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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Biomedika Paediatrica Indonesiana Journal Orthopaedi and Traumatology Surabaya (JOINTS) Indonesian Journal of Cancer Indonesian Journal of Biomedicine and Clinical Sciences
Idulhaq, Mujaddid
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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GIANT CELL TUMOR OF THE RIGHT DISTAL FEMUR REGION IN A MALE 25 YEARS OLD WITH HIV POSITIVE (RARE CASE) Riyadli, Muhammad; Idulhaq, Mujaddid; Utomo, Pamudji
Biomedika Vol 11, No 2 (2019): Biomedika Agustus 2019
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v11i2.8279

Abstract

Giant cell tumor (GCT) with Human Immunodeficiency Virus (HIV) infection is a rare case. At present, few literatures reported about GCT with HIV positive patients and there are no effective treatments of this disease currently. The aim of this article is to report the change the surgical treatment from limb salvage (wide excision and endoprostheses) to another way limb salvage (wide excision and knee arthrodesis) to minimize risk and further complication. A case of male, 25 years old, with diagnosis GCT of the right distal femur with HIV positive. In this case we administered antiretroviral treatment (ARV) and planned to limb salvage surgery (wide excision and knee arthrodesis).We follow up this patient in the first 4 weeks. There were no complaints, good postoperative wounds, no signs of infection, and histopathological examination postoperative showed the positive results of a GCT. The conclusion the surgical treatment from limb salvage (wide excision and endoprostheses) to another way limb salvage (wide excision and knee arthrodesis) could minimize risk and further complication.Keywords: Giant Cell Tumor, HIV,Limb Salvage Surgery, Wide Excision, Arthrodesis KneeGiant Cell Tumor (GCT) disertai dengan infeksi Human Imminodeficiency Virus (HIV) merupakan kasus yang jarang terjadi. Pada saat ini hanya sedikit literatur yang melaporkan kejadian pasien GCT dengan HIV positif dan belum ada standar terapi yang efektif. Tujuan dari artikel ini adalah melaporkan penggantian penatalaksanaan operatif sebelumnya berupa limb salvage (eksisi luas dan pemasangan endoprosthesis) menjadi eksisi luas dan arthrodesis knee untuk meminimalisir risiko dan kompikasi lebih lanjut. Kasus seorang laki-laki usia 25 tahun dengan diagnosis GCT pada distal femur kanan dengan infeksi HIV positif. Pada kasus ini, terapi yang diberikan adalah Anti Retroviral (ARV) dan operatif dengan limb salvage (eksisi luas dan arthrodesis lutut). Follow up pasien ini pada 4 minggu pertama post operasi. Keluhan nyeri berkurang, luka operasi baik, tidak ada tanda infeksi dan pemeriksaan histopatologi menunjukkan hasil GCT.Kesimpulannya bahwa penatalaksanaan operatif sebelumnya berupa limb salvage (eksisi luas dan pemasangan endoprosthesis) menjadi eksisi luas dan arthrodesis knee dapat meminimalisir risiko dan kompikasi lebih lanjut. Kata Kunci: Giant Cell Tumor, Hiv, Limb Salvage, Eksisiluas, Arthrodesis Lutut
ANEURYSMAL BONE CYST (ABC) IN FIFTH METACARPAL RIGHT HAND OF A MALE CHILD WITH HEMOPHILIA TREATED BY STEROID INJECTION: A CASE REPORT Wahyudi, Agus; Idulhaq, Mujaddid; Saputra, Rhyan Darma; Utomo, Pamudji
Biomedika Vol 12, No 2 (2020): Biomedika Agustus 2020
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v12i2.10541

