%, 12.5%, 25%, 50%, 75%, and 100%, with 70% alcohol and 5% phenol as control. They were tested against five types of ATCC standard bacterial isolates.Results: Phytochemical screening of the tested infusion revealed the presence of phenolic compounds, flavonoids, alkaloids, tannins, saponins, and terpenoids. The inhibition zone area increased with concentration, with PB+CH 100% producing the most significant effect. ANOVA and post-hoc Duncan test analysis (p < 0.05) showed significant differences between treatment groups. PB+CH infusion at 75-100% produced antibacterial effects exceeding the control for all bacteria tested, except S. typhi. Phenol coefficient tests (dilution 1:20-1:250) showed the effectiveness of PB+CH infusion as a potential antiseptic. The infusion had a phenol equivalent coefficient of 5% against S. aureus, S. epidermidis, E. coli, and P. aeruginosa but only 0.99 ± 0.07 for S. typhi. The 70% alcohol coefficient value was < 1. Conclusion: The combined infusion of betel leaves and kaffir lime demonstrates significant antibacterial activity and shows a potential candidate as an effective natural antiseptic.
Visualization of bleeding site on 24-hour imaging in lower gastrointestinal bleeding with 99mTc-nanocolloid: A case report Alyani, Hilmi; Budiawan, Hendra; Nugrahadi, Trias
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art14

Abstract

Gastrointestinal bleeding can be diagnosed by history taking, physical examination, and diagnostic examinations. However, localization of gastrointestinal bleeding via a nuclear medicine examination can indicate an accurate examination to detect the location of bleeding. Radiopharmaceuticals can be selected according to a patient’s condition. Good image results are needed so that the results are conclusive and lead to further examination and management. A 2-years-old girl patient was hospitalized in a paediatric ward due to a large number of loose stools mixed with fresh blood for months after experiencing diarrhoea. The patient was active, absence any decreased appetite, pain, activity disturbances, or significant weight loss . Her parents took her for treatment to several hospitals but no improvement. The patient was referred to the Nuclear Medicine Department to undergo localization of gastrointestinal bleeding study. 99mTc-nanocolloid was injected as radiopharmaceuticals, followed by a dynamic and serial static imaging after 30 minutes. No focus of radioactivity extravasation was found. Examination was continued at 1, 2, and 24 hours. Diffuse radioactivity extravasation was found in the descending colon 24 hours after injection of the radiopharmaceutical, and she was confirmed by colonoscopy and biopsy a week later. 99mTc-labeled colloid had not been used after a few studies showed that 99mTc-red blood cell (RBC) in vitro was better at localizing gastrointestinal bleeding. Usually, 99mTc-labeled colloid remains in circulation for only 30 minutes due to rapid distribution to the reticuloendothelial system. The visualization of the bleeding site on 24-hour imaging was unusual. However, these findings suggest that 99mTc-labeled colloid can still be used with due regard to the patient's clinical active bleeding and imaging techniques.
Navigating risk factors and interventions on early-onset attention deficit hyperactivity disorder: A case report Tristan, Christopher Daniel; Rahman, Awalil Rifqi Kurnia; Kurniawan, Avenetus Immanuel Gifta; Anggriawan, Fatkan Hidayat; Bangun, Susi Rutmalem
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art16

Abstract

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental illness primarily affecting children. The peak onset age for ADHD is around 7.5 years with early-onset ADHD linked with worse clinical outcomes if not properly managed. We reported a 3-year-old girl presented with symptoms including self-harm, aggression toward her sibling and peers, hyperactivity, inability to focus, and distractibility. The patient had a history of post-term birth and oligohydramnios, and her symptoms were exacerbated by reduced maternal care, limited parental care, and inconsistent-lacked firmness parenting style. A multiaxial evaluation confirmed the diagnosis of ADHD, supported by Skala Penilaian Perilaku Anak Hiperaktif Indonesia (SPPAHI) score. The patient received a comprehensive non-pharmacological intervention, including applied behavior analysis (ABA) therapy with a discrete trial training (DTT) approach, family therapy to address parenting dynamics, and occupational and speech therapy to target fine motor and language delay. At 6-month follow-up, significant improvements were observed in behavior, attention, and total quality of life. This case highlights the complex interplay of genetic disorders, maternal stress, post-term birth, pregnancy-related complications, and problematic family dynamics in early-onset ADHD. Therapeutic management in early-onset ADHD must emphasize behavioral and family-focused therapies with DTT and family therapy proving effectiveness, while pharmacological treatment is considered as a last resort.
Potential of shallot peels as a daily antioxidant supplement against cigarette smoke-induced lung damage Helianti, Dina; Dewi, Rosita; Munawaroh, Ayu; Rachmania, Sheilla; Maulana, Aditha Satria; Abrori, Cholis; Sumadi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art10

