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Indonesian Journal of Cancer

ijoc
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Published by National Cancer Center-Dharmais Cancer Hospital

ISSN : 19783744 EISSN : 23556811 DOI : https://www.doi.org/ 10.33371

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

Indonesian Journal of Cancer is a peer-reviewed and open-access journal. This journal is published quarterly (in March, June, September, and December) by Dharmais Cancer Hospital - National Cancer Center. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted acceptance for publication. The journal publishes original research articles, case reports, and review articles under the following categories: cancer management, cancer prevention, cancer etiology, epidemiology, molecular oncology, cancer diagnosis and therapy, tumor pathology, surgical oncology, medical oncology, radiation oncology, interventional radiology, as well as early detection.

Arjuna Subject : Kedokteran - Onkologi

Articles 562 Documents

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The Infection of COVID-19 among Health Care Workers in Dharmais Cancer Hospital Mutiara Adelina; Fifi Dwijayanti
Indonesian Journal of Cancer Vol 15, No 1 (2021): March
Publisher : National Cancer Center - Dharmais Cancer Hospital

Infectious diseases are one of the biggest threats to humans. Currently, the world is in the outbreak condition causes of the COVID-19 virus which is started from Wuhan, China in December 2019. This disease was spread out rapidly throughout the World and was announced as a pandemic by the World Health Organization (WHO) on March 11, 2020(1). The infected number of SARS-CoV-2 was over 84 million people and caused over 1 million death cases in the worldwide. Indonesia had more than 800.000 infectious cases and 23.000 of death cases with the highest cases in Jakarta (2). This virus can be transmitted by two ways, such as direct contact (cough, sneeze, and droplet inhalation) and contact transmission (contact with oral, nasal, and eye mucous membranes) of person with COVID-19 (3). The current COVID-19 pandemic makes various challenges in prevention and control of infections in hospitals. Health care workers (HCWs) have been providing care to suspected, probable or confirmed COVID-19 patients that make them in high-risk condition. Several study indicated that many HCWs have been infected with SARS-CoV-2 in many hospitals worldwide (4)(5)(6).

Aktifitas Caspase 3 sebagai Indikator Apoptosis pada Sel Kanker Ovarium Bambang Dwipoyono
Indonesian Journal of Cancer Vol 1, No 2 (2007): Apr - Jun 2007
Publisher : National Cancer Center - Dharmais Cancer Hospital

Kematian yang diakibatkan oleh kanker ovarium masih tetap tinggi meskipun sudah dengan penanganan yang agresif. Pemberian kemoterapi merupakan bagian penting selain tindakan operasi di dalam pengobatan kanker ovarium. Obat sitostatika yang digunakan bertujuan mempengaruhi DNA dan pada akhirnya memicu henti siklus sel dan apoptosis.Untuk mengetahui aktifitas caspase 3 sebagai indikator terjadinya apoptosis pada sel kanker ovarium setelah terpapar dengan sitostatika.Penelitian in vitro dengan memaparkan sel kanker ovarium primer yang berasal dari asi tes dan/atau "established" sel kanker ovarium dengan sitostatika dengan dosis dan waktu yang berbeda. Kemudian dilakukan perhitungan aktifitas caspase 3 dari kedua sel kanker ovarium tersebut.Penelitian ini dilakukan terhadap penderita kanker ovarium yang dilakukan operasi pada "Yale New Haven Hospital". Sel tumor yang berasal dari cairan asites menjalani isolasi dan kultur untuk mendapatkan kultur primer. Dilakukan pemaparan sel kanker ovarium primer dan "established" dengan carbo-platin dan docetaxel selama 24 dan 48 jam dengan dosis yang berbeda. Apoptosis yang terjadi diketahui dengan melihat aktifitas spesifik caspase 3 dari masing-masing kelompok sel kanker ovarium tersebut.Dari 11 pasien kanker ovarium stadium lanjut (III-IV, FIGO) dengan jenis epithelial didapatkan bahwa carboplatin dosis 100-400mg/ml dapat menginduksi aktifitas caspase 3 dari "established" sel kanker ovarium maupun sel kanker ovarium primer. Docetaxel dosis 5ng/ml dan 500ng/ ml juga dapat menginduksi aktifitas caspase 3 pada kedua kelompok sel kanker ovarium.Aktifitas caspase 3 dapat ditimbulkan dengan melakukan pemaparan sel kanker ovarium baik primer maupun "established" terhadap carboplatin dan docetaxel.

