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INDONESIA
Buletin Kedokteran dan Kesehatan Prima
Published by Universitas Prima Indonesia
ISSN : 28289994     EISSN : 28289994     DOI : https://doi.org/10.34012/bkkp
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health
Media publikasi ilmiah di bidang kedokteran dan kesehatan yang terbit dua kali dalam setahun yaitu pada bulan Maret dan September. Berisi tulisan hasil penelitian lapangan atau laboratorium maupun studi pustaka dari bidang ilmu seperti kedokteran klinis, kedokteran tropis, kedokteran gigi, biomedis, farmasi klinis dan kesehatan masyarakat.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 224 Documents
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Antibacterial activity of dali ni horbo protein extract modified with citrus and pineapple juice Tesa, Catrin Angelica Putri; Razoki, Razoki; Piska, Finna
Buletin Kedokteran & Kesehatan Prima Vol. 5 No. 1 (2026): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v5i1.7889

Abstract

Background: The global rise in antibiotic resistance highlights the urgent need to identify novel, natural antimicrobial agents. Fermented dairy products represent potential sources of bioactive peptides with inherent antibacterial properties. Dali ni horbo is a traditional fermented buffalo milk product from North Sumatra, Indonesia. This study aimed to evaluate the in vitro antimicrobial activity of a crude protein extract from dali ni horbo, modified with orange and pineapple juice, against selected pathogenic microorganisms. Methods: This experimental laboratory study employed disk diffusion and well diffusion methods on agar media to assess the extract’s activity against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Propionibacterium acnes, and Candida albicans. Results: The results showed no inhibition zones for any treatment against all tested microorganisms. The absence of detectable antimicrobial activity may be attributed to the low concentration or biological activity of antibacterial compounds in the crude extract, the possible degradation of bioactive peptides during extraction, and the limited diffusion capacity of high‑molecular‑weight proteins in solid agar media. Conclusion: In conclusion, under the experimental conditions and methods applied, the crude protein extract of dali ni horbo did not exhibit antimicrobial activity against the tested bacterial and fungal species. Further studies involving protein purification, bioactive peptide isolation, and alternative liquid-based susceptibility assays are recommended.
The association between anxiety, daily behaviors, and insomnia among university students Ismardi, Dita Anisa; Edlin, Edlin; Lubis, Yolanda Eliza Putri; Davin, Radhitya Qowiyyul; Ishak, Muhammad Raihan
Buletin Kedokteran & Kesehatan Prima Vol. 5 No. 1 (2026): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v5i1.7890

Abstract

Background: Insomnia is a common problem among university students and is often associated with psychological factors such as anxiety and modifiable daily behaviors. This study aimed to examine the relationships between anxiety levels, specific daily habits (including caffeine consumption, physical activity, and academic stress), and the occurrence of insomnia among students aged 20 to 25 years at Universitas Prima Indonesia. Methods: An observational analytic study with a cross-sectional design was conducted in May 2025. A total of 94 students participated as respondents. Data were collected using structured questionnaires, including the Hamilton Anxiety Rating Scale (HAM-A) and the Insomnia Severity Index (ISI). The chi-square test was applied to analyze the associations between variables. Results: Most respondents were female (61.7%) with a mean age of 21.21 years. Descriptive analysis showed trends suggesting that higher anxiety and physical activity levels were associated with increased insomnia rates. However, statistical analysis revealed no significant relationship between anxiety and insomnia (p = 0.203) or between physical activity and insomnia (p = 0.190). In contrast, caffeine consumption showed a statistically significant association with insomnia severity (p = 0.006). Conclusion: Although anxiety and physical activity were not significantly related to insomnia in this study, caffeine consumption was identified as a significant modifiable risk factor. These findings emphasize the need for targeted health education programs to improve sleep hygiene among students, particularly by addressing caffeine intake to enhance sleep quality.
Antidiabetic potential of andaliman: Histopathological and glycemic improvements in diabetic rats Simbolon, Boyke Marthin; Lina, Juliana; Saragih, Ayu Theresia
Buletin Kedokteran & Kesehatan Prima Vol. 5 No. 1 (2026): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v5i1.7891

Abstract

Background: Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia and pancreatic dysfunction, particularly involving the Islets of Langerhans. Andaliman (Zanthoxylum acanthopodium) is a plant rich in flavonoids and antioxidants, which are believed to have antidiabetic effects. This study aimed to evaluate the effectiveness of the ethanol extract of Andaliman fruit on pancreatic histopathology in alloxan-induced diabetic rats. Methods: This study employed a true experimental design with a pre-test and post-test control group structure. Twenty-four male Wistar rats were randomly assigned to six groups: a normal control, a positive control (metformin 9 mg/kg), a diabetic control (alloxan 90 mg/kg), and three treatment groups induced with alloxan followed by administration of Andaliman extract at doses of 150, 250, and 350 mg/kg body weight, respectively. Treatments were administered for 14 days, after which blood glucose analysis (pre- and post-treatment) and pancreatic histopathological assessments were performed. Results: Statistical analysis revealed a significant reduction in blood glucose levels following treatment (p = 0.001). Histopathological examination showed that Andaliman extract ameliorated alloxan-induced damage to the Islets of Langerhans. The 350 mg/kg body weight dose resulted in the most pronounced tissue regeneration compared to the other treatment groups. Conclusion: The ethanol extract of Andaliman fruit effectively improves pancreatic histopathology and lowers blood glucose levels in diabetic rats.
Factors influencing infant basic immunization uptake at Bestari Community Health Center, Medan Simangunsong, Pahala Maringan Jubel; Wau, Herbert; Gulo, Lincewan Lestari
Buletin Kedokteran & Kesehatan Prima Vol. 5 No. 1 (2026): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v5i1.7970

Abstract

Background: Immunization is one of the most effective public health interventions for preventing infectious diseases and reducing mortality rates. However, complete basic immunization coverage in Indonesia, particularly in North Sumatra, remains suboptimal. This study aimed to analyze the relationship between maternal characteristics (age, education, employment, knowledge, and attitudes) and the provision of complete basic immunization for infants at the Bestari Community Health Center in Medan. Methods: The research employed an analytical survey with a cross-sectional approach involving 60 mothers visiting integrated health posts in November 2022. Data were collected via questionnaires and analyzed using the chi-square test. Results: Results indicated significant associations between maternal age (p = 0.002), education level (p = 0.003), employment status (p = 0.000), knowledge (p = 0.000), and attitudes (p = 0.000) with infant immunization completeness. Conclusion: The study concludes that sociodemographic factors and maternal understanding play crucial roles in immunization coverage.

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