Abstract

Background: Cigarette smoking damages the alveoli through oxidative stress. Shallot peels containing flavonoids, especially quercetin, potentially serve as a daily antioxidant supplement to impede lung tissue damage induced by cigarette smoke. However, the maximum effective dose is yet to be determined. Objective: This research was designed to establish the maximum effective dose of shallot peel infusion (SPI) to prevent oxidative stress and histopathological lung damage induced by cigarette smoke. Methods: This experimental laboratory was a posttest-only control group design. A total of 24 male Rattus norvegicus Wistar strain, were allocated into 6 groups: a control group and 5 SPI-treated groups. All rats were exposed to 2 cigarettes/day and were treated for 28 days with aquabidest and different doses of SPI (0 mg/kgBW, 125 mg/kgBW, 250 mg/kgBW, 500 mg/kgBW, 1,000 mg/kgBW, and 2,000 mg/kgBW). The level of oxidative stress in serum was measured malondialdehyde (MDA) level with ELISA, and histopathological lung damage was estimated using the lung histopathological damage scoring method assessing inflammatory cells, alveolus lumen and inter-alveoli junction.Results: The quadratic regression analysis revealed the maximum effective dose of SPI to prevent oxidative stress and lung damage were 1,435 mg/kgBW and 1,206 mg/kgBW, respectively. In the histopathological examination of the lungs, the administration of SPI up to a dose of 1206 mg/kg BW prevents the inflammatory process caused by cigarette smoke, which is indicated by the number of inflammatory cells, the thickness of the alveolar septum, and the increasingly normal shape of the alveolar lumen.Conclusion: SPI doses of less than 1,206 mg/kgBW are safe and effective daily antioxidant supplements in rats exposed to cigarette smoke and have the potential to be further studied for application in humans.
Balancing act: Parental choice vs children’s health rights Widyasari, Vita
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art1

Abstract

The importance of spatial analysis in health studies Widayani, Prima
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art2

Abstract

The diagnostic challenge of orbital tuberculosis in an otherwise healthy individual: A case report Kartiwa, Raden Angga; Elsyanty, Firda Muthia; Setiawan, Grace; Dewi, Niluh Putu Ayu; Boesoirie, Shanti Fitrianti; Dahlan, Mohammad Rinaldi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art15

Abstract

Ocular tuberculosis occurs in 1.5-18% of all extrapulmonary tuberculosis cases, with orbital tuberculosis being a very small proportion of all cases of ocular tuberculosis. High variability of manifestations of orbital tuberculosis may result in delayed diagnosis. Children are the populations most affected by this disease. This study aims to report a case of orbital tuberculosis in a patient without systemic tuberculosis symptoms. We presents a 13-year-old girl who is reported protrusion of the right eye for four months. She complained diplopia and pain in the right eye radiating to the head. She reported no other systemic symptoms. Ophthalmological examination revealed that her best corrected visual acuity of the right eye was 0.25, and the left eye was 1.0. The movement of the right eye was limited to the superior, temporal, and nasal directions. Anterior segment examinations demonstrated proptosis of the right eye with 3 mm of lagophthalmos. The patient then underwent an orbitotomy and biopsy procedure. Histopathological analysis revealed chronic granulomatous inflammation with Langerhans cells, indicative of tuberculosis. The patient was diagnosed with proptosis of the right eye and multiple cranial nerve palsy due to orbital tuberculosis. The patient was subsequently prescribed an antituberculosis treatment and attended regular monthly follow-ups. Ten months after surgery and completed antituberculosis treatment, the proptosis improves and there is no further growth of the mass. Orbital tuberculosis is a rare condition and is often challenging to diagnose, particularly in healthy individuals. Thorough history taking, physical examination, and ancillary testing are essential to establish an accurate diagnosis. This case emphasizes the necessity for heightened suspicion of tuberculosis in atypical presentations, particularly in pediatric patients in endemic areas, to prevent morbidity and ensure timely treatment.
The potential of herbal medicine as a promising complement and synergistic effects with anti-tuberculosis drugs: Term and condition apply Silvia Merry, Maria
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art2

Abstract

Combat stunting in Indonesia: Quo vadis? Azmi Choironi, Emi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art1

Abstract

Analysis of determinant diabetic neuropathy symptom score factors in diabetes mellitus patients Nurul Aktifah; Umi Budi Rahayu; Muhammad Ghilang Maulud Setyawan; Firman Faradisi; Dwi Fijianto
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 14, No 3, (2023)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol14.Iss3.art7

Abstract

Background: Diabetes peripheral neuropathy (DPN) is a set of signs and symptoms of peripheral nervous system dysfunction in diabetes mellitus patients. Abdominal obesity is one of the main risk factors for DPN. Diabetic neuropathy symptom (DNS) is a reliable instrument with consistent results for the diagnosis of neuropathy. Objective: This study aimed to determine the correlation of abdominal obesity with scores. Methods: This research was a quantitative study with a cross-sectional approach. The sample of this study was 92 type 2 diabetes mellitus (T2DM) patients aged range 30-60 years who participated in the chronic disease management program (Prolanis) and the integrated healthcare center (Posbindu) for people in the area of three public health centers (Puskesmas) in Pekalongan Regency which purposively selected. Instruments used to measure DPN were DNS sheets, and abdominal obesity was measured by waist circumference using a midline. The bivariate analysis was performed using the Pearson correlation and linear regression tests. Results: There was a correlation between abdominal obesity and DNS scores with a p value of 0.043 with a correlation coefficient of 0.212. The DNS score was influenced by age, gender, duration of diabetes, and body mass index by 13.4%. Conclusion: There was a correlation between abdominal obesity and DNS scores. It indicated that the higher the value of abdominal obesity was, the higher DNS scores increased.

Page 42 of 47 | Total Record : 468

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