The Profile of Soft Tissue Sarcoma Patients who Undergo Radiotherapy in Dr. Hasan Sadikin General Hospital Bandung Antony Abel Adibrata; Marhendra Satria Utama; Adji Kusumadjati
Indonesian Journal of Cancer Vol 16, No 1 (2022): March
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Soft Tissue Sarcoma is one of the rare cancers that increased in number in the last few years, but information about soft tissue sarcoma patients was still limited, especially in West Java, Indonesia. This study aimed to find out the patient profile and the histopathological cell distribution of soft tissue sarcoma patients who undergo radiotherapy. Methods: The study design was retrospective descriptive quantitative with the total sampling method. This study was done by observing all patients’ medical records registered from January 1, 2018, until December 31, 2019, in the Hospital-Based Cancer Registry of Radiology Department of Dr. Hasan Sadikin General Hospital Bandung, with the inclusion criterion of patients diagnosed with soft tissue sarcoma. Results: A total of 5% (n = 75) from 1,388 cases registered were soft tissue sarcoma. The most common patient profile was female (57.3%) and age group 45–54 years (21.3%). The chief complaint was dominated by a painless mass (56.0%) at the lower limb (37.8%) with the most frequent cell of fibrosarcoma (17.3%), the most intention of the radiotherapy of curative adjuvant (78.7%). Conclusions: The number of soft tissue sarcoma is small compared to other malignancies. It is more common in women, the most age group is from 45 to 54 years with the median of 47 years old, ranging from 9 to 90 years, it tends to occur in the lower limb with a chief complaint of a painless mass, and the most frequent cell is fibrosarcoma. The common treatment combination is surgery with radiotherapy

Diffuse Large B Cell Lymphoma, Bilateral Lower Extremity Lymphedema, and Ulcerated Inguinal Lymph Node NATA PRATAMA HARDJO LUGITO; ANDREE KURNIAWAN; THEO AUDI YANTO
Indonesian Journal of Cancer Vol 8, No 1 (2014): Jan - Mar 2014
Publisher : National Cancer Center - Dharmais Cancer Hospital

Lymphedema (LE) is a chronic medical condition characterized by lymphatic fluid retention, resulting in tissue swelling. There are two general classifications of LE; primary and secondary which are based on two mechanisms; lymphatic obstruction and lymphatic interruption. The most common cause of LE in the developing world is secondary to an infection known as filariasis. Cancer including Hodgkin and non-Hodgkin lymphomas; and its treatment are some causes of secondary LE. LE also could maintain the persistence of an occult localization of lymphoma. This case illustration describes a female, 57 year-old with stage II lymphedema of both legs, bilateral inguinal lymphadenopathies that were biopsied. The filarial blood examination was negative. Biopsies showed diffuse large B-cell lymphoma.

Epidemiologi Kanker Serviks Imam Rasjidi
Indonesian Journal of Cancer Vol 3, No 3 (2009): Jul - Sep 2009
Publisher : National Cancer Center - Dharmais Cancer Hospital

Sampai saat ini, kanker mulut rahim masih merupakan masalah kesehatan perempuan di Indonesia sehubungan dengan angka kejadian dan angka kematiannya yang tinggi. Setiap tahun, di dunia terdapat 500.000 kasus baru kanker serviks dan lebih dari 250.000 kematian. Di Indonesia yang berpenduduk sekitar 220 juta jiwa, terdapat sekitar 52 juta perempuan yang terancam kanker serviks. Penyebab utama dari kanker serviks adalah infeksi HPV (Human Papilloma Virus). Proses terjadinya karsinoma serviks sangat erat hubungannya dengan proses metaplasia. Perubahan biasanya terjadi pada daerah sambungan skuamous kolumnar (SSK) atau daerah transformasi. Prognosis kanker serviks dibedakan berdasarkan kriteria morfometrik, penyebaran, serta usia.Kata kunci: epidemiologi deskriptif, riwayat alami, faktor prognostik, kanker serviks