Abstract

ABSTRACTAneurysma bone cyst (ABC) is a rare case, rapidly growing, and destructive benign bone tumor that rarely involves the bones of the hand. Pathogenesis of these tumors remains controversial and may be vascular, traumatic, or genetic disorders.  This study aimed to evaluate patient’s out come after steroid injection. A male child presented with a history of pain and local swelling over his fifth metacarpal right hand of two months duration with hemofilia condition. Physical and radiographic examination of the hand was consistent with aneurysmal bone cyst. The patient the VIII factor 2 hours before doing steroid injection on his lump over fifth metacarpal right hand. A month evaluation after injection for this patient, we had a good result clinically and radiologically. Radiological evaluation obtained appearance of cortex thickening on the bone affected. We concluded that steroid injection should be considered as one of ABC’s treatment with hemophilia, but the outcome still needed more evaluation.  Keywords: Aneurysmal Bone Cyst, Hemophilia, Steroid Injection ABSTRAK Kista tulang aneurisma adalah kasus yang jarang terjadi, tumbuh dengan cepat, dan tumor tulang jinak destruktif yang jarang melibatkan tulang-tulang tangan. Patogenesis tumor ini masih kontroversial dan mungkin bersifat kelainan vaskular, traumatis, atau genetik. Penelitian ini bertujuan untuk mengevaluasi pasien setelah injeksi steroid. Seorang anak laki-laki dengan riwayat nyeri dan pembengkakan lokal pada metacarpal kelima tangan kanannya selama dua bulan dengan kondisi hemofilia. Pemeriksaan fisik dan radiografi tangan menegakkan adanya kista tulang aneurisma. Pasien diberi faktor VIII 2 jam sebelum injeksi steroid pada benjolan di atas metacarpal kelima tangan kanannya. Evaluasi sebulan setelah injeksi untuk pasien ini, kami memiliki hasil yang baik secara klinis dan radiologis. Evaluasi radiologis diperoleh penampilan penebalan korteks pada tulang yang terkena. Kami menyimpulkan bahwa injeksi steroid harus dipertimbangkan sebagai salah satu pengobatan kista tulang aneurisma dengan hemofilia, namun hasilnya masih perlu evaluasi lebih lanjut.Kata kunci: Kista Tulang Aneurisma, Hemofilia, Injeksi steroid
Osteokondroma Raksasa Pada Rami Pubis: Laporan Kasus Idulhaq, Mujaddid; Utomo, Pamudji; Jiwandono, Bayu Sakti; Tulandi, M qathar RF Tulandi
JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 8 No. 2 (2020): JAMBI MEDICAL JOURNAL Jurnal Kedokteran Dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (297.109 KB) | DOI: 10.22437/jmj.v8i2.10451

Abstract

ABSTRAK Pendahuluan Osteokondroma adalah tumor tulang jinak yang paling umum. Osteokondroma merupakan malformasi perkembangan daripada neoplasma sejati.Osteokondroma biasanya mempengaruhi tulang yang berkembang oleh osifikasi endokondral dan jarang berasal dari tulang yang berkembang secara osifikasi intramembran seperti tulang rami pubis, skapula, klavikula, dan tulang rusuk. Objektif Makalah ini dimaksudkan untuk menyajikan kasus osteokondroma pubis yang jarang terjadi dan mengevaluasi hasil setelah eksisi luas. Kasus Seorang pria 34 tahun dengan benjolan di daerah selangkangan kanan mengeluh selama 10 tahun. Di RSO Prof Soeharso, pasien menjalani eksisi lebar ramus pubis kanan, di mana banyak struktur berbahaya yang harus dihindari. Kami mendapatkan seluruh jaringan tumor dengan diameter 12 sentimeter. Menurut Konferensi Klinikopatologi tumor disimpulkan sebagai osteokondroma. Lokasi tumor dan presentasi klinis jarang terjadi. Tumor ini tidak memiliki keterlibatan viseral atau vaskular meskipun lesi tersebut sangat dekat dengan banyak struktur vital pada ramus pubis superior. Hasil Setelah 1 tahun evaluasi, kondisi klinis pasien baik. Pasien tidak merasakan keluhan apapun, tidak ada tanda-tanda kambuh, dan tidak ada komplikasi pada luka operasi. Kesimpulan Kami telah melakukan eksisi ekstensif tumor di ramus pubis pria berusia 34 tahun. Hasil pemeriksaan histopatologi sesuai dengan gambaran osteokondroma. Osteokondroma yang muncul dari panggul adalah presentasi yang tidak biasa yang harus diingat sebagai diagnosis banding saat mengevaluasi pasien dengan massa di panggul.
Survival and prognostic factors in pediatric osteosarcoma: A 5-year single-center experience in Central Java, Indonesia Riza, Muhammad; Salimo, Harsono; Wasita, Brian; Idulhaq, Mujaddid; Saputra, Rhyan Darma; Widyaningsih, Vitri; Soestrisno, Soestrisno; Zahidah, Fairuz; Wayanshakty, Janur
Paediatrica Indonesiana Vol. 64 No. 1 (2024): January 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.1.2024.10-6

