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INDONESIA
Indonesian Journal of Cancer
Published by National Cancer Center-Dharmais Cancer Hospital
ISSN : 19783744     EISSN : 23556811     DOI : https://www.doi.org/ 10.33371
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health
Indonesian Journal of Cancer is a peer-reviewed and open-access journal. This journal is published quarterly (in March, June, September, and December) by Dharmais Cancer Hospital - National Cancer Center. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted acceptance for publication. The journal publishes original research articles, case reports, and review articles under the following categories: cancer management, cancer prevention, cancer etiology, epidemiology, molecular oncology, cancer diagnosis and therapy, tumor pathology, surgical oncology, medical oncology, radiation oncology, interventional radiology, as well as early detection.
Arjuna Subject : Kedokteran - Onkologi
Articles 18 Documents
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Search results for , issue "Vol 18, No 1 (2024): March" : 18 Documents clear
Performance of Pre-Operative IOTA Three-Step Algorithm in Detecting Ovarian Carcinoma in a Referral Center in Indonesia Kurniadi, Andi; Permadi, Wiryawan; Kusuma, Aria Yusti; Kireina, Jessica; Andarini, Mia Yasmina; Winarno, Gatot Nyarumenteng Adhipurnawan; Harsono, Ali Budi
Indonesian Journal of Cancer Vol 18, No 1 (2024): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i1.1044

Abstract

Background: To assess the diagnostic performance of a three-step algorithm using the International Ovarian Tumor Analysis (IOTA) Group ‘simple rules’, ‘simple descriptors’, and Assessment of Different NEoplasias in the adneXa (ADNEX) model for discriminating benign and malignant adnexal masses. Methods:  This was a retrospective observational study, performed at a tertiary-care university hospital, on women diagnosed with adnexal mass on ultrasonography from January 2021 and February 2022. The examiner first classified the mass using ‘simple descriptors’ (first step) and, if not possible, using ‘simple rules’ (second step). For inconclusive masses, an assessment using the ADNEX model was done as the third step. All masses were managed surgically. Histopathology results were used as the reference standard.Results: One hundred and forty-one women were included (median age of 48 years). Histopathology results showed 104 (73.76%) mass to be malignant, and 37 (26.24%) mass to be benign. Twelve (8.51%) of 141 masses could be classified using simple descriptors, 89 (63.12%) masses were classified using simple rules, and 40 (28.37%) masses were classified using the ADNEX model. Overall accuracy, sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, and negative likelihood ratio of the three-step algorithm were 89.36%, 94.23%, 75.68%, 91.59%, 82.35%, 3.87, and 0.08 respectively.Conclusions: The IOTA three-step algorithm, based on the sequential use of simple descriptors, simple rules, and ADNEX model, performs well for classifying adnexal masses as benign or malignant
A Rare Parathyroid Carcinoma in Young Adult Man: Therapeutic Challenges in Tertiary Hospital with its Limitations Sitanggang, Rupita Sari Endangena; Azhar, Yohana; Agustina, Hasrayati
Indonesian Journal of Cancer Vol 18, No 1 (2024): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i1.1172

Abstract

Introduction: Parathyroid carcinoma is a rare malignant neoplasm. The symptoms that arise are related to hyperparathyroid conditions, which are clinically difficult to distinguish between benign and malignant disorders. These conditions make the diagnosis and treatment of parathyroid carcinoma challenging. Case Presentation: : In this case report, a 27-year-old male presented with weak limbs and a history of multiple recurrent fractures. Serum calcium ions and parathyroid hormone levels were increased. A comprehensive history taking, laboratory testing, and radiographic examination were used to confirm the diagnosis of parathyroid cancer. However, a histological study is still necessary to make a certain diagnosis. The patient underwent parathyroidectomy accompanied by intraoperative frozen section examination, then confirmed to have parathyroid carcinoma. Calcium serum evaluations were performed on the patient after surgery. Conclusions: Parathyroid carcinoma is a very rare case. Clinical manifestations and the results of investigations that are not typical and rarely found together in one patient’s condition make the diagnosis of this case very difficult. Although recommendations or standard protocols in the management of parathyroid carcinoma do not yet exist, the results of case reports are expected to increase the knowledge and management of parathyroid carcinoma patients.
Profile of Thyroid Cancer at Dr. Kariadi General Hospital Semarang in 2020 Sudarmanto, Alif Muhammad; Prajoko, Yan Wisnu; Istiadi, Hermawan; Yudhanto, Eka
Indonesian Journal of Cancer Vol 18, No 1 (2024): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i1.1017