Comparison of Nuclear Matrix Protein-22 and Urine Cytology in Diagnosing Bladder Cancer Mohamad Adi Soedarso; YinYin Wahyuni; Maria Immaculata Tjahjati
Indonesian Journal of Cancer Vol 12, No 3 (2018): July-September
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Urine cytology (UC) is a classic marker used to detect bladder malignancy through urine examination microscopically at the presence of malignant transitional cells that are released. UC is also used to evaluate recurrence after past treatment. A new method that is simpler, faster and easier is by measuring protein in urine produced by malignant cells, namely nuclear matrix protein-22 (NMP-22). The aim of this study was to compare the diagnostic value of NMP-22 and UC to histopathological biopsy in diagnosing bladder carcinoma and to evaluate whether the NMP-22 test could be used for bladder carcinoma screening and recurrence monitoring.Methods: Diagnostic tests on 24 suspected bladder malignancies were performed by taking urine samples for NMP22 examination and UC. Sensitivity, specificity, positive predictive value and negative NMP-22 and UC on histopathological biopsy were analyzed.Results: Positive results were obtained in 21 (87.5%) and negative in 3 (12.5%) NMP22 examinations. The sensitivity, specificity, positive and negative predictive values of NMP-22 on histopathological biopsy were 95%; 67%, 95%, 67%. Sensitivity, specificity,positive predictive value and negative UC on histopathological biopsy were 38.1%; 100%, 100%, 18.8%.Conclusions: NMP-22 sensitivity is higher than UC in diagnosing bladder carcinoma. NMP-22 can be used for bladder carcinoma screening and for recurrence monitoring

Hubungan antara Genotyping DNA Human Pappillomavirus (HPV) dengan Respons Terapi Radiasi pada Adenokarsinoma Serviks WIDYORINI LESTARI HARDJOLUKITO
Indonesian Journal of Cancer Vol 9, No 1 (2015): Jan - Mar 2015
Publisher : National Cancer Center - Dharmais Cancer Hospital

ABSTRACTThe object of this study to know the type of DNA Human Papilloma Virus genotyping in adenocarcinoma cervical cancer,espescially in Cipto Mangunkusomo Hospital and Cancer Centre Dharmais Hospital. The importance of humanpapilloma virus (HPV) infection in the outcome of cervical cancer after radiotherapy remains unknown. Our studyexplored whether the HPV status of tumors and also persistence of the HPV infection is related with the outcome ofradiotherapy in patients with cervical cancer.The biopsy cervix samples taken from 12 patients with Adenocarcinoma cervical cancer (Stage IIB-IIIB) that met in theinclusion criteria. The HPV genotyping examination was conducted twice, before and 3 month after radiation therapy. Thesubjects treated by radiation therapy without sensitizer according to standard procedures. After underwent completeradiation, response of radiation therapy was conducted by clinical assessment and repeated HPV genotyping test.Result: a total of 12 patients had been collected in this study. From this sample, there were found HPV-positive tumors in91,7% (11 cases ) of patients, with the details of a single infection of 75% and 16,7% multiple infections. Based on the typeof HPV type 18 was obtained (66,7%), type 45: 8,3%. Persistent infection with HPV after radiation encountered by 41,7%.Complete clinical responsse observed in the single infection group number of 66,7%, while in the group of multipleinfections by 50% (p = 1,000). While HPV infection settled with a complete clinical responsse by 16,7% (p = 0,015).There werent clinically relationships between clinical complete responsse with single or multiple HPV infection (p =1,000). There were clinically relationship between persistent HPV infection with complete clinical responsse (p = 0,015).Keyword: cervical cancer, genotyping HPV DNA, persistent infection, clinical responsseABSTRAKPenelitian ini bertujuan untuk mengetahui jenis genotipe DNA HPV pada kasus adenokarsinoma serviks , terutama diRSUPN Cipto Mangunkusumo dan RS Kanker Dharmais. Penelitian ini juga bertujuan untuk mengetahui hubunganantara genotipe DNA HPV dengan respons klinis radiasi serta mengetahui terjadinya infeksi HPV menetap responsklinis terapi radiasi.Dua belas penderita kanker serviks stadium IIB-IIIB dengan hasil histopatologi adenokarsinoma serviks sesuai dengankriteria inklusi dilakukan pemeriksaan genotipe HPV DNA yang berasal dari biopsi serviks. Sampel penelitian diberikantata laksana dengan terapi radiasi tanpa sensitizer sesuai prosedur standar. Tiga bulan setelah dinyatakan selesairadiasi, dilakukan penilaian respons klinis radiasi dan pemeriksaan genotipe DNA HPV ulang.Dari 12 sampel penelitian, didapatkan infeksi HPV sebelum radiasi 11 sampel (91,7%) dengan perincian infeksi tunggal75% dan infeksi multipel 16,7%. Berdasarkan tipe HPV, diperoleh infeksi tunggal tipe 18 (66,7%) dan tipe 45 (8,3%).Infeksi menetap HPV setelah radiasi, baik pada infeksi tunggal maupun multipel sebesar 41,7%. Respons klinis komplitdijumpai pada kelompok infeksi tunggal sejumlah 66,7%; sedangkan pada kelompok infeksi multipel sebesar 50%(p=1,000) dan infeksi HPV menetap dengan respons klinis komplit sebesar 20,0% (p=0,015). Penelitian ini menyimpulkan bahwa tipe HPV DNA terbanyak dijumpai pada penderita adenokarsinoma serviks adalah tipe 18, yaitu 83,4%. Infeksi HPV menetap setelah radiasi sebanyak 41,7%. Tidak terdapat perbedaan respons klinis antara infeksi tunggal dan infeksi multipel HPV, tetapi tidak terdapat hubungan yang signifikan (p=1,000). Infeksi menetap HPV berhubungan secara klinis dengan respons klinis terapi radiasi (p=0,015).Kata Kunci: kanker serviks, adenokarsinoma, tipe DNA HPV, infeksi HPV menetap, respons terapi.