Abstract

Background The advent of chemotherapy with multimodal treatment has improved the survival rate of osteosarcoma. However, the survival rate of patients with osteosarcoma in low- and middle-income countries (LMICs) remains lower than in high-income countries (HICs). Objective To assess prognostic factors associated with survival rate of pediatric patients with osteosarcoma in Moewardi Hospital, Surakarta. Methods This retrospective study was performed in pediatric osteosarcoma patients at Moewardi Hospital, Surakarta from 2018 to 2022. We described patients’ clinical presentations and assessed prognostic factors. Survival rate was calculated using Kaplan–Meier survival analysis. Prognostic factors were analyzed using univariate and multivariate Cox regression methods. Results Of the 82 patients included in the study, 40 (48.8%) were male and 42 (51.2%) were female. Most subjects (75.6%) were diagnosed with osteosarcoma at the age of >10 years, 45 patients (54.9%) had primary tumors in the femur, and 16 patients (19.5%) had limb salvage surgery. The mean event-free survival duration was 13.6 (95%CI 9.7 to 17.5) months. The mean duration of overall survival was 22.7 (95%CI 17.3 to 28.1) months, with a 44.1% survival probability. Type of surgery was a significant prognostic factor (P=0.018), with limb salvage having better survival probability (93.3%) than amputation (19.8%). Conclusion The overall survival rate of osteosarcoma patients at our center is still lower than in other regional centers. Limb salvage surgery was a significant prognostic factor for survival, while gender, location of primary tumor, histological subtype, and metastasis at the time of diagnosis were not.
Total Knee Replacement of Synovial Haemangioma of The Knee Joint in a 44-Year-Old Male: A Case Report Idulhaq, Mujaddid; Saputra, Rhyan Darma; Wasita, Brian; Sabariyah, Lely; Gardjito, Fajar Baskoro; Nursulistyo, Fajar
Indonesian Journal of Cancer Vol 18, No 1 (2024): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i1.911

Abstract

Introduction: Synovial hemangioma is a rare illness frequently misdiagnosed, leading to years of inaction. In this study, we aim to discover the consequences of untreated hemangioma of the knee joint. Case Presentation: Our patient was a 44-year-old male who experienced recurring pain in his left knee. The previous year, the patient experienced pain in his left knee while walking, which has subsided with rest. Although he has been performing radiography at multiple hospitals since 2019, no problems have been recorded. We detected a mass after performing magnetic resonance imaging. The T1-weighted sequence + contras near the medial femoral condyle revealed a homogeneous mass with high intensity. We decided to conduct surgical intervention and total knee replacement. Postsurgical, the patient regained symptom-free. Conclusions: Because of the limited radiographic capacity, synovial hemangioma is uncommon and challenging to diagnose on an outpatient basis. Magnetic resonance imaging and angiography are highly beneficial. If intraarticular hemangiomas are not considered, they can cause bony dysplasia and multiple clinical manifestations. Initial total excision can be conducted to decrease the chance of hemarthrosis.
Umbilical cord mesenchymal stem cells and their secretome in peripheral nerve regeneration: a narrative review promising therapeutic strategy Sumarwoto, Tito; Hadinoto, Seti Aji; Romaniyanto; Rhatomy, Sholahudin; Utomo, Pamudji; Idulhaq, Mujaddid; Santoso, Asep; Suroto, Heri
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 4 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i4.24055