Abstract

Background: Thyroid cancer is ranked ninth among the most common type originating from the endocrine glands globally, accounting for approximately 59.7% of cases in Asia. According to 2020 health data, thyroid cancer ranked twelfth in Indonesia, comprising 13,114 cases. Despite the number of cases recorded, there is a lack of comprehensive data regarding the condition of thyroid cancer in the country. Therefore, this research aimed to describe the thyroid cancer profile in Dr. Kariadi General Hospital Semarang.Methods: This descriptive research was carried out using 154 medical records selected through consecutive sampling from Dr. Kariadi General Hospital Semarang from January to December 2020. Categorical scale data were described through frequencies and percentages, while numerical scale data were presented as mean and standard deviation.Results: This research discovered that 57.8% of patients belonged to the 40–59-year-old age group, predominantly consisting of 79.9% females. Additionally, 39.6% of patients had normal thyroid function, with Papillary Thyroid Cancer being the most common type, constituting 92.7% of cases. The results showed that 46.8% of cases were bilateral, 37.7% had a condition of T3, 59.7% had N0, and 89.6% had M0, while 66.2% were classified as stage I.Conclusions: The majority of thyroid cancer patients were 45–64 years old and female. The results showed Papillary Thyroid Cancer as the most prevalent type, with the majority of cases diagnosed at stage I and showing bilaterally presentation. Most of the data correlated with previous research, except thyroid function and histopathology-type percentages.
Cerebral Tuberculomas Mimicking A Brain Tumor: Report of Two Cases Gill, Arwinder Singh; Firdaus, Muhammad; Sugiarto, Yosafat Kurniawan; Rayhani, Farilaila; Andriani, Rini; Faried, Ahmad
Indonesian Journal of Cancer Vol 18, No 1 (2024): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i1.1084

Abstract

Introduction : Cerebral tuberculoma, a seldom encountered and severe manifestation of tuberculosis (TB), arises from the dissemination of Mycobacterium tuberculosis through the bloodstream. Its symptoms and radiological characteristics lack specificity, often resulting in diagnostic errors. Management predominantly involves medical intervention, with the treatment duration for cerebral tuberculoma ranging from 6 to 36 months. In specific instances, surgical intervention may be advised. Case presentation: We reported two cases of cerebral tuberculoma occurring in patients who presented with seizures, with space-occupying lesions evident on magnetic resonance imaging of the brain. There were no symptoms of concurrent extra cranial TB. Surgery was performed on both of the cases and anti-TB treatment began as soon as the diagnosis was made with corticosteroid as adjuvant treatment. Conclusion: : A combination of clinical, radiological, and histopathological examination is needed to confirm the diagnosis and determine the appropriate therapy. If ICP is increased as a result of the lesion and medical therapy has failed, surgical excision is required.
Diffused Pulmonary Uptake of Tc-99m Methylene Diphosphonate Bone Scan in Patient with Prostate Cancer without Blood Test and Correlative/Cross-Sectional Imaging Abnormalities: A Case Report Imaniar, Junan; Suh, Minseok; Dewi, Ayu Rosemeilia; Tuti, Yustia
Indonesian Journal of Cancer Vol 18, No 1 (2024): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i1.1063

Abstract

Introduction: Bone scan using Tc-99m methylene diphosphonate (MDP) is a commonly used procedure for evaluating bone metastasis in cancer patients. Extra-osseous pulmonary uptake in bone scans is mostly an incidental finding and occurs in a multitude of disorders. Clinicians should be alert to any findings on clinical or complementary diagnostic tools. We presented a case of prostate cancer male patients who demonstrated diffuse pulmonary uptake on Tc-99m MDP bone scan without any blood test and correlative/cross-sectional imaging abnormality Case Presentation: An 80-year-old male with adenocarcinoma of the prostate with a Gleason score of 6 (3+3). The PSA level was 0.009. The patient had a history of recurrent atrial fibrillation (AF), postural dizziness, HTN, Gout, and chronic renal failure, but all of these comorbidities were under control. The patient underwent a bone scan to annually check for the presence of bone metastases. Three hours after administering 740 MBq Tc-99m MDP intravenously. The reports didn’t show any increased uptake that would indicate metastases in the bones. Instead, diffuse bilateral pulmonary uptake and a mild increase in cardiac uptake were present. On the same day, a computed tomography (CT) scan of the thorax revealed 3 micro-nodules in the right upper lung that were described as benign lesions, and a chest X-ray confirmed normal results. The patient’s laboratory results were within normal range, and there were no clinical lung symptoms or complaints. Considering the patient history of persistent AF, chronic renal failure, and a complaint of postural dizziness, the bone scan finding may indicate involvement of amyloidosis. The relationship between amyloidosis and cancer was also widely noted. Conclusions: Tc-99m MDP may play a role in evaluating amyloidosis involvement in an uncommon place such as the lungs. Future research should focus on analyzing diagnostic options in the patient’s condition in this situation. Keywords: cancer, diffused pulmonary uptake, amyloidosis, bone scan
A Qualitative Study To Explore the Impact of Having Children with Cancer and Parental Adjustment Nurhidayah, Ikeu; Nurhaeni, Nani; Allenidekania, Allenidekania; Gayatri, Dewi; Hendrawati, Sri
Indonesian Journal of Cancer Vol 18, No 1 (2024): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i1.1048