Simultaneous Kidney and Liver Resection in Renal Cell Carcinoma Liver Metastases: A Tale of Two Cases Indah Jamtani; Adianto Nugroho; Syamsu Hudaya; Rofi Y. Saunar; Aditomo Widarso; Taslim Poniman
Indonesian Journal of Cancer Vol 14, No 4 (2020): December
Publisher : National Cancer Center - Dharmais Cancer Hospital

Introduction: Resection of renal cell carcinoma liver metastases (RCCLM) is known to provide a good survival outcome. Simultaneous RCCLM resection with the primary tumor is commonly done in cases with direct extension of locally advanced RCC to liver parenchyma. Cases of safe simultaneous resection of liver and kidney in malignancy have not been reported before in Indonesia. Case Presentation: We aim to describe two cases of left-sided RCC with right-sided RCCLM who underwent simultaneous kidney and liver resection. Both patients had good short-term survival with no intra-operative and post-operative complications.Conclusion: Although simultaneous kidney and liver resection poses challenges of substantial morbidity, a safe surgical and multidisciplinary approach could be implemented in selected cases with a good surgical outcome.

Gambaran Kualitas Hidup Anak Usia 6-18 Tahun yang Menjalani Kemoterapi di Rumah Sakit Kanker Dharmais, Jakarta Barat MURDINI UMIATI; WINDY RAKHMAWATI; BANGUN SIMANGUNSONG
Indonesian Journal of Cancer Vol 4, No 2 (2010): Apr - Jun 2010
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v4i2.83

Quality of life is defined as minimal presence of the adverse impact of treatment on the patients perceptions of his or her own functioning. This study is to describe the quality of life among children who received chemotherapy. Twenty two children of age 6 to 18 years of age participated in this study. Data was collected by using the Pediatric Cancer Quality of Life Inventory-32 (PCQL-32) total scale. The result was measured and analyzed by using T score, lower score indicated better quality of life. The most frequent children who received chemotherapy reported high quality of life, 53,3% for 6-12 years and 57,1% for 13-18 years. The result of this study provides information on social functioning which supports interventions for the children who received chemotherapy. The findings indicated the importance for the health worker to provide attention during treatment of the related symptoms, whether physical, psychological or cognitive functioning. Keywords: quality of life, children, chemotherapy