Abstract

The injuries of peripheral nerves remain a substantial clinical challenge because of their limited regenerative capacity, the complexity of nerve repair, and limitations of current treatment strategies. Umbilical cord mesenchymal stem cells (UC-MSCs) and their secretome have shown promise as regenerative treatments due to their distinct biological characteristics. This review explores the possibility of UC-MSCs and their secretome in promoting peripheral nerve regeneration, by their action mechanisms, therapeutic applications, and current preclinical - clinical evidence. UC-MSCs have proven to be capable of support Wallerian degeneration, improving axonal growth, reducing inflammation, and improving functional recovery in both animal models and early clinical studies. Their secretome has been shown to promote neuroprotection and functional repair, avoiding the risks of receiving a direct stem cell transplant. Challenges remain in standardizing UC-MSC-based therapies, ensuring long-term safety, and enhancing delivery strategies. Further clinical trials are needed to determine the efficacy, safety, and scalability of UC-MSC therapies for widespread clinical use. UC-MSCs and their secretome provide a unique, cell-free and cell-based strategy to peripheral nerve regeneration. Future advancements in biomaterial integration, gene editing, and personalized medicine will be essential to implementing these treatments in clinical settings.
Biological Reconstruction with Liquid Nitrogen for Osteosarcoma of the Distal Tibia: A Case Report Idulhaq, Mujaddid; Gardjito, Fajar Baskoro; Wiranegara, Tanri Hadinata
(JOINTS) Journal Orthopaedi and Traumatology Surabaya Vol. 15 No. 1 (2026): April 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v15i1.2026.75-81

Abstract

Background: Osteosarcoma, a primary malignant bone tumor, typically requires limb salvage surgery to maintain function while ensuring complete tumor resection. This case report presents a rare instance of distal tibial osteosarcoma treated through biological reconstruction utilizing liquid nitrogen.Case Report: This report describes a 17-year-old female patient who was initially diagnosed with low-grade osteosarcoma via biopsy, but was later confirmed to have high-grade osteosarcoma after undergoing wide excision and reconstruction using a liquid nitrogen-treated autograft. After the extensive removal of the tumor, the resected bone was devitalized using liquid nitrogen, followed by treatment with liquid nitrogen, reimplantation, and stabilization using double-plate fixation.Discussion: This method significantly diminished the likelihood of local recurrence while restoring both the structural integrity and biological function of the bone defect. This case highlights the benefits of biological reconstruction, specifically the use of recycled autografts with liquid nitrogen, as a cost-effective and sustainable approach for limb preservation in osteosarcoma patients. Conclusion: In this instance, biological reconstruction utilizing liquid nitrogen demonstrated efficacy as a limb salvage method. Liquid nitrogen freezing and inactivation provide a precise and effective method for devitalizing tumor bone while maintaining structural integrity and biological potential.
Co-Authors Agus Wahyudi Andryanto, Aryo Budiyogo Brian Wasita Brilianto, Bagus Iman Gardjito, Fajar Baskoro Hadinoto, Seti Aji Harsono Salimo Heri Suroto Jiwandono, Bayu Sakti Muhammad Riza Nursulistyo, Fajar Rhatomy, Sholahudin Riyadli, Muhammad Romaniyanto Sabariyah, Lely Santoso, Asep Saputra, Rhyan Darma Satriadi, Anung Budi Soestrisno, Soestrisno Sumarwoto, Tito Tulandi, M qathar RF Tulandi Utomo, Pamudji Vitri Widyaningsih Wayanshakty, Janur Wiranegara, Tanri Hadinata Zahidah, Fairuz