Abstract

Background: Cancer diagnosis in children impacts not only the children themselves but also their parents, and the role of providing support during the treatment process is crucial. The illness’s complexity, the diagnosis process, and the course of treatment can have various effects on parents and family life. To cope with the challenges of caring for their chronically ill children, families adopt a normalization process to restore their routines. Therefore, this study aims to investigate the implications of a childhood cancer diagnosis on families and how parents normalize their daily lives in the face of this difficult situation. Methods: The study was a qualitative study conducted in a pediatric cancer shelter house in Bandung, Indonesia, from May to August 2018. Ten parents who had children with cancer were included in the study. Data were collected through interviews and thematically analyzed.  Results: This study yielded five themes: 1) parents’ negative feelings when children are first diagnosed with the illness, 2) various changes in the family’s life, 3) the impact on the family’s quality of life, 4) family’s extra effort to overcome the illness’s impact and 5) parents’ expectations for social support. Conclusions: Cancer in children has a significant impact on the lives of the entire family, particularly parents. Normalizing the lives of parents who have children with cancer entails several adaptation or adjustment tasks. Nurses can assist families in adapting by guiding how to deal with the changes they are experiencing and accepting this as the new normal. Nurses can help families normalize their daily routines, provide social support, improve coping strategies, increase family closeness, and identify the source of support from other families or the community.
Neutrophil to Hemoglobin Lymphocyte Ratio (NHLR) as a Novel Biomarker is Superior to Neutrophil Lymphocyte Ratio (NLR) and Platelet Lymphocyte Ratio (PLR) as Predictors of Advanced Colorectal Cancer Purnomo, Heri; Handaya, Yuda; Setyawan, Nurcahya
Indonesian Journal of Cancer Vol 18, No 1 (2024): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i1.1099

Abstract

Background: Neutrophils, Hemoglobin, and Lymphocytes are biological markers that may be related to the colorectal cancer stage. Neutrophils to Hemoglobin-Lymphocytes Ratio (NHLR) is a new biomarker that will be tested with Neutrophil Lymphocyte Ratio (NLR) and Platelet Lymphocyte Ratio (PLR) as common biomarkers that have been shown to have predictive value with colorectal cancer stage. This study aims to prove NHLR as a new biomarker that can predict advanced colorectal cancer in terms of staging and site of cancer compared to NLR and PLR. Methods: This is a retrospective cross-sectional study. Data obtained from the medical records of colorectal cancer patients undergoing surgery at Dr Sardjito Hospital from 2020 until 2022. Results: 386 patients enrolled in the study, and 62 patients met the inclusion criteria. Twentyeight patients (45.16 %) were male, and 34 (54.84 %) were female. The mean age is 58.82 years. Bivariate analysis showed a significant relationship between NHLR, NLR, and PLR with colorectal cancer stage and significant differences between NHLR and NLR with early and advanced colorectal cancer, but not with PLR. There are also significant differences between NHLR, NLR, and PLR with colorectal cancer sites in the colon and rectum. Still, in locally advanced stages of colorectal cancer, there is no significant association between NLR and cancer sites. On the contrary, there are significant differences between colon and rectal cancer sites with NHLR and PLR. Conclusions: NHLR is superior to NLR and PLR in predicting the stage and site of advanced colorectal cancer.
The Impact of COVID-19 Pandemic on Ocular Oncology Services at Cipto Mangunkusumo Hospital, Indonesia Anggraini, Neni; Nursanti, Hanifah Rahmani; Mahyuddin, Mutmainah
Indonesian Journal of Cancer Vol 18, No 1 (2024): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i1.1011