Uncommon Glomus Tumor at The Volar Area of Distal Phalang: a Case Report WAHYU WIDODO; ARYO NUGROHO TRIYUDANTO
Indonesian Journal of Cancer Vol 11, No 1 (2017): Jan-Mar
Publisher : National Cancer Center - Dharmais Cancer Hospital

ABSTRACTIntroduction: Glomus tumor, a benign rare neoplasmic perivascular lesion arising from glomus neuromial-arterial tissue. Glomus cells, which are found in the dermis throughout the body, are responsible for thermoregulation. In this tumor, its cells proliferate and surround the vascular canals, producing a classic clinical sign such as spontaneous pain, pain on light touching, and temperature hyperesthesia. Despite its rare occurrence, it is necessary to know how recognize and treat this variant of perionychium tumor. Case Illustration: A forty-seven-year old woman came with pain on the tip of her ring finger since 3 years before admission. Over time, the tingling sensation worsened and eventually pain emerged. The appearance of her ring finger and nail were normal. However, the patient felt pain after a light touch and paresthesia especially at the volar side of her ring finger. Having normal radiograph appearance, excisional biopsy was then performed. Histologic examination showed a well-defined lesion encapsulated by a fibrous capsule. The lesion consisted of several thin-walled flared vascular containments with layers of glomus cells around it, which is in accordance with characteristic of benign glomus tumor.At the latest follow up, there were no complication or recurrence found. The pain and paresthesia around the ring finger were also diminished. Conclusion: Despite its rare occurrence, the diagnosis of Glomus Tumor can be performed clinically. Excisional biopsy is the definitive treatment and specific diagnostic modality for Glomus Tumor.ABSTRAKGlomus tumor adalah tumor jaringan lunak yang cukup jarang ditemui dan merupakan lesi perivaskular yang muncul dari arteri glomus neuromial. Sel glomus berproliferasi dan mengelilingi kanal vaskular. Tumor ini sering ditemukan pada area subungual. Tanda khasnya adalah nyeri spontan, nyeri pada sentuhan ringan, dan sensitivitas terhadap suhu. Kemampuan mengenali dan mengobati tumor perionychium ini penting. Wanita usia 47 tahun datang dengan keluhan utama nyeri pada jari manis sejak 3 tahun lalu. Seiring waktu, sensasi kesemutan dan nyeri memburuk. Pada pemeriksaan fisik di regio distal phalang tidak ditemukan bengkak dan kemerahan, deformitas, atau massa. Kulit intak tanpa perubahan warna dengan sekitar. Kuku tampak normal. Pada palpasi didapatkan nyeri pada sentuhan ringan di area volar dengan VAS 4-5 dan paresthesia pada sisi volar. Pemeriksaan x-ray menunjukkan hasil normal. Pada pemeriksaan biopsi eksisional dan pemeriksaan histopatologi ditemukan lesi berbatas tegas yang terdiri atas kapsula fibrosa dengan beberapa lapis dinding dan vaskular serta sel glomus yang menutupinya. Tiga bulan pasca-operasi tidak ditemukan nyeri dan paresthesia pada lokasi tumor. Tumor glomus adalah tumor yang jarang dan dapat didiagnosis melalui tampilan klinis. Biopsi eksisional merupakan pengobatan definit, sekaligus modalitas diagnostik spesifik.

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Home Page

OAI Link

Editorial Team

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Reviewer

Google Scholar

Contact Name Bayu Brahma

Contact Email journal.cancer@gmail.com

Phone +628176389956

Journal Mail Official admin@indonesianjournalofcancer.or.id

Editorial Address National Cancer Center - Dharmais Cancer Hospital Research and Development Building, 3rd-floor Jl. Letjen S. Parman Kav. 84-86, Slipi West Jakarta

Location Kota adm. jakarta barat, Dki jakarta INDONESIA

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Abstract

Contact Name
Bayu Brahma

Contact Email
journal.cancer@gmail.com

Phone
+628176389956

Journal Mail Official
admin@indonesianjournalofcancer.or.id

Editorial Address
National Cancer Center - Dharmais Cancer Hospital Research and Development Building, 3rd-floor Jl. Letjen S. Parman Kav. 84-86, Slipi West Jakarta

Location
Kota adm. jakarta barat,

Dki jakarta

INDONESIA