Abstract

Background:: Delay of diagnosis and treatment in ocular oncology services due to the COVID-19 pandemic is very disadvantageous. This study aimed to evaluate the impact of COVID-19 on new patients with suspected eye tumors in terms of volume, characteristics, and waiting time for a procedure. Methods: : A retrospective study based on hospital records of new patients was held in the ocular oncology clinic of Cipto Mangunkusumo Hospital, a tertiary eye care center in Jakarta, Indonesia. Patients were analyzed descriptively based on three time periods: pre-COVID-19, COVID-19 social restriction, and post-COVID-19 social restriction. Each patient was stratified according to case priority during the COVID-19 pandemic suggested by Indonesia’s Ophthalmologist Association (IOA). Results: During the COVID-19 social restriction between March to June 2020, new patient volume decreased by 73.1%, with a 75.5% decline in referrals from the governmental hospital. Elderly, pediatric, and highly educated patients were less likely to visit the clinic. Patients with acute onset, invasive or metastatic tumors, and advanced T-stage were more likely to be referred to the hospital. Third-priority cases referred with a lower ratio during COVID-19 social restriction (29% vs 44.9% in pre-COVID-19 and 35.1% in post-COVID-19 social restriction) and had to wait longer for the procedure (41 (18–60) days vs 28.5 (11–63) days in pre-COVID-19 and 16.5 (7–67) days in post-COVID-19 social restriction). Conclusions: : As the healthcare service was overwhelmed by COVID-19 patients, referral to ocular oncology services was severely disrupted, particularly in elderly, pediatric, and early T-stage patients. Strategies are needed to ensure that highly prioritized cases may access the services.
Total Knee Replacement of Synovial Haemangioma of The Knee Joint in a 44-Year-Old Male: A Case Report Idulhaq, Mujaddid; Saputra, Rhyan Darma; Wasita, Brian; Sabariyah, Lely; Gardjito, Fajar Baskoro; Nursulistyo, Fajar
Indonesian Journal of Cancer Vol 18, No 1 (2024): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i1.911

Abstract

Introduction: Synovial hemangioma is a rare illness frequently misdiagnosed, leading to years of inaction. In this study, we aim to discover the consequences of untreated hemangioma of the knee joint. Case Presentation: Our patient was a 44-year-old male who experienced recurring pain in his left knee. The previous year, the patient experienced pain in his left knee while walking, which has subsided with rest. Although he has been performing radiography at multiple hospitals since 2019, no problems have been recorded. We detected a mass after performing magnetic resonance imaging. The T1-weighted sequence + contras near the medial femoral condyle revealed a homogeneous mass with high intensity. We decided to conduct surgical intervention and total knee replacement. Postsurgical, the patient regained symptom-free. Conclusions: Because of the limited radiographic capacity, synovial hemangioma is uncommon and challenging to diagnose on an outpatient basis. Magnetic resonance imaging and angiography are highly beneficial. If intraarticular hemangiomas are not considered, they can cause bony dysplasia and multiple clinical manifestations. Initial total excision can be conducted to decrease the chance of hemarthrosis.
Differentiation of Serous and Non-serous Epithelial Ovarian Cancer by Radiological Imaging Yudistiarta, Devina; Dhamiyati, Wigati; Choridah, Lina
Indonesian Journal of Cancer Vol 18, No 1 (2024): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i1.1007

Abstract

Background: Ovarian cancer has a high incidence and fatality rate, with the most prevalent type is epithelial origin. The serous subtype of epithelial cancer predominates. For therapy selection, it is important to differentiate this subtype by histopathological examination as a gold standard method. Since some patients are not eligible for a biopsy, radiological modalities such as Magnetic Resonance Imaging (MRI) are superior in discriminating tissue compared to computed tomography (CT) or ultrasound. The use of the T1 weighted imaging (T1WI) and T2WI sequences can best differentiate between a cystic and a solid lesion. The goal of this study was to use radiological examination to assist in the identification of ovarian cancer.Methods: This cross-sectional study used secondary data from histopathology and MRI results from patients with ovarian cancer. Data was gathered utilizing electronic medical records in Dr. Sardjito Hospital between January 2017 and May 2022. The following MRI characteristics are evaluated including ascites, papillary projection, solid nodule, signal intensity of solid and cystic components, size, configuration, enhancement of contrast, and bilateral of the lesion.Results: Thirty-eight subjects made up the study’s sample, and 63% of them had serous subtypes. Bilateral lesion suggested a three times greater likelihood that it was serous ovarian cancer (p 0.02; binary logistic regression). Age 50 years old and strong enhancement on contrast was also relevant for separating the serous subtype from other subtypes (enhancement p 0.02; age p 0.044). Conclusions: A bilateral lesion with a significantly enhanced pattern can be seen on the MRI of a serous subtype of epithelial ovarian cancer. The elderly are also more likely to develop this cancer.

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